DRSC/TRiP Functional Genomics Resources

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Protein Alignment crb and NOTCH3

DIOPT Version :9

Sequence 1:NP_001247284.1 Gene:crb / 42896 FlyBaseID:FBgn0259685 Length:2253 Species:Drosophila melanogaster
Sequence 2:NP_000426.2 Gene:NOTCH3 / 4854 HGNCID:7883 Length:2321 Species:Homo sapiens


Alignment Length:2012 Identity:494/2012 - (24%)
Similarity:678/2012 - (33%) Gaps:718/2012 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   226 LLDGPGLQFVNNSTVQNVVFGHCPLTPGPCSDHDLFTRLPDNFCLNDPCMGHGTCSSSP-EGYEC 289
            ||.|||                  ....||.|             ..||...|.|:..| ....|
Human    32 LLAGPG------------------AAAPPCLD-------------GSPCANGGRCTQLPSREAAC 65

  Fly   290 RCTARYSGKNCQKDNGSPCAKNPCENGGSCLEN---SRGDYQCFCDPNHSGQHCETEVNIHPLCQ 351
            .|...:.|:.||.::  ||...||...|.|..:   ....:.|.|.....|..|    ::...|.
Human    66 LCPPGWVGERCQLED--PCHSGPCAGRGVCQSSVVAGTARFSCRCPRGFRGPDC----SLPDPCL 124

  Fly   352 TNPCLNNGACVVIGGSGALTCECPKGYAGARCEVDTDEC-ASQPCQNNGSCIDRINGFSCDCSGT 415
            ::||.:...|.| |..|...|.||.||.|..|..|.||| ..:||::.|:|::....|.|.|. .
Human   125 SSPCAHGARCSV-GPDGRFLCSCPPGYQGRSCRSDVDECRVGEPCRHGGTCLNTPGSFRCQCP-A 187

  Fly   416 GYTGAFCQTNVDECDKNPCLNGGRCFDTYG-WYTCQCLDGWGGEICDRPM-TCQTQQCLNGGTCL 478
            ||||..|:.....|..:||.|||.|..:.. .|.|.||.|:.|:.|:..: .|...:|||||||:
Human   188 GYTGPLCENPAVPCAPSPCRNGGTCRQSGDLTYDCACLPGFEGQNCEVNVDDCPGHRCLNGGTCV 252

  Fly   479 DKPIGFQCLCPPEYTGELCQIAPSCAQQCPIDSECVGGKCVCKPGSSGPIGHCLPTTTTPTPEQE 543
            |....:.|.||||:||:.|             :|.| .:|..:|                     
Human   253 DGVNTYNCQCPPEWTGQFC-------------TEDV-DECQLQP--------------------- 282

  Fly   544 PTTTPRTTPNPNPAIPNTLTTTTKIPPITTSRTLVGTTTGSRRPPQQPLQSPTQRSASLNACPQE 608
                                                                       |||.  
Human   283 -----------------------------------------------------------NACH-- 286

  Fly   609 NCLNGGTCLGYSGNYSCICASGYTGYNCQTSTGDGASALALTPINCNATNGKCLNGGTC--SMNG 671
               |||||....|.:||:|.:|:||.:|..:..|.|:|:             |.:|.||  .:..
Human   287 ---NGGTCFNTLGGHSCVCVNGWTGESCSQNIDDCATAV-------------CFHGATCHDRVAS 335

  Fly   672 THCYCAVGYSGDRCEKAENCSPLNCQEPMVCVQNQ------CLCP---ENKVCNQ----CA--TQ 721
            .:|.|.:|.:|..|...:.|....|.|..:|..|.      |.||   ....|:|    |:  ..
Human   336 FYCACPMGKTGLLCHLDDACVSNPCHEDAICDTNPVNGRAICTCPPGFTGGACDQDVDECSIGAN 400

  Fly   722 PCQNGGECVDLPNGDYECKCTRGWTGRTCGNDVDECTLHPKICGN-GICKNEKGSYKCYCTPGFT 785
            ||::.|.||: ..|.:.|:|.||:||..|..||:||...|  |.| ..|.:..|.:.|.|..|||
Human   401 PCEHLGRCVN-TQGSFLCQCGRGYTGPRCETDVNECLSGP--CRNQATCLDRIGQFTCICMAGFT 462

  Fly   786 GVHCDSDVDECLSFPCLNGATCHNKINAYECVCQPGYEGENCEVDIDECGSNPCSNGSTCIDRIN 850
            |.:|:.|:|||.|.||:||..|.:::|.:.|.|..|:.|..|::|:|||.|.||.||:.|:|:.:
Human   463 GTYCEVDIDECQSSPCVNGGVCKDRVNGFSCTCPSGFSGSTCQLDVDECASTPCRNGAKCVDQPD 527

  Fly   851 NFTCNCIPGMTGRICDIDIDDCVGDPCLNGGQCIDQLGGFRCDCSGTGYEGENCELNIDECLSNP 915
            .:.|.|..|..|.:||.::|||..||| :.|:|:|.:..|.|.|: .||.|..||..:|||.|.|
Human   528 GYECRCAEGFEGTLCDRNVDDCSPDPC-HHGRCVDGIASFSCACA-PGYTGTRCESQVDECRSQP 590

  Fly   916 CTNGAKCLDRVKDYFCDCHNGYKGKNCEQDINECESNPCQYNGNCLERSNITLYQMSRITDLPKV 980
            |.:|.||||.|..|.|.|.:|..|.|||.:|::|.||||.: |.|.:..|               
Human   591 CRHGGKCLDLVDKYLCRCPSGTTGVNCEVNIDDCASNPCTF-GVCRDGIN--------------- 639

  Fly   981 FSQPFSFENASGYECVCVPGIIGKNCEININECDSNPCSKHGNCNDGIGTYTCECEPGFEGTHCE 1045
                       .|:|||.||..|..|.:.||||.|:||.:.|:|.||...:.|.|.||.....|.
Human   640 -----------RYDCVCQPGFTGPLCNVEINECASSPCGEGGSCVDGENGFRCLCPPGSLPPLCL 693

  Fly  1046 INIDECDRYNPCQRGTCYDQIDDYDCDCDANYGGKNCSVLL--KGCDQNPCLNGGACLPYLINEV 1108
            .....| .:.||..|.|||....:.|.|:..:.|..||..|  ..|:..||..||.|....:.  
Human   694 PPSHPC-AHEPCSHGICYDAPGGFRCVCEPGWSGPRCSQSLARDACESQPCRAGGTCSSDGMG-- 755

  Fly  1109 THLYNCTCENGFQGDKCEKTTTLSMVATSLISVTTEREEGYDINLQFRTTLPNGVLAFGTTGEKN 1173
               ::|||..|.||.:||           |:|..|                ||.....|.     
Human   756 ---FHCTCPPGVQGRQCE-----------LLSPCT----------------PNPCEHGGR----- 785

  Fly  1174 EPVSYILELINGRLNLHSSLLNKWEGVFIGSKLNDSNWHKVFVAINTSHLVLSANDEQA-IFPVG 1237
                  .|...|:|.: .|....|:|......:                      ||.| ..|.|
Human   786 ------CESAPGQLPV-CSCPQGWQGPRCQQDV----------------------DECAGPAPCG 821

  Fly  1238 SYETANNSQPSFPRTYLGG-TIPNLKSYLRHLTHQPSAFVGCMQDIMVNGKWIFPDEQDANISYT 1301
            .:....|...||..|..|| |.|:                 |.|||                   
Human   822 PHGICTNLAGSFSCTCHGGYTGPS-----------------CDQDI------------------- 850

  Fly  1302 KLENVQSGCPRTEQCKPNPCHSNGECTDLWHTFACHCPRPFFGHTCQHNMTAATFGHENTTHSAV 1366
                        ..|.||||.:.|.|.|...:|:|.|...|.|..|..::.              
Human   851 ------------NDCDPNPCLNGGSCQDGVGSFSCSCLPGFAGPRCARDVD-------------- 889

  Fly  1367 IVETTDVARRAIRSILDISMFIRTREPTGQVFYLGTDPRKAPTKNIGDSYVAAKLHGGELLVKMQ 1431
                                                                             
Human   890 ----------------------------------------------------------------- 889

  Fly  1432 FSGTPEAYTVGGQKLDNGYNHLIEVVRNQTLVQVKLNGTEYFRKTLSTTGLLDAQVLYLGGPAPT 1496
                                   |.:.|..                              ||...
Human   890 -----------------------ECLSNPC------------------------------GPGTC 901

  Fly  1497 RESLLG--ATTEPGIIPVPGAGIPIEDTTVPKEADDSRDYFKGIIQDVKVSNGSLNLIVEMYSLN 1559
            .:.:..  .|..||.     .|...|                   ||                  
Human   902 TDHVASFTCTCPPGY-----GGFHCE-------------------QD------------------ 924

  Fly  1560 VTDVQVNAKPLGAVTIDRASVLPGEVSDDLCRKNPCLHNAECRNTWNDYTCKCPNGYKGKNCQ-E 1623
                                 ||.      |..:.|.:...|.:..|.::|.|..||.|.:|| |
Human   925 ---------------------LPD------CSPSSCFNGGTCVDGVNSFSCLCRPGYTGAHCQHE 962

  Fly  1624 IEFCQHVTCPGQSLCQNLDDGYECVTNTTFTGQERSPLAFFYFQEQQSDDIVSEASPKQTLKPVI 1688
            .:.|....|....:|.....|:.|....:|||.:...|..:..::           |.|      
Human   963 ADPCLSRPCLHGGVCSAAHPGFRCTCLESFTGPQCQTLVDWCSRQ-----------PCQ------ 1010

  Fly  1689 DIAFRTRAGGTLLYIDNVDGFFEIGVNGGRVTITWKLSALHFGESARFEKENTDGEWSRIYLRAH 1753
                                      ||||...|                    |.:        
Human  1011 --------------------------NGGRCVQT--------------------GAY-------- 1021

  Fly  1754 NSKLEGGWKGWESMVDPTPAFSTDIDQAAFQSLIATSTQVYLGGMPESRQARGSTLSAQQGSQFK 1818
             .....||.|                                                       
Human  1022 -CLCPPGWSG------------------------------------------------------- 1030

  Fly  1819 GCVGEARVGDL-LLPYFSMAELYSRTNVSVQQKAQFRLNATRPEEGCILCFQSDCKNDGFCQSPS 1882
                  |:.|: .||   ..|..::..|.::|.                     |:..|.|....
Human  1031 ------RLCDIRSLP---CREAAAQIGVRLEQL---------------------CQAGGQCVDED 1065

  Fly  1883 DEYACTCQPGFEGDDCGTDIDECLNTECLNNGTCINQVAAFFCQCQPGFEGQHCEQNIDECADQP 1947
            ..:.|.|..|..|..|..::|.||...|.:.|||...:..:.|:|.||:.|.:||.::||||.||
Human  1066 SSHYCVCPEGRTGSHCEQEVDPCLAQPCQHGGTCRGYMGGYMCECLPGYNGDNCEDDVDECASQP 1130

  Fly  1948 CHNGGNCTDLIASYVCDCPEDYMGPQCDVLKQMTCENEPCRNGSTC-QNGFNASTGNNFTCTCVP 2011
            |.:||:|.||:|.|:|.||...:|..|::.:.......|..:|..| .||........|.|||.|
Human  1131 CQHGGSCIDLVARYLCSCPPGTLGVLCEINEDDCGPGPPLDSGPRCLHNGTCVDLVGGFRCTCPP 1195

  Fly  2012 GFEGPLCDIPFCEITPCDNGGL-------CL-TTGAVPMCKCSLGYTGRLCEQDINECESNPCQN 2068
            |:.|..|:   .:|..|.:|..       || ..|....|.|..|::|..|:..::.|||.|||:
Human  1196 GYTGLRCE---ADINECRSGACHAAHTRDCLQDPGGGFRCLCHAGFSGPRCQTVLSPCESQPCQH 1257

  Fly  2069 GGQCKDLVG-----RYECDCQGTGFEGIRCENDIDECNMEGDYCGGLGRCFNKPGSFQCICQKPY 2128
            ||||:...|     .:.|.| ...|.|.|||.....|...  .|.....|...|...:|.|....
Human  1258 GGQCRPSPGPGGGLTFTCHC-AQPFWGPRCERVARSCREL--QCPVGVPCQQTPRGPRCACPPGL 1319

  Fly  2129 CGAYC-NFT-DPCNATDL------CSNGGRCVESCGAKPDYYCECPEGFAGKNCTAPITAKE 2182
            .|..| :|. .|..|::.      |.:||.| ......|.:.|.|.:|:.|..|.||..|.|
Human  1320 SGPSCRSFPGSPPGASNASCAAAPCLHGGSC-RPAPLAPFFRCACAQGWTGPRCEAPAAAPE 1380

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
crbNP_001247284.1 LamG 91..228 CDD:238058 1/1 (100%)
EGF_CA 386..423 CDD:238011 15/37 (41%)
EGF_CA 425..460 CDD:238011 13/35 (37%)
EGF 466..495 CDD:278437 15/28 (54%)
EGF 605..633 CDD:278437 11/27 (41%)
EGF_CA 716..750 CDD:238011 14/39 (36%)
EGF_CA 753..789 CDD:238011 15/36 (42%)
EGF_CA 792..828 CDD:238011 15/35 (43%)
EGF_CA 830..865 CDD:238011 15/34 (44%)
EGF_CA 868..905 CDD:238011 15/36 (42%)
EGF_CA 907..943 CDD:238011 18/35 (51%)
EGF_CA 1009..1045 CDD:238011 15/35 (43%)
EGF_CA 1047..1082 CDD:238011 10/34 (29%)
Laminin_G_1 1155..1290 CDD:278483 26/136 (19%)
EGF 1316..1346 CDD:278437 13/29 (45%)
Laminin_G_1 1388..1550 CDD:278483 11/163 (7%)
EGF_CA <1593..1622 CDD:238011 8/28 (29%)
Laminin_G_2 1692..1828 CDD:280389 10/135 (7%)
EGF_CA 1901..1937 CDD:238011 12/35 (34%)
EGF_CA 1939..1974 CDD:238011 18/34 (53%)
EGF_CA 2057..2094 CDD:238011 16/41 (39%)
EGF_CA 2096..2133 CDD:238011 7/36 (19%)
EGF_CA 2137..2175 CDD:238011 11/43 (26%)
NOTCH3NP_000426.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..26
EGF_CA 158..195 CDD:238011 15/37 (41%)
EGF_CA 236..272 CDD:238011 17/48 (35%)
EGF_CA 274..311 CDD:238011 18/122 (15%)
EGF_CA 314..349 CDD:238011 11/47 (23%)
EGF_CA 391..429 CDD:238011 13/38 (34%)
EGF_CA 431..467 CDD:238011 15/37 (41%)
EGF_CA 469..505 CDD:238011 15/35 (43%)
EGF_CA 507..542 CDD:238011 15/34 (44%)
EGF_CA 545..580 CDD:238011 15/36 (42%)
EGF_CA 583..618 CDD:238011 18/34 (53%)
EGF_CA 620..654 CDD:238011 16/60 (27%)
EGF_CA 657..>686 CDD:214542 13/28 (46%)
EGF_CA 810..846 CDD:238011 13/74 (18%)
EGF_CA 849..884 CDD:238011 15/65 (23%)
EGF_CA 887..922 CDD:238011 8/171 (5%)
EGF_CA 929..960 CDD:238011 8/30 (27%)
EGF_CA 1085..1120 CDD:238011 12/34 (35%)
EGF_CA 1122..1158 CDD:238011 18/35 (51%)
EGF_CA 1171..1203 CDD:238011 11/31 (35%)
Notch 1384..1418 CDD:278494
LNR 1 1387..1427
Notch 1425..1459 CDD:278494
LNR 2 1428..1458
Notch 1464..1500 CDD:278494
LNR 3 1467..1505
NOD 1508..1557 CDD:284282
NODP 1578..1637 CDD:284987
ANKYR <1777..1893 CDD:223738
ANK <1779..1892 CDD:238125
ANK repeat 1788..1836 CDD:293786
ANK repeat 1838..1869 CDD:293786
ANK 1 1838..1867
Ank_5 1858..1913 CDD:290568
ANK 1866..1992 CDD:238125
ANK repeat 1871..1903 CDD:293786
ANK 2 1871..1901
ANK repeat 1905..1936 CDD:293786
ANK 3 1905..1934
Ank_2 1910..2002 CDD:289560
ANK repeat 1938..1969 CDD:293786
ANK 4 1938..1967
ANK repeat 1971..2002 CDD:293786
ANK 5 1971..2000
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2024..2120
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2190..2321
DUF3454 2212..2273 CDD:288764
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E33208_3BAFT
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100271
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.710

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