DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment crb and NOTCH2

DIOPT Version :9

Sequence 1:NP_001247284.1 Gene:crb / 42896 FlyBaseID:FBgn0259685 Length:2253 Species:Drosophila melanogaster
Sequence 2:NP_077719.2 Gene:NOTCH2 / 4853 HGNCID:7882 Length:2471 Species:Homo sapiens


Alignment Length:2041 Identity:501/2041 - (24%)
Similarity:688/2041 - (33%) Gaps:843/2041 - (41%)


- Green bases have known domain annotations that are detailed below.


  Fly   272 DPCMGHGTCSS--SPEGYECRCTARYSGKNCQKDNGSPCAKNPCENGGSCLENSR-GDYQCFCDP 333
            :||:..|.|.:  :..|| |:|...:.|:.||  :..||.||.|:|||:|:..:. |...|.|..
Human    33 EPCVNEGMCVTYHNGTGY-CKCPEGFLGEYCQ--HRDPCEKNRCQNGGTCVAQAMLGKATCRCAS 94

  Fly   334 NHSGQHCETEVNIHPLCQTNPCLNNGACVVIGGSGALTCECPKGYAGARCEVDTDECASQPCQNN 398
            ..:|:.|:...: ||...:.||||.|.|.:: ......|.|..|:.|..|:. ||.|.|.||.|.
Human    95 GFTGEDCQYSTS-HPCFVSRPCLNGGTCHML-SRDTYECTCQVGFTGKECQW-TDACLSHPCANG 156

  Fly   399 GSCIDRINGFSCDCSGTGYTGAFCQTNVDECD-KNPCLNGGRCFDTYGWYTCQCLDGWGGEICDR 462
            .:|....|.|||.|. ||:||..|:|:|:||| ...|.:||.|.:..|.|.|||..|:.|:.||.
Human   157 STCTTVANQFSCKCL-TGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCPQGFTGQYCDS 220

  Fly   463 -PMTCQTQQCLNGGTCLDKPIG---FQCLCPPEYTGELCQIAPSCAQQCPIDSECVGGKCVCKPG 523
             .:.|....|:|||||  :..|   |:|.|.|.:.|..|:                         
Human   221 LYVPCAPSPCVNGGTC--RQTGDFTFECNCLPGFEGSTCE------------------------- 258

  Fly   524 SSGPIGHCLPTTTTPTPEQEPTTTPRTTPNPNPAIPNTLTTTTKIPPITTSRTLVGTTTGSRRPP 588
                                                                             
Human   259 ----------------------------------------------------------------- 258

  Fly   589 QQPLQSPTQRSASLNACPQENCLNGGTCLGYSGNYSCICASGYTGYNCQTSTGDGASALALTPIN 653
                       .:::.||...|.|||.|:.....|:|.|...:||..|.....:           
Human   259 -----------RNIDDCPNHRCQNGGVCVDGVNTYNCRCPPQWTGQFCTEDVDE----------- 301

  Fly   654 CNATNGKCLNGGTC-SMNGTH-CYCAVGYSGDRC-EKAENCSPLNCQEPMVCVQN----QCLCPE 711
            |......|.||||| :.||.: |.|..|:|||.| |..::|:..:|.....|:..    .|:|||
Human   302 CLLQPNACQNGGTCANRNGGYGCVCVNGWSGDDCSENIDDCAFASCTPGSTCIDRVASFSCMCPE 366

  Fly   712 NK---VC---NQCATQPCQNGGECVDLP-NGDYECKCTRGWTGRTCGNDVDECTL-HPKICGN-G 767
            .|   :|   :.|.:.||..|..|...| ||.|.|.|.:|:.|..|..|||||.: :...|.: |
Human   367 GKAGLLCHLDDACISNPCHKGALCDTNPLNGQYICTCPQGYKGADCTEDVDECAMANSNPCEHAG 431

  Fly   768 ICKNEKGSYKCYCTPGFTGVHCDSDVDECLSFPCLNGATCHNKINAYECVCQPGYEGENCEVDID 832
            .|.|..|::.|.|..|:.|..|:.|::||.|.||.|.|||.:||..:.|:|.||::|.:||::|:
Human   432 KCVNTDGAFHCECLKGYAGPRCEMDINECHSDPCQNDATCLDKIGGFTCLCMPGFKGVHCELEIN 496

  Fly   833 ECGSNPCSNGSTCIDRINNFTCNCIPGMTGRICDIDIDDCVGDPCLNGGQCIDQLGGFRCDCSGT 897
            ||.||||.|...|:|::|.|.|.|.||.||.:|.||||||...|||||.:|||...|:.|.|: |
Human   497 ECQSNPCVNNGQCVDKVNRFQCLCPPGFTGPVCQIDIDDCSSTPCLNGAKCIDHPNGYECQCA-T 560

  Fly   898 GYEGENCELNIDECLSNPCTNGAKCLDRVKDYFCDCHNGYKGKNCEQDINECESNPCQYNGNCLE 962
            |:.|..||.|||.|..:||.:| :|.|.:..|.|.|:.||.|..|...|:||.|:||..:|.|::
Human   561 GFTGVLCEENIDNCDPDPCHHG-QCQDGIDSYTCICNPGYMGAICSDQIDECYSSPCLNDGRCID 624

  Fly   963 RSNITLYQMSRITDLPKVFSQPFSFENASGYECVCVPGIIGKNCEININECDSNPCSKHGNCNDG 1027
            ..|                          ||:|.|.||..|.|||||.::|.||||. ||.|.||
Human   625 LVN--------------------------GYQCNCQPGTSGVNCEINFDDCASNPCI-HGICMDG 662

  Fly  1028 IGTYTCECEPGFEGTHCEINIDECDRYNPCQRG---------------------TCYDQIDD--- 1068
            |..|:|.|.|||.|..|.|:|||| ..|||::|                     :||.|:::   
Human   663 INRYSCVCSPGFTGQRCNIDIDEC-ASNPCRKGATCINGVNGFRCICPEGPHHPSCYSQVNECLS 726

  Fly  1069 --------------YDCDCDANYGGKNCSVLLKGCDQNPCLNGGACLPYLINEVTHLYNCTCENG 1119
                          |.|.|||.:.|.||.|....|..|||.|||.|     :.:.:.|.|||:.|
Human   727 NPCIHGNCTGGLSGYKCLCDAGWVGINCEVDKNECLSNPCQNGGTC-----DNLVNGYRCTCKKG 786

  Fly  1120 FQGDKCEKTTTLSMVATSLISVTTEREEGYDINLQFRTTLPNGVLAFGTTGEKNEPVSYILELIN 1184
            |:|..|:                        :|:                               
Human   787 FKGYNCQ------------------------VNI------------------------------- 796

  Fly  1185 GRLNLHSSLLNKWEGVFIGSKLNDSNWHKVFVAINTSHLVLSANDEQAIFPVGSYETANNSQPSF 1249
                                                                             
Human   797 ----------------------------------------------------------------- 796

  Fly  1250 PRTYLGGTIPNLKSYLRHLTHQPSAFVGCMQDIMVNGKWIFPDEQDANISYTKLENVQSGCPRTE 1314
                                                                            :
Human   797 ----------------------------------------------------------------D 797

  Fly  1315 QCKPNPCHSNGECTDLWHTFACHCPRPFFGHTCQHNMTAATFGHENTTHSAVIVETTDVARRAIR 1379
            :|..|||.:.|.|.|....:.|||..|:.|..||                               
Human   798 ECASNPCLNQGTCFDDISGYTCHCVLPYTGKNCQ------------------------------- 831

  Fly  1380 SILDISMFIRTREPTGQVFYLGTDPRKAPTKNIGDSYVAAKLHGGELLVKMQFSGTPEAYTVGGQ 1444
            ::|                                                              
Human   832 TVL-------------------------------------------------------------- 834

  Fly  1445 KLDNGYNHLIEVVRNQTLVQVKLNGTEYFRKTLSTTGLLDAQVLYLGGPAPTRESLLGATTEPGI 1509
                                                             ||              
Human   835 -------------------------------------------------AP-------------- 836

  Fly  1510 IPVPGAGIPIEDTTVPKEADDSRDYFKGIIQDVKVSNGSLNLIVEMYSLNVTDVQVNAKPLGAVT 1574
                                                                             
Human   837 ----------------------------------------------------------------- 836

  Fly  1575 IDRASVLPGEVSDDLCRKNPCLHNAECRNTWN--DYTCKCPNGYKGKNCQ-EIEFCQHVTCPGQS 1636
                           |..|||.:.|.|:.:.|  .|||.|..|::|:.|. :|:.|....|....
Human   837 ---------------CSPNPCENAAVCKESPNFESYTCLCAPGWQGQRCTIDIDECISKPCMNHG 886

  Fly  1637 LCQNLDDGYECVTNTTFTGQERSPLAFFYFQEQQSDDIVSEASPKQTLKPVIDIAFRTRAGGTLL 1701
            ||.|....|.|.....|:|.:         .|:..||.:  |:|.|                   
Human   887 LCHNTQGSYMCECPPGFSGMD---------CEEDIDDCL--ANPCQ------------------- 921

  Fly  1702 YIDNVDGFFEIGVNGGRVTITWKLSALHFGESARFEKENTDGEWSRIYLRAHNSKLEGGWKGWES 1766
                         |||                                                |
Human   922 -------------NGG------------------------------------------------S 925

  Fly  1767 MVDPTPAFSTDIDQAAFQSLIATSTQVYLGGMPESRQARGSTLSAQQGSQFKGCVGEARVGDLLL 1831
            .:|....||                                            |        |.|
Human   926 CMDGVNTFS--------------------------------------------C--------LCL 938

  Fly  1832 PYFSMAELYSRTNVSVQQKAQFRLNATRPEEGCILCFQSDCKNDGFCQSPSDEYACTCQPGFEGD 1896
            |.|:            ..|.|..:|.         |....|||.|.|....:.|.|.||.||:|.
Human   939 PGFT------------GDKCQTDMNE---------CLSEPCKNGGTCSDYVNSYTCKCQAGFDGV 982

  Fly  1897 DCGTDIDECLNTECLNNGTCINQVAAFFCQCQPGFEGQHCEQNIDECADQPCHNGGNCTDLIASY 1961
            .|..:|:||..:.|.|.|||::.:.:|.|.|..||.|..|...|:||:..||.|.|.|.|.:.:|
Human   983 HCENNINECTESSCFNGGTCVDGINSFSCLCPVGFTGSFCLHEINECSSHPCLNEGTCVDGLGTY 1047

  Fly  1962 VCDCPEDYMGPQCDVLKQMTCENEPCRNGSTCQNGFNASTGNNFTCTCVPGFEGPLCDIP--FCE 2024
            .|.||..|.|..|..|..: |...||:|..||......|     .|.|..|:.|..||:|  .|:
Human  1048 RCSCPLGYTGKNCQTLVNL-CSRSPCKNKGTCVQKKAES-----QCLCPSGWAGAYCDVPNVSCD 1106

  Fly  2025 ITP----------CDNGGLCLTTGAVPMCKCSLGYTGRLCEQDINECESNPCQNGGQCKDLVGRY 2079
            |..          |.:.|:|:..|....|:|.|||||..||:.::||.|||||:|..|.|.:|.|
Human  1107 IAASRRGVLVEHLCQHSGVCINAGNTHYCQCPLGYTGSYCEEQLDECASNPCQHGATCSDFIGGY 1171

  Fly  2080 ECDCQGTGFEGIRCENDIDECNMEGDYCGGLGRCFNKPGSFQCICQKPYCGAYCNFT-DPCNATD 2143
            .|:|. .|::|:.||.::|||  :...|...|.|.:....|:|.|.....|..|... |.|....
Human  1172 RCECV-PGYQGVNCEYEVDEC--QNQPCQNGGTCIDLVNHFKCSCPPGTRGLLCEENIDDCARGP 1233

  Fly  2144 LCSNGGRCVESCGAKPDYYCECPEGFAGKNCTAPITAKEDGPSTTDIAIIVIPVVVVLLLIAGAL 2208
            .|.|||:|::..|.   |.|.|..||||:.|...|......|.:::.::..|           .|
Human  1234 HCLNGGQCMDRIGG---YSCRCLPGFAGERCEGDINECLSNPCSSEGSLDCI-----------QL 1284

  Fly  2209 LGTFLVMARNKRATRGTYSPSAQEYC 2234
            ...:|.:.|:  |..|.:..:..:.|
Human  1285 TNDYLCVCRS--AFTGRHCETFVDVC 1308

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
crbNP_001247284.1 LamG 91..228 CDD:238058
EGF_CA 386..423 CDD:238011 17/36 (47%)
EGF_CA 425..460 CDD:238011 15/35 (43%)
EGF 466..495 CDD:278437 12/31 (39%)
EGF 605..633 CDD:278437 10/27 (37%)
EGF_CA 716..750 CDD:238011 13/34 (38%)
EGF_CA 753..789 CDD:238011 14/37 (38%)
EGF_CA 792..828 CDD:238011 17/35 (49%)
EGF_CA 830..865 CDD:238011 18/34 (53%)
EGF_CA 868..905 CDD:238011 19/36 (53%)
EGF_CA 907..943 CDD:238011 15/35 (43%)
EGF_CA 1009..1045 CDD:238011 19/35 (54%)
EGF_CA 1047..1082 CDD:238011 17/72 (24%)
Laminin_G_1 1155..1290 CDD:278483 0/134 (0%)
EGF 1316..1346 CDD:278437 12/29 (41%)
Laminin_G_1 1388..1550 CDD:278483 2/161 (1%)
EGF_CA <1593..1622 CDD:238011 12/30 (40%)
Laminin_G_2 1692..1828 CDD:280389 8/135 (6%)
EGF_CA 1901..1937 CDD:238011 14/35 (40%)
EGF_CA 1939..1974 CDD:238011 15/34 (44%)
EGF_CA 2057..2094 CDD:238011 16/36 (44%)
EGF_CA 2096..2133 CDD:238011 10/36 (28%)
EGF_CA 2137..2175 CDD:238011 15/37 (41%)
NOTCH2NP_077719.2 EGF_CA 182..218 CDD:238011 15/35 (43%)
EGF_CA 260..296 CDD:238011 12/35 (34%)
EGF_CA 298..335 CDD:238011 15/47 (32%)
EGF_CA 415..454 CDD:238011 14/38 (37%)
EGF_CA 456..492 CDD:238011 17/35 (49%)
EGF_CA 495..530 CDD:238011 18/34 (53%)
EGF_CA 532..568 CDD:238011 19/36 (53%)
EGF_CA 570..604 CDD:238011 15/34 (44%)
EGF_CA 608..643 CDD:238011 17/60 (28%)
EGF_CA 645..679 CDD:238011 19/34 (56%)
EGF_CA 682..717 CDD:238011 8/35 (23%)
EGF_CA 757..793 CDD:238011 15/40 (38%)
EGF_CA 795..831 CDD:238011 13/195 (7%)
EGF_CA 873..909 CDD:238011 10/44 (23%)
EGF_CA 911..947 CDD:238011 18/181 (10%)
EGF_CA 949..985 CDD:238011 14/44 (32%)
EGF_CA 987..1022 CDD:238011 14/34 (41%)
EGF_CA 1026..1061 CDD:238011 15/34 (44%)
EGF_CA 1117..1147 CDD:238011 11/29 (38%)
EGF_CA 1151..1185 CDD:238011 16/34 (47%)
EGF_CA 1188..1223 CDD:238011 10/36 (28%)
EGF_CA 1225..1262 CDD:238011 15/39 (38%)
EGF_CA 1264..1302 CDD:238011 8/50 (16%)
EGF_CA <1312..1343 CDD:238011
Notch 1423..1456 CDD:278494
Notch 1463..1497 CDD:278494
Notch 1501..1534 CDD:278494
NOD 1540..1591 CDD:284282
NODP 1620..1673 CDD:284987
Ank_2 <1820..1907 CDD:289560
ANK repeat 1827..1874 CDD:293786
ANK 1872..1997 CDD:238125
ANK repeat 1877..1907 CDD:293786
Ank_2 1881..1974 CDD:289560
ANK 1938..2062 CDD:238125
ANK repeat 1943..1974 CDD:293786
Ank_2 1948..2040 CDD:289560
ANK repeat 1976..2007 CDD:293786
ANK repeat 2009..2040 CDD:293786
Chorion_3 <2292..2421 CDD:253174
DUF3454 2381..2444 CDD:288764
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E33208_3BAFT
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100271
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.710

Return to query results.
Submit another query.