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Protein Alignment crb and NOTCH1

DIOPT Version :9

Sequence 1:	NP_001247284.1	Gene:	crb / 42896	FlyBaseID:	FBgn0259685	Length:	2253	Species:	Drosophila melanogaster
Sequence 2:	NP_060087.3	Gene:	NOTCH1 / 4851	HGNCID:	7881	Length:	2555	Species:	Homo sapiens

Alignment Length:	1991	Identity:	493/1991 - (24%)
Similarity:	669/1991 - (33%)	Gaps:	808/1991 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly   253 GP-CSDHDLFTRLPDNFCLNDPCMGHGTCSSSPEGYECRCTARYSGKNCQKDNGSPCAKNPCENG 316
            || ||.       |...|||.     |.|.::.....|.|...:.|..||..|  ||...||:|.
Human    21 GPRCSQ-------PGETCLNG-----GKCEAANGTEACVCGGAFVGPRCQDPN--PCLSTPCKNA 71

  Fly   317 GSC-LENSRG--DYQCFCDPNHSGQHCETEVNIHPL---CQTNPCLNNGACVVIGGSGALT---C 372
            |:| :.:.||  ||.|.|....||..|.|     ||   |.||||.|.|.|.::    .||   |
Human    72 GTCHVVDRRGVADYACSCALGFSGPLCLT-----PLDNACLTNPCRNGGTCDLL----TLTEYKC 127

  Fly   373 ECPKGYAGARCEVDTDECASQPCQNNGSCIDRINGFSCDCSGTGYTGAFCQTNVDECDKNP--CL 435
            .||.|::|..|: ..|.|||.||.|.|.|:.....:.|.|. ..:.|..|:.:|:||.:.|  |.
Human   128 RCPPGWSGKSCQ-QADPCASNPCANGGQCLPFEASYICHCP-PSFHGPTCRQDVNECGQKPGLCR 190

  Fly   436 NGGRCFDTYGWYTCQCLDGWGGEICDRP-MTCQTQQCLNGGTCLDKPIG---FQCLCPPEYTGEL 496
            :||.|.:..|.|.|.|.....|..|:|| :.|....|.|||||  :|.|   .:|.|.|.:||:.
Human   191 HGGTCHNEVGSYRCVCRATHTGPNCERPYVPCSPSPCQNGGTC--RPTGDVTHECACLPGFTGQN 253

  Fly   497 CQIAPSCAQQCPIDSECVGGKCVCKPGSSGPIGHCLPTTTTPTPEQEPTTTPRTTPNPNPAIPNT 561
            |:
Human   254 CE--------------------------------------------------------------- 255

  Fly   562 LTTTTKIPPITTSRTLVGTTTGSRRPPQQPLQSPTQRSASLNACPQENCLNGGTCLGYSGNYSCI 626
                                                  .:::.||..||.|||.|:.....|:|.
Human   256 --------------------------------------ENIDDCPGNNCKNGGACVDGVNTYNCR 282

  Fly   627 CASGYTGYNCQTSTGDGASALALTPINCNATNGKCLNGGTC--SMNGTHCYCAVGYSGDRC-EKA 688
            |...:||..|.....:           |......|.|||||  :..|.:|.|..|::|:.| |..
Human   283 CPPEWTGQYCTEDVDE-----------CQLMPNACQNGGTCHNTHGGYNCVCVNGWTGEDCSENI 336

  Fly   689 ENCSPLNCQEPMVC----VQNQCLCPENK---VC---NQCATQPCQNGGECVDLP-NGDYECKCT 742
            ::|:...|.....|    ....|.||..:   :|   :.|.:.||..|..|...| ||...|.|.
Human   337 DDCASAACFHGATCHDRVASFYCECPHGRTGLLCHLNDACISNPCNEGSNCDTNPVNGKAICTCP 401

  Fly   743 RGWTGRTCGNDVDECTLHPKICGN-GICKNEKGSYKCYCTPGFTGVHCDSDVDECLSFPCLNGAT 806
            .|:||..|..|||||:|....|.: |.|.|..||::|.|..|:||..|:.||:||:|.||.|.||
Human   402 SGYTGPACSQDVDECSLGANPCEHAGKCINTLGSFECQCLQGYTGPRCEIDVNECVSNPCQNDAT 466

  Fly   807 CHNKINAYECVCQPGYEGENCEVDIDECGSNPCSNGSTCIDRINNFTCNCIPGMTGRICDIDIDD 871
            |.::|..::|:|.|||||.:|||:.|||.|:||.:...|:|:||.|.|.|..|.||.:|..|:|:
Human   467 CLDQIGEFQCICMPGYEGVHCEVNTDECASSPCLHNGRCLDKINEFQCECPTGFTGHLCQYDVDE 531

  Fly   872 CVGDPCLNGGQCIDQLGGFRCDCSGTGYEGENCELNIDECLSNPCTNGAKCLDRVKDYFCDCHNG 936
            |...||.||.:|:|....:.|.|: .||.|.:||::||||..:||..|: |.|.|..:.|.|..|
Human   532 CASTPCKNGAKCLDGPNTYTCVCT-EGYTGTHCEVDIDECDPDPCHYGS-CKDGVATFTCLCRPG 594

  Fly   937 YKGKNCEQDINECESNPCQYNGNCLERSNITLYQMSRIT-------DLPKVFSQPFS----FENA 990
            |.|.:||.:||||.|.||::.|.|.:|.|..|....:.|       :|....|.|..    .:..
Human   595 YTGHHCETNINECSSQPCRHGGTCQDRDNAYLCFCLKGTTGPNCEINLDDCASSPCDSGTCLDKI 659

  Fly   991 SGYECVCVPGIIGKNCEININECDSNPCSKHGNCNDGIGTYTCECEPGFEGTHCEINIDECDRYN 1055
            .||||.|.||..|..|.|||:||..|||...|.|.|||..:||.|..|:....|...::||:. |
Human   660 DGYECACEPGYTGSMCNINIDECAGNPCHNGGTCEDGINGFTCRCPEGYHDPTCLSEVNECNS-N 723

  Fly  1056 PCQRGTCYDQIDDYDCDCDANYGGKNCSVLLKGCDQNPCLNGGACLPYLINEVTHLYNCTCENGF 1120
            ||..|.|.|.::.|.||||..:.|.||.:....|:.|||:|||.|     .::|..|.|||..||
Human   724 PCVHGACRDSLNGYKCDCDPGWSGTNCDINNNECESNPCVNGGTC-----KDMTSGYVCTCREGF 783

  Fly  1121 QGDKCEKTTTLSMVATSLISVTTEREEGYDINLQFRTTLPNGVLAFGTTGEKNEPVSYILELING 1185
            .|..|:         |::                                  ||..|
Human   784 SGPNCQ---------TNI----------------------------------NECAS-------- 797

  Fly  1186 RLNLHSSLLNKWEGVFIGSKLNDSNWHKVFVAINTSHLVLSANDEQAIFPVGSYETANNSQPSFP 1250
                 :..||:      |:.::|...:|.                ..:.|
Human   798 -----NPCLNQ------GTCIDDVAGYKC----------------NCLLP--------------- 820

  Fly  1251 RTYLGGTIPNLKSYLRHLTHQPSAFVGCMQDIMVNGKWIFPDEQDANISYTKLENVQSGCPRTEQ 1315
              |.|.|                    |  ::::                             ..
Human   821 --YTGAT--------------------C--EVVL-----------------------------AP 832

  Fly  1316 CKPNPCHSNGEC--TDLWHTFACHCPRPFFGHTCQHNMTAATFGHENTTHSAVIVETTDVARRAI 1378
            |.|:||.:.|||  ::.:.:|:|.||..:.|.||
Human   833 CAPSPCRNGGECRQSEDYESFSCVCPTGWQGQTC------------------------------- 866

  Fly  1379 RSILDISMFIRTREPTGQVFYLGTDPRKAPTKNIGDSYVAAKLHGGELLVKMQFSGTPEAYTVGG 1443

Human   867 ----------------------------------------------------------------- 866

  Fly  1444 QKLDNGYNHLIEVVRNQTLVQVKLNGTEYFRKTLSTTGLLDAQVLYLGGPAPTRESLLGATTEPG 1508

Human   867 ----------------------------------------------------------------- 866

  Fly  1509 IIPVPGAGIPIEDTTVPKEADDSRDYFKGIIQDVKVSNGSLNLIVEMYSLNVTDVQVNAKPLGAV 1573
                                                                 :|.:|.
Human   867 -----------------------------------------------------EVDINE------ 872

  Fly  1574 TIDRASVLPGEVSDDLCRKNPCLHNAECRNTWNDYTCKCPNGYKGKNCQ-EIEFCQHVTCPGQSL 1637
                            |..:||.|.|.|:||...|.|.|..||.|:||: :|:.|:...|.....
Human   873 ----------------CVLSPCRHGASCQNTHGGYRCHCQAGYSGRNCETDIDDCRPNPCHNGGS 921

  Fly  1638 CQNLDDGYECVTNTTFTGQERSPLAFFYFQEQQSDDIVSEASPKQTLKPVIDIAFRTRAGGTLLY 1702
            |   .||    .||.|
Human   922 C---TDG----INTAF------------------------------------------------- 930

  Fly  1703 IDNVDGFFEIGVNGGRVTITWKLSALHFGESARFEKENTDGEWSRIYLRAHNSKLEGGWKGWESM 1767

Human   931 ----------------------------------------------------------------- 930

  Fly  1768 VDPTPAFSTDIDQAAFQSLIATSTQVYLGGMPESRQARGSTLSAQQGSQFKGCVGEARVGDLLLP 1832
            .|..|.|                              ||
Human   931 CDCLPGF------------------------------RG-------------------------- 939

  Fly  1833 YFSMAELYSRTNVSVQQKAQFRLNATRPEEGCILCFQSDCKNDGFCQSPSDEYACTCQPGFEGDD 1897
                                     |..||....|....|:|...|....|.|.|||..||.|..
Human   940 -------------------------TFCEEDINECASDPCRNGANCTDCVDSYTCTCPAGFSGIH 979

  Fly  1898 CGTDIDECLNTECLNNGTCINQVAAFFCQCQPGFEGQHCEQNIDECADQPCHNGGNCTDLIASYV 1962
            |..:..:|..:.|.|.|||::.:.:|.|.|.|||.|.:|:.:::||..|||.:||.|.|...||.
Human   980 CENNTPDCTESSCFNGGTCVDGINSFTCLCPPGFTGSYCQHDVNECDSQPCLHGGTCQDGCGSYR 1044

  Fly  1963 CDCPEDYMGPQCDVLKQMTCENEPCRNGSTCQNGFNASTGNNFTCTCVPGFEGPLCDIP--FCEI 2025
            |.||:.|.||.|..|... |::.||:||..|.     .|...:.|.|..|:.|..||:|  .||:
Human  1045 CTCPQGYTGPNCQNLVHW-CDSSPCKNGGKCW-----QTHTQYRCECPSGWTGLYCDVPSVSCEV 1103

  Fly  2026 TP----------CDNGGLCLTTGAVPMCKCSLGYTGRLCEQDINECESNPCQNGGQCKDLVGRYE 2080
            ..          |.:||||:..|....|:|..||||..||..::||..:|||||..|.|.:|.|.
Human  1104 AAQRQGVDVARLCQHGGLCVDAGNTHHCRCQAGYTGSYCEDLVDECSPSPCQNGATCTDYLGGYS 1168

  Fly  2081 CDCQGTGFEGIRCENDIDECNMEGDYCGGLGRCFNKPGSFQCICQKPYCGAYCNF--------TD 2137
            |.|. .|:.|:.|..:||||....  |...|.|.:.|.:::|.|.:...|.:|..        .|
Human  1169 CKCV-AGYHGVNCSEEIDECLSHP--CQNGGTCLDLPNTYKCSCPRGTQGVHCEINVDDCNPPVD 1230

  Fly  2138 PCNATDLCSNGGRCVESCGAKPDYYCECPEGFAGKNCTAPI 2178
            |.:.:..|.|.|.||:..|.   |.|.||.||.|:.|...:
Human  1231 PVSRSPKCFNNGTCVDQVGG---YSCTCPPGFVGERCEGDV 1268

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.