DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment crb and Ser

DIOPT Version :9

Sequence 1:	NP_001247284.1	Gene:	crb / 42896	FlyBaseID:	FBgn0259685	Length:	2253	Species:	Drosophila melanogaster
Sequence 2:	NP_001287558.1	Gene:	Ser / 43275	FlyBaseID:	FBgn0004197	Length:	1407	Species:	Drosophila melanogaster

Alignment Length:	1279	Identity:	307/1279 - (24%)
Similarity:	449/1279 - (35%)	Gaps:	414/1279 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 QRQAETATTTTTTVAA------SVETATTTARSRDRTKSAAQITSHL-----LKRAISVYSSPQW 68
            :|:..|:::..:|:.:      |.:|||...|.|.|....|.:.|.:     ||.|.::.:
  Fly    10 RRKPATSSSLESTIESADSLGMSKKTATKRQRPRHRVPKIATLPSTIRDCRSLKSACNLIA---- 70

  Fly    69 IPLFILIYLATDVASVA---------VPTKEAYFNG--------------------STYLRL--- 101
               .|||.|...:::..         ..|.....||                    :|..||
  Fly    71 ---LILILLVHKISAAGNFELEILEISNTNSHLLNGYCCGMPAELRATKTIGCSPCTTAFRLCLK 132

  Fly   102 ---TTPMPIWDHSAISFRSCRGGEILAQQYNKNSIVISVLNDFLQISLAGPAVHGPNNRLDVKLP 163
               ||     :..|.....|..|....:....:|.|:|           .|.|..      :.||
  Fly   133 EYQTT-----EQGASISTGCSFGNATTKILGGSSFVLS-----------DPGVGA------IVLP 175

  Fly   164 YQLLDNRWHTLQFKYEYGNLYLHVDRAASIFANSTYNSQFLTNQDIGYKDA-ILILGNSFSGCLL 227
            :..   || |..|                     |...|.|...:..|.|| .||...|:||.:|
  Fly   176 FTF---RW-TKSF---------------------TLILQALDMYNTSYPDAERLIEETSYSGVIL 215

  Fly   228 DGPGLQFVN----NSTVQNVVFGHCPLTPGPCSDHDLFTRLPDNFCL-NDPCMGHGTCSSSPEGY 287
            ..|..:.::    |:.:...|...|.:|        .:......||. .|...||..|.|  ||.
  Fly   216 PSPEWKTLDHIGRNARITYRVRVQCAVT--------YYNTTCTTFCRPRDDQFGHYACGS--EGQ 270

  Fly   288 ECRCTARYSGKNCQK--------------DNGSPCAKNP---------------CENGGSCLENS 323
            :. |...:.|.||::              |....|...|               |:: |||   :
  Fly   271 KL-CLNGWQGVNCEEAICKAGCDPVHGKCDRPGECECRPGWRGPLCNECMVYPGCKH-GSC---N 330

  Fly   324 RGDYQCFCDPNHSGQHCETEVNIHPLCQTN-PCLNNGACVVIGGSGALTCECPKGYAGARCEVDT 387
            ...::|.||.|..|..|:.::|   .|.|: ||.:.|.|... ......|.|.:|.:|.:||:..
  Fly   331 GSAWKCVCDTNWGGILCDQDLN---FCGTHEPCKHGGTCENT-APDKYRCTCAEGLSGEQCEIVE 391

  Fly   388 DECASQPCQNNGSC----------------------------------IDR-------ING---- 407
            ..||::||:|.|:|                                  :|.       :||
  Fly   392 HPCATRPCRNGGTCTLKTSNRTQAQVYRTSHGRSNMGRPVRRSSSMRSLDHLRPEGQALNGSSSP 456

  Fly   408 -----------------FSCDCSGTGYTGAFCQTNVDECDKNPCLNGGRCFDTYGWYTCQCLDGW 455
                             |:|||: .|:||..|:.|:|||...||.:||.|.|..|
  Fly   457 GLVSLGSLQLQQQLAPDFTCDCA-AGWTGPTCEINIDECAGGPCEHGGTCIDLIG---------- 510

  Fly   456 GGEICDRPMTCQTQQCLNGGTCLDKPIGFQCLCPPEYTGELCQIAPSCAQQCPIDSECVGGKCVC 520
                                       ||:|.||||:.|::||:..         :||..
  Fly   511 ---------------------------GFRCECPPEWHGDVCQVDV---------NECEA----- 534

  Fly   521 KPGSSGPIGHCLPTTTTPTPEQEPTTTPRTTPNPNPAIPNTLTTTTKIPPITTSRTLVGTTTGSR 585
             |.|:|...:.|.|||.                 ...|.:.|::|..:..:|::
  Fly   535 -PHSAGIAANALLTTTA-----------------TAIIGSNLSSTALLAALTSA----------- 570

  Fly   586 RPPQQPLQSPTQRSASLNACPQENCLNGGTCLGYSGNYSCICASGYTGYNCQTSTGDGASALALT 650
                       ..|.||...|   |:|...|....|:::|||..|:.|..|..:..|..
  Fly   571 -----------VASTSLAIGP---CINAKECRNQPGSFACICKEGWGGVTCAENLDDCV------ 615

  Fly   651 PINCNATNGKCLNGGTC--SMNGTHCYCAVGYSGDRCEKAENCSPLNCQEPMVCVQNQCLCPENK 713
                    |:|.||.||  .:|...|.||.|:.|..||..
  Fly   616 --------GQCRNGATCIDLVNDYRCACASGFKGRDCETD------------------------- 647

  Fly   714 VCNQCATQPCQNGGECVDLPNGDYECKCTRGWTGRTCGNDVDECTLHPKICGNGICKNEKGSYKC 778
             .::|||.||:|||||||:. |.:.|.|..|::|..|....:.||  |..|..|.|.|....|.|
  Fly   648 -IDECATSPCRNGGECVDMV-GKFNCICPLGYSGSLCEEAKENCT--PSPCLEGHCLNTPEGYYC 708

  Fly   779 YCTPGFTGVHCDSDVDECLSFPCLNGATCHNKINAYECVCQPGYEGENCEVDIDECGSNPCSNGS 843
            :|.|...|.||:.....|...||..|...:..:...................:.:....|||...
  Fly   709 HCPPDRAGKHCEQLRPLCSQPPCNEGCFANVSLATSATTTTTTTTTATTTRKMAKPSGLPCSGHG 773

  Fly   844 TC-IDRINNFTCNCIPGMTGRICDIDIDDCVGDPCLNGGQCIDQLGGFRCDCSGTGYEGENCELN 907
            :| :..:..| |.|..|.||..|:.::::|..:||.|||.|:|..|.|.|:|. :|:.|:.|...
  Fly   774 SCEMSDVGTF-CKCHVGHTGTFCEHNLNECSPNPCRNGGICLDGDGDFTCECM-SGWTGKRCSER 836

  Fly   908 IDECLSNPCTNGAKCL----DRVKDYFCDCHNGYKGKNCEQDINECESNPCQYNGNCLERSNITL 968
            ...|.:..|.||..|:    |:.....|.|..|:.|..|.:.|::|...||...|.|
  Fly   837 ATGCYAGQCQNGGTCMPGAPDKALQPHCRCAPGWTGLFCAEAIDQCRGQPCHNGGTC-------- 893

  Fly   969 YQMSRITDLPKVFSQPFSFENASG-YECVCVPGIIGKNCEININECDSNPCSKHGNCNDGIGTYT 1032
                               |:.:| :.|||..|..|.:|.||:|||...||.....|.||||.|:
  Fly   894 -------------------ESGAGWFRCVCAQGFSGPDCRINVNECSPQPCQGGATCIDGIGGYS 939

  Fly  1033 CECEPGFEGTHCEINIDECDRYNPCQRGTCYDQIDDYDCDCDANYGGKNCSVLLKG-------CD 1090
            |.|.||..|..|||.:.  |..:.||..:  :.|..|..   .|.......:.|.|       |:
  Fly   940 CICPPGRHGLRCEILLS--DPKSACQNAS--NTISPYTA---LNRSQNWLDIALTGRTEDDENCN 997

  Fly  1091 QNPCLNGGACLPYLINEVTHLYNCTCENGFQGDKCEKTTTLSMV 1134
            ...|.||       .:..|:|: |...|.::.|...|::.||.|
  Fly   998 ACVCENG-------TSRCTNLW-CGLPNCYKVDPLSKSSNLSGV 1033

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crb	NP_001247284.1	LamG	91..228	CDD:238058	32/163 (20%)
		EGF_CA	386..423	CDD:238011	17/98 (17%)
		EGF_CA	425..460	CDD:238011	11/34 (32%)
		EGF	466..495	CDD:278437	7/28 (25%)
		EGF	605..633	CDD:278437	9/27 (33%)
		EGF_CA	716..750	CDD:238011	17/33 (52%)
		EGF_CA	753..789	CDD:238011	12/35 (34%)
		EGF_CA	792..828	CDD:238011	4/35 (11%)
		EGF_CA	830..865	CDD:238011	10/35 (29%)
		EGF_CA	868..905	CDD:238011	14/36 (39%)
		EGF_CA	907..943	CDD:238011	10/39 (26%)
		EGF_CA	1009..1045	CDD:238011	17/35 (49%)
		EGF_CA	1047..1082	CDD:238011	6/34 (18%)
		Laminin_G_1	1155..1290	CDD:278483
		EGF	1316..1346	CDD:278437
		Laminin_G_1	1388..1550	CDD:278483
		EGF_CA	<1593..1622	CDD:238011
		Laminin_G_2	1692..1828	CDD:280389
		EGF_CA	1901..1937	CDD:238011
		EGF_CA	1939..1974	CDD:238011
		EGF_CA	2057..2094	CDD:238011
		EGF_CA	2096..2133	CDD:238011
		EGF_CA	2137..2175	CDD:238011
Ser	NP_001287558.1	MNNL	83..161	CDD:284966	11/82 (13%)
		DSL	220..282	CDD:279722	15/72 (21%)
		EGF_CA	350..388	CDD:238011	11/41 (27%)
		EGF_CA	490..526	CDD:238011	19/72 (26%)
		EGF_CA	610..645	CDD:238011	13/48 (27%)
		EGF_CA	647..683	CDD:238011	17/62 (27%)
		EGF_CA	798..833	CDD:238011	14/35 (40%)
		EGF_CA	879..913	CDD:238011	13/60 (22%)
		EGF_CA	916..952	CDD:238011	17/35 (49%)
		VWC_out	<993..1053	CDD:214565	13/49 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BAFT
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24044
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.910