DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment crb and frac

DIOPT Version :9

Sequence 1:NP_001247284.1 Gene:crb / 42896 FlyBaseID:FBgn0259685 Length:2253 Species:Drosophila melanogaster
Sequence 2:NP_001137905.1 Gene:frac / 38850 FlyBaseID:FBgn0035798 Length:1618 Species:Drosophila melanogaster


Alignment Length:1771 Identity:381/1771 - (21%)
Similarity:559/1771 - (31%) Gaps:629/1771 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   133 IVISVLNDFLQISLAGPAVHGPNNRLDVKLPYQLLDNRWHTLQFKYEYGNLYLHVDRAASIFANS 197
            |||.:.:|.     |...|.......:.:...::|:|.   ...|.|.....|:...|:....|.
  Fly   181 IVIEINDDH-----ANEVVESEPALAETETENEVLENE---TPLKAEVQTDVLNSSNASVKVTND 237

  Fly   198 TYNSQFLTNQDIGYKDAILILGNSFSGC------LLDGPGLQFVNNSTVQNVVFGHCPLTPGPCS 256
            .|...||.|.          .|....||      ||.....|.:|.                 |.
  Fly   238 PYEPTFLDNN----------CGEDNGGCAHICKRLLYPDENQPINK-----------------CD 275

  Fly   257 DHDLFTRLPDNF--CLN-DPCM-GHGTCS----SSPEGYECRCTARY----SGKNCQKDNGSPCA 309
            ..:.:|..|:::  ||: |.|: .:|.||    :.|..|:|.|...|    |||:|...|  .||
  Fly   276 CREGYTLDPNDYASCLDIDECLESNGGCSEICENLPGEYKCSCQEGYYLDESGKSCVDIN--ECA 338

  Fly   310 KNP-----CENGGSCLENSRGDYQCFCDPNHSGQHCETEVNIHPLCQTNPCLNNGACVVIGGSGA 369
             ||     |:  |:| ||..|.|:| .:|....... |||..:|:.:||                
  Fly   339 -NPELSSNCQ--GAC-ENLPGSYRC-VEPLEENPEI-TEVVENPIEKTN---------------- 381

  Fly   370 LTCECPKGYAGARCEVDTDECASQPCQNNGSCIDRINGFSCDCSGTGYTGAFCQTNVDECD---- 430
                          ||..:...|||.....:     :||.....||.     || :::||:    
  Fly   382 --------------EVPVNVSESQPAGKTCN-----SGFQLSADGTD-----CQ-DINECEVDGP 421

  Fly   431 ---KNPCLNGGRCFDTYGWYTCQCLDGWGGEICDRPMTCQTQQC-------LN----GGTCLDKP 481
               .|..:...:|.:|.|.:.|.|::|:  .:.:...:|....|       ||    ...|.|.|
  Fly   422 EDLDNNAVCQQKCENTIGSFRCTCVEGY--HLLEDQRSCALDSCTDLENPQLNRTRCAHECQDLP 484

  Fly   482 IG-FQCLCPPEYTGELCQIAPSCAQQCPIDSECVGGKCV--CKPGSSGPIGHCLPTTTTPTPEQE 543
            .| ::|:||..|  ||.:...||..|   :|.|...|.|  |.||:      ||.:...      
  Fly   485 EGSYRCVCPKGY--ELSEDQHSCLVQ---ESPCSTEKGVEKCSPGT------CLASEDN------ 532

  Fly   544 PTTTPRTTPNPNPAIPNTLTTTTKIPPITTSRTLVGTTTGSRRPPQQPLQSPTQRSASLNACPQE 608
                               |:.:.|.|           ||.|        |.......::.|.::
  Fly   533 -------------------TSFSCICP-----------TGYR--------SEAFSCQDIDECAED 559

  Fly   609 NCLNGGTCLGYSGNYSCICASGYT---GYNCQTSTGDGASALALTPINCNATNGKCL--NGGTCS 668
            ..|...||....|.|.|.|..|..   .|.|....        |..:|.|.....||  .||.|:
  Fly   560 THLCSHTCQNTPGGYQCQCPEGLNLVEEYTCLAEN--------LCEVNNNGCEQICLTARGGVCA 616

  Fly   669 MNGTHCYCAVGY----SGDRCEKAENCSPLN--CQEPMVCVQN-----QCLCP------------ 710
                   |..|:    .|..||..:.|...|  ||:  || :|     .|:|.            
  Fly   617 -------CREGFRLSADGKSCEDVDECLVNNGGCQQ--VC-RNLPGSYGCICAAGYELLKLDGIR 671

  Fly   711 ----ENKVCNQCATQPCQNGGECVDLPNGDYECKCTRGW-------------------------- 745
                :...|:| .|..|.:...|.:| ||.|.|.|..|:                          
  Fly   672 GYCFDIDECSQ-RTHGCSDQMLCENL-NGSYTCLCPPGYALGLDNHIVTSLNSSFITDSTSSETP 734

  Fly   746 TGRTCGNDVDECTLHPKICGNGICKNEKGSYKCYCTPGFT---GVHCDSDVDECLSFPCLNGATC 807
            :..|| .|:|||:|....|.: .|:||.|.::|.|..|:.   .:....|:||||.........|
  Fly   735 SAHTC-LDIDECSLANGNCSH-FCQNEPGGFQCACPLGYALSEDMRTCQDIDECLDSNGQCSQLC 797

  Fly   808 HNKINAYECVCQPGYE----GENCEVDIDECGSNPCSNGSTCIDRINNFTCNCIPG---MTGRIC 865
            .|:...:.|.|:.|:|    |..| .|||||..:..:....||:.:....|.|..|   ...::.
  Fly   798 LNQPGGFACACETGFELTPDGFGC-ADIDECSQDYGNCSDICINLLGTHACACERGYELAKDKLS 861

  Fly   866 DIDIDDCVGDPCLNGG---QCIDQLGGFRCDCSGTGY----EGENCELNIDECLSNPCTNGAKCL 923
            .:|:|:|.|  .|:||   :||::.|.|.|.|. .||    :|.:|...:..|......:...|.
  Fly   862 CLDVDECAG--LLSGGCSHECINKAGTFECGCP-LGYILNDDGRSCSPALVGCPPGTQRSADGCA 923

  Fly   924 DRVKDYFCDCHNGY---KGKNCEQDINECESNPCQYNGNCLERSNITLYQMSRITDLPKVFSQPF 985
            .      .:|:.||   ....| .||:||:    :.||.|..|.:                    
  Fly   924 P------IECNPGYTLGSDDKC-VDIDECQ----KQNGGCSHRCS-------------------- 957

  Fly   986 SFENASG-YECVCVPGI----IGKNCEININECDSNPCS-KHGNCNDGIGTYTCEC--------- 1035
               |..| ::|.|.||.    ..|.|: :|:|||.:..| ..|.|.:.||.:.||.         
  Fly   958 ---NTEGSFKCSCPPGYELDSDQKTCQ-DIDECDQDKTSCITGTCINEIGGFRCEFPKFPVLPEI 1018

  Fly  1036 ------------------------------------------EPGF------EG----------- 1041
                                                      ||.|      ||           
  Fly  1019 PTASSLPESPKIELKTPKYPDFTELSNEIPENPKKPAEFDYPEPKFPSLPKWEGLPKLPPLADIP 1083

  Fly  1042 -THCEINI-----------------------------DECDRYNPCQRGTCYDQIDDYDC--DCD 1074
             :...:.:                             ..|:||...|:...|.:     |  .|:
  Fly  1084 TSKAPVPLRPEVPKSLWVNQLQPRDLCPRFQAPRNGKSHCNRYRHKQKLFYYSR-----CRISCN 1143

  Fly  1075 ANYGGKNCSVL----LKGCDQNPCLNG----------------GAC--LPYLINEVTHLYNCTCE 1117
            :.|      :|    :|.||.|....|                |.|  |....|.|....:||..
  Fly  1144 SGY------ILQGPEIKSCDANGIWEGPETKCVAINQPRAQSPGICPALKPAQNGVILPASCTQG 1202

  Fly  1118 NGFQGDKCEKTTTLSMVATSLISVTTEREEGY----DINLQFRTTLPNGVLAFGTTGEKNEP--- 1175
            ....||.|........|:|..:.......:|:    |:|.|   ...||:|....:...|.|   
  Fly  1203 PSRFGDVCRLQCNAGFVSTGSLLTACMMLQGWSFGADLNCQ---PFGNGLLGNQLSPMWNSPKTV 1264

  Fly  1176 -------VSYILELIN-----------GRLNLHSSLLNKWEGVFIGSKLNDSNW----------- 1211
                   |..|...||           |....|.:|......|..|..:....|           
  Fly  1265 TPHQIQNVEQIRPYINCPENVVILLHAGEQKAHVTLQRPQTNVKNGRLVAHPAWAGQLQGHLPAG 1329

  Fly  1212 -HKVFVAINTSHLVLSANDEQAIFPVGSYETANNSQPSFPRTYLGGTIPNLKSYLRHLTHQPSAF 1275
             |||...:|.....|:......|....:  |...|.|.        |:..:..|.|....:|:.|
  Fly  1330 VHKVDFRVNDPETKLTIKCHTIITVKAA--TPRESNPF--------TLFRISDYSRSSLPRPAPF 1384

  Fly  1276 VGCMQDIMVNGKWIFP-----DEQDANISYTKLENVQSGCPRTEQCKPNPCHSNGECTDLWHTFA 1335
            .    .:.....:.||     |.....:|:||.:..    |.:|..:    ||....:..:..  
  Fly  1385 A----TLSTGSSFSFPAFKALDATPKPVSFTKFQVF----PDSESSE----HSKLGSSSFFRL-- 1435

  Fly  1336 CHCPRPFFGHTCQHNMTAATFGHENTTHSAVIVETTDVARRAIRSILDISMFIRTREPTGQVFYL 1400
                .|.| |.....::||....|||.    :...:|.:.....|   |.::::..:....|.: 
  Fly  1436 ----EPLF-HESSKLISAAPASSENTR----VDLGSDTSNYCPPS---IEVYLKENQNLRSVVW- 1487

  Fly  1401 GTDPRKAPTKNIGDSYVAAKLHGGELL--VKMQFSGTPEAYTVGGQKLDNGYNHLIEVVRNQTLV 1463
             .:||                ..|:||  .|..|.|:  .:.||        :|.|         
  Fly  1488 -DEPR----------------FEGKLLKIYKSHFPGS--LFKVG--------DHAI--------- 1516

  Fly  1464 QVKLNGTEYFRKTLSTTGLLDAQVLYLGGPAPTRESLLGATTEPGIIPVPGAGIPIEDTTVPKEA 1528
              |...|....||||.|..     :|:....||     .|.|||.|      ....|..|:   :
  Fly  1517 --KYEATTTDGKTLSCTFF-----IYVRSAKPT-----PAPTEPKI------SFDSEPETL---S 1560

  Fly  1529 DDSRDYFKGIIQDVKVSNGSLNLIVEMYSLNVTDVQVNAKPLGAVTIDRASVLPGEVSDDLCRKN 1593
            |.|:.|.      |......:.:..|..||.|.....|.:|        .|..|.|         
  Fly  1561 DVSQTYV------VCPDKEPVRVTAESVSLPVGCTLKNIRP--------KSRSPKE--------- 1602

  Fly  1594 PCLHNAECRNTWNDYT 1609
              |...:..:.|:.||
  Fly  1603 --LKRGKLTSLWHQYT 1616

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
crbNP_001247284.1 LamG 91..228 CDD:238058 21/100 (21%)
EGF_CA 386..423 CDD:238011 7/36 (19%)
EGF_CA 425..460 CDD:238011 9/41 (22%)
EGF 466..495 CDD:278437 12/40 (30%)
EGF 605..633 CDD:278437 9/30 (30%)
EGF_CA 716..750 CDD:238011 11/59 (19%)
EGF_CA 753..789 CDD:238011 13/38 (34%)
EGF_CA 792..828 CDD:238011 12/39 (31%)
EGF_CA 830..865 CDD:238011 10/37 (27%)
EGF_CA 868..905 CDD:238011 16/43 (37%)
EGF_CA 907..943 CDD:238011 5/38 (13%)
EGF_CA 1009..1045 CDD:238011 16/105 (15%)
EGF_CA 1047..1082 CDD:238011 8/65 (12%)
Laminin_G_1 1155..1290 CDD:278483 29/167 (17%)
EGF 1316..1346 CDD:278437 4/29 (14%)
Laminin_G_1 1388..1550 CDD:278483 34/163 (21%)
EGF_CA <1593..1622 CDD:238011 4/17 (24%)
Laminin_G_2 1692..1828 CDD:280389
EGF_CA 1901..1937 CDD:238011
EGF_CA 1939..1974 CDD:238011
EGF_CA 2057..2094 CDD:238011
EGF_CA 2096..2133 CDD:238011
EGF_CA 2137..2175 CDD:238011
fracNP_001137905.1 FXa_inhibition 296..331 CDD:291342 12/34 (35%)
cEGF 396..415 CDD:289433 6/29 (21%)
FXa_inhibition 425..458 CDD:291342 7/34 (21%)
FXa_inhibition 476..505 CDD:291342 10/30 (33%)
vWFA <550..586 CDD:294047 9/35 (26%)
FXa_inhibition 596..630 CDD:291342 10/40 (25%)
FXa_inhibition 636..>664 CDD:291342 9/30 (30%)
EGF_CA 676..715 CDD:284955 12/40 (30%)
FXa_inhibition 745..780 CDD:291342 10/35 (29%)
FXa_inhibition 786..821 CDD:291342 9/34 (26%)
FXa_inhibition 827..862 CDD:291342 6/34 (18%)
FXa_inhibition 874..904 CDD:291342 11/30 (37%)
FXa_inhibition 945..980 CDD:291342 12/61 (20%)
CCP 1110..1170 CDD:153056 14/70 (20%)
CCP 1183..1235 CDD:153056 12/51 (24%)
DUF5011 1468..1536 CDD:295940 22/114 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
10.910

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