DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment crb and JAG2

DIOPT Version :9

Sequence 1:NP_001247284.1 Gene:crb / 42896 FlyBaseID:FBgn0259685 Length:2253 Species:Drosophila melanogaster
Sequence 2:NP_002217.3 Gene:JAG2 / 3714 HGNCID:6189 Length:1238 Species:Homo sapiens


Alignment Length:1064 Identity:273/1064 - (25%)
Similarity:393/1064 - (36%) Gaps:312/1064 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   168 DNRWHTLQFKYEYGNLYLHVD-RAASIFANSTYNSQFLTNQDIGYKDAILILGNSFSGCLLDGPG 231
            ::||.:|.|.....:|.|.:. |....:.::|.|.......|..........||  ..|:....|
Human   175 EDRWKSLHFSGHVAHLELQIRVRCDENYYSATCNKFCRPRNDFFGHYTCDQYGN--KACMDGWMG 237

  Fly   232 LQFVNNSTVQ--NVVFGHCPLTPGPC-SDHDLFTRLPDNFCLNDPCMGHGTCSSSPEGYECRCTA 293
            .:.......|  |::.|.|.: ||.| ..:....|..|. |:..|...||:|   .|.::|.|..
Human   238 KECKEAVCKQGCNLLHGGCTV-PGECRCSYGWQGRFCDE-CVPYPGCVHGSC---VEPWQCNCET 297

  Fly   294 RYSGKNCQKDNGSPCAKNPCENGGSCLENSRGDYQCFCDPNHSGQHCETEVNIHPLCQTNPCLNN 358
            .:.|..|.||.....:.:||.|||:|:......|:|.|...:||::||   .....|.:|||.|.
Human   298 NWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCE---KAEHACTSNPCANG 359

  Fly   359 GACVVIGGSGALTCECPKGYAGARCEVDTDECASQPCQNNGSCIDRINGFSCDCSGTGYTGAFCQ 423
            |:|..:  .....|.||.|::|..|.:|.|||||.||...|:|:|:::||.|.|. ..:.||.||
Human   360 GSCHEV--PSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDGFECICP-EQWVGATCQ 421

  Fly   424 TNVDECDKNPCLNGGRCFDTYGWYTCQCLDGWGGEICDRPMTCQTQQCLNGGTCLDKPIGFQCLC 488
            .:.:||:..||||...|.:..|.|.|.|:.||.|..|...:.....||.:||||.|...|:||:|
Human   422 LDANECEGKPCLNAFSCKNLIGGYYCDCIPGWKGINCHINVNDCRGQCQHGGTCKDLVNGYQCVC 486

  Fly   489 PPEYTGELCQIAPSCAQQCPIDSECVGGKCVCKPGSSGPIGHCLPTTTTPTPEQEPTTTPRTTPN 553
            |..:.|..|::                                         |::.         
Human   487 PRGFGGRHCEL-----------------------------------------ERDE--------- 501

  Fly   554 PNPAIPNTLTTTTKIPPITTSRTLVGTTTGSRRPPQQPLQSPTQRSASLNACPQENCLNGGTCLG 618
                                                                             
Human   502 ----------------------------------------------------------------- 501

  Fly   619 YSGNYSCICASGYTGYNCQTSTGDGASALALTPINCNATNGKCLNGGTCS--MNGTHCYCAVGYS 681
                    |||                             ..|.:||.|.  .:|.||:|..|:|
Human   502 --------CAS-----------------------------SPCHSGGLCEDLADGFHCHCPQGFS 529

  Fly   682 GDRCE-KAENCSPLNCQEPMVCVQNQCLCPENKVCNQCATQPCQNGGECVDLPNGDYECKCTRGW 745
            |..|| ..:.|.|                           .||:||..|.:| .|||.|.|...:
Human   530 GPLCEVDVDLCEP---------------------------SPCRNGARCYNL-EGDYYCACPDDF 566

  Fly   746 TGRTCG-----------NDVDEC----------TLHPKICG-NGICKNEK-GSYKCYCTPGFTGV 787
            .|:.|.           ..:|.|          |....:|| :|.|.::. |::.|.|..||||.
Human   567 GGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGT 631

  Fly   788 HCDSDVDECLSFPCLNGATCHNKINAYECVCQPGYEGENCEVDIDECGSNPCSNGSTCIDRINNF 852
            :|..::|:||..||.||.||.::::|:.|.|..|:|||.|:.:.::|..:||.:...|.|.:|:|
Human   632 YCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDF 696

  Fly   853 TCNCIPGMTGRICDIDIDDCVGDPCLNGGQCIDQLGGFRCDCSGTGYEGENCEL-NIDECLSNPC 916
            .|.|..|..|:.|......|....|.|||.|.|....|||.|. .|::|..|.: ....||.|||
Human   697 YCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACP-PGWKGSTCAVAKNSSCLPNPC 760

  Fly   917 TNGAKCLDRVKDYFCDCHNGYKGKNCEQDINECESNPCQYNGNCLERSNITLYQMSRITDLPKVF 981
            .||..|:.....:.|.|.:|::|:.|..:.|:|...||...|.|::..|                
Human   761 VNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVN---------------- 809

  Fly   982 SQPFSFENASGYECVCVPGIIGKNCEININECDSNPCSKHGNCNDGIGTYTCECEPGFEGTHCEI 1046
                      .:.|.|.||..|.:|.|||:||.|:||:....|.|.|..|.|.|.||..|..|:.
Human   810 ----------WFRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQE 864

  Fly  1047 NID---EC-DRYNPCQRGTCYDQIDDYDCD-CDANYGGKNCSVLLKGCDQNPCLNGG-------- 1098
            .|.   .| .|..|...|:.:.:    ||: |....|.::||.:  .|...|||..|        
Human   865 VIGFGRSCWSRGTPFPHGSSWVE----DCNSCRCLDGRRDCSKV--WCGWKPCLLAGQPEALSAQ 923

  Fly  1099 ----------------------------------ACLPYLINEVTHLYNCTCEN---GFQGDKCE 1126
                                              .|||    ...||.| .|..   .|..|...
Human   924 CPLGQRCLEKAPGQCLRPPCEAWGECGAEEPPSTPCLP----RSGHLDN-NCARLTLHFNRDHVP 983

  Fly  1127 KTTTLSMVATSLISVTTEREEGYD 1150
            :.||:..:.:.:.|:...|....|
Human   984 QGTTVGAICSGIRSLPATRAVARD 1007

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
crbNP_001247284.1 LamG 91..228 CDD:238058 13/60 (22%)
EGF_CA 386..423 CDD:238011 17/36 (47%)
EGF_CA 425..460 CDD:238011 14/34 (41%)
EGF 466..495 CDD:278437 12/28 (43%)
EGF 605..633 CDD:278437 3/27 (11%)
EGF_CA 716..750 CDD:238011 12/33 (36%)
EGF_CA 753..789 CDD:238011 14/47 (30%)
EGF_CA 792..828 CDD:238011 16/35 (46%)
EGF_CA 830..865 CDD:238011 11/34 (32%)
EGF_CA 868..905 CDD:238011 13/36 (36%)
EGF_CA 907..943 CDD:238011 12/35 (34%)
EGF_CA 1009..1045 CDD:238011 16/35 (46%)
EGF_CA 1047..1082 CDD:238011 9/39 (23%)
Laminin_G_1 1155..1290 CDD:278483
EGF 1316..1346 CDD:278437
Laminin_G_1 1388..1550 CDD:278483
EGF_CA <1593..1622 CDD:238011
Laminin_G_2 1692..1828 CDD:280389
EGF_CA 1901..1937 CDD:238011
EGF_CA 1939..1974 CDD:238011
EGF_CA 2057..2094 CDD:238011
EGF_CA 2096..2133 CDD:238011
EGF_CA 2137..2175 CDD:238011
JAG2NP_002217.3 MNNL 28..102 CDD:284966
DSL 178..240 CDD:279722 13/63 (21%)
EGF_CA 307..345 CDD:238011 12/37 (32%)
EGF 351..381 CDD:278437 12/31 (39%)
EGF_CA 385..421 CDD:238011 17/36 (47%)
EGF_CA 423..458 CDD:238011 14/34 (41%)
EGF_CA 461..496 CDD:238011 13/34 (38%)
EGF_CA 500..534 CDD:238011 14/144 (10%)
EGF_CA 536..571 CDD:238011 14/62 (23%)
EGF_CA 636..671 CDD:238011 16/34 (47%)
EGF_CA 676..709 CDD:238011 11/32 (34%)
EGF 716..746 CDD:278437 13/30 (43%)
EGF_CA 757..787 CDD:238011 10/29 (34%)
EGF_CA 789..824 CDD:238011 12/60 (20%)
EGF_CA 827..863 CDD:238011 16/35 (46%)
VWC_out 872..943 CDD:214565 15/76 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1114..1139
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1156..1238
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E33208_3BAFT
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

Return to query results.
Submit another query.