DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment crb and EYS

DIOPT Version :9

Sequence 1:NP_001247284.1 Gene:crb / 42896 FlyBaseID:FBgn0259685 Length:2253 Species:Drosophila melanogaster
Sequence 2:NP_001278938.1 Gene:EYS / 346007 HGNCID:21555 Length:3165 Species:Homo sapiens


Alignment Length:2838 Identity:605/2838 - (21%)
Similarity:919/2838 - (32%) Gaps:1044/2838 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   221 SFSGCLLDGPGLQFVNNSTVQNVVFG------------------HCPLT-----PGPCSDHDLFT 262
            ||.||:        .|.:|...::||                  |..:|     |.||   .|..
Human   110 SFVGCV--------QNTTTEDQLLFGCRLKGMHTVNSKWLSVGTHYFITVMASGPSPC---PLGL 163

  Fly   263 RL----PDNFC----LNDPCMGHGTCSSS--PEGYECRCTARYSGKNCQKDNGSPCAKNPCENGG 317
            ||    ...||    .::.|.|||.|.|.  .:.|.|.|...:|||.||:.:.  |:..||:|.|
Human   164 RLNVTVKQQFCQESLSSEFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQELDA--CSFKPCKNNG 226

  Fly   318 SCLENSRGD-----YQCFCDPNHSGQH-------CETEVNIH---------------------PL 349
            ||: |.|.:     |:|.|.|..:|::       |:..|..|                     |.
Human   227 SCI-NKRENWDEQAYECVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSNSFICECDEQFSGPF 290

  Fly   350 CQTN--PCLN-----NGACVVIGGSGALTCECPKGYAGARCEVDTDECASQPCQNNGSCIDRING 407
            |:.:  ||::     .|.|.  ..|.|.|.|||||.:....|.|..|.:..||||...||...|.
Human   291 CEVSAKPCVSLLFWKRGICP--NSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCIKISND 353

  Fly   408 FSCDCSGTGYTGAFCQTNVDECDKNPCLNGGRCFDTYGWYTCQCLDGWGGEICDRPMT-CQ--TQ 469
            ..|.||.. :|...|::....|:..|..|...|......|.|.|:.|:..:.|::.:. |:  :.
Human   354 VMCICSPI-FTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCISGFTEKNCEKAIDHCKLLSI 417

  Fly   470 QCLNGGTCLDKPIGFQCLCPP---------------------------------------EYT-- 493
            .|||...|.:....|:.:|.|                                       ||.  
Human   418 NCLNEEWCFNIIGRFKYVCIPGCTKNPCWFLKNVYLIHQHLCYCGVTFHGICQDKGPAQFEYVWQ 482

  Fly   494 -------GELCQ--------IAPSCAQQC-----PID--SEC----VGGKCVCKPGSSGPIGHCL 532
                   ||.||        :|.:|.:..     |.|  |.|    .|.|.:|..|.|     ||
Human   483 LGFAGSEGEKCQGVIDAYFFLAANCTEDATYVNDPEDNNSSCWFPHEGTKEICANGCS-----CL 542

  Fly   533 PTTTTPTPEQEPTTTPR---------------TTPNPNPAIPNTLTTTTKI--PPITTSRTLVG- 579
                    .:|.:...|               ||.:......:......:|  |..:.|.:.:| 
Human   543 --------SEEDSQEYRYLCFLRWAGNMYLENTTDDQENECQHEAVCKDEINRPRCSCSLSYIGR 599

  Fly   580 ----------------------------TTTGSRRPPQQPLQSPTQRSASLNACPQENCLNGGTC 616
                                        ..:|.:|..:...:..|:      .|...:|.||.|.
Human   600 LCVVNVDYCLGNHSISVHGLCLALSHNCNCSGLQRYERNICEIDTE------DCKSASCKNGTTS 658

  Fly   617 LGYSGNYSCICASGYTGYNCQTSTGDGASALALTPINCNATNGKCLNGGTC-------------- 667
            ....|.:...|..|:.|..|:....:.||             ..|.||.||              
Human   659 THLRGYFFRKCVPGFKGTQCEIDIDECAS-------------HPCKNGATCIDQPGNYFCQCVPP 710

  Fly   668 --SMNGTHCYCAVGYSGDRCEK-AENCSPLNCQEPMVC----VQNQCLCP---ENKVC----NQC 718
              .::|..|.|..||.|.|||: .::|....|:....|    :..||:|.   |...|    |:|
Human   711 FKVVDGFSCLCNPGYVGIRCEQDIDDCILNACEHNSTCKDLHLSYQCVCLSDWEGNFCEQESNEC 775

  Fly   719 ATQPCQNGGECVDLPNGDYECKCTRGWTGRTCGNDVDECTLHPKICGN-GICKNE--KGSYKCYC 780
            ...||:|...|.||.. .|.|:||.||||:.|..:::||...|  |.| |:|...  .|.:.|.|
Human   776 KMNPCKNNSTCTDLYK-SYRCECTSGWTGQNCSEEINECDSDP--CMNGGLCHESTIPGQFVCLC 837

  Fly   781 TPGFTG------------VH-----------------------------CDSDVDECLSFPCLNG 804
            .|.:||            :|                             |:.||.:||...|.:.
Human   838 PPLYTGQFCHQRYNLCDLLHNPCRNNSTCLALVDANQHCICREEFEGKNCEIDVKDCLFLSCQDY 902

  Fly   805 ATCHNKINAYECVCQPGYEGENCEVDIDECGSNPCSNGSTCIDRINNFTCNCIPGMTGRICDIDI 869
            ..|.:.:|.:.|:|:||:.|..||::|:||.|.||.|..||:|..|.|.|||.|...|..|::|:
Human   903 GDCEDMVNNFRCICRPGFSGSLCEIEINECSSEPCKNNGTCVDLTNRFFCNCEPEYHGPFCELDV 967

  Fly   870 DDCVGDPCLNGGQCIDQLGGFRCDCSGTGYEGENCELNIDECLSNPCTNGAKCLDRVKDYFCDCH 934
            :.|...|||:...|:.:..|:.|.|: .||.|.|||:|:|||||.||.:...|:|.:..|.|||.
Human   968 NKCKISPCLDEENCVYRTDGYNCLCA-PGYTGINCEINLDECLSEPCLHDGVCIDGINHYTCDCK 1031

  Fly   935 NGYKGKNCEQDINECESNPCQYNGNCLERSNITLYQMS------------RITDLPKV--FSQPF 985
            :|:.|.:||.:.|:|.|||| .:|.|.|.  |..|..|            :|.|...:  .::.|
Human  1032 SGFFGTHCETNANDCLSNPC-LHGRCTEL--INEYPCSCDADGTSTQCKIKINDCTSIPCMNEGF 1093

  Fly   986 SFENASGYECVCVPGIIGKNCEININEC-----DSNPCSKHGNCNDGIG-TYTCECEPGFEGTHC 1044
            ..::|.|:.|:|..|..|..||.:|:.|     :|..|...|.|.||.| |:.|.|.|||.|..|
Human  1094 CQKSAHGFTCICPRGYTGAYCEKSIDNCAEPELNSVICLNGGICVDGPGHTFDCRCLPGFSGQFC 1158

  Fly  1045 EINIDECDRYNPCQRGT-CYDQIDDYDCDCDANYGGKNCSVLLKGCDQNPCLNGGACLPYLINEV 1108
            ||||:||.. :||..|. |.|.|:.|.|.|...:.|.:|...|: |..|.|:: ..|:.   ||.
Human  1159 EININECSS-SPCLHGADCEDHINGYVCKCQPGWSGHHCENELE-CIPNSCVH-ELCME---NEP 1217

  Fly  1109 THLYNCTCENGFQ--------GDKCEKTTTLSMV--------------------ATSLISVTTER 1145
            ..  .|.|..||.        ||:..:.|.|:.:                    .:|..|:...|
Human  1218 GS--TCLCTPGFMTCSIGLLCGDEIRRITCLTPIFQRTDPISTQTYTIPPSETLVSSFPSIKATR 1280

  Fly  1146 ----EEGYDINLQFRTT-------LPNGVLAFGTTGEKNEPV-SYILE--LINGRLNLHSSLLNK 1196
                .:.|.::...:.|       ||...||   |...:.|: ||:|:  ::...|:...|||:.
Human  1281 IPAIMDTYPVDQGPKQTGIVKHDILPTTGLA---TLRISTPLESYLLQELIVTRELSAKHSLLSS 1342

  Fly  1197 WE---------GVFIGSKLNDSNWHKVFVAINTS---------------HLVLSANDEQAIFPVG 1237
            .:         |:...:::.........:.|.||               ..::|:.....|||..
Human  1343 ADVSSSRFLNFGIRDPAQIVQDKTSVSHMPIRTSAATLGFFFPDRRARTPFIMSSLMSDFIFPTQ 1407

  Fly  1238 S--YETANN-SQPSFPRTYLGGTIP------NLKSYLRH--------LTHQPSAFVGCMQDIMVN 1285
            |  :|.... :..:.|.|.:..:||      |.:|.|..        ::..|....|..:||   
Human  1408 SLLFENCQTVALSATPTTSVIRSIPGADIELNRQSLLSRGFLLIAASISATPVVSRGAQEDI--- 1469

  Fly  1286 GKWIFPDEQDANISYTKLENVQSGCPRTEQCKPNPCHSNGECTDLWHTFACHCPRPFFGHTCQHN 1350
                  :|..|:...::.|:.:...|......|.....:.:.|.|             ..:..|.
Human  1470 ------EEYSADSLISRREHWRLLSPSMSPIFPAKVIISKQVTIL-------------NSSALHR 1515

  Fly  1351 MTAATFG---HENTTHSAVIVETTDVARRAIRSILDISMFIRT---------REPTGQV------ 1397
            .:...|.   ::..|.::.....|::..:|..|:.::|....|         ||.:.||      
Human  1516 FSTKAFNPSEYQAITEASSNQRLTNIKSQAADSLRELSQTCATCSMTEIKSSREFSDQVLHSKQS 1580

  Fly  1398 -FY----------------LGTDPRKAPTKNIGDSYVAAKLHGGELLVKMQFSGTPEAY------ 1439
             ||                :|     |.|...|.|:.:|.    |:...:.|:..|..:      
Human  1581 HFYETFWMNSAILASWYALMG-----AQTITSGHSFSSAT----EITPSVAFTEVPSLFPSKKSA 1636

  Fly  1440 --TVGGQKLDNGY-------------NHLIEVVRNQTLVQVKLNGTEYFRKTLSTTGLLDAQVLY 1489
              |:....|:...             ...:.:|.:||:....:|.....:.|.....:.: .:|.
Human  1637 KRTILSSSLEESITLSSNLDVNLCLDKTCLSIVPSQTISSDLMNSDLTSKMTTDELSVSE-NILK 1700

  Fly  1490 L---------GGPAP--TRESLLGATTEPGIIPVPGAGIPIEDTTVPK--EADDSRDYFKGIIQD 1541
            |         .||..  .:||||......|            ..|:.|  .:|.|.|:       
Human  1701 LLKIRQYGITMGPTEVLNQESLLDMEKSKG------------SHTLFKLHPSDSSLDF------- 1746

  Fly  1542 VKVSNGSLNL------IVEMYS--LNVTDVQVNAKPL-GAV-------------TIDRASVLPGE 1584
                  .|||      .::.||  .:..|.:.|..|| |:|             |:.....|..:
Human  1747 ------ELNLQIYPDVTLKTYSEITHANDFKNNLPPLTGSVPDFSEVTTNVAFYTVSATPALSIQ 1805

  Fly  1585 VSDDLCRKNPCLHNAECRNTW---NDYTCKCPNGYKGK----------NCQEIEF---CQHVTCP 1633
            .|..:         :..|..|   .||........|..          :.|..||   .:|:...
Human  1806 TSSSM---------SVIRPDWPYFTDYMTSLKKEVKTSSEWSKWELQPSVQYQEFPTASRHLPFT 1861

  Fly  1634 GQSLCQNLDDGYECVTNTTFTGQERSPLAFFYFQEQQSDDIVSEASPKQTLKPVIDIAFRTRAG- 1697
            ......:|:         :....:|..::.|.......|..:...:.....:..|.:.|:|.:. 
Human  1862 RSLTLSSLE---------SILAPQRLMISDFSCVRYYGDSYLEFQNVALNPQNNISLEFQTFSSY 1917

  Fly  1698 GTLLYIDN----VDGFF-EIGVNGGRVTITWKLSALHF---GESARFEKENT-----DGEWSRIY 1749
            |.|||:..    ||||| ::.:..|  |:.:     ||   || |:|:..||     :|:...:.
Human  1918 GLLLYVKQDSNLVDGFFIQLFIENG--TLKY-----HFYCPGE-AKFKSINTTVRVDNGQKYTLL 1974

  Fly  1750 LRAHNSKLEGGWKGWESMVDPTPA------FSTDIDQAAFQSL---IATSTQVYLGGMPESRQAR 1805
            :|..              :||..|      .:|.|.::....|   :..|..|::||.|:   ..
Human  1975 IRQE--------------LDPCNAELTILGRNTQICESINHVLGKPLPKSGSVFIGGFPD---LH 2022

  Fly  1806 GSTLSAQQGSQFKGCVGEARVGDLLLPYFSMAELYSRTNVSVQQKAQFRLNATRPEEGCILCFQS 1870
            |..........|.||:....:.:.            |:.:..:....:.:|              
Human  2023 GKIQMPVPVKNFTGCIEVIEINNW------------RSFIPSKAVKNYHIN-------------- 2061

  Fly  1871 DCKNDGFCQSPSDEYACTCQPGFEGDDCGTDIDE--------------CLNTECLNNGTC----- 1916
            :|::.||..||:..:.       :..|....:|.              |....|.|.|||     
Human  2062 NCRSQGFMLSPTASFV-------DASDVTQGVDTMWTSVSPSVAAPSVCQQDVCHNGGTCHAIFL 2119

  Fly  1917 INQVAAFFCQCQPGFEGQHCEQ------------------------------------------- 1938
            .:.:.:|.|.|...|.|:.||:                                           
Human  2120 SSGIVSFQCDCPLHFTGRFCEKDAGLFFPSFNGNSYLELPFLKFVLEKEHNRTVTIYLTIKTNSL 2184

  Fly  1939 -------NIDECADQ---------------PCHNGGNCTDLIASYVCD------------CPEDY 1969
                   |.:.|..|               .|.|..|...:.|:|..:            .|...
Human  2185 NGTILYSNGNNCGKQFLHLFLVEGRPSVKYGCGNSQNILTVSANYSINTNAFTPITIRYTTPVGS 2249

  Fly  1970 MGPQCDVLKQMTCENEP------------------------------------------------ 1986
            .|..|.:  :||.:.:|                                                
Human  2250 PGVVCMI--EMTADGKPPVQKKDTEISHASQAYFESMFLGHIPANVQIHKKAGPVYGFRGCILDL 2312

  Fly  1987 -------------------------------CRNGSTCQNGFNASTGNNFTCTCVPGFEGPLCDI 2020
                                           |||..||     .|...|..|.|...:.|.||..
Human  2313 QVNNKEFFIIDEARHGKNIENCHVPWCAHHLCRNNGTC-----ISDNENLFCECPRLYSGKLCQF 2372

  Fly  2021 PFCEITPCDNGGLCL-TTGAVPMCKCSLGYTGRLCEQDINECESNPCQNG------------GQC 2072
            ..||..||.||..|: .:|...:|.|..|.:|.||...||  .:.|..:|            .:.
Human  2373 ASCENNPCGNGATCVPKSGTDIVCLCPYGRSGPLCTDAIN--ITQPRFSGTDAFGYTSFLAYSRI 2435

  Fly  2073 KDLVGRYECDCQ----------------------------------------------GTGFEGI 2091
            .|:...||...:                                              |:|...|
Human  2436 SDISFHYEFHLKFQLANNHSALQNNLIFFTGQKGHGLNGDDFLAVGLLNGSVVYSYNLGSGIASI 2500

  Fly  2092 RCENDIDECNME-GDYCGGLGRCF-----------NK----PGSF--QCICQKPYCGAY------ 2132
            |.|    ..|:. |.:...||:.|           ||    ||..  ..:..:.|.|.|      
Human  2501 RSE----PLNLSLGVHTVHLGKFFQEGWLKVDDHKNKSIIAPGRLVGLNVFSQFYVGGYSEYTPD 2561

  Fly  2133 --------------CNFT--------------------------------DPCNATDLCSNGGRC 2151
                          |.||                                .||:... |.|||.|
Human  2562 LLPNGADFKNGFQGCIFTLQVRTEKDGHFRGLGNPEGHPNAGRSVGQCHASPCSLMK-CGNGGTC 2625

  Fly  2152 VESCGAKPDYYCECPEGFAGKNCTAPITA---KEDGP--STTDIAIIVIPVVVVLLLIAGALLGT 2211
            :||   ....||.|..|:.|..||..::.   :.|.|  .:.....|.:|.........|     
Human  2626 IES---GTSVYCNCTTGWKGSFCTETVSTCDPEHDPPHHCSRGATCISLPHGYTCFCPLG----- 2682

  Fly  2212 FLVMARNKRATRGTYSPSAQEYCNPRLEMDNVL-KPPPEERLI 2253
                      |.|.       ||...|.:..:| ||.|.||.:
Human  2683 ----------TTGI-------YCEQALILIVILEKPKPAERKV 2708

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
crbNP_001247284.1 LamG 91..228 CDD:238058 4/6 (67%)
EGF_CA 386..423 CDD:238011 13/36 (36%)
EGF_CA 425..460 CDD:238011 8/34 (24%)
EGF 466..495 CDD:278437 10/78 (13%)
EGF 605..633 CDD:278437 8/27 (30%)
EGF_CA 716..750 CDD:238011 16/33 (48%)
EGF_CA 753..789 CDD:238011 14/79 (18%)
EGF_CA 792..828 CDD:238011 12/35 (34%)
EGF_CA 830..865 CDD:238011 17/34 (50%)
EGF_CA 868..905 CDD:238011 13/36 (36%)
EGF_CA 907..943 CDD:238011 16/35 (46%)
EGF_CA 1009..1045 CDD:238011 16/41 (39%)
EGF_CA 1047..1082 CDD:238011 14/35 (40%)
Laminin_G_1 1155..1290 CDD:278483 35/185 (19%)
EGF 1316..1346 CDD:278437 3/29 (10%)
Laminin_G_1 1388..1550 CDD:278483 37/227 (16%)
EGF_CA <1593..1622 CDD:238011 5/41 (12%)
Laminin_G_2 1692..1828 CDD:280389 38/158 (24%)
EGF_CA 1901..1937 CDD:238011 12/54 (22%)
EGF_CA 1939..1974 CDD:238011 10/61 (16%)
EGF_CA 2057..2094 CDD:238011 11/94 (12%)
EGF_CA 2096..2133 CDD:238011 12/74 (16%)
EGF_CA 2137..2175 CDD:238011 14/37 (38%)
EYSNP_001278938.1 Plasmod_Pvs28 195..>283 CDD:283826 25/90 (28%)
EGF_CA 681..731 CDD:238011 14/62 (23%)
EGF_CA 733..769 CDD:238011 7/35 (20%)
EGF_CA 773..806 CDD:238011 16/33 (48%)
EGF_CA 810..846 CDD:238011 13/37 (35%)
EGF_CA 890..926 CDD:238011 12/35 (34%)
EGF_CA 929..964 CDD:238011 17/34 (50%)
EGF_CA 966..1002 CDD:238011 13/36 (36%)
EGF_CA 1004..1040 CDD:238011 16/35 (46%)
EGF_CA 1080..1115 CDD:238011 9/34 (26%)
EGF_CA 1118..1159 CDD:238011 16/40 (40%)
EGF_CA 1161..1197 CDD:238011 14/36 (39%)
LamG 1886..2044 CDD:238058 40/182 (22%)
LamG 2149..2315 CDD:238058 14/167 (8%)
Laminin_G_2 2461..2582 CDD:280389 20/124 (16%)
EGF_CA 2657..2689 CDD:238011 8/53 (15%)
LamG 2740..2877 CDD:214598
Laminin_G_2 3007..3138 CDD:280389
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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