DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment crb and Dlk2

DIOPT Version :9

Sequence 1:	NP_001247284.1	Gene:	crb / 42896	FlyBaseID:	FBgn0259685	Length:	2253	Species:	Drosophila melanogaster
Sequence 2:	XP_017451911.1	Gene:	Dlk2 / 316232	RGDID:	1309143	Length:	405	Species:	Rattus norvegicus

Alignment Length:	262	Identity:	100/262 - (38%)
Similarity:	128/262 - (48%)	Gaps:	27/262 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   699 PMVCVQNQCLCPENKVCNQC---ATQPCQNGGEC---VDLPNG----DYECKCTRGWTGRTCGND 753
            |.:.:.:.|.| .|.||..|   ||.......:|   .||.:|    |..|:|..||.|..|
  Rat    20 PELTMPSGCRC-LNLVCLLCILGATSQPARADDCSSHCDLAHGCCAPDGSCRCDPGWEGLHC--- 80

  Fly   754 VDECTLHPKICGNGICKNEKGSYKCYCTPGFTGVHCDSDVDECLS-FPCLNGATC-HNKINAYEC 816
             :.|...|. |.:|.|..   .::|.|..|:.|..||.|...|.| .||.||..| ::....|.|
  Rat    81 -ERCVRMPG-CQHGTCHQ---PWQCICHSGWAGKFCDKDEHICTSQSPCQNGGQCVYDGGGEYHC 140

  Fly   817 VCQPGYEGENCEVDIDEC--GSNPCSNGSTCIDRIN---NFTCNCIPGMTGRICDIDIDDCVGDP 876
            ||.||:.|..||.....|  ...||.||..|.|...   ||||.|:.|..|..|::::|||:..|
  Rat   141 VCLPGFRGRGCERKAGPCEQAGFPCQNGGQCQDNQGFALNFTCRCLAGFMGAHCEVNVDDCLMRP 205

  Fly   877 CLNGGQCIDQLGGFRCDCSGTGYEGENCELNIDECLSNPCTNGAKCLDRVKDYFCDCHNGYKGKN 941
            |.||..|||.:..|.|.|. .|:.|..|.:|:|:|.|.||..||:|.|||.|:.|.|.:||.||.
  Rat   206 CANGATCIDGINRFSCLCP-EGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKT 269

  Fly   942 CE 943
            ||
  Rat   270 CE 271

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crb	NP_001247284.1	LamG	91..228	CDD:238058
		EGF_CA	386..423	CDD:238011
		EGF_CA	425..460	CDD:238011
		EGF	466..495	CDD:278437
		EGF	605..633	CDD:278437
		EGF_CA	716..750	CDD:238011	13/43 (30%)
		EGF_CA	753..789	CDD:238011	9/35 (26%)
		EGF_CA	792..828	CDD:238011	15/37 (41%)
		EGF_CA	830..865	CDD:238011	14/39 (36%)
		EGF_CA	868..905	CDD:238011	15/36 (42%)
		EGF_CA	907..943	CDD:238011	19/35 (54%)
		EGF_CA	1009..1045	CDD:238011
		EGF_CA	1047..1082	CDD:238011
		Laminin_G_1	1155..1290	CDD:278483
		EGF	1316..1346	CDD:278437
		Laminin_G_1	1388..1550	CDD:278483
		EGF_CA	<1593..1622	CDD:238011
		Laminin_G_2	1692..1828	CDD:280389
		EGF_CA	1901..1937	CDD:238011
		EGF_CA	1939..1974	CDD:238011
		EGF_CA	2057..2094	CDD:238011
		EGF_CA	2096..2133	CDD:238011
		EGF_CA	2137..2175	CDD:238011
Dlk2	XP_017451911.1	EGF_CA	112..152	CDD:238011	16/39 (41%)
		EGF_CA	<164..195	CDD:238011	13/30 (43%)
		EGF_CA	197..233	CDD:238011	15/36 (42%)
		EGF_CA	235..271	CDD:238011	19/35 (54%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000