DRSC/TRiP Functional Genomics Resources

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Protein Alignment crb and N

DIOPT Version :9

Sequence 1:NP_001247284.1 Gene:crb / 42896 FlyBaseID:FBgn0259685 Length:2253 Species:Drosophila melanogaster
Sequence 2:NP_001245510.1 Gene:N / 31293 FlyBaseID:FBgn0004647 Length:2703 Species:Drosophila melanogaster


Alignment Length:2071 Identity:528/2071 - (25%)
Similarity:732/2071 - (35%) Gaps:753/2071 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   194 FANSTYNSQFLTNQDIGYKDAILILGNSFSGCLLDGPGLQFVNNSTVQNVVFGHCPLTPGPCSDH 258
            |||       |.|...|...|::....:..||...|..:..:|..|       :|     .|..|
  Fly    43 FAN-------LPNTVRGTDTALVAASCTSVGCQNGGTCVTQLNGKT-------YC-----ACDSH 88

  Fly   259 DLFTRLPD-----NFCLNDPCMGHGTCS----SSPEGYECRCTARYSGKNCQKDNGSPCAKNPCE 314
                .:.|     |.|.:..|...|||.    :...|..|:|...:....|:....:.|....|.
  Fly    89 ----YVGDYCEHRNPCNSMRCQNGGTCQVTFRNGRPGISCKCPLGFDESLCEIAVPNACDHVTCL 149

  Fly   315 NGGSCLENSRGDYQCFCDPNHSGQHCETEVNIHPLCQTNPCLNNGACVVIGGSGALTCECPKGYA 379
            |||:|...:..:|.|.|...::|:.|||:    .||.::||.|...|..:.||.:.||.||.|:.
  Fly   150 NGGTCQLKTLEEYTCACANGYTGERCETK----NLCASSPCRNGATCTALAGSSSFTCSCPPGFT 210

  Fly   380 GARCEVDTDECASQPCQNNGSCIDRINGFSCDCSGTGYTGAFCQTNVDECDKNPCLNGGRCFDTY 444
            |..|..|.:||.|.||:..|:|::....:.|.|. |||||..|.|....|..:||.|||.|....
  Fly   211 GDTCSYDIEECQSNPCKYGGTCVNTHGSYQCMCP-TGYTGKDCDTKYKPCSPSPCQNGGICRSNG 274

  Fly   445 GWYTCQCLDGWGGEICDRPM-TCQTQQCLNGGTCLDKPIGFQCLCPPEYTGELCQ-IAPSCAQQC 507
            ..|.|:|..|:.|:.|::.. .|....|.|||||:|....:.|.|||.:||..|| ....|||: 
  Fly   275 LSYECKCPKGFEGKNCEQNYDDCLGHLCQNGGTCIDGISDYTCRCPPNFTGRFCQDDVDECAQR- 338

  Fly   508 PIDSECVGGKCVCKPGSSGPIGHCLPTTTTPTPEQEPTTTPRTTPNPNPAIPNTLTTTTKIPPIT 572
                                                                             
  Fly   339 ----------------------------------------------------------------- 338

  Fly   573 TSRTLVGTTTGSRRPPQQPLQSPTQRSASLNACPQENCLNGGTCLGYSGNYSCICASGYTGYNCQ 637
                            ..|:                 |.||.||....|:|||||.:|:.|.:|.
  Fly   339 ----------------DHPV-----------------CQNGATCTNTHGSYSCICVNGWAGLDCS 370

  Fly   638 TSTGD--------GASAL-ALTPINCNATNGK----CLNGGTCSMNGTH---------------C 674
            .:|.|        ||:.: .:....|..|.||    |.....|:.|..|               |
  Fly   371 NNTDDCKQAACFYGATCIDGVGSFYCQCTKGKTGLLCHLDDACTSNPCHADAICDTSPINGSYAC 435

  Fly   675 YCAVGYSGDRC-EKAENC---SPLNCQEPMVCVQN----QCLCPENKV---C----NQCATQPCQ 724
            .||.||.|..| |..:.|   ||  |:...:||..    :|.|.:...   |    |:|.:.|||
  Fly   436 SCATGYKGVDCSEDIDECDQGSP--CEHNGICVNTPGSYRCNCSQGFTGPRCETNINECESHPCQ 498

  Fly   725 NGGECVDLPNGDYECKCTRGWTGRTCGNDVDECTLHPKICGN-GICKNEKGSYKCYCTPGFTGVH 788
            |.|.|:|.| |.:.|.|..|:||..|..|:|||..:|  |.| |.|.::...:||.|..||||..
  Fly   499 NEGSCLDDP-GTFRCVCMPGFTGTQCEIDIDECQSNP--CLNDGTCHDKINGFKCSCALGFTGAR 560

  Fly   789 CDSDVDECLSFPCLNGATCHNKINAYECVCQPGYEGENCEVDIDECGSNPCSNGSTCIDRINNFT 853
            |..::|:|.|.||.|...||:.|..|.|.|.|||.|.:||::|::|.||||..|. |||.:|:|.
  Fly   561 CQINIDDCQSQPCRNRGICHDSIAGYSCECPPGYTGTSCEININDCDSNPCHRGK-CIDDVNSFK 624

  Fly   854 CNCIPGMTGRICDIDIDDCVGDPCLNGGQCIDQLGGFRCDCSGTGYEGENCELNIDECLSNPCTN 918
            |.|.||.||.||...|::|..:||...|.|.|::|.:.|.|. .|..|:|||:|::||.||||.|
  Fly   625 CLCDPGYTGYICQKQINECESNPCQFDGHCQDRVGSYYCQCQ-AGTSGKNCEVNVNECHSNPCNN 688

  Fly   919 GAKCLDRVKDYFCDCHNGYKGKNCEQDINECESNPCQYNGNCLERSNITLYQMSRITDLPKVFSQ 983
            ||.|:|.:..|.|.|..|:.|::||::::||.|:||..||.|:::.|                  
  Fly   689 GATCIDGINSYKCQCVPGFTGQHCEKNVDECISSPCANNGVCIDQVN------------------ 735

  Fly   984 PFSFENASGYECVCVPGIIGKNCEININECDSNPCSKHGNCNDGIGTYTCECEPGFEGTHCEINI 1048
                    ||:|.|..|....:|..:::||.||||...|.|.|||..:.|.|.||:.|..||::|
  Fly   736 --------GYKCECPRGFYDAHCLSDVDECASNPCVNEGRCEDGINEFICHCPPGYTGKRCELDI 792

  Fly  1049 DECDRYNPCQR-GTCYDQIDDYDCDCDANYGGKNCSVLLKGCDQNPCLNGGACLPYLINEVTHLY 1112
            |||.. ||||. |||||:::.:.|.|...|.|:.|...:..|..|||.|||.|:     :..:.|
  Fly   793 DECSS-NPCQHGGTCYDKLNAFSCQCMPGYTGQKCETNIDDCVTNPCGNGGTCI-----DKVNGY 851

  Fly  1113 NCTCENGFQGDKCE-----------KTTTLSMVATSLISVTTEREEGY-------DIN-LQFRTT 1158
            .|.|:..|.|..||           |.......:::.:..:...:.||       ||: ....:.
  Fly   852 KCVCKVPFTGRDCESKMDPCASNRCKNEAKCTPSSNFLDFSCTCKLGYTGRYCDEDIDECSLSSP 916

  Fly  1159 LPNGVLAFGTTGEKNEPVSYILELINGRLNLHSSLLNKWEGVFIGSKLNDSNWHKVFVAINTSHL 1223
            ..||....      |.|.||......|           :||       .|       .||||   
  Fly   917 CRNGASCL------NVPGSYRCLCTKG-----------YEG-------RD-------CAINT--- 947

  Fly  1224 VLSANDEQAIFPVGSYETANNSQPSFPRTYLGGT-IPNLKSYLRHLTHQPSAFVGCMQDIMVNGK 1287
                 |:.|.||..:                ||| :..:..|            .|:.....:||
  Fly   948 -----DDCASFPCQN----------------GGTCLDGIGDY------------SCLCVDGFDGK 979

  Fly  1288 WIFPDEQDANISYTKLENVQSGCPRTEQCKPNPCHSNGECTDLWHTFACHCPRPFFGHTCQHNMT 1352
            ..   |.|.|                 :|...||.:...|:...:::.|.||..|.|..||.|  
  Fly   980 HC---ETDIN-----------------ECLSQPCQNGATCSQYVNSYTCTCPLGFSGINCQTN-- 1022

  Fly  1353 AATFGHENTTHSAVIVETTDVARRAIRSILDISMFIRTREPTGQVFYLGTDPRKAPTKNIGDSYV 1417
                 .|:.|.|:.:                                                  
  Fly  1023 -----DEDCTESSCL-------------------------------------------------- 1032

  Fly  1418 AAKLHGGELLVKMQFSGTPEAYTVGGQKLD--NGYNHLIEVVRNQTLVQVKLNGTEYFRKTLSTT 1480
                                   .||..:|  ||||                             
  Fly  1033 -----------------------NGGSCIDGINGYN----------------------------- 1045

  Fly  1481 GLLDAQVLYLGGPAPTRESLLGATTEPGIIPVPGAGIPIEDTTVPKEADDSRDYFKGIIQDVKVS 1545
                  ...|.|.:       ||..:                                       
  Fly  1046 ------CSCLAGYS-------GANCQ--------------------------------------- 1058

  Fly  1546 NGSLNLIVEMYSLNVTDVQVNAKPLGAVTIDRASVLPGEVSDDLCRKNPCLHNAECRNTWNDYTC 1610
                      |.||                             .|..||||:.|.|....|:|||
  Fly  1059 ----------YKLN-----------------------------KCDSNPCLNGATCHEQNNEYTC 1084

  Fly  1611 KCPNGYKGKNCQE-IEFCQHVTCPGQSLCQNLDDGYECVTNTTFTGQERSPLAFFYFQEQQSDDI 1674
            .||:|:.||.|.| :::|....|...:.|..:...:.|                           
  Fly  1085 HCPSGFTGKQCSEYVDWCGQSPCENGATCSQMKHQFSC--------------------------- 1122

  Fly  1675 VSEASPKQTLKPVIDIAFRTRAGGTLLYIDNVDGFFEIGVNGGRVTITWKLSALHFGESARFEKE 1739
                                                                             
  Fly  1123 ----------------------------------------------------------------- 1122

  Fly  1740 NTDGEWSRIYLRAHNSKLEGGWKGWESMVDPTPAFSTDIDQAAFQSLIATSTQVYLGGMPESRQA 1804
                            |...||.|  .:.|.                                  
  Fly  1123 ----------------KCSAGWTG--KLCDV---------------------------------- 1135

  Fly  1805 RGSTLSAQQGSQFKGCVGEARVGDLLLPYFSMAELYSRTNVSVQQKAQFRLNATRPEEGCILCFQ 1869
              .|:|.|..:..||                         :|::|                ||  
  Fly  1136 --QTISCQDAADRKG-------------------------LSLRQ----------------LC-- 1155

  Fly  1870 SDCKNDGFCQSPSDEYACTCQPGFEGDDCGTDIDECLNTECLNNGTCINQVAAFFCQCQPGFEGQ 1934
                |:|.|:...:.:.|.|..|:.|..|..:||||.:..|.|.|||.:.:.|:.|||:.||:||
  Fly  1156 ----NNGTCKDYGNSHVCYCSQGYAGSYCQKEIDECQSQPCQNGGTCRDLIGAYECQCRQGFQGQ 1216

  Fly  1935 HCEQNIDECADQPCHNGGNCTDLIASYVCDCPEDYMGPQCDVLKQMTCENEPCRNGSTCQNGFNA 1999
            :||.|||:||..||.|||.|.|.:.::.|.||...||..|::.|      :.|:.|:...||...
  Fly  1217 NCELNIDDCAPNPCQNGGTCHDRVMNFSCSCPPGTMGIICEINK------DDCKPGACHNNGSCI 1275

  Fly  2000 STGNNFTCTCVPGFEGPLC--DIPFCEITPCDNGGLCLTTGAVPM-----CKCSLGYTGRLCEQD 2057
            .....|.|.|.|||.|..|  ||..|...||.|.|   |...|.:     |.|..|:.||.||..
  Fly  1276 DRVGGFECVCQPGFVGARCEGDINECLSNPCSNAG---TLDCVQLVNNYHCNCRPGHMGRHCEHK 1337

  Fly  2058 INECESNPCQNGGQCKDLVGRYECDCQGTGFEGIRCENDIDECNMEGDYCGGLGRCF--NKPGSF 2120
            ::.|..:||||||.|......:.|.| ..||.|..||....:|  :.:.| .:|.|.  ::...:
  Fly  1338 VDFCAQSPCQNGGNCNIRQSGHHCIC-NNGFYGKNCELSGQDC--DSNPC-RVGNCVVADEGFGY 1398

  Fly  2121 QCICQKPYCGAYCNF--TDPCNATDLCSNGGRCVESCGAKPDYYCECPEGFAGKNC 2174
            :|.|.:...|.:|..  .|.|:... |:.|..|.:..|   ||.|.||..:.||.|
  Fly  1399 RCECPRGTLGEHCEIDTLDECSPNP-CAQGAACEDLLG---DYECLCPSKWKGKRC 1450

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
crbNP_001247284.1 LamG 91..228 CDD:238058 9/33 (27%)
EGF_CA 386..423 CDD:238011 15/36 (42%)
EGF_CA 425..460 CDD:238011 12/34 (35%)
EGF 466..495 CDD:278437 13/28 (46%)
EGF 605..633 CDD:278437 12/27 (44%)
EGF_CA 716..750 CDD:238011 16/33 (48%)
EGF_CA 753..789 CDD:238011 16/36 (44%)
EGF_CA 792..828 CDD:238011 16/35 (46%)
EGF_CA 830..865 CDD:238011 18/34 (53%)
EGF_CA 868..905 CDD:238011 13/36 (36%)
EGF_CA 907..943 CDD:238011 17/35 (49%)
EGF_CA 1009..1045 CDD:238011 16/35 (46%)
EGF_CA 1047..1082 CDD:238011 17/35 (49%)
Laminin_G_1 1155..1290 CDD:278483 25/135 (19%)
EGF 1316..1346 CDD:278437 9/29 (31%)
Laminin_G_1 1388..1550 CDD:278483 11/163 (7%)
EGF_CA <1593..1622 CDD:238011 15/28 (54%)
Laminin_G_2 1692..1828 CDD:280389 10/135 (7%)
EGF_CA 1901..1937 CDD:238011 17/35 (49%)
EGF_CA 1939..1974 CDD:238011 17/34 (50%)
EGF_CA 2057..2094 CDD:238011 13/36 (36%)
EGF_CA 2096..2133 CDD:238011 7/38 (18%)
EGF_CA 2137..2175 CDD:238011 14/38 (37%)
NNP_001245510.1 EGF_CA 179..214 CDD:238011 14/34 (41%)
EGF_CA 217..252 CDD:238011 15/35 (43%)
EGF_CA 260..291 CDD:238011 11/30 (37%)
EGF_CA 295..329 CDD:238011 14/33 (42%)
EGF_CA 331..369 CDD:238011 17/136 (13%)
EGF_CA 449..486 CDD:238011 8/38 (21%)
EGF_CA 488..524 CDD:238011 16/36 (44%)
EGF_CA 526..562 CDD:238011 16/37 (43%)
EGF_CA 564..600 CDD:238011 16/35 (46%)
EGF_CA 602..637 CDD:238011 19/35 (54%)
EGF_CA 640..675 CDD:238011 13/35 (37%)
EGF_CA 677..713 CDD:238011 17/35 (49%)
EGF_CA 715..750 CDD:238011 14/60 (23%)
EGF_CA 753..789 CDD:238011 16/35 (46%)
EGF_CA 791..827 CDD:238011 17/36 (47%)
EGF_CA 829..865 CDD:238011 13/40 (33%)
EGF_CA 907..943 CDD:238011 12/66 (18%)
EGF_CA 946..982 CDD:238011 13/74 (18%)
EGF_CA 984..1020 CDD:238011 11/52 (21%)
EGF_CA 1027..1058 CDD:238011 13/145 (9%)
EGF_CA 1062..1095 CDD:238011 17/61 (28%)
EGF_CA 1184..1219 CDD:238011 17/34 (50%)
EGF_CA 1221..1257 CDD:238011 17/35 (49%)
EGF_CA 1259..1295 CDD:238011 12/41 (29%)
EGF_CA 1297..1335 CDD:238011 14/40 (35%)
EGF_CA 1417..1450 CDD:238011 13/36 (36%)
NL 1476..1512 CDD:197463
Notch 1519..1553 CDD:278494
Notch 1565..1593 CDD:278494
NOD 1599..1648 CDD:284282
NODP 1680..1731 CDD:284987
ANK 1896..2038 CDD:238125
ANK repeat 1902..1948 CDD:293786
ANK repeat 1951..1981 CDD:293786
Ank_5 1970..2025 CDD:290568
ANK 1978..2104 CDD:238125
ANK repeat 1984..2015 CDD:293786
ANK repeat 2017..2048 CDD:293786
Ank_2 2022..2114 CDD:289560
ANK repeat 2050..2081 CDD:293786
ANK repeat 2083..2114 CDD:293786
DUF3454 2627..2682 CDD:288764
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E33208_3BAFT
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D3609at33392
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm14569
orthoMCL 1 0.900 - - OOG6_100271
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
54.720

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