DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment crb and dld

DIOPT Version :9

Sequence 1:	NP_001247284.1	Gene:	crb / 42896	FlyBaseID:	FBgn0259685	Length:	2253	Species:	Drosophila melanogaster
Sequence 2:	NP_571030.2	Gene:	dld / 30138	ZFINID:	ZDB-GENE-990415-47	Length:	717	Species:	Danio rerio

Alignment Length:	589	Identity:	181/589 - (30%)
Similarity:	253/589 - (42%)	Gaps:	131/589 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   483 GFQCLCPPEYTGELC------QIAPSCAQQCPIDSECVGGKCVCKPGSSGPIGHCLPTTTTPTPE 541
            |.||.|...:  .:|      .::|        |..|..|      |:..|:   |.:.:...||
Zfish    50 GLQCECKTFF--RICLKHYQANVSP--------DPPCTYG------GAVTPV---LGSNSFQVPE 95

  Fly   542 QEPTTTPRTTPNPNP-----AIPNTLTTTTKIPPITTSRTLVGTTTGSRRPPQQPLQSPTQRSAS 601
            ..|.:   :..||.|     ..|.|.:..  |..:.|..|   ....:..|.:...:..|||..:
Zfish    96 SFPDS---SFTNPIPFAFGFTWPGTFSLI--IEALHTDST---DDLSTENPDRLISRMTTQRHLT 152

  Fly   602 L-NACPQENCLNGGTCLGYSGNYSCICASGYTGYNCQTSTGDGASALALTPINCNATNGKCLNGG 665
            : ....|:..:.|.|.|.||  |..:|...|.|..|.              :.|...: ......
Zfish   153 VGEEWSQDLQVGGRTELKYS--YRFVCDEHYYGEGCS--------------VFCRPRD-DTFGHF 200

  Fly   666 TCSMNGTHCYCAVGYSGDRCEKAENCSPLNCQEPMVCVQNQCLCPENKVCNQCATQPCQNGGECV 730
            ||...| ...|..|:.|.           .|.|| :|:..   |.|:.             |.|
Zfish   201 TCGERG-EIICNSGWKGQ-----------YCTEP-ICLPG---CDEDH-------------GFC- 235

  Fly   731 DLPNGDYECKCTRGWTGRTCGNDVDECTLHPKICGNGICKNEKGSYKCYCTPGFTGVHCDSDVDE 795
            |.|.   ||||..|::|:.|    |:|..:|. |.:|.|:.   .::|.|..|:.|:.|:.|::.
Zfish   236 DKPG---ECKCRVGFSGKYC----DDCIRYPG-CLHGTCQQ---PWQCNCQEGWGGLFCNQDLNY 289

  Fly   796 CLSF-PCLNGATCHNK-INAYECVCQPGYEGENCEVDIDECGSNPCSNGSTCIDRINNFTCNCIP 858
            |... ||.|||||.|. ..:|.|.|:||:.|::||::::||..:||.||.:|.|..|.::|.|.|
Zfish   290 CTHHKPCQNGATCTNTGQGSYTCSCRPGFTGDSCEIEVNECSGSPCRNGGSCTDLENTYSCTCPP 354

  Fly   859 GMTGRICDIDIDDCVGDPCLNGGQCIDQ-LGGFRCDCSGTGYEGENCELNIDECLSNPCTNGAKC 922
            |..||.|::....|...||.|||||.|. .||:.|.|. .||.|.|||..||.|.||||:|.|:|
Zfish   355 GFYGRNCELSAMTCADGPCFNGGQCADNPEGGYFCQCP-MGYAGFNCEKKIDHCSSNPCSNDAQC 418

  Fly   923 LDRVKDYFCDCHNGYKGKNCEQDINECESNPCQYNGNCLERSNITLYQMSRITDLPKVFSQPFSF 987
            ||.|..|.|.|..|:.|.:||.:|:||.:.|||..|.|.
Zfish   419 LDLVDSYLCQCPEGFTGTHCEDNIDECATYPCQNGGTCQ-------------------------- 457

  Fly   988 ENASGYECVCVPGIIGKNCEININECDSNPCSKHGNCNDGIGTYTCECEPGFEGTHCEINIDECD 1052
            :..|.|.|.|.||..||||...:|:|..|||.....|::..|.|.|.|.||:.|.:|:..:.|
Zfish   458 DGLSDYTCTCPPGYTGKNCTSAVNKCLHNPCHNGATCHEMDGRYVCACIPGYGGRNCQFLLPE-- 520

  Fly  1053 RYNP 1056
              ||
Zfish   521 --NP 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crb	NP_001247284.1	LamG	91..228	CDD:238058
		EGF_CA	386..423	CDD:238011
		EGF_CA	425..460	CDD:238011
		EGF	466..495	CDD:278437	4/11 (36%)
		EGF	605..633	CDD:278437	9/27 (33%)
		EGF_CA	716..750	CDD:238011	10/33 (30%)
		EGF_CA	753..789	CDD:238011	10/35 (29%)
		EGF_CA	792..828	CDD:238011	16/37 (43%)
		EGF_CA	830..865	CDD:238011	15/34 (44%)
		EGF_CA	868..905	CDD:238011	17/37 (46%)
		EGF_CA	907..943	CDD:238011	18/35 (51%)
		EGF_CA	1009..1045	CDD:238011	13/35 (37%)
		EGF_CA	1047..1082	CDD:238011	3/10 (30%)
		Laminin_G_1	1155..1290	CDD:278483
		EGF	1316..1346	CDD:278437
		Laminin_G_1	1388..1550	CDD:278483
		EGF_CA	<1593..1622	CDD:238011
		Laminin_G_2	1692..1828	CDD:280389
		EGF_CA	1901..1937	CDD:238011
		EGF_CA	1939..1974	CDD:238011
		EGF_CA	2057..2094	CDD:238011
		EGF_CA	2096..2133	CDD:238011
		EGF_CA	2137..2175	CDD:238011
dld	NP_571030.2	MNNL	20..90	CDD:284966	12/58 (21%)
		DSL	157..219	CDD:128366	18/90 (20%)
		EGF_CA	286..324	CDD:238011	16/37 (43%)
		EGF_CA	327..362	CDD:238011	15/34 (44%)
		EGF_CA	<371..401	CDD:238011	16/30 (53%)
		EGF_CA	404..439	CDD:238011	18/34 (53%)
		EGF_CA	441..477	CDD:238011	17/61 (28%)
		EGF_CA	480..515	CDD:238011	13/34 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	649..693
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910