DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment crb and dla

DIOPT Version :9

Sequence 1:	NP_001247284.1	Gene:	crb / 42896	FlyBaseID:	FBgn0259685	Length:	2253	Species:	Drosophila melanogaster
Sequence 2:	NP_571029.2	Gene:	dla / 30131	ZFINID:	ZDB-GENE-980526-29	Length:	772	Species:	Danio rerio

Alignment Length:	577	Identity:	175/577 - (30%)
Similarity:	236/577 - (40%)	Gaps:	147/577 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   513 CVGG------KCVCKPGSSGPIGHCLPT-----------TTTPTPEQEPTTTPRTTPN---PNP- 556
            |.||      :|.||......:.|..|.           |.||.........|.|.|:   .||
Zfish    46 CKGGLTTSYQQCECKTFFRICLKHYQPNASPEPPCTYGGTVTPVLGSNSFQVPDTLPDGSFTNPI 110

  Fly   557 ------AIPNTLT-------------TTTKIPPITTSRTLVGTTTGSRRPPQQPLQSPTQRSASL 602
                  ..|.|.:             .||:.|     ..::.|.|             |||..::
Zfish   111 RMNFGFTWPGTFSLIIEALHADSKEDLTTENP-----ERIISTMT-------------TQRHLTV 157

  Fly   603 NA-CPQENCLNGGTCLGYSGNYSCICASGYTGYNCQTSTGDGASALALTPINCNATNGKCLNGGT 666
            .. ..|:....|.|.|.||  |..:|...|.|..|.              :.|...: ......|
Zfish   158 GEDWSQDLHSVGRTELKYS--YRFVCDEHYYGEGCS--------------VFCRPRD-DAFGHFT 205

  Fly   667 CSMNGTHCYCAVGYSGDRCEKAENCSPLNCQEPMVCVQNQCLCPENKVCNQCATQPCQNGGECVD 731
            |...| ...|..|:.|.           .|.|| :|:..   |.|....       |:..|
Zfish   206 CGERG-EIICDAGWKGQ-----------YCTEP-ICLPG---CDEEHGF-------CEKPG---- 243

  Fly   732 LPNGDYECKCTRGWTGRTCGNDVDECTLHPKICGNGICKNEKGSYKCYCTPGFTGVHCDSDVDEC 796
                  ||||..|:.||.|    |||..:|. |.:|.|:.   .::|.|..|:.|:.|:.|::.|
Zfish   244 ------ECKCRVGFKGRYC----DECIRYPG-CLHGTCQQ---PWQCNCQEGWGGLFCNQDLNYC 294

  Fly   797 LSF-PCLNGATCHNK-INAYECVCQPGYEGENCEVDIDECGSNPCSNGSTCIDRINNFTCNCIPG 859
            ... ||||||||.|. ..:|.|.|:||:.|.:||::::||..|||.||.:|.|..|.::|.|.||
Zfish   295 THHKPCLNGATCSNTGQGSYTCSCRPGFSGASCEIEVNECTGNPCRNGGSCTDMENTYSCTCPPG 359

  Fly   860 MTGRICDIDIDDCVGDPCLNGGQCIDQL-GGFRCDCSGTGYEGENCELNIDECLSNPCTNGAKCL 923
            ..|:.|::....|...||.|||:|.|.. ||:.|.|. |||.|.|||..||.|.|:||:|||:|:
Zfish   360 FYGKNCELSAMTCADGPCFNGGRCADNPDGGYFCQCP-TGYAGFNCEKKIDHCSSSPCSNGARCV 423

  Fly   924 DRVKDYFCDCHNGYKGKNCEQDINECESNPCQYNGNCLERSNITLYQMSRITDLPKVFSQPFSFE 988
            |.|..|.|.|.:|:.|.||::..:||...|||..|.|.                          |
Zfish   424 DLVNSYLCQCPDGFTGMNCDRAGDECSMYPCQNGGTCQ--------------------------E 462

  Fly   989 NASGYECVCVPGIIGKNCEININECDSNPCSKHGNCNDGIGTYTCECEPGFEGTHCE 1045
            .||||.|.|.||..|:||...::.|..|||.....|::....|.|.|..|:.|.:|:
Zfish   463 GASGYMCTCPPGYTGRNCSSPVSRCQHNPCHNGATCHERNNRYVCACVSGYGGRNCQ 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crb	NP_001247284.1	LamG	91..228	CDD:238058
		EGF_CA	386..423	CDD:238011
		EGF_CA	425..460	CDD:238011
		EGF	466..495	CDD:278437
		EGF	605..633	CDD:278437	9/27 (33%)
		EGF_CA	716..750	CDD:238011	9/33 (27%)
		EGF_CA	753..789	CDD:238011	11/35 (31%)
		EGF_CA	792..828	CDD:238011	17/37 (46%)
		EGF_CA	830..865	CDD:238011	15/34 (44%)
		EGF_CA	868..905	CDD:238011	17/37 (46%)
		EGF_CA	907..943	CDD:238011	18/35 (51%)
		EGF_CA	1009..1045	CDD:238011	10/35 (29%)
		EGF_CA	1047..1082	CDD:238011
		Laminin_G_1	1155..1290	CDD:278483
		EGF	1316..1346	CDD:278437
		Laminin_G_1	1388..1550	CDD:278483
		EGF_CA	<1593..1622	CDD:238011
		Laminin_G_2	1692..1828	CDD:280389
		EGF_CA	1901..1937	CDD:238011
		EGF_CA	1939..1974	CDD:238011
		EGF_CA	2057..2094	CDD:238011
		EGF_CA	2096..2133	CDD:238011
		EGF_CA	2137..2175	CDD:238011
dla	NP_571029.2	MNNL	23..94	CDD:284966	11/47 (23%)
		DSL	161..223	CDD:128366	18/90 (20%)
		EGF_CA	290..328	CDD:238011	17/37 (46%)
		EGF_CA	331..366	CDD:238011	15/34 (44%)
		EGF_CA	<375..405	CDD:238011	16/30 (53%)
		EGF_CA	408..442	CDD:238011	17/33 (52%)
		EGF_CA	447..480	CDD:238011	17/58 (29%)
		EGF_CA	488..519	CDD:238011	9/30 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	688..722
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000