DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment crb and Notch2

DIOPT Version :9

Sequence 1:NP_001247284.1 Gene:crb / 42896 FlyBaseID:FBgn0259685 Length:2253 Species:Drosophila melanogaster
Sequence 2:NP_077334.2 Gene:Notch2 / 29492 RGDID:3188 Length:2471 Species:Rattus norvegicus


Alignment Length:2036 Identity:506/2036 - (24%)
Similarity:682/2036 - (33%) Gaps:835/2036 - (41%)


- Green bases have known domain annotations that are detailed below.


  Fly   272 DPCMGHGTCSS--SPEGYECRCTARYSGKNCQKDNGSPCAKNPCENGGSCLENSR-GDYQCFCDP 333
            :||:..|||.:  :..|| |||...:.|:.||  :..||.||.|:|||:|:..:. |...|.|.|
  Rat    33 EPCVNEGTCVTYHNGTGY-CRCPEGFLGEYCQ--HRDPCEKNRCQNGGTCVTQAMLGKATCRCAP 94

  Fly   334 NHSGQHCETEVNIHPLCQTNPCLNNGACVVIGGSGALTCECPKGYAGARCEVDTDECASQPCQNN 398
            ..:|:.|:...: ||...:.||.|.|.|.::... ...|.|..|:.|.:|:. ||.|.|.||:|.
  Rat    95 GFTGEDCQYSTS-HPCFVSRPCQNGGTCHMLSWD-TYECTCQVGFTGKQCQW-TDVCLSHPCENG 156

  Fly   399 GSCIDRINGFSCDCSGTGYTGAFCQTNVDECD-KNPCLNGGRCFDTYGWYTCQCLDGWGGEICDR 462
            .:|....|.|||.|. .|.||..|..:::||| ...|.:||.|.:..|.|.|||..|:.|:.||.
  Rat   157 STCSSVANQFSCRCP-AGITGQKCDADINECDIPGRCQHGGTCLNLPGSYRCQCPQGFTGQHCDS 220

  Fly   463 P-MTCQTQQCLNGGTCLDKPIGFQCLCPPEYTGELCQIAPSCAQQCPIDSECVGGKCVCKPGSSG 526
            | :.|....|:|||||             ..||:             ..|||             
  Rat   221 PYVPCAPSPCVNGGTC-------------RQTGD-------------FTSEC------------- 246

  Fly   527 PIGHCLPTTTTPTPEQEPTTTPRTTPNPNPAIPNTLTTTTKIPPITTSRTLVGTTTGSRRPPQQP 591
               ||||.......|:                                                 
  Rat   247 ---HCLPGFEGSNCER------------------------------------------------- 259

  Fly   592 LQSPTQRSASLNACPQENCLNGGTCLGYSGNYSCICASGYTGYNCQTSTGDGASALALTPINCNA 656
                     :::.||...|.|||.|:.....|:|.|...:||..|.....:           |..
  Rat   260 ---------NIDDCPNHKCQNGGVCVDGVNTYNCRCPPQWTGQFCTEDVDE-----------CLL 304

  Fly   657 TNGKCLNGGTC-SMNGTH-CYCAVGYSGDRC-EKAENCSPLNCQEPMVCVQN----QCLCPENK- 713
            ....|.||||| :.||.: |.|..|:|||.| |..::|:..:|.....|:..    .|||||.| 
  Rat   305 QPNACQNGGTCTNRNGGYGCVCVNGWSGDDCSENIDDCAFASCTPGSTCIDRVASFSCLCPEGKA 369

  Fly   714 --VC---NQCATQPCQNGGECVDLP-NGDYECKCTRGWTGRTCGNDVDECTL-HPKICGN-GICK 770
              :|   :.|.:.||..|..|...| ||.|.|.|.:|:.|..|..|||||.: :...|.: |.|.
  Rat   370 GLLCHLDDACISNPCHKGALCDTNPLNGQYICTCPQGYKGADCTEDVDECAMANSNPCEHAGKCV 434

  Fly   771 NEKGSYKCYCTPGFTGVHCDSDVDECLSFPCLNGATCHNKINAYECVCQPGYEGENCEVDIDECG 835
            |..|::.|.|..|:.|..|:.|::||.|.||.|.|||.:||..:.|:|.||::|.:||::::||.
  Rat   435 NTDGAFHCECLKGYAGPRCEMDINECHSDPCQNDATCLDKIGGFTCLCMPGFKGVHCELEVNECQ 499

  Fly   836 SNPCSNGSTCIDRINNFTCNCIPGMTGRICDIDIDDCVGDPCLNGGQCIDQLGGFRCDCSGTGYE 900
            ||||.|...|:|::|.|.|.|.||.||.:|.||||||...|||||.:|||...|:.|.|: ||:.
  Rat   500 SNPCVNNGQCVDKVNRFQCLCPPGFTGPVCQIDIDDCSSTPCLNGAKCIDHPNGYECQCA-TGFT 563

  Fly   901 GENCELNIDECLSNPCTNGAKCLDRVKDYFCDCHNGYKGKNCEQDINECESNPCQYNGNCLERSN 965
            |..|:.|||.|..:||.:| :|.|.:..|.|.|:.||.|..|...|:||.|:||..:|.|::..|
  Rat   564 GTLCDENIDNCDPDPCHHG-QCQDGIDSYTCICNPGYMGAICSDQIDECYSSPCLNDGRCIDLVN 627

  Fly   966 ITLYQMSRITDLPKVFSQPFSFENASGYECVCVPGIIGKNCEININECDSNPCSKHGNCNDGIGT 1030
                                      ||:|.|.||..|.|||||.::|.|||| .||.|.|||..
  Rat   628 --------------------------GYQCNCQPGTSGLNCEINFDDCASNPC-LHGACVDGINR 665

  Fly  1031 YTCECEPGFEGTHCEINIDECDRYNPCQRG---------------------TCYDQIDD------ 1068
            |:|.|.|||.|..|.|:|||| ..|||::|                     :||.|:::      
  Rat   666 YSCVCSPGFTGQRCNIDIDEC-ASNPCRKGATCINDVNGFRCMCPEGPHHPSCYSQVNECLSSPC 729

  Fly  1069 -----------YDCDCDANYGGKNCSVLLKGCDQNPCLNGGACLPYLINEVTHLYNCTCENGFQG 1122
                       |.|.|||.:.|.||.|....|..|||.|||.|     |.:.:.|.|||:.||:|
  Rat   730 IHGNCTGGLSGYKCLCDAGWVGINCEVDKNECLSNPCQNGGTC-----NNLVNGYRCTCKKGFKG 789

  Fly  1123 DKCEKTTTLSMVATSLISVTTEREEGYDINLQFRTTLPNGVLAFGTTGEKNEPVSYILELINGRL 1187
            ..|:                        :|:                                  
  Rat   790 YNCQ------------------------VNI---------------------------------- 796

  Fly  1188 NLHSSLLNKWEGVFIGSKLNDSNWHKVFVAINTSHLVLSANDEQAIFPVGSYETANNSQPSFPRT 1252
                                                                             
  Rat   797 ----------------------------------------------------------------- 796

  Fly  1253 YLGGTIPNLKSYLRHLTHQPSAFVGCMQDIMVNGKWIFPDEQDANISYTKLENVQSGCPRTEQCK 1317
                                                                         ::|.
  Rat   797 -------------------------------------------------------------DECA 800

  Fly  1318 PNPCHSNGECTDLWHTFACHCPRPFFGHTCQHNMTAATFGHENTTHSAVIVETTDVARRAIRSIL 1382
            .|||.:.|.|.|....:.|||..|:.|..||                                  
  Rat   801 SNPCLNQGTCLDDVSGYTCHCMLPYTGKNCQ---------------------------------- 831

  Fly  1383 DISMFIRTREPTGQVFYLGTDPRKAPTKNIGDSYVAAKLHGGELLVKMQFSGTPEAYTVGGQKLD 1447
                                                                             
  Rat   832 ----------------------------------------------------------------- 831

  Fly  1448 NGYNHLIEVVRNQTLVQVKLNGTEYFRKTLSTTGLLDAQVLYLGGPAPTRESLLGATTEPGIIPV 1512
                                                                         .:..
  Rat   832 -------------------------------------------------------------TVLA 835

  Fly  1513 PGAGIPIEDTTVPKEADDSRDYFKGIIQDVKVSNGSLNLIVEMYSLNVTDVQVNAKPLGAVTIDR 1577
            |.:..|.|:..|.|||.:...:                                          .
  Rat   836 PCSPNPCENAAVCKEAPNFESF------------------------------------------T 858

  Fly  1578 ASVLPG------EVSDDLCRKNPCLHNAECRNTWNDYTCKCPNGYKGKNCQEIEFCQHVTCPGQS 1636
            ....||      .|..|.|...||::|..|.||...|.|:||.|:.|.:|:|             
  Rat   859 CLCAPGWQGQRCTVDVDECVSKPCMNNGICHNTQGSYMCECPPGFSGMDCEE------------- 910

  Fly  1637 LCQNLDDGYECVTNTTFTGQERSPLAFFYFQEQQSDDIVSEASPKQTLKPVIDIAFRTRAGGTLL 1701
                  |..:|:.|                             |.|                   
  Rat   911 ------DINDCLAN-----------------------------PCQ------------------- 921

  Fly  1702 YIDNVDGFFEIGVNGGRVTITWKLSALHFGESARFEKENTDGEWSRIYLRAHNSKLEGGWKGWES 1766
                         |||                                                |
  Rat   922 -------------NGG------------------------------------------------S 925

  Fly  1767 MVDPTPAFSTDIDQAAFQSLIATSTQVYLGGMPESRQARGSTLSAQQGSQFKGCVGEARVGDLLL 1831
            .||....||                                            |        |.|
  Rat   926 CVDKVNTFS--------------------------------------------C--------LCL 938

  Fly  1832 PYFSMAELYSRTNVSVQQKAQFRLNATRPEEGCILCFQSDCKNDGFCQSPSDEYACTCQPGFEGD 1896
            |.|            |..|.|..:|.         |....|||.|.|....:.|.|||..||.|.
  Rat   939 PGF------------VGDKCQTDMNE---------CLSEPCKNGGTCSDYVNSYTCTCPAGFHGV 982

  Fly  1897 DCGTDIDECLNTECLNNGTCINQVAAFFCQCQPGFEGQHCEQNIDECADQPCHNGGNCTDLIASY 1961
            .|..:||||..:.|.|.|||::.:.:|.|.|..||.|..|..:|:||:..||.|.|.|.|.:.:|
  Rat   983 HCENNIDECTESSCFNGGTCVDGINSFSCLCPVGFTGPFCLHDINECSSNPCLNSGTCVDGLGTY 1047

  Fly  1962 VCDCPEDYMGPQCDVLKQMTCENEPCRNGSTCQNGFNASTGNNFTCTCVPGFEGPLCDI--PFCE 2024
            .|.||..|.|..|..|..: |...||:|..||     |.......|.|.||::|..||:  ..|:
  Rat  1048 RCTCPLGYTGKNCQTLVNL-CSPSPCKNKGTC-----AQEKARPRCLCPPGWDGAYCDVLNVSCK 1106

  Fly  2025 ITP----------CDNGGLCLTTGAVPMCKCSLGYTGRLCEQDINECESNPCQNGGQCKDLVGRY 2079
            ...          |.:.|:|:..|....|:|.|||||..||:.::||.|||||:|..|.|.:|.|
  Rat  1107 AAALQKGVPVEHLCQHSGICINAGNTHHCQCPLGYTGSYCEEQLDECASNPCQHGATCSDFIGGY 1171

  Fly  2080 ECDCQGTGFEGIRCENDIDECNMEGDYCGGLGRCFNKPGSFQCICQKPYCGAYCNFT-DPCNATD 2143
            .|:|. .|::|:.||.::|||  :...|...|.|.:....|:|.|.....|..|... |.|....
  Rat  1172 RCECV-PGYQGVNCEYEVDEC--QNQPCQNGGTCIDLVNHFKCSCPPGTRGLLCEENIDDCAGGP 1233

  Fly  2144 LCSNGGRCVESCGAKPDYYCECPEGFAGKNCTAPITAKEDGPSTTDIAIIVIPV-----VVVLLL 2203
            .|.|||:||:..|.   |.|.|..||||:.|...|......|.:::.::..|.:     .|....
  Rat  1234 HCLNGGQCVDRIGG---YSCRCLPGFAGERCEGDINECLSNPCSSEGSLDCIQLKNNYQCVCRSA 1295

  Fly  2204 IAGALLGTFLVMARNKRATRG 2224
            ..|....|||.:...|....|
  Rat  1296 FTGRHCETFLDVCPQKPCLNG 1316

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
crbNP_001247284.1 LamG 91..228 CDD:238058
EGF_CA 386..423 CDD:238011 16/36 (44%)
EGF_CA 425..460 CDD:238011 14/35 (40%)
EGF 466..495 CDD:278437 8/28 (29%)
EGF 605..633 CDD:278437 10/27 (37%)
EGF_CA 716..750 CDD:238011 13/34 (38%)
EGF_CA 753..789 CDD:238011 14/37 (38%)
EGF_CA 792..828 CDD:238011 17/35 (49%)
EGF_CA 830..865 CDD:238011 17/34 (50%)
EGF_CA 868..905 CDD:238011 19/36 (53%)
EGF_CA 907..943 CDD:238011 15/35 (43%)
EGF_CA 1009..1045 CDD:238011 19/35 (54%)
EGF_CA 1047..1082 CDD:238011 17/72 (24%)
Laminin_G_1 1155..1290 CDD:278483 0/134 (0%)
EGF 1316..1346 CDD:278437 12/29 (41%)
Laminin_G_1 1388..1550 CDD:278483 7/161 (4%)
EGF_CA <1593..1622 CDD:238011 12/28 (43%)
Laminin_G_2 1692..1828 CDD:280389 9/135 (7%)
EGF_CA 1901..1937 CDD:238011 15/35 (43%)
EGF_CA 1939..1974 CDD:238011 15/34 (44%)
EGF_CA 2057..2094 CDD:238011 16/36 (44%)
EGF_CA 2096..2133 CDD:238011 10/36 (28%)
EGF_CA 2137..2175 CDD:238011 16/37 (43%)
Notch2NP_077334.2 EGF_CA 109..143 CDD:238011 9/34 (26%)
EGF_CA 182..218 CDD:238011 14/35 (40%)
EGF_CA 260..296 CDD:238011 12/35 (34%)
EGF_CA 298..335 CDD:238011 15/47 (32%)
EGF_CA 415..454 CDD:238011 14/38 (37%)
EGF_CA 456..492 CDD:238011 17/35 (49%)
EGF_CA 495..530 CDD:238011 17/34 (50%)
EGF_CA 532..567 CDD:238011 19/35 (54%)
EGF_CA 570..604 CDD:238011 15/34 (44%)
EGF_CA 608..643 CDD:238011 17/60 (28%)
EGF_CA 645..679 CDD:238011 19/34 (56%)
EGF_CA 682..717 CDD:238011 8/35 (23%)
EGF_CA 757..793 CDD:238011 16/40 (40%)
EGF_CA 795..831 CDD:238011 13/195 (7%)
EGF_CA 873..909 CDD:238011 14/35 (40%)
EGF_CA 911..947 CDD:238011 20/208 (10%)
EGF_CA 949..985 CDD:238011 14/44 (32%)
EGF_CA 987..1022 CDD:238011 15/34 (44%)
EGF_CA 1025..1061 CDD:238011 15/35 (43%)
EGF_CA 1117..1147 CDD:238011 11/29 (38%)
EGF_CA 1151..1185 CDD:238011 16/34 (47%)
EGF_CA 1188..1223 CDD:238011 10/36 (28%)
EGF_CA 1225..1262 CDD:238011 16/39 (41%)
EGF_CA 1264..1302 CDD:238011 5/37 (14%)
EGF_CA <1312..1343 CDD:238011 1/5 (20%)
Notch 1423..1456 CDD:278494
Negative regulatory region (NRR). /evidence=ECO:0000250 1425..1677
Notch 1463..1497 CDD:278494
Notch 1501..1534 CDD:278494
NOD 1540..1591 CDD:284282
NODP 1619..1673 CDD:284987
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1751..1788
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1794..1813
Ank_2 <1820..1907 CDD:289560
ANK repeat 1827..1874 CDD:293786
ANK 1 1827..1871
ANK 1872..1997 CDD:238125
ANK 2 1876..1905
ANK repeat 1877..1907 CDD:293786
Ank_2 1881..1974 CDD:289560
ANK 3 1909..1939
ANK 1938..2062 CDD:238125
ANK repeat 1943..1974 CDD:293786
ANK 4 1943..1972
Ank_2 1948..2040 CDD:289560
ANK repeat 1976..2007 CDD:293786
ANK 5 1976..2005
ANK repeat 2009..2040 CDD:293786
ANK 6 2009..2038
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2097..2116
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2380..2471
DUF3454 2381..2439 CDD:288764
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E33208_3BAFT
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100271
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
43.710

Return to query results.
Submit another query.