DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment crb and Scube3

DIOPT Version :9

Sequence 1:	NP_001247284.1	Gene:	crb / 42896	FlyBaseID:	FBgn0259685	Length:	2253	Species:	Drosophila melanogaster
Sequence 2:	XP_008771027.1	Gene:	Scube3 / 294297	RGDID:	1304880	Length:	1015	Species:	Rattus norvegicus

Alignment Length:	1149	Identity:	245/1149 - (21%)
Similarity:	352/1149 - (30%)	Gaps:	423/1149 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   308 CAKNPCENGGSCLENSRGDYQCFCDPNHSGQHCETEVNIHPLCQTNPCLNNGACVVIGGSGALTC 372
            |...|..:...|:|.:              .||    :|..:||..|             .:..|
  Rat    27 CLPLPGPDVDECVEGT--------------DHC----HIDAICQNTP-------------RSYKC 60

  Fly   373 ECPKGYA--GARCEVDTDECASQPCQNNGSCI-DRIN---GFSCDCSG---TGYTGAFCQTNVDE 428
            .|..||.  |..|: |.|||..   ::|..|: |.:|   .:.|.|..   ..:.|..| .:|||
  Rat    61 ICKSGYTGDGKHCK-DVDECER---EDNAGCVHDCVNIPGNYRCTCYDGFHLAHDGHNC-LDVDE 120

  Fly   429 CDKNPCLNGG---RCFDTYGWYTCQCLDGWGGEICDRPMTC-----QTQQCLN-----GGTCLDK 480
            |.:.   |||   .|.:..|.|.|.|.||:  .:.|...||     :...|:|     ...|.:.
  Rat   121 CAEG---NGGCQQSCVNMMGSYECHCRDGF--FLSDNQHTCIQRPEEGMNCMNKNHGCAHICRET 180

  Fly   481 PI-GFQCLCPPEYTGELCQIAPSCAQQCPIDSECVGGKCVCKPGSSGPIGHCLPTTTTPTPEQEP 544
            |. |..|.|.|.:  ||.:....|             |..|..|:.|....|..|      ||.|
  Rat   181 PKGGIACECRPGF--ELTKNQRDC-------------KLTCNYGNGGCQHTCDDT------EQGP 224

  Fly   545 TTTPRTTPNPNPAIPNTLTTTTKIPPITTSRTLVGTTTGSRRPPQQPLQSPTQRSASLNACPQEN 609
            ..        ...:...|.|..|            |..|.||..|   ..|||      |...|.
  Rat   225 RC--------GCHVKFVLHTDGK------------TCIGERRLEQ---HGPTQ------AVSNET 260

  Fly   610 C-LNGGTCLGYSGNYSCICASGYTGYNCQTSTGDGASALALTPINCNATNGKCLNGGTCSMNGTH 673
            | :|.|.|                                         :.||.:..|    |.|
  Rat   261 CAVNNGGC-----------------------------------------DSKCHDAAT----GVH 280

  Fly   674 CYCAVGYSGDRCEKAENCSPLNCQEPMVCVQNQCLCPENKVCNQCATQPCQNGGECVDLPN---G 735
            |.|.||:                          .|.|:.|.|.........||| |..:..   |
  Rat   281 CSCPVGF--------------------------MLQPDRKTCKDIDECRLHNGG-CDHICRNTVG 318

  Fly   736 DYECKCTRGW----TGRTCGNDVDECTLHPKICGNGICKNEKGSYKCYCTPGFT--GV-HCDSDV 793
            .:||.|.:|:    ..|:| .|:|||:. .:.|.: :|.|..||::|.|..|:.  |: || .||
  Rat   319 SFECSCKKGYKLLINERSC-QDIDECSF-DRTCDH-MCVNTPGSFQCLCHRGYLLYGISHC-GDV 379

  Fly   794 DECLSFPCLNGATCH----NKINAYECVCQPG-----YEGENCEVDIDECGSN--------PCSN 841
            |||    .:|...|.    |...:|:|.|..|     :.|::|...: :|.|:        .||.
  Rat   380 DEC----SINKGGCRFGCINTPGSYQCTCPAGQGRLHWNGKDCTEPV-KCQSSSGASKAMLSCSR 439

  Fly   842 GS-------TCIDRI-------NNFTCNC-------------IPGMTGRICDIDIDDCVGDPCLN 879
            ..       ||..|.       |.||.:|             .||          :..:.:.|..
  Rat   440 SGKKDTCALTCPSRARFLPESENGFTVSCGTPSPKAAAGRAIHPG----------NSTISNSCHE 494

  Fly   880 GGQC-IDQLGGFRCDCSGTGYEGENCELNI------DECLS-NPCTNGAKCLD-RVKDYFCDCHN 935
            .... :.|...|:       .:...|.|::      :|... .|...||.|.| :|......|.:
  Rat   495 AAVLPVKQRASFK-------IKDAKCRLHLRNKGKAEEASGRTPGPGGASCSDCQVTFIHLKCDS 552

  Fly   936 GYKGK-----------------NCEQDINECESNPCQYNGNCLERSNITLYQMSR-----ITDLP 978
            ..|||                 ..|.:: ..|.........||.:      :|.|     :..|.
  Rat   553 SRKGKGRRARTPPGKEVTRLTLELEAEV-RAEETTAGCGLTCLRQ------RMERRLKGSLKMLR 610

  Fly   979 KVFSQPFSFENASG--YECVCVPGI-IGKNCEININECDSN------------------------ 1016
            |..:|.......:|  ||....||: .|...|: :..|...
  Rat   611 KSINQDRFLLRLAGLDYELAHKPGLAAGDRAEL-VEVCRPGQHRAGTKCVSCPQGTYYHGQTEQC 674

  Fly  1017 -PCSKHGNCNDGIGTYTCECEPGFE--GTHCEINIDEC-----------DRYNPCQ---RGTCYD 1064
             ||.. |...:..|..:|:..||.:  |.....|:..|           |.:.|||   |||...
  Rat   675 VPCPA-GTFQEREGQLSCDLCPGSDAHGPLGATNVTTCAGQCPPGQHSGDGFKPCQPCPRGTYQP 738

  Fly  1065 QIDDYDC-DCDANYGGKN-CSVLLKGCDQNPCLNGGACLPYLINEVTHLYNCT------CENG-F 1120
            :.....| .|......|: .:|..:.||...     .|.|      .|.||.:      |..| :
  Rat   739 EAGRTLCFPCGGGLTTKHEGAVSFQDCDTKV-----QCSP------GHYYNTSIHRCIRCAVGSY 792

  Fly  1121 QGD-------KCEKTTTLSMVATSLISVTTEREEGYDINLQFRTTLPNGVLAFGTTGEKNEPVSY 1178
            |.|       :|...|:.....::.::....|:.|                     ||..|...|
  Rat   793 QPDFRQNFCTRCPGNTSTDFDGSTSVAQCKNRQCG---------------------GELGEFTGY 836

  Fly  1179 ILELINGRLNLHSSLLNKWEGVFIGSKLNDSNWHKVFVAINTSHLVLSANDEQAIFPVGSYETAN 1243
            | |..|...|..:.:...|       .:|.....|:.:.:  ..:.|.:.||.....|    ...
  Rat   837 I-ESPNYPGNYPAGVECIW-------NINPPPKRKILIVV--PEIFLPSEDECGDVLV----MRK 887

  Fly  1244 NSQPSFPRTYLGGTIPNLKSYLRHLTHQPSAFVGCMQDIMVNGK 1287
            ||.||...||     ...::|.|     |.||....:.:.:|.|
  Rat   888 NSSPSSITTY-----ETCQTYER-----PIAFTARSRKLWINFK 921

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crb	NP_001247284.1	LamG	91..228	CDD:238058
		EGF_CA	386..423	CDD:238011	11/43 (26%)
		EGF_CA	425..460	CDD:238011	14/37 (38%)
		EGF	466..495	CDD:278437	9/39 (23%)
		EGF	605..633	CDD:278437	5/28 (18%)
		EGF_CA	716..750	CDD:238011	10/40 (25%)
		EGF_CA	753..789	CDD:238011	13/38 (34%)
		EGF_CA	792..828	CDD:238011	13/44 (30%)
		EGF_CA	830..865	CDD:238011	13/69 (19%)
		EGF_CA	868..905	CDD:238011	3/37 (8%)
		EGF_CA	907..943	CDD:238011	11/60 (18%)
		EGF_CA	1009..1045	CDD:238011	9/62 (15%)
		EGF_CA	1047..1082	CDD:238011	12/50 (24%)
		Laminin_G_1	1155..1290	CDD:278483	28/133 (21%)
		EGF	1316..1346	CDD:278437
		Laminin_G_1	1388..1550	CDD:278483
		EGF_CA	<1593..1622	CDD:238011
		Laminin_G_2	1692..1828	CDD:280389
		EGF_CA	1901..1937	CDD:238011
		EGF_CA	1939..1974	CDD:238011
		EGF_CA	2057..2094	CDD:238011
		EGF_CA	2096..2133	CDD:238011
		EGF_CA	2137..2175	CDD:238011
Scube3	XP_008771027.1	EGF_3	38..73	CDD:289699	13/65 (20%)
		FXa_inhibition	81..115	CDD:291342	7/36 (19%)
		FXa_inhibition	121..156	CDD:291342	12/39 (31%)
		FXa_inhibition	166..202	CDD:291342	10/37 (27%)
		FXa_inhibition	206..241	CDD:291342	11/60 (18%)
		FXa_inhibition	261..296	CDD:291342	16/105 (15%)
		FXa_inhibition	302..337	CDD:291342	10/35 (29%)
		vWFA	<334..370	CDD:294047	14/38 (37%)
		EGF_CA	378..419	CDD:214542	13/44 (30%)
		GCC2_GCC3	664..711	CDD:285001	9/47 (19%)
		GCC2_GCC3	718..765	CDD:285001	11/46 (24%)
		GCC2_GCC3	774..821	CDD:285001	9/46 (20%)
		CUB	826..937	CDD:238001	29/141 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000