DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment crb and Jag2

DIOPT Version :9

Sequence 1:	NP_001247284.1	Gene:	crb / 42896	FlyBaseID:	FBgn0259685	Length:	2253	Species:	Drosophila melanogaster
Sequence 2:	XP_038967750.1	Gene:	Jag2 / 29147	RGDID:	2938	Length:	1247	Species:	Rattus norvegicus

Alignment Length:	1044	Identity:	284/1044 - (27%)
Similarity:	407/1044 - (38%)	Gaps:	270/1044 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   168 DNRWHTLQFKYEYGNLYLHVD-RAASIFANSTYNSQFLTNQDI----------------GY---- 211
            ::||.:|.|.....:|.|.:. |....:.::|.|.......|.                |:
  Rat   175 EDRWKSLHFSGHVAHLELQIRVRCDENYYSATCNKFCRPRNDFFGHYTCDQYGNKACMDGWMGKE 239

  Fly   212 -KDAILILGNSFSGCLLDGPGLQFVNNSTVQNVVFGHCPLTPGPC-SDHDLFTRLPDNFCLNDPC 274
             |:|:     ...||                |::.|.|.: ||.| ..:....:..|. |:..|.
  Rat   240 CKEAV-----CKQGC----------------NLLHGGCTV-PGECRCSYGWQGKFCDE-CVPYPG 281

  Fly   275 MGHGTCSSSPEGYECRCTARYSGKNCQKDNGSPCAKNPCENGGSCLENSRGDYQCFCDPNHSGQH 339
            ..||:|   .|.:.|.|...:.|..|.||.....:.:||.|||:|:......|.|.|...:.|::
  Rat   282 CVHGSC---VEPWHCDCETNWGGLLCDKDLNYCGSHHPCVNGGTCINAEPDQYLCACPDGYLGKN 343

  Fly   340 CETEVNIHPLCQTNPCLNNGAC-VVIGGSGALTCECPKGYAGARCEVDTDECASQPCQNNGSCID 403
            ||   .....|.:|||.|.|:| .|:.|   ..|.||.|::|..|.:|.|||||.||...|:|:|
  Rat   344 CE---RAEHACASNPCANGGSCHEVLSG---FECHCPSGWSGPTCALDIDECASNPCAAGGTCVD 402

  Fly   404 RINGFSCDCSGTGYTGAFCQTNVDECDKNPCLNGGRCFDTYGWYTCQCLDGWGGEICDRPMTCQT 468
            :::||.|.|. ..:.||.||.:.:||:..||||...|.:..|.|.|.||.||.|..|...:....
  Rat   403 QVDGFECICP-EQWVGATCQLDANECEGKPCLNAFSCKNLIGGYYCDCLPGWKGANCHININDCH 466

  Fly   469 QQCLNGGTCLDKPIGFQCLCPPEYTGELCQI-----APSCAQQCPIDSECVGG-KCVCKPGSSGP 527
            .||.:||||.|...|:||:||..:.|..|::     |.|..::..|..:.|.| :|.|..|.|||
  Rat   467 GQCQHGGTCKDLVNGYQCVCPRGFGGRHCELEYYKCASSPCRRGGICEDLVDGFRCHCPRGLSGP 531

  Fly   528 IGHCLPTTTTPTPEQEPTTTPRTTPNPNPAIPNTLTTTTKIPPITTSRTLVGTTTGSRRPPQQPL 592
            :  |
  Rat   532 L--C------------------------------------------------------------- 533

  Fly   593 QSPTQRSASLNACPQENCLNGGTCLGYSGNYSCICASGYTGYNC----QTSTGDGASALALTPIN 653
                  ...::.|....||||..|.....:|.|.|...:.|.||    :|..| ||
  Rat   534 ------EVDVDLCEPNPCLNGARCYNLEDDYYCACPEDFGGKNCSVPRETCPG-GA--------- 582

  Fly   654 CNATNGKCLNGGTCSMNGTHCYCAVGYSGDRCEKAENCSPLNCQEPMVCVQNQCLCPENKVCNQC 718
            |...:|.....|:                    :|...:|
  Rat   583 CRVIDGCGFEAGS--------------------RAHGAAP------------------------- 602

  Fly   719 ATQPCQNGGECVDLPNGDYECKCTRGWTGRTCGNDVDECTLHPKICGN-GICKNEKGSYKCYCTP 782
             :..|...|.||.||.|::.|.|..|:||..|..::|:|...|  |.| |.|.:|..|::|:|..
  Rat   603 -SGVCGPHGHCVSLPGGNFSCICDSGFTGTYCHENIDDCMGQP--CRNGGTCIDEVDSFRCFCPS 664

  Fly   783 GFTGVHCDSDVDECLSFPCLNGATCHNKINAYECVCQPGYEGENCEVDIDECGSNPCSNGSTCID 847
            |:.|..||.:.::||..||.:...|::.:|.:.|||..|::|:.|.....:|.:..||||.||.|
  Rat   665 GWEGELCDINPNDCLPDPCHSRGRCYDLVNDFYCVCDDGWKGKTCHSREFQCDAYTCSNGGTCYD 729

  Fly   848 RINNFTCNCIPGMTGRICDI-DIDDCVGDPCLNGGQCIDQLGGFRCDCSGTGYEGENCELNIDEC 911
            ..:.|.|.|.||..|..|.| ....||.:||:|||.|:.....|.|.|. .|:||..|..|.::|
  Rat   730 SGDTFRCACPPGWKGSTCTIAKNSSCVPNPCVNGGTCVGSGDSFSCICR-DGWEGRTCTHNTNDC 793

  Fly   912 LSNPCTNGAKCLDRVKDYFCDCHNGYKGKNCEQDINECESNPCQYNGNCLERSNITLYQMSRITD 976
            ...||.||..|:|.|..:.|:|..|:.|.:|..:|:||:|:||.|...|::..|
  Rat   794 NPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEIN----------- 847

  Fly   977 LPKVFSQPFSFENASGYECVCVPGIIGKNCE---ININECDSNPCS-KHG-----NCNDGIGTYT 1032
                           ||.|.|.||..|..|:   |....|.|...| .||     :||      :
  Rat   848 ---------------GYRCSCPPGRSGPRCQEVVIFTRPCWSRGVSFPHGSSWVEDCN------S 891

  Fly  1033 CECEPGFEGTHCEINIDECDR----YNPCQRGTCYDQIDDYDCDCDANYGGKNCSVLLKG-CDQN 1092
            |.|..|..         :|.:    :.||   ....|.......|..   |:.|.....| |.|.
  Rat   892 CRCLDGHR---------DCSKVWCGWKPC---LLSPQPSALSAQCPP---GQQCREKAMGQCLQP 941

  Fly  1093 PCLNGGAC-----LP---YLINEVTHLYNCTCEN---GFQGDKCEKTTTLSMVATSLISVTTERE 1146
            ||.|.|.|     ||   ..:...|||.| .|..   .|..|:..:.||:..:.:.:.::...|.
  Rat   942 PCENWGECTAEDPLPPSTPCLPRTTHLDN-NCARLTLHFNRDQVPQGTTVGAICSGIRALPATRA 1005

  Fly  1147 EGYD 1150
            ...|
  Rat  1006 AARD 1009

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crb	NP_001247284.1	LamG	91..228	CDD:238058	15/81 (19%)
		EGF_CA	386..423	CDD:238011	17/36 (47%)
		EGF_CA	425..460	CDD:238011	15/34 (44%)
		EGF	466..495	CDD:278437	12/28 (43%)
		EGF	605..633	CDD:278437	9/27 (33%)
		EGF_CA	716..750	CDD:238011	12/33 (36%)
		EGF_CA	753..789	CDD:238011	13/36 (36%)
		EGF_CA	792..828	CDD:238011	11/35 (31%)
		EGF_CA	830..865	CDD:238011	14/34 (41%)
		EGF_CA	868..905	CDD:238011	14/36 (39%)
		EGF_CA	907..943	CDD:238011	13/35 (37%)
		EGF_CA	1009..1045	CDD:238011	10/41 (24%)
		EGF_CA	1047..1082	CDD:238011	6/38 (16%)
		Laminin_G_1	1155..1290	CDD:278483
		EGF	1316..1346	CDD:278437
		Laminin_G_1	1388..1550	CDD:278483
		EGF_CA	<1593..1622	CDD:238011
		Laminin_G_2	1692..1828	CDD:280389
		EGF_CA	1901..1937	CDD:238011
		EGF_CA	1939..1974	CDD:238011
		EGF_CA	2057..2094	CDD:238011
		EGF_CA	2096..2133	CDD:238011
		EGF_CA	2137..2175	CDD:238011
Jag2	XP_038967750.1	MNNL	28..103	CDD:400141
		DSL	178..240	CDD:396134	10/61 (16%)
		EGF_CA	307..345	CDD:238011	11/37 (30%)
		EGF	351..381	CDD:394967	14/32 (44%)
		EGF_CA	385..421	CDD:238011	17/36 (47%)
		EGF_CA	423..458	CDD:238011	15/34 (44%)
		EGF_CA	461..496	CDD:238011	13/34 (38%)
		EGF_CA	502..534	CDD:238011	12/100 (12%)
		EGF_CA	536..571	CDD:238011	10/34 (29%)
		EGF_CA	636..671	CDD:238011	13/36 (36%)
		EGF_CA	676..709	CDD:238011	11/32 (34%)
		EGF	716..746	CDD:394967	14/29 (48%)
		EGF_CA	757..787	CDD:238011	12/30 (40%)
		EGF_CA	<797..824	CDD:238011	11/26 (42%)
		EGF_CA	827..863	CDD:238011	16/61 (26%)
		VWC_out	872..943	CDD:214565	20/91 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	49	1.000	Domainoid score	I11490
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910