DRSC/TRiP Functional Genomics Resources

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Protein Alignment crb and Jag1

DIOPT Version :9

Sequence 1:NP_001247284.1 Gene:crb / 42896 FlyBaseID:FBgn0259685 Length:2253 Species:Drosophila melanogaster
Sequence 2:NP_062020.2 Gene:Jag1 / 29146 RGDID:2937 Length:1219 Species:Rattus norvegicus


Alignment Length:1240 Identity:326/1240 - (26%)
Similarity:465/1240 - (37%) Gaps:421/1240 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    91 AYFNGSTYLRLTTPMPIWDHSAISFRSCRGGEILAQQYNKNSIVISVLNDFLQISLAGPAVHGPN 155
            ::.:|||        |:...:..:.::.||.:       :|.||       |..|.|.|.     
  Rat    93 SFGSGST--------PVIGGNTFNLKASRGND-------RNRIV-------LPFSFAWPR----- 130

  Fly   156 NRLDVKLPYQLLDNRWHTLQFKYEYGNLYLHVDRAASIFANSTYNSQFLTNQDIGYKDAILILGN 220
                   .|.||...|.:                     :|.|..           .|:| |...
  Rat   131 -------SYTLLVEAWDS---------------------SNDTIQ-----------PDSI-IEKA 155

  Fly   221 SFSGCLLDGPGLQFVNNSTVQNVVFGH----CPLTPGPCSDH------DLFTRLPDNF-----C- 269
            |.||.:  .|..|:  .:..||....|    ..:|   |.||      :.|.|..|:|     | 
  Rat   156 SHSGMI--NPSRQW--QTLKQNTGIAHFEYQIRVT---CDDHYYGFGCNKFCRPRDDFFGHYACD 213

  Fly   270 --LNDPCM-------------------GHGTCSSSPEGYECRCTARYSGKNCQKDNGSPCAKNPC 313
              .|..||                   .||:|....   :|||...:.|..|.|     |..:|.
  Rat   214 QNGNKTCMEGWMGPECNKAICRQGCSPKHGSCKLPG---DCRCQYGWQGLYCDK-----CIPHPG 270

  Fly   314 ENGGSCLENSRGDYQCFCDPNHSGQHCETEVNIHPLCQTN-PCLNNGACVVIGGSGALTCECPKG 377
            ...|:|.|    .:||.|:.|..||.|:.::|   .|.|: ||||.|.|... |.....|.||:|
  Rat   271 CVHGTCNE----PWQCLCETNWGGQLCDKDLN---YCGTHQPCLNRGTCSNT-GPDKYQCSCPEG 327

  Fly   378 YAGARCEVDTDECASQPCQNNGSCIDRINGFSCDCSGTGYTGAFCQTNVDECDKNPCLNGGRCFD 442
            |:|..||:....|.|.||.|.|||.:..:||.|:|| .|:||..|.||:|:|..|          
  Rat   328 YSGPNCEIAEHACLSDPCHNRGSCKETSSGFECECS-PGWTGPTCSTNIDDCSPN---------- 381

  Fly   443 TYGWYTCQCLDGWGGEICDRPMTCQTQQCLNGGTCLDKPIGFQCLCPPEYTGELCQIAPSCAQQC 507
                                       .|.:||||.|...||:|:|||::||:.||:        
  Rat   382 ---------------------------NCSHGGTCQDLVNGFKCVCPPQWTGKTCQL-------- 411

  Fly   508 PIDSECVGGKCVCKPGSSGPIGHCLPTTTTPTPEQEPTTTPRTTPNPNPAIPNTLTTTTKIPPIT 572
                                                                             
  Rat   412 ----------------------------------------------------------------- 411

  Fly   573 TSRTLVGTTTGSRRPPQQPLQSPTQRSASLNACPQENCLNGGTCLGYSGNYSCICASGYTGYNCQ 637
                                        ..|.|..:.|:|..:|.....:|.|.|..|:.|.||.
  Rat   412 ----------------------------DANECEAKPCVNARSCKNLIASYYCDCLPGWMGQNCD 448

  Fly   638 TSTGDGASALALTPINCNATNGKCLNGGTCS--MNGTHCYCAVGYSGDRCEK-AENCSPLNCQEP 699
                          ||.|...|:|.|..:|.  :||..|.|..||:||.||: .:.|:...|...
  Rat   449 --------------ININDCLGQCQNDASCRDLVNGYRCICPPGYAGDHCERDIDECASNPCLNG 499

  Fly   700 MVCVQN-----QCLCP---ENKVC----NQCATQPCQNGGECVDLPNGDYECKCTRGWTGRTCGN 752
            ..| ||     |||||   ...:|    :.|...|||||.:|.:..: ||.|||...:.|:.|.:
  Rat   500 GHC-QNEINRFQCLCPTGFSGNLCQLDIDYCEPNPCQNGAQCYNRAS-DYFCKCPEDYEGKNCSH 562

  Fly   753 DVDECTLHP-------------------------KICG-NGICKNEK-GSYKCYCTPGFTGVHCD 790
            ..|.|...|                         .:|| :|.||:|. |.:.|.|..||||.:|.
  Rat   563 LKDHCRTTPCEVIDSCTVAMASNDTPEGVRYISSNVCGPHGKCKSESGGKFTCDCNKGFTGTYCH 627

  Fly   791 SDVDECLSFPCLNGATCHNKINAYECVCQPGYEGENCEVDIDECGSNPCSNGSTCIDRINNFTCN 855
            .::::|...||.||.||.:.:|:|:|:|..|:||.:||.:|::|..|||..|.||.|.:|:|.|:
  Rat   628 ENINDCEGNPCTNGGTCIDGVNSYKCICSDGWEGAHCENNINDCSQNPCHYGGTCRDLVNDFYCD 692

  Fly   856 CIPGMTGRICDIDIDDCVGDPCLNGGQCIDQLGGFRCDCSGTGYEGENCEL-NIDECLSNPCTNG 919
            |..|..|:.|......|....|.|||.|.|::..|:|.|.| |:||..|.: ....||.|||.||
  Rat   693 CKNGWKGKTCHSRDSQCDEATCNNGGTCYDEVDTFKCMCPG-GWEGTTCNIARNSSCLPNPCHNG 756

  Fly   920 AKCLDRVKDYFCDCHNGYKGKNCEQDINECESNPCQYNGNCLERSNITLYQMSRITDLPKVFSQP 984
            ..|:.....:.|.|..|::|..|.|:.|:|..:||..:|.|::..|                   
  Rat   757 GTCVVNGDSFTCVCKEGWEGPICTQNTNDCSPHPCYNSGTCVDGDN------------------- 802

  Fly   985 FSFENASGYECVCVPGIIGKNCEININECDSNPCSKHGNCNDGIGTYTCECEPGFEGTHC-EINI 1048
                   .|.|.|.||..|.:|.||||||.|:||:....|.|.|..|.|.|.||..|..| |::.
  Rat   803 -------WYRCECAPGFAGPDCRININECQSSPCAFGATCVDEINGYQCICPPGHSGAKCHEVSG 860

  Fly  1049 DEC--------DRYNPCQRGTCYDQIDDYDCD-CDANYGGKNCSVLLKGCDQNPCL--------- 1095
            ..|        |       |..:|.    ||: |....|...||.:  .|...||.         
  Rat   861 RSCITMGRVILD-------GAKWDD----DCNTCQCLNGRVACSKV--WCGPRPCQLHKGHGECP 912

  Fly  1096 NGGACLPYLINEVTHLYNCTCENGFQGDKCEKTTTLSMVATSLISVTTEREEGYDINLQFRTTLP 1160
            ||.:|:| ::::...:..||     ...:| ::::|..|.|...|.:..::...:|...|...: 
  Rat   913 NGQSCIP-VLDDQCFVRPCT-----GAGEC-RSSSLQPVKTKCTSDSYYQDNCANITFTFNKEM- 969

  Fly  1161 NGVLAFGTTGEKNEPVSYILELINGRLNLHSSLLNKWEGVFIGSKLNDSNWHKVFVAINTSHLVL 1225
               ::.|.|.|                ::.|.|.|      :....|.|..:.:::|...|   |
  Rat   970 ---MSPGLTTE----------------HICSELRN------LNILKNVSAEYSIYIACEPS---L 1006

  Fly  1226 SANDE 1230
            |||:|
  Rat  1007 SANNE 1011

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
crbNP_001247284.1 LamG 91..228 CDD:238058 25/136 (18%)
EGF_CA 386..423 CDD:238011 16/36 (44%)
EGF_CA 425..460 CDD:238011 4/34 (12%)
EGF 466..495 CDD:278437 13/28 (46%)
EGF 605..633 CDD:278437 8/27 (30%)
EGF_CA 716..750 CDD:238011 13/33 (39%)
EGF_CA 753..789 CDD:238011 16/62 (26%)
EGF_CA 792..828 CDD:238011 14/35 (40%)
EGF_CA 830..865 CDD:238011 15/34 (44%)
EGF_CA 868..905 CDD:238011 14/36 (39%)
EGF_CA 907..943 CDD:238011 12/35 (34%)
EGF_CA 1009..1045 CDD:238011 18/36 (50%)
EGF_CA 1047..1082 CDD:238011 8/43 (19%)
Laminin_G_1 1155..1290 CDD:278483 16/76 (21%)
EGF 1316..1346 CDD:278437
Laminin_G_1 1388..1550 CDD:278483
EGF_CA <1593..1622 CDD:238011
Laminin_G_2 1692..1828 CDD:280389
EGF_CA 1901..1937 CDD:238011
EGF_CA 1939..1974 CDD:238011
EGF_CA 2057..2094 CDD:238011
EGF_CA 2096..2133 CDD:238011
EGF_CA 2137..2175 CDD:238011
Jag1NP_062020.2 MNNL 32..107 CDD:400141 4/21 (19%)
DSL 167..229 CDD:396134 15/66 (23%)
Important for interaction with NOTCH1. /evidence=ECO:0000250 199..207 3/7 (43%)
EGF_CA 296..334 CDD:238011 16/41 (39%)
EGF 340..370 CDD:394967 16/30 (53%)
EGF_CA 374..410 CDD:238011 18/72 (25%)
EGF_CA 412..447 CDD:238011 10/34 (29%)
EGF_CA 450..485 CDD:238011 14/34 (41%)
EGF_CA 487..523 CDD:238011 10/36 (28%)
EGF_CA 525..560 CDD:238011 13/35 (37%)
EGF_CA 629..665 CDD:238011 14/35 (40%)
EGF_CA 667..702 CDD:238011 15/34 (44%)
EGF_CA <714..740 CDD:238011 13/26 (50%)
EGF 748..777 CDD:394967 11/28 (39%)
EGF_CA 782..817 CDD:238011 13/60 (22%)
EGF_CA 820..855 CDD:238011 17/34 (50%)
VWC_out 863..930 CDD:214565 17/80 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1182..1219
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 49 1.000 Domainoid score I11490
eggNOG 1 0.900 - - E33208_3BAFT
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.810

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