DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment crb and Ltbp1

DIOPT Version :9

Sequence 1:NP_001247284.1 Gene:crb / 42896 FlyBaseID:FBgn0259685 Length:2253 Species:Drosophila melanogaster
Sequence 2:NP_064303.2 Gene:Ltbp1 / 268977 MGIID:109151 Length:1712 Species:Mus musculus


Alignment Length:1652 Identity:357/1652 - (21%)
Similarity:537/1652 - (32%) Gaps:631/1652 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly   283 SPEGYECRCTARYSGKNCQK--------DNGSPC----AKN--------PCENGGSCLENSRGDY 327
            :|...:..||......:|||        :||...    |.|        ||.|||.|  :||.  
Mouse   349 TPSICKVTCTKGNCQNSCQKGNTTTLISENGHAADTLTATNFRVVICHLPCMNGGQC--SSRD-- 409

  Fly   328 QCFCDPNHSGQHCETEV----------------------NIH-----PLCQTN---------PCL 356
            :|.|.||.:|:.|:..|                      .||     ||..|:         |.:
Mouse   410 KCQCPPNFTGKLCQIPVLGASMPKLYQHAQQQGKALGSHVIHSTHTLPLTMTSQQGVKVKFPPNI 474

  Fly   357 NN-------GACVVIGGSGALTCECPKGYAGARCEVDTDECASQ--PCQNN-------------- 398
            .|       .|.|.|.....:  :.|.|......:....:.:.|  |.|..              
Mouse   475 VNIHVKHPPEASVQIHQVSRI--DSPGGQKVKEAQPGQSQVSYQGLPVQKTQTVHSTYSHQQLIP 537

  Fly   399 -----------GSCIDRINGFSC-----------DCSGT--------------------GYT--- 418
                       |.|.....|..|           ||.||                    |||   
Mouse   538 HVYPVAAKTQLGRCFQETIGSQCGKALPGLSKQEDCCGTVGTSWGFNKCQKCPKKQSYHGYTQMM 602

  Fly   419 ----------GAFCQTNVDECDKNPCLNGGRCFDTYGWYTCQCLDGWGGE------ICDRPMTCQ 467
                      ..||| :::||........|.|.:|.|.|.|.|..|:|.:      :.|.|:..:
Mouse   603 ECLQGYKRVNNTFCQ-DINECQLQGVCPNGECLNTMGSYRCSCKMGFGPDPTFSSCVPDPPVISE 666

  Fly   468 TQQCLNGGTC--LDKPIGFQCLCP--PEYTGELCQIA------PSCAQQCPIDSE------CVGG 516
            .:     |.|  |..| |..|:.|  ...|.::|..:      |.| ::||:...      |.||
Mouse   667 EK-----GPCYRLVSP-GRHCMHPLSVHLTKQICCCSVGKAWGPHC-EKCPLPGTAAFKEICPGG 724

  Fly   517 ---------------------KCVCKPGSSGPIGHCLPTTTTPTP---EQEP--TTTPRTTPNPN 555
                                 ....||.::.|:.    .:|.|.|   ::||  ..|......|.
Mouse   725 MGYTVSGVHRRRPIHQHIGKEAVYVKPKNTQPVA----KSTHPPPLPAKEEPVEALTSSWEHGPR 785

  Fly   556 PAIPNTLTT--TTKIPPITTSRTLV---------GTTTGSRRP----------PQQPLQ------ 593
            .|.|..:|.  ..:||.:...:|.:         |.:|....|          |..|::      
Mouse   786 GAEPEVVTAPPEKEIPSLDQEKTRLEPGQPQLSPGVSTIHLHPQFPVVVEKTSPPVPVEVAPEAS 850

  Fly   594 --------SPTQRSASLNACP-QENCLNGGTCLGYSGNYSCICASGYTGYNCQTSTGDGASALAL 649
                    :||| ...:|.|. ..:....|.|:.....|:|||   |.||...............
Mouse   851 TSSASQVIAPTQ-VTEINECTVNPDICGAGHCINLPVRYTCIC---YEGYKFSEQLRKCVDIDEC 911

  Fly   650 TPINCNATNGKCLNGGTCSMNGTH-CYCAVGYSGDRCEKAENCSPLN-CQEPMVCVQNQCL---- 708
            ..:....:.|:|.|     ..|:. |.|..|:...  |:..||..:: |..|.:|...:|:    
Mouse   912 AQVRHLCSQGRCEN-----TEGSFLCVCPAGFMAS--EEGTNCIDVDECLRPDMCRDGRCINTAG 969

  Fly   709 ------------------CPENKVCNQCATQPCQNGGECVDLPNGDYEC-KCT---RGWTGRTCG 751
                              |.:...|.:.:|.|.:   :||:.| |.|:| .||   |||.|:.. 
Mouse   970 AFRCEYCDSGYRMSRRGYCEDIDECLKPSTCPEE---QCVNTP-GSYQCVPCTEGFRGWNGQCL- 1029

  Fly   752 NDVDECTLHPKICGNGICKNEKGSYKCYCTPGFTGV----HCDSDVDECLSFP-CLNGATCHNKI 811
             ||||| |.||:|.||.|.|.:|||.|.|..|::..    || .|:|||.... |:|| .|.|..
Mouse  1030 -DVDEC-LQPKVCTNGSCTNLEGSYMCSCHRGYSPTPDHRHC-QDIDECQQGNLCMNG-QCRNTD 1090

  Fly   812 NAYECVCQPGYE----GENCEVDIDECGSNP-CSNGSTCIDRINNFTCNCIPGMTGRICDIDIDD 871
            .::.|.|..||:    .:.|| |||||..:. ||:                              
Mouse  1091 GSFRCTCGQGYQLSAAKDQCE-DIDECEHHHLCSH------------------------------ 1124

  Fly   872 CVGDPCLNGGQCIDQLGGFRCDCSGTGYE----GENCELNIDECL--SNPCTNGAKCLDRVKDYF 930
                     |||.:..|.|:|.|: .||.    |::|| :|:|||  |:.| .|..|::....|.
Mouse  1125 ---------GQCRNTEGSFQCVCN-QGYRASVLGDHCE-DINECLEDSSVC-QGGDCINTAGSYD 1177

  Fly   931 CDCHNGYK---GKNCEQDINEC-ESNPCQYNGNCLERSNITLYQMSRITDLPKVFSQPFSFENAS 991
            |.|.:|::   .|.| |||||| :...|..:|.||                           |..
Mouse  1178 CTCPDGFQLNDNKGC-QDINECAQPGLCGSHGECL---------------------------NTQ 1214

  Fly   992 G-YECVCVPGII----GKNCEININECDSNP-CSKHGNCNDGIGTYTCECEPGF----EGTHCEI 1046
            | :.|||..|..    |:.|| :|:||.:|. |..||.|::..|::.|.|..||    :|..| :
Mouse  1215 GSFHCVCEQGFSISADGRTCE-DIDECVNNTVCDSHGFCDNTAGSFRCLCYQGFQAPQDGQGC-V 1277

  Fly  1047 NIDECDRYN-PCQRGTCYDQIDDYDCDC-DAN--YG---GKNCSVLLK--GCDQNPCLNGGACLP 1102
            :::||:..: .|....|.:....:.|.| |.|  |.   |:..|.:.:  |.|:.|......|. 
Mouse  1278 DVNECELLSGVCGEAFCENVEGSFLCVCADENQEYSPMTGQCRSRVTEDSGVDRQPREEKKECY- 1341

  Fly  1103 YLINEVTHLYN----------CTCENGF-QGDKCEKTTTLSMVATSLISVTTEREEGYDINLQFR 1156
            |.:|:.:...|          |.|.:|. .||.|| .....:..|:..:....|.:|        
Mouse  1342 YNLNDASLCDNVLAPNVTKQECCCTSGAGWGDNCE-IFPCPVQGTAEFTEMCPRGKG-------- 1397

  Fly  1157 TTLPNGVLAFGTTGEKNEPVSYILELINGRLNLHSSLLNKWEGVFIGSKLNDSNWHKVFVAINTS 1221
             .:|.|..::.|.||..:..                                             
Mouse  1398 -LVPAGESSYDTGGENYKDA--------------------------------------------- 1416

  Fly  1222 HLVLSANDEQAIFPVGSYETANNSQPSFPRTYLGGTIPNLKSYLRHLTHQPSAFVGCMQDIMVNG 1286
                   ||..:|   ..|...|.       |...|.|..:.|             |.|.     
Mouse  1417 -------DECLLF---GEEICKNG-------YCLNTQPGYECY-------------CKQG----- 1446

  Fly  1287 KWIFPDEQDANISYTKLENVQSGCPRTEQCK-PNPCHSNGECTDLWHTFACHCPRPFFGHTCQHN 1350
                          |..:.|:..|...::|: ||.| .:|:|.:...::.|.|..|......:..
Mouse  1447 --------------TYYDPVKLQCFDMDECQDPNSC-IDGQCVNTEGSYNCFCTHPMVLDASEKR 1496

  Fly  1351 MTAATFGHENTTHSAVIVETTDVARRAIRSILDISMFIRTREPTGQVFYLGTDPRKAPTKNIGDS 1415
            ....|..:|.       :|.|||.:       |:..                       :::.:.
Mouse  1497 CVQPTESNEQ-------IEETDVYQ-------DLCW-----------------------EHLSEE 1524

  Fly  1416 YVAAKLHGGELLVKMQFSGTPEAYTVGGQ-----------KLDNGYNHLIEVVRNQTLVQVKLNG 1469
            ||.::     .||..|.:.| |...:.|:           |..:.|         ..|..:.:.|
Mouse  1525 YVCSR-----PLVGKQTTYT-ECCCLYGEAWGMQCALCPMKDSDDY---------AQLCNIPVTG 1574

  Fly  1470 TEYFRKTLSTTGLLDAQVLYLGGPAPTRESLLGATTEPGIIPVPGAGIPIEDTTVPKEADDSRDY 1534
            .   |:......|:|....|            |..|:|..|                     :|.
Mouse  1575 R---RRPYGRDALVDFSEQY------------GPETDPYFI---------------------QDR 1603

  Fly  1535 FKGIIQDVKV---------SNGSLNLIVEMYSLNVTD-VQVNAKPLGAVTIDRASVLPGEVSDDL 1589
            |....::::.         .||....:.|.|:.:..| ..::...:..|.::..|.|...:|  |
Mouse  1604 FLNSFEELQAEECGILNGCENGRCVRVQEGYTCDCFDGYHLDMAKMTCVDVNECSELNNRMS--L 1666

  Fly  1590 CRKNPCLHNAECRNTWNDYTCKCPNGY 1616
            |:      ||:|.||...|.|.|..||
Mouse  1667 CK------NAKCINTEGSYKCLCLPGY 1687

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
crbNP_001247284.1 LamG 91..228 CDD:238058
EGF_CA 386..423 CDD:238011 15/107 (14%)
EGF_CA 425..460 CDD:238011 11/40 (28%)
EGF 466..495 CDD:278437 8/32 (25%)
EGF 605..633 CDD:278437 8/28 (29%)
EGF_CA 716..750 CDD:238011 14/37 (38%)
EGF_CA 753..789 CDD:238011 19/39 (49%)
EGF_CA 792..828 CDD:238011 13/40 (33%)
EGF_CA 830..865 CDD:238011 7/35 (20%)
EGF_CA 868..905 CDD:238011 10/40 (25%)
EGF_CA 907..943 CDD:238011 13/40 (33%)
EGF_CA 1009..1045 CDD:238011 14/40 (35%)
EGF_CA 1047..1082 CDD:238011 10/41 (24%)
Laminin_G_1 1155..1290 CDD:278483 16/134 (12%)
EGF 1316..1346 CDD:278437 9/30 (30%)
Laminin_G_1 1388..1550 CDD:278483 24/181 (13%)
EGF_CA <1593..1622 CDD:238011 10/24 (42%)
Laminin_G_2 1692..1828 CDD:280389
EGF_CA 1901..1937 CDD:238011
EGF_CA 1939..1974 CDD:238011
EGF_CA 2057..2094 CDD:238011
EGF_CA 2096..2133 CDD:238011
EGF_CA 2137..2175 CDD:238011
Ltbp1NP_064303.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 65..118
EGF_CA 618..>648 CDD:214542 9/29 (31%)
TB 681..716 CDD:279073 8/35 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 753..799 11/49 (22%)
EGF_CA 907..947 CDD:284955 8/46 (17%)
EGF_CA 949..985 CDD:214542 4/35 (11%)
EGF_CA 990..1023 CDD:238011 11/36 (31%)
EGF_CA 1030..1070 CDD:214542 21/41 (51%)
EGF_CA 1071..1102 CDD:214542 12/31 (39%)
EGF_CA 1112..1152 CDD:214542 17/79 (22%)
EGF_CA 1153..1189 CDD:214542 12/36 (33%)
EGF_CA 1194..1235 CDD:214542 16/67 (24%)
EGF_CA 1236..1277 CDD:214542 15/41 (37%)
8-Cys3 region. /evidence=ECO:0000250|UniProtKB:Q14766 1335..1402 15/77 (19%)
TB 1350..1387 CDD:279073 9/37 (24%)
EGF_CA 1458..>1484 CDD:214542 7/26 (27%)
C-terminal domain. /evidence=ECO:0000250|UniProtKB:Q14766 1498..1712 50/286 (17%)
TB 1527..1563 CDD:279073 7/41 (17%)
EGF_CA 1653..>1687 CDD:214542 13/41 (32%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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