DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment crb and GAS6

DIOPT Version :9

Sequence 1:	NP_001247284.1	Gene:	crb / 42896	FlyBaseID:	FBgn0259685	Length:	2253	Species:	Drosophila melanogaster
Sequence 2:	NP_000811.1	Gene:	GAS6 / 2621	HGNCID:	4168	Length:	678	Species:	Homo sapiens

Alignment Length:	610	Identity:	147/610 - (24%)
Similarity:	232/610 - (38%)	Gaps:	133/610 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   883 CIDQLGGFRCDCSGTGYEGENCELNI-DECLSNPC-TNGAK-CLDRVKDYFCDCHNGYKGKNCEQ 944
            ||::.|......||..    .|..|: |:|..||| ..|.: |.|.:.::||.|..|:.|:.|::
Human    95 CINKYGSPYTKNSGFA----TCVQNLPDQCTPNPCDRKGTQACQDLMGNFFCLCKAGWGGRLCDK 155

  Fly   945 DINECESNPCQYNGNCLERSNITLYQMSRITDLPKVFSQPFSFENASGYECVCVPGI----IGKN 1005
            |:|||.    |.||.||:..:                ::|.||      .|.|..|.    .|:.
Human   156 DVNECS----QENGGCLQICH----------------NKPGSF------HCSCHSGFELSSDGRT 194

  Fly  1006 CEININEC-DSNPCSKHGNCNDGIGTYTCECEPGF----EGTHCEINIDECDRYNPCQRGTCYDQ 1065
            |: :|:|| ||..|.: ..|.:..|:|:|.|:.||    :...|. ::||| ....|:: .|.:.
Human   195 CQ-DIDECADSEACGE-ARCKNLPGSYSCLCDEGFAYSSQEKACR-DVDEC-LQGRCEQ-VCVNS 254

  Fly  1066 IDDYDCDCDANYGGKNCSVLLKGCDQNPCLNGGACLPYLI-NEVTHLYNCTCENGFQGDKCEKTT 1129
            ...|.|.||.. ||...|.     |.:.|.:...|:|:.: ..|..||   ....|.|....:..
Human   255 PGSYTCHCDGR-GGLKLSQ-----DMDTCEDILPCVPFSVAKSVKSLY---LGRMFSGTPVIRLR 310

  Fly  1130 TLSMVATSLISVTTEREEGYDINLQFRTTLPNGVLAFGTTGEKNEPVSYILELINGRLNLHSSLL 1194
            ...:..|.|::           ...|||..|.|:|.|  .|...:....:|.|..|||.|..
Human   311 FKRLQPTRLVA-----------EFDFRTFDPEGILLF--AGGHQDSTWIVLALRAGRLELQL--- 359

  Fly  1195 NKWEGV----FIGSKLNDSNWHKVFVAINTSHLVLSANDEQAIFPVGSYETANNSQPSFPRTYLG 1255
             ::.||    ..|..:|...|..:.|.....:||:..| ..|:..:.  ...:..||.....:|.
Human   360 -RYNGVGRVTSSGPVINHGMWQTISVEELARNLVIKVN-RDAVMKIA--VAGDLFQPERGLYHLN 420

  Fly  1256 GTIPNLKSYLRHLTHQP--SAFVGCMQDIMVNGKWIFPDEQDANISYTKLENVQSGC-PRTEQCK 1317
            .|:..:..:.:.|. ||  ....|||:      .|.:.:.:|..|..|...|.:..| ..||:..
Human   421 LTVGGIPFHEKDLV-QPINPRLDGCMR------SWNWLNGEDTTIQETVKVNTRMQCFSVTERGS 478

  Fly  1318 PNPCHSNGECTDLWHTFACHCPRPFFGHTCQHNMTAATFGHENTTHSAVIVETTDVARRAIRSIL 1382
            ..|  .:|                |..::..:..|....|.|:|....|:..
Human   479 FYP--GSG----------------FAFYSLDYMRTPLDVGTESTWEVEVVAH------------- 512

  Fly  1383 DISMFIRTREPTGQVFYL-GTDPRKAP-TKNIGDSYVAAKLHGGELLVKMQFSGTPEAYTVGGQK 1445
                 ||....||.:|.| ..|.|..| :..:.|.:...||.  :.||.:....|  |..:...|
Human   513 -----IRPAADTGVLFALWAPDLRAVPLSVALVDYHSTKKLK--KQLVVLAVEHT--ALALMEIK 568

  Fly  1446 LDNGYNHLIEVVRNQTLVQVKLNGT 1470
            :.:|..|::.|........::::||
Human   569 VCDGQEHVVTVSLRDGEATLEVDGT 593

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crb	NP_001247284.1	LamG	91..228	CDD:238058
		EGF_CA	386..423	CDD:238011
		EGF_CA	425..460	CDD:238011
		EGF	466..495	CDD:278437
		EGF	605..633	CDD:278437
		EGF_CA	716..750	CDD:238011
		EGF_CA	753..789	CDD:238011
		EGF_CA	792..828	CDD:238011
		EGF_CA	830..865	CDD:238011
		EGF_CA	868..905	CDD:238011	5/21 (24%)
		EGF_CA	907..943	CDD:238011	14/38 (37%)
		EGF_CA	1009..1045	CDD:238011	13/40 (33%)
		EGF_CA	1047..1082	CDD:238011	11/34 (32%)
		Laminin_G_1	1155..1290	CDD:278483	35/140 (25%)
		EGF	1316..1346	CDD:278437	3/29 (10%)
		Laminin_G_1	1388..1550	CDD:278483	22/85 (26%)
		EGF_CA	<1593..1622	CDD:238011
		Laminin_G_2	1692..1828	CDD:280389
		EGF_CA	1901..1937	CDD:238011
		EGF_CA	1939..1974	CDD:238011
		EGF_CA	2057..2094	CDD:238011
		EGF_CA	2096..2133	CDD:238011
		EGF_CA	2137..2175	CDD:238011
GAS6	NP_000811.1	Gla	53..92	CDD:306960
		EGF_CA	118..153	CDD:238011	13/34 (38%)
		FXa_inhibition	160..195	CDD:317114	13/60 (22%)
		EGF_CA	197..>227	CDD:214542	11/30 (37%)
		vWFA	<232..273	CDD:320736	13/49 (27%)
		LamG	298..450	CDD:238058	39/178 (22%)
		Laminin_G_2	513..651	CDD:308045	22/85 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910