DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment crb and CNTNAP2

DIOPT Version :9

Sequence 1:NP_001247284.1 Gene:crb / 42896 FlyBaseID:FBgn0259685 Length:2253 Species:Drosophila melanogaster
Sequence 2:NP_054860.1 Gene:CNTNAP2 / 26047 HGNCID:13830 Length:1331 Species:Homo sapiens


Alignment Length:962 Identity:191/962 - (19%)
Similarity:310/962 - (32%) Gaps:306/962 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly  1065 QIDDYDCDCDANYGG------------KNCSVLLKGCDQNPCLNGGACLPYLINEVTHLYNCTCE 1117
            :.|..|.|.:..:||            ||    .|||.::...||     ..|.::.........
Human   304 EFDYLDLDYEITFGGIPFSGKPSSSSRKN----FKGCMESINYNG-----VNITDLARRKKLEPS 359

  Fly  1118 N-GFQGDKCEKTTTLSMV--ATSLISVTTE-REEGYDINLQFRTTLPNGVLAFGTTGEKNEPVSY 1178
            | |.....|.:..|:.:.  |||.:.|... .::.:.::.||||..|||:|.|....:....|. 
Human   360 NVGNLSFSCVEPYTVPVFFNATSYLEVPGRLNQDLFSVSFQFRTWNPNGLLVFSHFADNLGNVE- 423

  Fly  1179 ILELINGRLNLHSSLL-NKWEGVFI--GSKLNDSNWHKVFVAINTSHLVLSANDEQAIFPVGSYE 1240
             ::|...::.:|.::. .|...:.|  ||.|||..||:|......:..:|:.:.::|    .:..
Human   424 -IDLTESKVGVHINITQTKMSQIDISSGSGLNDGQWHEVRFLAKENFAILTIDGDEA----SAVR 483

  Fly  1241 TANNSQPSFPRTYLGGTIPNLKSYLRHLTHQPSAFVGCMQDIMVNGKWIFPDEQDANISYT---- 1301
            |.:..|......|..|...|..:...|...||| |.||||.|.|       |:|..|:...    
Human   484 TNSPLQVKTGEKYFFGGFLNQMNNSSHSVLQPS-FQGCMQLIQV-------DDQLVNLYEVAQRK 540

  Fly  1302 --KLENVQ-SGCPRTEQCKPNPCHSNGECTDLWHTFACHCPRP-FFGHTCQHNMTAATFGHENTT 1362
              ...||. ..|...::|.||.|...|:|:..|.:|.|.|... :.|.|| ||.           
Human   541 PGSFANVSIDMCAIIDRCVPNHCEHGGKCSQTWDSFKCTCDETGYSGATC-HNS----------- 593

  Fly  1363 HSAVIVETTDVARRAIRSILDISMFIRTREPTGQVFYLGTD------PRKAPTKNIGDSYVAAKL 1421
                |.|.:..|.:.:..             |...:::..|      |.|.......|.......
Human   594 ----IYEPSCEAYKHLGQ-------------TSNYYWIDPDGSGPLGPLKVYCNMTEDKVWTIVS 641

  Fly  1422 HGGELLVKMQFSG-TPEAYTVGGQKLDNGYNHLIEVVRNQTLVQVK--LNGTEY----------F 1473
            |  :|.::....| .||.|:|            .::|.:.::.|:.  .:..||          .
Human   642 H--DLQMQTPVVGYNPEKYSV------------TQLVYSASMDQISAITDSAEYCEQYVSYFCKM 692

  Fly  1474 RKTLST---------TGLLDAQVLYLGGPAPTRESLLGATTEPGIIPVPGAGIPIEDTTVPK--- 1526
            .:.|:|         .|..:.:..|.||..|.             |.....||. .:.|.||   
Human   693 SRLLNTPDGSPYTWWVGKANEKHYYWGGSGPG-------------IQKCACGIE-RNCTDPKYYC 743

  Fly  1527 --EADDSRDYFKGIIQDVKVSNGSLNLIVEMYSLNVTDVQVNAKPLGAVTIDRASVLPGEVSDDL 1589
              :||     :|...:|....:...:|.|....:..||.|.:...|        ||.|.....| 
Human   744 NCDAD-----YKQWRKDAGFLSYKDHLPVSQVVVGDTDRQGSEAKL--------SVGPLRCQGD- 794

  Fly  1590 CRKNPCLHNAECRNTWNDYTCKCPNGYKGKNCQEIEFCQHVTCPGQSLCQNLDDGYECVTNTTFT 1654
                        ||.||..:...|:.|       :.|                        :||.
Human   795 ------------RNYWNAASFPNPSSY-------LHF------------------------STFQ 816

  Fly  1655 GQERSPLAFF---------YFQEQQSDDIVSEASPKQTLKPVIDIAFRTRAGGTLLYIDNVDGFF 1710
            |:..:.::|:         :.:....:|.:     |..||...:::|.                |
Human   817 GETSADISFYFKTLTPWGVFLENMGKEDFI-----KLELKSATEVSFS----------------F 860

  Fly  1711 EIGVNGGRVTITWKLSALHFGESARFEKENTDGEWSRIYLRAHNSKLEGGWKGWESMVDPTPAFS 1775
            ::|  .|.|.|.           .|......|.:|.|:       ..|...|.....||..|   
Human   861 DVG--NGPVEIV-----------VRSPTPLNDDQWHRV-------TAERNVKQASLQVDRLP--- 902

  Fly  1776 TDIDQAAFQ--SLIATSTQVYLGGMPESRQARGSTLSAQQGSQFKGCVGEARVGDLLLPYFSMAE 1838
            ..|.:|..:  :.:...:|:::||           ...|||  |.||:...|:..:.|       
Human   903 QQIRKAPTEGHTRLELYSQLFVGG-----------AGGQQG--FLGCIRSLRMNGVTL------- 947

  Fly  1839 LYSRTNVSVQQKAQFRLNATRPEEGCILCFQSDCKNDGFCQSPSDEYACTC-QPGFEGDDCGTDI 1902
                   .::::|:..........|....:.::|:|.|.|......|:|.| ...::|..|..| 
Human   948 -------DLEERAKVTSGFISGCSGHCTSYGTNCENGGKCLERYHGYSCDCSNTAYDGTFCNKD- 1004

  Fly  1903 DECLNTECLNNGTCINQVAAFFCQCQ--------PGFEGQHCEQNIDECADQ 1946
                             |.|||.:..        |....:.....:|...||
Human  1005 -----------------VGAFFEEGMWLRYNFQAPATNARDSSSRVDNAPDQ 1039

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
crbNP_001247284.1 LamG 91..228 CDD:238058
EGF_CA 386..423 CDD:238011
EGF_CA 425..460 CDD:238011
EGF 466..495 CDD:278437
EGF 605..633 CDD:278437
EGF_CA 716..750 CDD:238011
EGF_CA 753..789 CDD:238011
EGF_CA 792..828 CDD:238011
EGF_CA 830..865 CDD:238011
EGF_CA 868..905 CDD:238011
EGF_CA 907..943 CDD:238011
EGF_CA 1009..1045 CDD:238011
EGF_CA 1047..1082 CDD:238011 6/28 (21%)
Laminin_G_1 1155..1290 CDD:278483 39/137 (28%)
EGF 1316..1346 CDD:278437 11/30 (37%)
Laminin_G_1 1388..1550 CDD:278483 33/194 (17%)
EGF_CA <1593..1622 CDD:238011 6/28 (21%)
Laminin_G_2 1692..1828 CDD:280389 27/137 (20%)
EGF_CA 1901..1937 CDD:238011 6/43 (14%)
EGF_CA 1939..1974 CDD:238011 3/8 (38%)
EGF_CA 2057..2094 CDD:238011
EGF_CA 2096..2133 CDD:238011
EGF_CA 2137..2175 CDD:238011
CNTNAP2NP_054860.1 FA58C 34..181 CDD:214572
FA58C <70..180 CDD:238014
Laminin_G_2 216..345 CDD:280389 12/49 (24%)
Laminin_G_2 401..529 CDD:280389 40/141 (28%)
EGF_CA 555..590 CDD:238011 11/34 (32%)
COLFI 609..>632 CDD:295304 3/22 (14%)
LamG 800..943 CDD:238058 38/230 (17%)
LamG 1050..1185 CDD:214598
4.1m 1282..1300 CDD:128590
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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