DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment crb and Egfl7

DIOPT Version :9

Sequence 1:	NP_001247284.1	Gene:	crb / 42896	FlyBaseID:	FBgn0259685	Length:	2253	Species:	Drosophila melanogaster
Sequence 2:	XP_006233730.1	Gene:	Egfl7 / 245963	RGDID:	708507	Length:	282	Species:	Rattus norvegicus

Alignment Length:	180	Identity:	49/180 - (27%)
Similarity:	70/180 - (38%)	Gaps:	46/180 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly  1786 LIATSTQVYLGGMPE-----SRQARGSTLSAQQGSQFKGCVGEARVGDLLLPYFSMAE------- 1838
            |:|....:..||..|     ||  |..|:....||     :.|..|..:..||.:..:
  Rat    11 LVAWFLVLAAGGTTEHVYRPSR--RVCTVGVSGGS-----ISETFVQRVYQPYLTTCDGHRACST 68

  Fly  1839 ---LYSRTNVSVQQKAQFRLNATRPEEGC----------------ILCFQSDCKNDGFCQSPSDE 1884
               :| ||...:..:....|..:||...|                .:| |..|.|:|.|..|.
  Rat    69 YRTIY-RTAYRIAYRHSPGLTPSRPRYACCPGWKRTNGLPGACGAAIC-QPPCGNEGSCIRPG-- 129

  Fly  1885 YACTCQPGFEGDDCGTDIDECLNTECLNNGTCINQVAAFFCQCQPGFEGQ 1934
             .|.|..|::||.|..|:|||...|......|:|.|.:::|||   :|||
  Rat   130 -RCRCPVGWQGDTCQIDVDECSTGEARCPQRCVNTVGSYWCQC---WEGQ 175

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crb	NP_001247284.1	LamG	91..228	CDD:238058
		EGF_CA	386..423	CDD:238011
		EGF_CA	425..460	CDD:238011
		EGF	466..495	CDD:278437
		EGF	605..633	CDD:278437
		EGF_CA	716..750	CDD:238011
		EGF_CA	753..789	CDD:238011
		EGF_CA	792..828	CDD:238011
		EGF_CA	830..865	CDD:238011
		EGF_CA	868..905	CDD:238011
		EGF_CA	907..943	CDD:238011
		EGF_CA	1009..1045	CDD:238011
		EGF_CA	1047..1082	CDD:238011
		Laminin_G_1	1155..1290	CDD:278483
		EGF	1316..1346	CDD:278437
		Laminin_G_1	1388..1550	CDD:278483
		EGF_CA	<1593..1622	CDD:238011
		Laminin_G_2	1692..1828	CDD:280389	13/46 (28%)
		EGF_CA	1901..1937	CDD:238011	14/34 (41%)
		EGF_CA	1939..1974	CDD:238011
		EGF_CA	2057..2094	CDD:238011
		EGF_CA	2096..2133	CDD:238011
		EGF_CA	2137..2175	CDD:238011
Egfl7	XP_006233730.1	EMI	32..101	CDD:400092	16/76 (21%)
Egfl7	XP_006233730.1	EGF_CA	145..184	CDD:311536	14/34 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910