DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment crb and CRB1

DIOPT Version :9

Sequence 1:	NP_001247284.1	Gene:	crb / 42896	FlyBaseID:	FBgn0259685	Length:	2253	Species:	Drosophila melanogaster
Sequence 2:	XP_016856341.1	Gene:	CRB1 / 23418	HGNCID:	2343	Length:	1451	Species:	Homo sapiens

Alignment Length:	1724	Identity:	507/1724 - (29%)
Similarity:	738/1724 - (42%)	Gaps:	381/1724 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   605 CPQENCLNGGTCLGYSGNYSCICASGYTGYNCQTSTGDGASALALTPINCNATNGKCLNGGTCSM 669
            |...:|.|..||..:|.:..|.|:.  |..|......:........|...:||   |:|  |...
Human    34 CLSNSCQNNSTCKDFSKDNDCSCSD--TANNLDKDCDNMKDPCFSNPCQGSAT---CVN--TPGE 91

  Fly   670 NGTHCYCAVGYSGDRCEKAENCSPLNCQEPMVCVQNQCLCPENKVCNQCATQPCQNGGECVDLPN 734
            ....|.|..||||..||                          .....|....||:||.|...|
Human    92 RSFLCKCPPGYSGTICE--------------------------TTIGSCGKNSCQHGGICHQDP- 129

  Fly   735 GDYE-CKCTRGWTGRTCGNDVDECTLHPKICGNG-ICKNEKGSYKCYCTPGFTGVHCDSDVDECL 797
             .|. |.|..|:.||.|..|.|||...|  |.|| :|::....|.|:|.||:.|.|||.:||||.
Human   130 -IYPVCICPAGYAGRFCEIDHDECASSP--CQNGAVCQDGIDGYSCFCVPGYQGRHCDLEVDECA 191

  Fly   798 SFPCLNGATCHNKINAYECVCQPGYEGENCEVDIDECGSNPCSNGSTCIDRINNFTCNCIPGMTG 862
            |.||.|.|||.|:|..|.|:|...|.|.|||::||||.|.||.||:||.|.:..:.|:|.||..|
Human   192 SDPCKNEATCLNEIGRYTCICPHNYSGVNCELEIDECWSQPCLNGATCQDALGAYFCDCAPGFLG 256

  Fly   863 RICDIDIDDCVGDPCLNGGQCIDQLGGFRCDCSGTGYEGENCELNIDECLSNPCTNGAKCLDRVK 927
            ..|:::.|:|...|||:||.|:|....:.|:|:|:|:.|.:||..:..|.|.||.|.|.|.|.|.
Human   257 DHCELNTDECASQPCLHGGLCVDGENRYSCNCTGSGFTGTHCETLMPLCWSKPCHNNATCEDSVD 321

  Fly   928 DYFCDCHNGYKGKNCEQDINECESNPCQYNGNCLERSNITLYQMSRITDLPKVFSQPFSFENASG 992
            :|.|.|..||.|..||.|:|||.|||||.||.|:|.|:...|  .|||.||    ..||:..|||
Human   322 NYTCHCWPGYTGAQCEIDLNECNSNPCQSNGECVELSSEKQY--GRITGLP----SSFSYHEASG 380

  Fly   993 YECVCVPGIIGKNCEININECDSNPCSKHGNCNDGIGTYTCECEPGFEGTHCEINIDECDRYNPC 1057
            |.|:|.||..|.:||.::|||.||||...|.|.:..|.|||.|.           .|...|
Human   381 YVCICQPGFTGIHCEEDVNECSSNPCQNGGTCENLPGNYTCHCP-----------FDNLSR---- 430

  Fly  1058 QRGTCYDQIDDYDCDCDANYGGKNCSVLLKGCDQNPCLNGGACLPYLINEVTHLYNCTCENGFQG 1122
                             ..|||::||.:|.||....|||.|.|:|: ..:..|.::|.|.:|:.|
Human   431 -----------------TFYGGRDCSDILLGCTHQQCLNNGTCIPH-FQDGQHGFSCLCPSGYTG 477

  Fly  1123 DKCEKTTTLSMVATSLI-----SVTTEREEGYDINLQFRTTLPNGVLAFGTTGEKNEPVSYILEL 1182
            ..||..||||......:     |||| :....:|.|:|:|..|..:|.|    ..|..|...|||
Human   478 SLCEIATTLSFEGDGFLWVKSGSVTT-KGSVCNIALRFQTVQPMALLLF----RSNRDVFVKLEL 537

  Fly  1183 INGRLNLHSSLLNKWEG-VFIGSKLNDSNWH---KVFVAINTSHLVLSANDEQAIFPVGSYETAN 1243
            ::|.::|...:.|:.:. :||....:|..||   .:|....|..|:..:..|:.|....:...::
Human   538 LSGYIHLSIQVNNQSKVLLFISHNTSDGEWHFVEVIFAEAVTLTLIDDSCKEKCIAKAPTPLESD 602

  Fly  1244 NSQPSFPRTYLGGTIPNLKS---YLRHLTHQPS--AFVGCMQDIMVNGKWIFPDEQDANISYTKL 1303
            .|..:|..::|||....:.|   .|.:..:.||  :||||:|||.::...|..:    |||....
Human   603 QSICAFQNSFLGGLPVGMTSNGVALLNFYNMPSTPSFVGCLQDIKIDWNHITLE----NISSGSS 663

  Fly  1304 ENVQSGCPRTEQCKPNPCHSNGECTDLWHTFACHCPRPFFGHTCQHNMTAATFGHENTTHSAVIV 1368
            .||::||.|.:.|:..||.|.|.|.:||.::.|.|.||:.|..|.....|..||.:::|  ..::
Human   664 LNVKAGCVRKDWCESQPCQSRGRCINLWLSYQCDCHRPYEGPNCLREYVAGRFGQDDST--GYVI 726

  Fly  1369 ETTDVARRAIRSILDISMFIRTREPTGQVFYLGTDPRKAPTKNIGDSYVAAKLHGGELLVKMQFS 1433
            .|.|   .:....:.:|||:||.:|:|.:..|         :|....|:...|..|.|.:.
Human   727 FTLD---ESYGDTISLSMFVRTLQPSGLLLAL---------ENSTYQYIRVWLERGRLAML---- 775

  Fly  1434 GTPEA-YTVGGQKLDNGYNHLIEVVRNQTLVQVKLNGTEYFRK-------TLSTTGLLDAQVLYL 1490
             ||.: ..|....|::|..|||.       :::|....|.::.       :.||..:....|:|:
Human   776 -TPNSPKLVVKFVLNDGNVHLIS-------LKIKPYKIELYQSSQNLGFISASTWKIEKGDVIYI 832

  Fly  1491 GGPAPTRESLLGATTEPGIIPVPGAGIPIEDTTVPKEADDSRDYFKGIIQDVKVSNGSL------ 1549
            ||....:|:.|..                             .:|||.||||:::|.:|
Human   833 GGLPDKQETELNG-----------------------------GFFKGCIQDVRLNNQNLEFFPNP 868

  Fly  1550 --NLIVEMYSLNVTD---------VQVNA----KPLGA------VTIDR--------------AS 1579
              |..:....:|||.         .|.|.    ..||:      |::.|              :|
Human   869 TNNASLNPVLVNVTQGCAGDNSCKRQTNVGRALTELGSRGPKYQVSLFRFCVGSWATGNTFFLSS 933

  Fly  1580 VLPGEVSDDLCRKNPCLHNAECRNTWNDYTCKCPNGYKGKNCQEIEFCQHVTCPGQSLCQNLDDG 1644
            :.||        .|||.:...|.:.|:|::|.||....||.|:|:::|....||..:.||.:..|
Human   934 IKPG--------SNPCHNGGVCHSRWDDFSCSCPALTSGKACEEVQWCGFSPCPHGAQCQPVLQG 990

  Fly  1645 YECVTNTTFTGQERSPLAFFYFQEQQSDDIVSEASPKQTLKPVIDIAFRTR-AGGTLLYIDNVDG 1708
            :||:.|..|.||....|.      :.:.:|..|.:.       |...|||| |...:|:.:....
Human   991 FECIANAVFNGQSGQILF------RSNGNITRELTN-------ITFGFRTRDANVIILHAEKEPE 1042

  Fly  1709 FFEIGVNGGRVTITWKLSALHFGESARFEKENTDGEWSRIYLR-----AHNSKLEGGWKGWESMV 1768
            |..|.:...|:....:.....:..|....:...||.|..:.|.     :..|:       |:..|
Human  1043 FLNISIQDSRLFFQLQSGNSFYMLSLTSLQSVNDGTWHEVTLSMTDPLSQTSR-------WQMEV 1100

  Fly  1769 DPTPAFSTDIDQAAFQSLIATSTQVYLGGMPESRQARGSTLSAQQGSQFKGCVGEARVGDLLLPY 1833
            |....|.|........:.:..:|.:|:|         ...:...:|.|  ||:....:|.:.|.|
Human  1101 DNETPFVTSTIATGSLNFLKDNTDIYVG---------DRAIDNIKGLQ--GCLSTIEIGGIYLSY 1154

  Fly  1834 FSMAELYSRTNVSVQQKAQF-RLNATRPEEGCI---LCFQSDCKNDGFCQSPSDEYACTCQPGFE 1894
            |.....:    ::..|:.|| :::......||:   :|..:.|.:.|.|:.....|.|:|..|:.
Human  1155 FENVHGF----INKPQEEQFLKISTNSVVTGCLQLNVCNSNPCLHGGNCEDIYSSYHCSCPLGWS 1215

  Fly  1895 GDDCGTDIDECLNTECLNNGTCINQVAAFFCQCQPGFEGQHCEQNIDECADQPCHNGGNCTDLIA 1959
            |..|..:||||.:..|: :|.|.::|||:.|.|:||:.|.:||.:||.|....|.||..|.....
Human  1216 GKHCELNIDECFSNPCI-HGNCSDRVAAYHCTCEPGYTGVNCEVDIDNCQSHQCANGATCISHTN 1279

  Fly  1960 SYVCDCPEDYMGPQCDVLKQMTCENEPCRNGSTCQNGFNASTGNNFTCTCVPGFEGPLCDIPFCE 2024
            .|.|.|..::.|..|   :|....:..|.|..|           |.||.
Human  1280 GYSCLCFGNFTGKFC---RQSRLPSTVCGNEKT-----------NLTCY---------------- 1314

  Fly  2025 ITPCDNGGLCLTTGAVPMCKCSLGYTGRLCEQDINECESNPCQNGGQCKDLVGRYECDCQGTGFE 2089
                 |||.|........|.|..|:||..||:||:||.|:||.|||.|:||:.:::|.|. ..|.
Human  1315 -----NGGNCTEFQTELKCMCRPGFTGEWCEKDIDECASDPCVNGGLCQDLLNKFQCLCD-VAFA 1373

  Fly  2090 GIRCENDIDECNMEGDYCGGLGRCFNKPGSFQCICQKPYCGAYCNFTDPCNATDLCSNGGRCVES 2154
            |.|||.|:                                           |.||.|
Human  1374 GERCEVDL-------------------------------------------ADDLIS-------- 1387

  Fly  2155 CGAKPDYYCECPEGFAGKNCTAPITAKEDGPSTTDIAIIVIPVVVVLLLIAGALLGTFLVMARNK 2219
                 |.:                         |.|..:.:.::::|||   |::.:  |:..||
Human  1388 -----DIF-------------------------TTIGSVTVALLLILLL---AIVAS--VVTSNK 1417

  Fly  2220 RATRGTYSPSAQEYCNPRLEMDNVLKPPPEERLI 2253
            |||:||||||.||....|:||.|::.||..||||
Human  1418 RATQGTYSPSRQEKEGSRVEMWNLMPPPAMERLI 1451

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crb	NP_001247284.1	LamG	91..228	CDD:238058
		EGF_CA	386..423	CDD:238011
		EGF_CA	425..460	CDD:238011
		EGF	466..495	CDD:278437
		EGF	605..633	CDD:278437	8/27 (30%)
		EGF_CA	716..750	CDD:238011	13/34 (38%)
		EGF_CA	753..789	CDD:238011	15/36 (42%)
		EGF_CA	792..828	CDD:238011	19/35 (54%)
		EGF_CA	830..865	CDD:238011	17/34 (50%)
		EGF_CA	868..905	CDD:238011	14/36 (39%)
		EGF_CA	907..943	CDD:238011	15/35 (43%)
		EGF_CA	1009..1045	CDD:238011	14/35 (40%)
		EGF_CA	1047..1082	CDD:238011	5/34 (15%)
		Laminin_G_1	1155..1290	CDD:278483	39/143 (27%)
		EGF	1316..1346	CDD:278437	13/29 (45%)
		Laminin_G_1	1388..1550	CDD:278483	37/177 (21%)
		EGF_CA	<1593..1622	CDD:238011	11/28 (39%)
		Laminin_G_2	1692..1828	CDD:280389	27/141 (19%)
		EGF_CA	1901..1937	CDD:238011	15/35 (43%)
		EGF_CA	1939..1974	CDD:238011	11/34 (32%)
		EGF_CA	2057..2094	CDD:238011	18/36 (50%)
		EGF_CA	2096..2133	CDD:238011	1/36 (3%)
		EGF_CA	2137..2175	CDD:238011	5/37 (14%)
CRB1	XP_016856341.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	52	1.000	Domainoid score	I11536
eggNOG	1	0.900	-	-		E33208_3BAFT
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	705	1.000	Inparanoid score	I665
Isobase	1	0.950	-	0	Normalized mean entropy	S6671
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D111153at2759
OrthoFinder	1	1.000	-	-		FOG0003041
OrthoInspector	1	1.000	-	-		otm40659
orthoMCL	1	0.900	-	-		OOG6_100271
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3765
SonicParanoid	1	1.000	-	-		X4671
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.750