DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment crb and Dner

DIOPT Version :9

Sequence 1:	NP_001247284.1	Gene:	crb / 42896	FlyBaseID:	FBgn0259685	Length:	2253	Species:	Drosophila melanogaster
Sequence 2:	NP_690879.1	Gene:	Dner / 227325	MGIID:	2152889	Length:	737	Species:	Mus musculus

Alignment Length:	788	Identity:	207/788 - (26%)
Similarity:	276/788 - (35%)	Gaps:	260/788 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   307 PCAKNPCENGGSCLENSRGDYQCFCDPNHSGQHCETEVNIHPLCQTNPCLNNGACVVIGGSGALT 371
            |||..||.|||.|...|..|.:                  ||.....|              ..:
Mouse    47 PCASQPCRNGGVCTPRSVTDQE------------------HPAADAEP--------------RYS 79

  Fly   372 CECPKGYAGARCEVDTDECASQPCQNNGSCIDRINGFSCDCSGTGYTGAFCQTNVDECDKNPCLN 436
            |.||.|.:|..|:...|.|||.||.:.          :|..|.:..:.:
Mouse    80 CTCPAGVSGTYCQFVADPCASNPCHHG----------NCSSSSSSSSDS---------------- 118

  Fly   437 GGRCFDTYGWYTCQCLDGWGGEICDRPMTCQTQQCLNGGTCLDKPIGFQCLCPPEYTGELCQIAP 501
                      |.|.|.||:.|..|::|:                                    |
Mouse   119 ----------YLCICNDGYEGLNCEQPL------------------------------------P 137

  Fly   502 SCAQQCPIDSECVGGKCVCKPGSSGPIGHCLPTTTTPTPEQEPTTTPRTTPNPNPAIPNTLTTTT 566
            |                                  .||.....:|.||.. .|.||        |
Mouse   138 S----------------------------------IPTSGWTESTAPRQL-QPVPA--------T 159

  Fly   567 KIPPITTSRTLVGTTTGSRRPPQQPLQSP---TQRSASLNACPQENCLN-------GGTCLGYS- 620
            :.|.|...|:....|.    |..||....   ..:...:...|...|.|       ||..:.:.
Mouse   160 QEPDIILPRSQATVTL----PTWQPKTGQKVVEMKWDQVEVVPDVACGNASSNNSAGGRLVSFEV 220

  Fly   621 -GNYSC---------------ICASGYTGYNCQTSTGDGASALALTPINCNATNGKCLNGGTCSM 669
             .|.|.               :.|:|:.    |.|..||.|   :||:  .|..|..|.....::
Mouse   221 PQNTSVKIRQDANSLLILLWKVTATGFQ----QCSLIDGRS---VTPL--QAPGGLVLLEEMLAL 276

  Fly   670 NGTHCYCAVGYSGDRCE------------KAENCSPLNCQEPMVCVQNQCLCPENKVCNQCATQP 722
            ...|   .:|:..|...            ||.||.|.:..      .|...|...   .:|||:|
Mouse   277 GPNH---FIGFVNDSVAKSIVALRLTLVVKASNCVPGDSH------SNDLECSGK---GKCATKP 329

  Fly   723 CQNGGECVDLPNGDYECKCTRGWTGRTCGNDVDECTLHPKICGNG---ICKNEK---GSYKCYCT 781
            .:          ..:.|.|...:.|..| .:.|.|...|  |.|.   |..|||   .::.|.|.
Mouse   330 SE----------ATFSCTCQDQYIGTFC-EEFDACQRKP--CQNEASCIDANEKQDGSNFTCLCL 381

  Fly   782 PGFTGVHCDSDVDECLSFPCLNGATCHNKINAYECVCQPGYEGENCEVDIDECGSNPCSNGSTC- 845
            ||:||..|.|.:|.|:..||.|||||.:.::.:.|.|..||.|..||..:|.|.|:||.|..||
Mouse   382 PGYTGELCQSKIDYCVLDPCRNGATCVSSLSGFTCQCLEGYFGSACEEKVDPCMSSPCQNNGTCY 446

  Fly   846 IDRINNFTCNCIPGMTGRICDIDIDDCVGDPCLNGGQCIDQLGGFRCDCSGTGYEGENCELNIDE 910
            :|.: :|||:|.||.||..|...:|.|...||.: |.|......::|.|. .||.|..||...:|
Mouse   447 VDGV-HFTCSCSPGFTGPTCAQLVDFCALSPCAH-GMCRSVGTSYKCLCD-PGYHGLYCEEEYNE 508

  Fly   911 CLSNPCTNGAKCLDRVKDYFCDCHNGYKGKNCEQDINECESNPCQYNGNCLERSNITLYQMSRIT 975
            |||.||.|.|.|.|.:..|.|.|...|||.:||...:.|.:..|...|.|
Mouse   509 CLSAPCLNAATCRDLINGYECVCLAEYKGTHCELYKDPCANISCLNGGTC--------------- 558

  Fly   976 DLPKVFSQPFSFENASGYECVCVPGIIGKNCEININECDSNPCSKHGNCNDGIGTYTCECEPGFE 1040
                      ..|..:| .|:|.||..|:.|:|:|||||||||...|.|.|....|||.|..|:.
Mouse   559 ----------DSEGLNG-TCICAPGFTGEECDIDINECDSNPCHHAGTCLDQPNGYTCHCPHGWV 612

  Fly  1041 GTHCEINI 1048
            |.:|||::
Mouse   613 GANCEIHL 620

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crb	NP_001247284.1	LamG	91..228	CDD:238058
		EGF_CA	386..423	CDD:238011	8/36 (22%)
		EGF_CA	425..460	CDD:238011	6/34 (18%)
		EGF	466..495	CDD:278437	0/28 (0%)
		EGF	605..633	CDD:278437	9/51 (18%)
		EGF_CA	716..750	CDD:238011	7/33 (21%)
		EGF_CA	753..789	CDD:238011	15/41 (37%)
		EGF_CA	792..828	CDD:238011	14/35 (40%)
		EGF_CA	830..865	CDD:238011	17/35 (49%)
		EGF_CA	868..905	CDD:238011	11/36 (31%)
		EGF_CA	907..943	CDD:238011	16/35 (46%)
		EGF_CA	1009..1045	CDD:238011	18/35 (51%)
		EGF_CA	1047..1082	CDD:238011	0/2 (0%)
		Laminin_G_1	1155..1290	CDD:278483
		EGF	1316..1346	CDD:278437
		Laminin_G_1	1388..1550	CDD:278483
		EGF_CA	<1593..1622	CDD:238011
		Laminin_G_2	1692..1828	CDD:280389
		EGF_CA	1901..1937	CDD:238011
		EGF_CA	1939..1974	CDD:238011
		EGF_CA	2057..2094	CDD:238011
		EGF_CA	2096..2133	CDD:238011
		EGF_CA	2137..2175	CDD:238011
Dner	NP_690879.1	Interaction with NOTCH1. /evidence=ECO:0000269\|PubMed:15965470	44..133		34/153 (22%)
		EGF_CA	393..428	CDD:238011	14/34 (41%)
		EGF_CA	431..465	CDD:238011	17/34 (50%)
		EGF_CA	507..541	CDD:238011	16/33 (48%)
		EGF_CA	581..617	CDD:238011	18/35 (51%)
		Interaction with AP1G1 and somatodendritic targeting. /evidence=ECO:0000269\|PubMed:11950833	677..680
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR24044
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010