DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment crb and FBN2

DIOPT Version :9

Sequence 1:NP_001247284.1 Gene:crb / 42896 FlyBaseID:FBgn0259685 Length:2253 Species:Drosophila melanogaster
Sequence 2:NP_001990.2 Gene:FBN2 / 2201 HGNCID:3604 Length:2912 Species:Homo sapiens


Alignment Length:2541 Identity:586/2541 - (23%)
Similarity:828/2541 - (32%) Gaps:951/2541 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly   219 GNSFS--------GCLLDGP---GLQFVNNSTVQNVVFGHCPLTPGPCSDHDLFTRLPDNFCLND 272
            ||.||        |....||   ||..:|.             |...|..|       .|.||| 
Human   464 GNGFSPGVGGAGVGAGGQGPIITGLTILNQ-------------TIDICKHH-------ANLCLN- 507

  Fly   273 PCMGHGTCSSSPEGYECRCTARYSGKNCQKDNG-----SPCAKNPCENGGSCLENSRGDYQCFCD 332
                 |.|..:...|.|.|...|.    |..||     ..|..|||.| |.|: |:.|.|.|.| 
Human   508 -----GRCIPTVSSYRCECNMGYK----QDANGDCIDVDECTSNPCTN-GDCV-NTPGSYYCKC- 560

  Fly   333 PNHSG-QHCETE---VNIHPLCQTNPCLNNGACVVIGGSGALTCECPKGYA----GARCEVDTDE 389
              |:| |...|:   ::|....|......||.||  ...|:..|.|..|:.    |..| ||.||
Human   561 --HAGFQRTPTKQACIDIDECIQNGVLCKNGRCV--NTDGSFQCICNAGFELTTDGKNC-VDHDE 620

  Fly   390 CASQPCQNNGSCIDRINGFSCDCSGTGY----TGAFCQTNVDECDKNP--CLNGGRCFDTYGWYT 448
            |.:.....||.||:....|.|.|. .|:    .|.:| |:|||| :.|  |:| |.|.::.|.:.
Human   621 CTTTNMCLNGMCINEDGSFKCICK-PGFVLAPNGRYC-TDVDEC-QTPGICMN-GHCINSEGSFR 681

  Fly   449 CQC----LDGWGGEIC-DRPMTCQTQQCLNGGTCLDKPI-----GFQCLCP-PEY-TGELCQIAP 501
            |.|    ..|..|.:| |..|.......:..|.|: :|.     ..:|.|. |:| .||.||..|
Human   682 CDCPPGLAVGMDGRVCVDTHMRSTCYGGIKKGVCV-RPFPGAVTKSECCCANPDYGFGEPCQPCP 745

  Fly   502 S---------CA------------QQCPIDSE-CVGG---------KCVCKPGSSGPIGHCLPTT 535
            :         |:            .:|.:|.: |..|         :|.|..|            
Human   746 AKNSAEFHGLCSSGVGITVDGRDINECALDPDICANGICENLRGSYRCNCNSG------------ 798

  Fly   536 TTPTPEQEPTTTPRTTPNPNPAIPNTLTTTTKIPPITTSRTLVGTTTGSRR---PPQQPLQSPTQ 597
                  .||..:.|...:.:..:.|.|         .....|...|.||..   ||....::.|:
Human   799 ------YEPDASGRNCIDIDECLVNRL---------LCDNGLCRNTPGSYSCTCPPGYVFRTETE 848

  Fly   598 RSASLNACPQENCLNGGTCLGYSGNYSCICASG----YTGYNCQTSTGDGASALALTPINCNAT- 657
            ....:|.|....|:| |.|....|:::|.|:.|    .||..|..|. .|...|.:....|... 
Human   849 TCEDINECESNPCVN-GACRNNLGSFNCECSPGSKLSSTGLICIDSL-KGTCWLNIQDSRCEVNI 911

  Fly   658 NGKCLNGGTCSMNGTHCYCAVGYSGDRCE------------KAENCSPLN-CQE-PMVCVQNQCL 708
            ||..|....|:..|    .|.|...:|||            |...|..:| |:. |.||...:|:
Human   912 NGATLKSECCATLG----AAWGSPCERCELDTACPRGLARIKGVTCEDVNECEVFPGVCPNGRCV 972

  Fly   709 ---------CPE-------NKVC---------------------------------------NQC 718
                     |||       .:||                                       .:|
Human   973 NSKGSFHCECPEGLTLDGTGRVCLDIRMEQCYLKWDEDECIHPVPGKFRMDACCCAVGAAWGTEC 1037

  Fly   719 ATQP----------CQNG-------------------GECVDLPN-----------GDYECKCTR 743
            ...|          |..|                   .||...|.           |.::|:|..
Human  1038 EECPKPGTKEYETLCPRGAGFANRGDVLTGRPFYKDINECKAFPGMCTYGKCRNTIGSFKCRCNS 1102

  Fly   744 GWT----GRTCGNDVDECTLHPKICGNGICKNEKGSYKCYCTPGFTG-----VHCDSDVDECLSF 799
            |:.    .|.| .|:|||.:.|.:||:|||.|..||::|.|..|:..     .:| .|:|||...
Human  1103 GFALDMEERNC-TDIDECRISPDLCGSGICVNTPGSFECECFEGYESGFMMMKNC-MDIDECERN 1165

  Fly   800 PCL-NGATCHNKINAYECVCQPGYE----GENCEVDIDEC--GSNPCSNGSTCIDRINNFTCNCI 857
            |.| .|.||.|...:::|.|..|:|    .|:| |||:||  ..|.|.||. |::.|..:.|:|.
Human  1166 PLLCRGGTCVNTEGSFQCDCPLGHELSPSREDC-VDINECSLSDNLCRNGK-CVNMIGTYQCSCN 1228

  Fly   858 PGMTG---RICDIDIDDCVGDPCLNGG---QCIDQLGGFRCDCSGTGY----EGENCELNIDECL 912
            ||...   |....|||:|:   .:|||   ||.:..|.:.|.|| .||    :|.:| .:||||.
Human  1229 PGYQATPDRQGCTDIDECM---IMNGGCDTQCTNSEGSYECSCS-EGYALMPDGRSC-ADIDECE 1288

  Fly   913 SNP--CTNGAKCLDRVKDYFCDCHNGYKG----KNCEQDINECE--SNPCQYNGNCLERSNITL- 968
            :||  | :|.:|.:...:|.|.|::|:..    |.| .|:|||:  ||.|.: |.|.......: 
Human  1289 NNPDIC-DGGQCTNIPGEYRCLCYDGFMASMDMKTC-IDVNECDLNSNICMF-GECENTKGSFIC 1350

  Fly   969 -----YQMSR----ITDLPKV------FSQPFSFENASG-YECVCVPGIIGKNCE-ININECD-- 1014
                 |.:.:    .||:.:.      .....|..|..| ::|.|..|.||...: |:::||.  
Human  1351 HCQLGYSVKKGTTGCTDVDECEIGAHNCDMHASCLNIPGSFKCSCREGWIGNGIKCIDLDECSNG 1415

  Fly  1015 SNPCSKHGNCNDGIGTYTCECEPGF--EGTHCEINIDEC-DRYNPCQRGTCYDQIDDYDCDCDAN 1076
            ::.||.:..|.:..|:|.|.|..||  :|..|. ::||| :..|.|:.|.|.:....|.|:|:..
Human  1416 THQCSINAQCVNTPGSYRCACSEGFTGDGFTCS-DVDECAENINLCENGQCLNVPGAYRCECEMG 1479

  Fly  1077 Y----GGKNCSVLLKGCDQNPCLNGGACLPYLINEVTHLYNCTCENGFQGDKCEKTTTLSMVATS 1137
            :    ..::|..:.:...||.|: .|.|     |.:..:::|.|::|::.|:.....|       
Human  1480 FTPASDSRSCQDIDECSFQNICV-FGTC-----NNLPGMFHCICDDGYELDRTGGNCT------- 1531

  Fly  1138 LISVTTEREEGYDINLQFRTTLPNGVLAFGTTGEKNEPVSYILELINGRLNLHSSLLNKWEGVFI 1202
                        ||:                  |..:|::    .:||                 
Human  1532 ------------DID------------------ECADPIN----CVNG----------------- 1545

  Fly  1203 GSKLNDSNWHKVFVAINTSHLVLSANDEQAIFPVGSYETANNSQPSFPRTYLG-GTIPNL--KSY 1264
                         :.:||.               |.||.  |..|.|.....| |.:.|.  ..|
Human  1546 -------------LCVNTP---------------GRYEC--NCPPDFQLNPTGVGCVDNRVGNCY 1580

  Fly  1265 LRHLTHQPSAFVGCMQDIMVN----------GK-WIFPDEQDANISYTKLENVQSGCPRTEQCKP 1318
            |: ...:....:.|..:|.|.          || |..|.|....::.|:...:   ||..|..:|
Human  1581 LK-FGPRGDGSLSCNTEIGVGVSRSSCCCSLGKAWGNPCETCPPVNSTEYYTL---CPGGEGFRP 1641

  Fly  1319 NP----------CH------SNGECTDLWHTFACHCPRPFF----GHTCQHNMTAATFGHENTTH 1363
            ||          |.      ..|.|.:.:.:|.|.||:.::    ...|:.  ....|.|.....
Human  1642 NPITIILEDIDECQELPGLCQGGNCINTFGSFQCECPQGYYLSEDTRICED--IDECFAHPGVCG 1704

  Fly  1364 SAVIVETTDVARRAIRSILDISMFIRTREPTGQVFYLGTDPRKAPTKNIGDSYVAAKLHGGELLV 1428
            ......|                             ||......|.:.:       :::||...:
Human  1705 PGTCYNT-----------------------------LGNYTCICPPEYM-------QVNGGHNCM 1733

  Fly  1429 KMQFSGTPEAYTVGGQKLDNGYNHLIEVVRNQTLVQVKLNGTEYFRKTLSTTGLLDAQVLYLGGP 1493
            .|:.|....:|  .|...:|               ::..|.|:  |....|         |..|.
Human  1734 DMRKSFCYRSY--NGTTCEN---------------ELPFNVTK--RMCCCT---------YNVGK 1770

  Fly  1494 APTRESLLGATTEPGIIPVPGAGIPIEDTTVPKEADDSRDYFKGIIQDV-----KVSNGSLNLIV 1553
            |..:                    |.|....|..||     ||.|..::     .:..|.     
Human  1771 AWNK--------------------PCEPCPTPGTAD-----FKTICGNIPGFTFDIHTGK----- 1805

  Fly  1554 EMYSLNVTDVQVNAKPLGAVTIDRASVLPGEVSDDLC---------------------------- 1590
                              ||.||....:||..::.:|                            
Human  1806 ------------------AVDIDECKEIPGICANGVCINQIGSFRCECPTGFSYNDLLLVCEDID 1852

  Fly  1591 ----RKNPCLHNAECRNTWNDYTCKCPNGYK---------GKNCQEI-EFCQHVTCPGQSLCQNL 1641
                ..|.|..||:|.|:...|.|:|..|:|         ...|.|| ..|.|      .||.:|
Human  1853 ECSNGDNLCQRNADCINSPGSYRCECAAGFKLSPNGACVDRNECLEIPNVCSH------GLCVDL 1911

  Fly  1642 DDGYECVTNTTFTGQERSPLAFFYFQEQQSDDIVSEASPKQTLKPVIDIAFRTRAG-GT------ 1699
            ...|:|:.:..|                       :||..||:...:|...|...| ||      
Human  1912 QGSYQCICHNGF-----------------------KASQDQTMCMDVDECERHPCGNGTCKNTVG 1953

  Fly  1700 ----LLY-------------IDNVDGFF-----------EIG-------------VNGGRVTITW 1723
                |.|             ||....||           |||             .:|.....|.
Human  1954 SYNCLCYPGFELTHNNDCLDIDECSSFFGQVCRNGRCFNEIGSFKCLCNEGYELTPDGKNCIDTN 2018

  Fly  1724 KLSALHFGESARFEKENTDGEWSRIYLRAHNSKLEGGWKGWESMVDP----------TPAFSTDI 1778
            :..||. |..:....:|.:|.:..|....:..|.|......|...||          ||      
Human  2019 ECVALP-GSCSPGTCQNLEGSFRCICPPGYEVKSENCIDINECDEDPNICLFGSCTNTP------ 2076

  Fly  1779 DQAAFQSLIATSTQVYLGGMP--ESRQA---------RGSTLSAQQGSQFKGCV----GEARVGD 1828
              ..||.|......:...|..  ::||:         :.|...|...::.|.|.    ||. .||
Human  2077 --GGFQCLCPPGFVLSDNGRRCFDTRQSFCFTNFENGKCSVPKAFNTTKAKCCCSKMPGEG-WGD 2138

  Fly  1829 LLLPYFSMAELYSRTN-VSVQQKAQF------RLNATRPEEGCILCFQSD--CKNDGFCQSPSDE 1884
                   ..||..:.: |:.|....:      .|:.||  |....|.:|.  |.| |.|.:....
Human  2139 -------PCELCPKDDEVAFQDLCPYGHGTVPSLHDTR--EDVNECLESPGICSN-GQCINTDGS 2193

  Fly  1885 YACTCQPGFEGDDCG---TDIDEC-LNTECLNNGTCINQVAAFFCQCQPGFEG---QHCEQNIDE 1942
            :.|.|..|:..|..|   .|.||| :...| .||||.|.:.:|.|.|..|||.   .:|| :|:|
Human  2194 FRCECPMGYNLDYTGVRCVDTDECSIGNPC-GNGTCTNVIGSFECNCNEGFEPGPMMNCE-DINE 2256

  Fly  1943 CADQPCHNGGNCTDLIASYVCDCPEDY------------------------MGPQCDVL------ 1977
            ||..|......|.:...||.|.||..|                        .|..|..|      
Human  2257 CAQNPLLCAFRCMNTFGSYECTCPIGYALREDQKMCKDLDECAEGLHDCESRGMMCKNLIGTFMC 2321

  Fly  1978 -----------------------KQMTCENEPCRN--GS---TCQNGFN---------------- 1998
                                   |...|||..|.|  ||   .|..||.                
Human  2322 ICPPGMARRPDGEGCVDENECRTKPGICENGRCVNIIGSYRCECNEGFQSSSSGTECLDNRQGLC 2386

  Fly  1999 -----------ASTGNNFT----CTC---------------------------VPGFEGPLCDIP 2021
                       ||:..|..    |.|                           .||:.....||.
Human  2387 FAEVLQTICQMASSSRNLVTKSECCCDGGRGWGHQCELCPLPGTAQYKKICPHGPGYTTDGRDID 2451

  Fly  2022 FCEITP--CDNGGLCLTTGAVPMCKCSLGYT----GRLCEQDINECESNPCQNGGQCKDLVGRYE 2080
            .|::.|  |.| |.|:.|.....|.|.:|||    |..| .|::||..:|......||:..|.|:
Human  2452 ECKVMPNLCTN-GQCINTMGSFRCFCKVGYTTDISGTSC-IDLDECSQSPKPCNYICKNTEGSYQ 2514

  Fly  2081 CDCQGTGF----EGIRCENDIDEC------------NMEGDY----------------------- 2106
            |.|. .|:    :|..|: |:|||            |..|.:                       
Human  2515 CSCP-RGYVLQEDGKTCK-DLDECQTKQHNCQFLCVNTLGGFTCKCPPGFTQHHTACIDNNECGS 2577

  Fly  2107 ----CGGLGRCFNKPGSFQCICQKPY----CGAYCNFTDPCNATDLCSNGGRCVESCGAKPDYYC 2163
                ||..|.|.|.||||.|.||:.:    .|..|...|.|:....|.:|  |....|.   |.|
Human  2578 QPSLCGAKGICQNTPGSFSCECQRGFSLDATGLNCEDVDECDGNHRCQHG--CQNILGG---YRC 2637

  Fly  2164 ECPEGF 2169
            .||:|:
Human  2638 GCPQGY 2643

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
crbNP_001247284.1 LamG 91..228 CDD:238058 5/16 (31%)
EGF_CA 386..423 CDD:238011 13/40 (33%)
EGF_CA 425..460 CDD:238011 14/40 (35%)
EGF 466..495 CDD:278437 7/35 (20%)
EGF 605..633 CDD:278437 9/31 (29%)
EGF_CA 716..750 CDD:238011 12/77 (16%)
EGF_CA 753..789 CDD:238011 16/40 (40%)
EGF_CA 792..828 CDD:238011 15/40 (38%)
EGF_CA 830..865 CDD:238011 15/39 (38%)
EGF_CA 868..905 CDD:238011 16/43 (37%)
EGF_CA 907..943 CDD:238011 14/41 (34%)
EGF_CA 1009..1045 CDD:238011 12/39 (31%)
EGF_CA 1047..1082 CDD:238011 10/39 (26%)
Laminin_G_1 1155..1290 CDD:278483 23/148 (16%)
EGF 1316..1346 CDD:278437 10/49 (20%)
Laminin_G_1 1388..1550 CDD:278483 26/166 (16%)
EGF_CA <1593..1622 CDD:238011 11/37 (30%)
Laminin_G_2 1692..1828 CDD:280389 40/208 (19%)
EGF_CA 1901..1937 CDD:238011 16/39 (41%)
EGF_CA 1939..1974 CDD:238011 13/58 (22%)
EGF_CA 2057..2094 CDD:238011 12/40 (30%)
EGF_CA 2096..2133 CDD:238011 19/79 (24%)
EGF_CA 2137..2175 CDD:238011 11/33 (33%)
FBN2NP_001990.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 27..52
Interaction with MFAP4. /evidence=ECO:0000269|PubMed:26601954 149..359
TB 225..258 CDD:279073
EGF_CA 276..>306 CDD:214542
EGF_CA 318..358 CDD:284955
TB 375..412 CDD:279073
EGF_CA 535..565 CDD:214542 14/34 (41%)
EGF_CA 575..616 CDD:214542 12/43 (28%)
EGF_CA 617..649 CDD:238011 12/32 (38%)
cEGF 638..661 CDD:289433 8/24 (33%)
EGF_CA 658..698 CDD:214542 14/41 (34%)
TB 715..751 CDD:279073 11/36 (31%)
cEGF 790..813 CDD:289433 6/40 (15%)
EGF_CA 810..845 CDD:238011 8/43 (19%)
TB 907..>935 CDD:279073 8/31 (26%)
TB 1012..1047 CDD:279073 2/34 (6%)
EGF_CA 1115..1149 CDD:214542 16/33 (48%)
EGF_CA 1158..1190 CDD:214542 13/31 (42%)
EGF_CA 1200..1232 CDD:214542 14/32 (44%)
cEGF 1223..1245 CDD:289433 7/21 (33%)
FXa_inhibition 1246..1281 CDD:291342 13/38 (34%)
Plasmod_Pvs28 1293..1446 CDD:283826 42/155 (27%)
EGF_3 1371..1406 CDD:289699 8/34 (24%)
EGF_3 1412..1447 CDD:289699 11/34 (32%)
EGF_CA 1532..1563 CDD:214542 13/99 (13%)
TB 1593..1628 CDD:279073 8/34 (24%)
EGF_CA 1650..1683 CDD:238011 7/32 (22%)
cEGF 1672..1695 CDD:289433 5/24 (21%)
Interaction with MFAP4. /evidence=ECO:0000269|PubMed:26601954 1735..2171 104/559 (19%)
TB 1749..1786 CDD:279073 11/82 (13%)
EGF_CA 1808..1840 CDD:214542 5/31 (16%)
vWFA <1847..1888 CDD:294047 11/40 (28%)
vWFA <1887..1929 CDD:294047 13/70 (19%)
EGF_CA 1934..1968 CDD:214542 7/33 (21%)
EGF_CA 1973..2015 CDD:214542 8/41 (20%)
EGF_CA 2056..2096 CDD:214542 9/47 (19%)
TB 2113..2150 CDD:279073 10/44 (23%)
EGF_CA 2171..2212 CDD:214542 11/41 (27%)
EGF_CA 2213..2252 CDD:214542 16/39 (41%)
vWFA <2251..2290 CDD:294047 14/39 (36%)
TB 2397..2432 CDD:279073 5/34 (15%)
EGF_CA 2449..2490 CDD:214542 16/42 (38%)
vWFA <2489..2529 CDD:294047 13/41 (32%)
vWFA <2527..2563 CDD:294047 8/36 (22%)
EGF_CA 2614..>2643 CDD:214542 10/33 (30%)
Cadherin_repeat <2826..>2873 CDD:206637
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 52 1.000 Domainoid score I11459
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.910

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