DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment crb and FBN1

DIOPT Version :9

Sequence 1:NP_001247284.1 Gene:crb / 42896 FlyBaseID:FBgn0259685 Length:2253 Species:Drosophila melanogaster
Sequence 2:NP_000129.3 Gene:FBN1 / 2200 HGNCID:3603 Length:2871 Species:Homo sapiens


Alignment Length:2477 Identity:585/2477 - (23%)
Similarity:830/2477 - (33%) Gaps:896/2477 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   264 LPDNFCLNDPCM------GHGTCSSSPEGYECRCTARYSGKNCQKD------NGSPCAKNPCENG 316
            ||.|  :.|.|.      .:|.|..:|..|.|.|     .|..|.|      :...|.||||. |
Human   445 LPVN--VTDYCQLVRYLCQNGRCIPTPGSYRCEC-----NKGFQLDLRGECIDVDECEKNPCA-G 501

  Fly   317 GSCLENSRGDYQCFCDPNHSGQHCETEV-NIHPLCQTNPCLNNGACVVIGGSGALTCECPKGY-- 378
            |.|: |::|.|.|.|...:......||. :|....|.....|||.|  |...|:..|.|..|:  
Human   502 GECI-NNQGSYTCQCRAGYQSTLTRTECRDIDECLQNGRICNNGRC--INTDGSFHCVCNAGFHV 563

  Fly   379 --AGARCEVDTDECASQPCQNNGSCIDRINGFSCDCSGTGY----TGAFCQTNVDECDKNP--CL 435
              .|..|| |.|||:.:....||.||:....|.|.|. .|:    .|.:|: :::||: .|  |:
Human   564 TRDGKNCE-DMDECSIRNMCLNGMCINEDGSFKCICK-PGFQLASDGRYCK-DINECE-TPGICM 624

  Fly   436 NGGRCFDTYGWYTCQCLDGWG----GEIC-DRPMTCQTQQCLNG---GTCLDKPI-----GFQCL 487
            | |||.:|.|.|.|:|..|..    |.:| |   |.....|..|   |.|: ||:     ..:|.
Human   625 N-GRCVNTDGSYRCECFPGLAVGLDGRVCVD---THMRSTCYGGYKRGQCI-KPLFGAVTKSECC 684

  Fly   488 C-PPEYT-GELCQIAPS---------CA------------QQCPIDSE-CVGG---------KCV 519
            | ..||. ||.||..|:         |:            .:|.:|.: |..|         ||:
Human   685 CASTEYAFGEPCQPCPAQNSAEYQALCSSGPGMTSAGSDINECALDPDICPNGICENLRGTYKCI 749

  Fly   520 CKPGSSGPIGHCLPTTTTPTPEQEPTTTPRTTPNPNPAIPNTLTTTTKIPPITTSRTLVGTTTGS 584
            |..|                  .|..:|.:...:.|..:.|:|         .........|.||
Human   750 CNSG------------------YEVDSTGKNCVDINECVLNSL---------LCDNGQCRNTPGS 787

  Fly   585 --RRPPQQPLQSPTQRSA-SLNACPQENCLNGGTCLGYSGNYSCICASGYTGYNCQTSTGDGASA 646
              ...|:..:..|..::. .::.|....|:| |.|....|::.|.|:|        .||.|....
Human   788 FVCTCPKGFIYKPDLKTCEDIDECESSPCIN-GVCKNSPGSFICECSS--------ESTLDPTKT 843

  Fly   647 LALTPI--NCNAT--NGKC---LNGGT-----CSMNG-------THC----YCAVGYS---GDRC 685
            :.:..|  .|..|  :|:|   :||.|     ||..|       |.|    .|..|||   |.:|
Human   844 ICIETIKGTCWQTVIDGRCEININGATLKSQCCSSLGAAWGSPCTLCQVDPICGKGYSRIKGTQC 908

  Fly   686 EKAENCS--PLNCQEPMVCVQN----QCLCPE--------------------------------- 711
            |..:.|.  |..|:..: ||..    :|.||.                                 
Human   909 EDIDECEVFPGVCKNGL-CVNTRGSFKCQCPSGMTLDATGRICLDIRLETCFLRYEDEECTLPIA 972

  Fly   712 -----------------NKVCNQC------------------ATQPCQNG-------GECVDLPN 734
                             .:.|.:|                  ||:...||       .||..:|:
Human   973 GRHRMDACCCSVGAAWGTEECEECPMRNTPEYEELCPRGPGFATKEITNGKPFFKDINECKMIPS 1037

  Fly   735 -----------GDYECKCTRGWT----GRTCGNDVDECTLHPKICGNGICKNEKGSYKCYCTPGF 784
                       |.::|:|..|:.    .|.| .|:|||.:.|.:||.|.|.|..|.::|.|..|:
Human  1038 LCTHGKCRNTIGSFKCRCDSGFALDSEERNC-TDIDECRISPDLCGRGQCVNTPGDFECKCDEGY 1101

  Fly   785 TG-----VHCDSDVDECLSFPCL-NGATCHNKINAYECVCQPGYE-GENCE--VDIDEC--GSNP 838
            ..     .:| .|:|||...|.| .|..|||...:|.|.|.||:: ..|..  :||:||  .::.
Human  1102 ESGFMMMKNC-MDIDECQRDPLLCRGGVCHNTEGSYRCECPPGHQLSPNISACIDINECELSAHL 1165

  Fly   839 CSNGSTCIDRINNFTCNCIPG---MTGRICDIDIDDCVGDPCLNGG---QCIDQLGGFRCDCSGT 897
            |.|| .|::.|..:.|.|.||   ...|:..:|||:|   ..:|||   .|.:..|.:.|.|. .
Human  1166 CPNG-RCVNLIGKYQCACNPGYHSTPDRLFCVDIDEC---SIMNGGCETFCTNSEGSYECSCQ-P 1225

  Fly   898 GY----EGENCELNIDECLSNP--CTNGAKCLDRVKDYFCDCHNGYKG----KNCEQDINECESN 952
            |:    :..:| .:||||..||  | :|.:|.:...:|.|.|::|:..    |.| .|:|||:.|
Human  1226 GFALMPDQRSC-TDIDECEDNPNIC-DGGQCTNIPGEYRCLCYDGFMASEDMKTC-VDVNECDLN 1287

  Fly   953 P--CQYNGNCLERSNITLYQMSRITDLPKVFSQPFSFENASG-YECVCVPGIIGK----NCEINI 1010
            |  | .:|.|                           ||..| :.|.|..|..||    .| .:|
Human  1288 PNIC-LSGTC---------------------------ENTKGSFICHCDMGYSGKKGKTGC-TDI 1323

  Fly  1011 NECD--SNPCSKHGNCNDGIGTYTCECEPGF--EGTHCEINIDECDR-YNPC-QRGTCYDQIDDY 1069
            |||:  ::.|.||..|.:..|::.|.|.||:  :|..| .::|||.. .:.| |...|.:.:..|
Human  1324 NECEIGAHNCGKHAVCTNTAGSFKCSCSPGWIGDGIKC-TDLDECSNGTHMCSQHADCKNTMGSY 1387

  Fly  1070 DCDCDANYGG--------KNCSVLLKGCDQNPCLN--GGACLPYLINEVTHLYNCTCENGF---- 1120
            .|.|...|.|        ..||..|..|....|||  ||             |.|.|:.||    
Human  1388 RCLCKEGYTGDGFTCTDLDECSENLNLCGNGQCLNAPGG-------------YRCECDMGFVPSA 1439

  Fly  1121 QGDKCEKTTTLSMVATSLISVTTEREEGYDINLQFRTTLPNGVLAFGTTGEKNEPVSYILELING 1185
            .|..||                       ||:   ..:||| :..|||.  .|.|          
Human  1440 DGKACE-----------------------DID---ECSLPN-ICVFGTC--HNLP---------- 1465

  Fly  1186 RLNLHSSLLNKWEGVF-----IGSKLNDS--NWHKVFVAINTSHLVLSANDEQAIFPVGSYETAN 1243
                         |:|     ||.:|:.|  |...|...::.: ..:|.|   .:...|||  ..
Human  1466 -------------GLFRCECEIGYELDRSGGNCTDVNECLDPT-TCISGN---CVNTPGSY--IC 1511

  Fly  1244 NSQPSFPRTYLGGTIPNLKSYLRHLTHQPSAFVG---CMQDIMVN----------GK-WIFPDEQ 1294
            :..|.|..........:.:|...:|..:|....|   |..:|.|.          || |..|.|.
Human  1512 DCPPDFELNPTRVGCVDTRSGNCYLDIRPRGDNGDTACSNEIGVGVSKASCCCSLGKAWGTPCEM 1576

  Fly  1295 DANISYTKLENVQSGCPRTEQCKPNP----------CH------SNGECTDLWHTFACHCPRPFF 1343
            ...::.::.:.:   ||..|..:|||          |.      ..|:|.:.:.:|.|.|     
Human  1577 CPAVNTSEYKIL---CPGGEGFRPNPITVILEDIDECQELPGLCQGGKCINTFGSFQCRC----- 1633

  Fly  1344 GHTCQHNMTAATFGHENTTHSAVIVETTDVARRAIRSILDISMFIRTREPTGQVFYLGTDPR--- 1405
                                                             |||  :||..|.|   
Human  1634 -------------------------------------------------PTG--YYLNEDTRVCD 1647

  Fly  1406 ---KAPTKNI---GDSYVAA------------KLHGGELLVKMQFSGTPEAY-----TVGGQKLD 1447
               :..|..|   |..|...            :::||...:.|:.|.....|     |..|:.|.
Human  1648 DVNECETPGICGPGTCYNTVGNYTCICPPDYMQVNGGNNCMDMRRSLCYRNYYADNQTCDGELLF 1712

  Fly  1448 N--------GYNHLIEVVRNQTLVQVKLNGTEYFRKTLSTTGLLDAQVLYLGGPAPTRESLLGAT 1504
            |        .||  |....|:...|..:..|:.|                         :.|..:
Human  1713 NMTKKMCCCSYN--IGRAWNKPCEQCPIPSTDEF-------------------------ATLCGS 1750

  Fly  1505 TEPGIIPVPGAGIPIEDTTVPKEADDSRDYFKGIIQDVKVSNGSLNLIVEMYSLNVTDVQVNAKP 1569
            ..||.:.....|:|:       :.|:.|: ..|:.:     ||....:|..:....        |
Human  1751 QRPGFVIDIYTGLPV-------DIDECRE-IPGVCE-----NGVCINMVGSFRCEC--------P 1794

  Fly  1570 LGAVTIDRASVLPGEVSDDLCRKNP-CLHNAECRNTWNDYTCKCPNGYK---------GKNCQEI 1624
            :|....|:..|..   ..|.|:..| |..||||.||...|.|.|..||:         ...||||
Human  1795 VGFFYNDKLLVCE---DIDECQNGPVCQRNAECINTAGSYRCDCKPGYRFTSTGQCNDRNECQEI 1856

  Fly  1625 -EFCQHVTC------------------PGQSLCQNLDDGYECVTNTTFTGQERSPLAFF------ 1664
             ..|.|..|                  ..|::|.:::   ||..:....|..|:.:..|      
Human  1857 PNICSHGQCIDTVGSFYCLCHTGFKTNDDQTMCLDIN---ECERDACGNGTCRNTIGSFNCRCNH 1918

  Fly  1665 -YFQEQQSD--DIVSEASPKQTLKPVIDIAFRTRAGGTLLYIDNVDGFFEIGVN-------GGRV 1719
             :.....:|  |:...||....|         .|.|..:    |..|.|:...|       .||.
Human  1919 GFILSHNNDCIDVDECASGNGNL---------CRNGQCI----NTVGSFQCQCNEGYEVAPDGRT 1970

  Fly  1720 TITWKLSALHFGESARFEKENTDGEWSRIY---LRAHNSKLEGGWKGWESMVDPTPAFSTDIDQA 1781
            .:......|...:.|....:|.||.:..|.   ....|.|.|                  |||:.
Human  1971 CVDINECLLEPRKCAPGTCQNLDGSYRCICPPGYSLQNEKCE------------------DIDEC 2017

  Fly  1782 AFQ-SLIATSTQVYLGGMPESRQARGSTLSAQ----QGSQFKGCVGEARVGDLLLPYFSMAELYS 1841
            ..: .:.|..|.....|..:.....|.:||:.    |..:...|..:...|....|   .:..:|
Human  2018 VEEPEICALGTCSNTEGSFKCLCPEGFSLSSSGRRCQDLRMSYCYAKFEGGKCSSP---KSRNHS 2079

  Fly  1842 RTNVSVQQKAQ-----FRLNATRPEE----------GCIL-----------CFQSDCKNDGFCQS 1880
            :.......|.:     ..|..|.|:|          |.|:           |.:.|....|.|.:
Human  2080 KQECCCALKGEGWGDPCELCPTEPDEAFRQICPYGSGIIVGPDDSAVDMDECKEPDVCKHGQCIN 2144

  Fly  1881 PSDEYACTCQPGF--EGDDCGTDIDECLNTECLNNGTCINQVAAFFCQCQPGFEG---QHCEQNI 1940
            ....|.|.|..|:  .|::| .|.|||.......||||.|.:..|.|.|:.|||.   ..|| :|
Human  2145 TDGSYRCECPFGYILAGNEC-VDTDECSVGNPCGNGTCKNVIGGFECTCEEGFEPGPMMTCE-DI 2207

  Fly  1941 DECADQPCHNGGNCTDLIASYVCDCPEDYM----------GPQCD------VLKQMTCEN----- 1984
            :|||..|......|.:...||.|.||..|:          ..:|:      ..|||.|:|     
Human  2208 NECAQNPLLCAFRCVNTYGSYECKCPVGYVLREDRRMCKDEDECEEGKHDCTEKQMECKNLIGTY 2272

  Fly  1985 --------------EPCRNGSTCQ-------NGFNASTGNNFTCTCVPGF-------------EG 2015
                          |.|.:.:.||       ||...:|..::||.|..||             ||
Human  2273 MCICGPGYQRRPDGEGCVDENECQTKPGICENGRCLNTRGSYTCECNDGFTASPNQDECLDNREG 2337

  Fly  2016 --------PLCDI----------------------PFCEITP----------CDNGGLCLTTGA- 2039
                    .:|.|                      |.|||.|          |.:|...:|.|| 
Human  2338 YCFTEVLQNMCQIGSSNRNPVTKSECCCDGGRGWGPHCEICPFQGTVAFKKLCPHGRGFMTNGAD 2402

  Fly  2040 VPMCK---------------------CSLGY----TGRLCEQDINECESNPCQNGGQCKDLVGRY 2079
            :..||                     |..||    ||..| .|:|||...|......||:..|.|
Human  2403 IDECKVIHDVCRNGECVNDRGSYHCICKTGYTPDITGTSC-VDLNECNQAPKPCNFICKNTEGSY 2466

  Fly  2080 ECDCQGTGF----EGIRCENDIDEC------------NMEGDY---------------------- 2106
            :|.|. .|:    :|..|: |:|||            |..|.:                      
Human  2467 QCSCP-KGYILQEDGRSCK-DLDECATKQHNCQFLCVNTIGGFTCKCPPGFTQHHTSCIDNNECT 2529

  Fly  2107 -----CGGLGRCFNKPGSFQCICQKPY----CGAYCNFTDPCNATDLCSNGGRCVESCGAKPDYY 2162
                 ||..|.|.|.||||.|.||:.:    .|:.|...|.|.....|.:|  |....|.   |.
Human  2530 SDINLCGSKGICQNTPGSFTCECQRGFSLDQTGSSCEDVDECEGNHRCQHG--CQNIIGG---YR 2589

  Fly  2163 CECPEGF 2169
            |.||:|:
Human  2590 CSCPQGY 2596

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
crbNP_001247284.1 LamG 91..228 CDD:238058
EGF_CA 386..423 CDD:238011 13/40 (33%)
EGF_CA 425..460 CDD:238011 15/40 (38%)
EGF 466..495 CDD:278437 10/38 (26%)
EGF 605..633 CDD:278437 9/27 (33%)
EGF_CA 716..750 CDD:238011 13/73 (18%)
EGF_CA 753..789 CDD:238011 14/40 (35%)
EGF_CA 792..828 CDD:238011 16/37 (43%)
EGF_CA 830..865 CDD:238011 14/39 (36%)
EGF_CA 868..905 CDD:238011 12/43 (28%)
EGF_CA 907..943 CDD:238011 14/41 (34%)
EGF_CA 1009..1045 CDD:238011 14/39 (36%)
EGF_CA 1047..1082 CDD:238011 11/44 (25%)
Laminin_G_1 1155..1290 CDD:278483 33/155 (21%)
EGF 1316..1346 CDD:278437 9/45 (20%)
Laminin_G_1 1388..1550 CDD:278483 37/195 (19%)
EGF_CA <1593..1622 CDD:238011 13/38 (34%)
Laminin_G_2 1692..1828 CDD:280389 28/150 (19%)
EGF_CA 1901..1937 CDD:238011 15/38 (39%)
EGF_CA 1939..1974 CDD:238011 12/44 (27%)
EGF_CA 2057..2094 CDD:238011 13/40 (33%)
EGF_CA 2096..2133 CDD:238011 19/79 (24%)
EGF_CA 2137..2175 CDD:238011 11/33 (33%)
FBN1NP_000129.3 TB 195..>228 CDD:334208
EGF_CA 246..>276 CDD:214542
EGF_CA 288..329 CDD:214542
TB 345..389 CDD:334208
EGF_CA 490..521 CDD:214542 13/32 (41%)
EGF_CA 530..571 CDD:214542 12/42 (29%)
EGF_CA 572..612 CDD:214542 13/40 (33%)
EGF_CA 613..646 CDD:214542 14/34 (41%)
TB 670..711 CDD:334208 12/41 (29%)
EGF_CA 723..763 CDD:311536 10/57 (18%)
EGF_CA 765..806 CDD:238011 8/49 (16%)
TB 862..>894 CDD:334208 9/31 (29%)
TB 967..1009 CDD:334208 2/41 (5%)
EGF_CA 1070..1104 CDD:214542 14/33 (42%)
EGF_CA 1113..1149 CDD:214542 15/35 (43%)
EGF_CA 1155..1188 CDD:214542 13/33 (39%)
vWFA <1194..1235 CDD:350880 12/44 (27%)
EGF_3 1326..1361 CDD:315598 11/34 (32%)
EGF_3 1367..1402 CDD:315598 9/34 (26%)
cEGF 1426..1449 CDD:338440 11/61 (18%)
EGF_CA 1446..1486 CDD:214542 17/68 (25%)
EGF_CA 1487..1518 CDD:214542 7/36 (19%)
TB 1549..1590 CDD:334208 8/43 (19%)
EGF_CA 1606..1638 CDD:214542 9/87 (10%)
EGF_CA 1648..1687 CDD:214542 6/38 (16%)
TB 1706..1749 CDD:334208 11/69 (16%)
EGF_CA 1766..>1797 CDD:214542 7/44 (16%)
EGF_CA 1808..1840 CDD:214542 14/31 (45%)
vWFA <1847..1886 CDD:350880 7/38 (18%)
EGF_CA 1930..1971 CDD:311536 12/53 (23%)
EGF_CA 1973..2008 CDD:238011 6/34 (18%)
EGF_CA 2013..2053 CDD:354843 9/39 (23%)
TB 2070..2112 CDD:334208 7/44 (16%)
EGF_CA 2127..2165 CDD:214542 10/38 (26%)
EGF_CA 2166..2205 CDD:214542 15/38 (39%)
vWFA <2289..2328 CDD:350880 11/38 (29%)
TB 2356..2391 CDD:334208 5/34 (15%)
vWFA <2442..2482 CDD:350880 14/41 (34%)
cEGF 2465..2488 CDD:338440 7/24 (29%)
EGF_CA 2485..>2516 CDD:354843 6/30 (20%)
EGF_CA 2524..2566 CDD:214542 13/41 (32%)
EGF_CA 2567..>2596 CDD:214542 10/33 (30%)
EGF_CA 2607..2638 CDD:214542
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 52 1.000 Domainoid score I11459
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.910

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