DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment crb and crb-1

DIOPT Version :9

Sequence 1:	NP_001247284.1	Gene:	crb / 42896	FlyBaseID:	FBgn0259685	Length:	2253	Species:	Drosophila melanogaster
Sequence 2:	NP_510822.1	Gene:	crb-1 / 181771	WormBaseID:	WBGene00000792	Length:	1722	Species:	Caenorhabditis elegans

Alignment Length:	2152	Identity:	520/2152 - (24%)
Similarity:	774/2152 - (35%)	Gaps:	699/2152 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   350 CQTNPCLNNGACVVIGGSGALTCECPKGYAGARCEVDTDECASQPCQNNGSCIDRINGFSCDCSG 414
            |..|.|||.|.|.|...:....||||||::|..|:
Worm    22 CSRNTCLNGGTCTVNDETRMFQCECPKGFSGLLCQ------------------------------ 56

  Fly   415 TGYTGAFCQTNVDECDKNPCLNGGRCFDTYGWYTCQCLDGWGGEICDRPMTCQTQQCLNGGTCLD 479
                        |.|..: ||:|.....|:|..||||.:||.|.:||..:|..
Worm    57 ------------DNCSLH-CLHGNCVKGTFGEETCQCSEGWMGSLCDNLVTDD------------ 96

  Fly   480 KPIGFQCLCPPEYTGELCQIAPSCAQQCPIDSEC---VGGKCVCKPGSSGPIGHCLPTTTTPTPE 541
                              ..|..|:.||..|..|   ..|..:|:                   .
Worm    97 ------------------DTAQKCSPQCGDDERCTKGADGSYICQ-------------------S 124

  Fly   542 QEPTTTPRTTPNPNPAIPNTLTTTTKIPPITTSRTLVGTTTGSRRPPQQPLQSPTQRSASLNACP 606
            .||                                                           :|.
Worm   125 NEP-----------------------------------------------------------SCA 130

  Fly   607 QENCLNGGTCLGYSGNYSCICASGYTGYNCQTSTGDGASALALTPINCNATNGKCLNGGTCSMNG 671
            ...|.|.|||:..:||..|.|..|:.|.:|:|...:
Worm   131 THTCQNNGTCVAENGNVKCACPPGFVGDHCETDEDE----------------------------- 166

  Fly   672 THCYCAVGYSGDRCEKAENCSPLNCQEPMVCVQNQCLCPENKVCNQCATQPCQNGGECVDLPNGD 736
                                                 |.||.         ||||.:|.:| .|.
Worm   167 -------------------------------------CKENF---------CQNGADCENL-KGS 184

  Fly   737 YECKCTRGWTGRTCG-NDVDECTLHPKIC-GNGICKNEKGSYKCYCTPGFTGVHCD--SDVDECL 797
            |||||.:|::|:.|. .|..:||  ...| .||.|.:......|.|:|||.|..|:  ::|:||:
Worm   185 YECKCLKGFSGKYCEIQDKKQCT--SDYCHNNGQCISTGSDLSCKCSPGFDGAFCELKAEVNECI 247

  Fly   798 SFPCLNGATCHNKIN----AYECVCQPGYEGENC-EVDIDECGSNPCSNGSTCIDRINN-FTCNC 856
               |.|.|...:.:|    ..:|.|..|:.|.:| |:....|...||.||..|:|...| |||.|
Worm   248 ---CENPAHVCSLVNGTSRTTQCECPSGFMGADCKELQARPCDREPCLNGGHCVDDGQNLFTCFC 309

  Fly   857 IPGMTGRICDIDIDDCV-GDPCLNGGQCIDQLGGFRCDCSGTGYEGENCELNIDECLSNP----- 915
            :|..||..|...:|..| |..|.|||:|:..|....|.|. .|:.|.|||:: :...|:|
Worm   310 LPSFTGIYCGEPVDCLVNGSDCKNGGKCVFALAATTCQCP-EGFNGSNCEIS-NSYRSHPTCSDI 372

  Fly   916 -CTNGAKC-LDRVKDYFCDCHNGYKGKNCEQDINECESNPCQYNGNCLERSNITLYQMSRITDLP 978
             |.||..| ||...:.||.|..|:.|..||.. :.|..||||..|.|
Worm   373 RCLNGGSCKLDAEGEPFCVCEEGFDGPFCEPK-SGCTINPCQNGGTC------------------ 418

  Fly   979 KVFSQPFSFENASG-YECVCVPGIIGKNCEININECDSNPCSKHGNCNDGIGTYTCECEPGFEG- 1041
                     ::|.| |.|.|..|..|.:|| .::| .|.|...       :||:......|.:|
Worm   419 ---------QDADGQYFCHCTSGFGGVHCE-TVDE-PSTPIPT-------LGTFPSFTTSGIDGF 465

  Fly  1042 THCEINIDECDRYNPCQRGTCYDQIDDYDCDCDANYGGKNCSVLLKGCDQNPCLNGGACLPYLIN 1106
            :..:|:.::|     .....|.|......|.||..|.|:.|......|.:..|.:|..|..  :|
Worm   466 SQSKISCEDC-----VNSSNCLDVESGPVCICDDGYFGQKCDQKHDKCSKVSCPSGQTCSQ--VN 523

  Fly  1107 E-VTHLYNCTCENGFQGDKCEKTTTLSMVATSL-------ISVTTEREE--GYDINLQFRTTLPN 1161
            : |.....|.||.|..|.:||..|:.:..|.||       .|:.|...|  .|::...||||:.|
Worm   524 DNVNITAQCGCEIGHFGQQCEMVTSATFSAKSLYIHQSSKFSLGTSSFENIAYELEFSFRTTVEN 588

  Fly  1162 GVLAFGTT--GEKNEPVSYILELINGRL--NLHSSLLNKWEGVFIGSKLNDSNWHKVFVAINTSH 1222
            ..||....  |||    ...::|::|.|  |:..:.|..    .:..:::|:.|:.|||....:.
Worm   589 THLASSENILGEK----ILSIQLLSGYLVFNMTGNSLEH----LLPMRVSDAQWYTVFVKGEDNK 645

  Fly  1223 LVLSANDEQAIFPVGSYETANNSQPSFPRTYLGGTIPNLKSYLRHL-----THQPSAFVGCMQDI 1282
            :.:..:.|.....|   :.:.|.|              |:.:|...     ||.   |:|||.|:
Worm   646 IQIEVSTENGFSLV---QKSVNGQ--------------LEVFLTRFGKISGTHH---FIGCMADV 690

  Fly  1283 MVNGKW-IFPDEQDANISYTKLENVQSGCPRTEQCKPNPCHSNGECTDLWHTFACHCPRPFFGHT 1346
            .|:|.. ||.|.:.|       .:::.||.|:|||....|.:.|.|.|.|.:.:|.|..|:....
Worm   691 RVDGDLIIFADNKRA-------IDIRKGCTRSEQCTRAYCQNEGICIDHWESSSCKCKPPYLKPN 748

  Fly  1347 CQHNMTAATFGHENTTHSAVIVETTDVARRAIRSILDISMFIRTREPTGQVFYLGTDPRKAPTKN 1411
            |.:.:...||||.:.. |.|.:.|::.....:|:.:::|..:.:.:|...:||:|       .|:
Worm   749 CVYFLPKTTFGHLDQP-SIVHLSTSESENHLLRNHIELSFLMHSGKPDAVLFYIG-------EKH 805

  Fly  1412 IGD---SYVAAKLHGGELLVKMQFSGTPEAYTVGGQKLDNGYNHLIEVVRNQTLVQVKLNGTEYF 1473
            ..|   :|:..|:.||.:.|:.:..|..|.......::|:...|.:::..::|..|:
Worm   806 AADVLTNYLVVKIAGGLITVRYRTGGRREIEFSSKNRVDDNQEHHVQIFLDKTTRQI-------- 862

  Fly  1474 RKTLSTTGLLDAQVLYLGGPAPTRESLLGATTEPGIIPVPGAGIPIEDTTVPKE---ADDSRDYF 1535
                    ::|..:               ..:|| ||........::|..:...   |.|| :::
Worm   863 --------IIDDLI---------------ECSEP-IISRMSQEFYVDDIVIGASNVVATDS-EFY 902

  Fly  1536 KGIIQDVKVSNGSLNLIVEMYSLNVTDVQVNAKPLGAVTIDR-------ASVLPGEVSDDLCRKN 1593
            ||.:||::::..|  :::...||               |||:       .:|:.|.|||.:|..:
Worm   903 KGYLQDIQINQKS--VVIHPTSL---------------TIDKIGKLERTQNVIEGAVSDPMCSSS 950

  Fly  1594 PCLHNAECRNTWNDYTCKCPNGYKGKNCQEIEFCQHVTCPGQSLCQNLDDGYEC-----VTNTTF 1653
            .|.| .||..|:||:||:|.:|..||.|.::::|:..:|...|.|:|.|:|:.|     ::|.:.
Worm   951 TCKH-GECSETFNDFTCRCSDGSTGKLCDKVDYCKDASCMKGSRCENADNGHYCIFPITISNGSM 1014

  Fly  1654 TGQERSPLAFFYF--------QEQQSDDIVSEASPKQTLKPVIDIAFRTRAGGTLLYIDNVDGFF 1710
            .....:|..|...        ...|:..|.:....|.||...:   |:.|              .
Worm  1015 LTYSLAPTKFMTLPSIEFSIKAHSQNGHIFTLTIDKSTLSAYL---FKKR--------------L 1062

  Fly  1711 EIGVNGGRVTITWKLSALHFGESARFEKENTDGEWSRIYLRAHNSKLEGGWKGWESMVDPTPAFS 1775
            .:..|.|..||            .:|:....||.|.:|.|..|                     .
Worm  1063 ALATNSGSGTI------------QKFDSVIADGNWHQIILNPH---------------------K 1094

  Fly  1776 TDIDQAAFQSLIATSTQVYLGGMPESRQARGSTLSAQQGSQFKGCVGEARVGDLLLPYFSMAE-- 1838
            ..||...|.|    ..|:|    |...::..|....:|..|        .|....|..|.|.|
Worm  1095 VLIDSVKFIS----DNQLY----PAESKSGASLFVGEQEPQ--------EVTFACLDLFKMGEYP 1143

  Fly  1839 LYSRTNVSVQQKAQFRLNATRPEE---GCILCFQ----SDCKNDGFCQSPSDEYACTCQPGFEGD 1896
            ..|.|.|.:...:: ..|.|....   ||:...|    |.|.|...|....::..|.|..||.|:
Worm  1144 TLSFTKVKIPTNSE-TWNLTDKASVGTGCMSTDQCGLYSTCLNGATCVDIWNKRKCVCPAGFAGE 1207

  Fly  1897 DCGTDIDECLNTECLNNGTCINQVAAFFCQCQPGFEGQHCEQNIDECADQPCHNGGNCT-DLIAS 1960
            :|..::::|...:|..:|.|::.:....|.|..||.|:|||...|||....|||||.|. :....
Worm  1208 NCEDNVNDCKFVDCGKHGYCLDGIDEAKCICNNGFHGEHCELAKDECEGVECHNGGKCVKNRSEK 1272

  Fly  1961 YVCDCPEDYMGPQCDVLKQMTCENEPCRNGSTCQNGFNASTGNNFTCTCVPGFEGPLC---DIPF 2022
            .||.|...:||..|:|.|...|::.||:|...|..    .|...|.|.|:.|:.|.||   |:..
Worm  1273 IVCQCGNSWMGDSCNVTKTTNCKDSPCQNFGQCMQ----KTDTFFECNCMDGYSGELCEQRDVNE 1333

  Fly  2023 CEITPCDNGGLCLTTGAVPMCKCSLGYTGRLCEQDINECESNP---------------------- 2065
            |....| |.|.|:.|.:.|.|:|.:|||||.||:.:|:|.||.
Worm  1334 CNHYDC-NRGHCVMTVSGPACQCEMGYTGRFCEKLLNQCSSNTCSSRGACSPVWNNTVCNCDNNW 1397

  Fly  2066 ----------------------------------------------------------------- 2065

Worm  1398 RGAHCQHQMDTCLDFPCNNDGVCRTNDENTFSCECQKFFMGTRCEIEGSCLKAQCVHGECIQLSP 1462

  Fly  2066 ----------------------------------------------------------------- 2065

Worm  1463 ETHTCSCNIGYEGDACDKKIDYCKAGPCLNGANCENKLTGYKCTCAVGFEGADCEINIDECALEF 1527

  Fly  2066 CQNGGQCKDLVGRYECDCQGTGFEGIRCENDIDECNMEGDYCGGLGRCFNKPGSFQCICQKPYCG 2130
            |:||.:|:|.:..|||.|.||||||..|..||:||....:...  |.|.|..|:::|.|:..:.|
Worm  1528 CKNGAKCRDKINDYECVCDGTGFEGRNCTTDINECANPNNCIN--GECTNTLGNYKCACRNGFIG 1590

  Fly  2131 AYCNFTDPCNATDLCSNG--------GRCV------ESCGAKPDYYCECPEGFAGKNCTAPITAK 2181
            ..|:..:||.| .:.||.        |:||      |.......|.|.|..|:.|..|:..|  |
Worm  1591 PRCSVRNPCTA-QIASNNISSVTCVHGKCVNPVVQIEKNREVAKYECACDRGYTGPTCSQRI--K 1652

  Fly  2182 EDGPSTTDIAIIVIPVVVVLLLIAGALLGTFLVMARNKRATRGTYSPSAQEYCNPRLEMDNVLKP 2246
            |...|........|..||::..|.|.||..|::  |...|..|.||||:.|:...|:.|..|:|.
Worm  1653 ESAMSNISYLFGPIIAVVIVFAILGCLLLFFVI--RGNNAMHGHYSPSSHEFTQNRMAMPTVIKL 1715

  Fly  2247 PPEERLI 2253
            ||:||||
Worm  1716 PPQERLI 1722

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crb	NP_001247284.1	LamG	91..228	CDD:238058
		EGF_CA	386..423	CDD:238011	0/36 (0%)
		EGF_CA	425..460	CDD:238011	14/34 (41%)
		EGF	466..495	CDD:278437	0/28 (0%)
		EGF	605..633	CDD:278437	11/27 (41%)
		EGF_CA	716..750	CDD:238011	14/33 (42%)
		EGF_CA	753..789	CDD:238011	13/36 (36%)
		EGF_CA	792..828	CDD:238011	12/40 (30%)
		EGF_CA	830..865	CDD:238011	15/35 (43%)
		EGF_CA	868..905	CDD:238011	14/37 (38%)
		EGF_CA	907..943	CDD:238011	13/42 (31%)
		EGF_CA	1009..1045	CDD:238011	7/36 (19%)
		EGF_CA	1047..1082	CDD:238011	8/34 (24%)
		Laminin_G_1	1155..1290	CDD:278483	35/144 (24%)
		EGF	1316..1346	CDD:278437	9/29 (31%)
		Laminin_G_1	1388..1550	CDD:278483	31/167 (19%)
		EGF_CA	<1593..1622	CDD:238011	13/28 (46%)
		Laminin_G_2	1692..1828	CDD:280389	24/135 (18%)
		EGF_CA	1901..1937	CDD:238011	10/35 (29%)
		EGF_CA	1939..1974	CDD:238011	14/35 (40%)
		EGF_CA	2057..2094	CDD:238011	19/188 (10%)
		EGF_CA	2096..2133	CDD:238011	11/36 (31%)
		EGF_CA	2137..2175	CDD:238011	14/51 (27%)
crb-1	NP_510822.1	EGF_CA	<132..161	CDD:238011	11/28 (39%)
		EGF_CA	163..199	CDD:238011	17/111 (15%)
		EGF_CA	408..439	CDD:238011	13/57 (23%)
		Laminin_G_2	582..694	CDD:280389	34/139 (24%)
		LamG	760..912	CDD:238058	36/192 (19%)
		LamG	1029..>1088	CDD:304605	15/87 (17%)
		EGF_CA	1175..1210	CDD:238011	10/34 (29%)
		EGF_CA	1482..1517	CDD:238011	0/34 (0%)
		EGF_CA	1519..1556	CDD:238011	15/36 (42%)
		EGF_CA	1558..1593	CDD:238011	11/36 (31%)
		PHA03099	<1613..1682	CDD:165381	21/70 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	49	1.000	Domainoid score	I7943
eggNOG	1	0.900	-	-		E33208_3BAFT
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H134710
Inparanoid	1	1.050	563	1.000	Inparanoid score	I589
Isobase	1	0.950	-	0	Normalized mean entropy	S6671
OMA	1	1.010	-	-		QHG52038
OrthoDB	1	1.010	-	-		D111153at2759
OrthoFinder	1	1.000	-	-		FOG0003041
OrthoInspector	1	1.000	-	-		otm14569
orthoMCL	1	0.900	-	-		OOG6_100271
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3765
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.720