DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment crb and Notch3

DIOPT Version :9

Sequence 1:NP_001247284.1 Gene:crb / 42896 FlyBaseID:FBgn0259685 Length:2253 Species:Drosophila melanogaster
Sequence 2:XP_017172782.1 Gene:Notch3 / 18131 MGIID:99460 Length:2330 Species:Mus musculus


Alignment Length:2012 Identity:506/2012 - (25%)
Similarity:679/2012 - (33%) Gaps:755/2012 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly   254 PCSDHDLFTRLPDNFCLNDPCMGHGTCSSSPEGYE--CRCTARYSGKNCQKDNGSPCAKNPCENG 316
            ||.|             ..||...|.|:......|  |.|...:.|:.||.::  ||...||...
Mouse    42 PCLD-------------GSPCANGGRCTHQQPSLEAACLCLPGWVGERCQLED--PCHSGPCAGR 91

  Fly   317 GSCLEN---SRGDYQCFCDPNHSGQHCETEVNIHPLCQTNPCLNNGACVVIGGSGALTCECPKGY 378
            |.|..:   ....:.|.|.....|..|...   .| |.:.||::...|.| |..|...|.||.||
Mouse    92 GVCQSSVVAGTARFSCRCLRGFQGPDCSQP---DP-CVSRPCVHGAPCSV-GPDGRFACACPPGY 151

  Fly   379 AGARCEVDTDECAS-QPCQNNGSCIDRINGFSCDCSGTGYTGAFCQTNVDECDKNPCLNGGRCFD 442
            .|..|:.|.|||.| ..|::.|:|::....|.|.|. .||||..|:..|..|..:||.|||.|..
Mouse   152 QGQSCQSDIDECRSGTTCRHGGTCLNTPGSFRCQCP-LGYTGLLCENPVVPCAPSPCRNGGTCRQ 215

  Fly   443 TYG-WYTCQCLDGWGGEICDRPM-TCQTQQCLNGGTCLDKPIGFQCLCPPEYTGELCQIAPSCAQ 505
            :.. .|.|.||.|:.|:.|:..: .|...:|||||||:|....:.|.||||:||:.|        
Mouse   216 SSDVTYDCACLPGFEGQNCEVNVDDCPGHRCLNGGTCVDGVNTYNCQCPPEWTGQFC-------- 272

  Fly   506 QCPIDSECVGGKCVCKPGSSGPIGHCLPTTTTPTPEQEPTTTPRTTPNPNPAIPNTLTTTTKIPP 570
                 :|.| .:|..:|                                                
Mouse   273 -----TEDV-DECQLQP------------------------------------------------ 283

  Fly   571 ITTSRTLVGTTTGSRRPPQQPLQSPTQRSASLNACPQENCLNGGTCLGYSGNYSCICASGYTGYN 635
                                            |||.     |||||....|.:||:|.:|:||.:
Mouse   284 --------------------------------NACH-----NGGTCFNLLGGHSCVCVNGWTGES 311

  Fly   636 CQTSTGDGASALALTPINCNATNGKCLNGGTC--SMNGTHCYCAVGYSGDRCEKAENCSPLNCQE 698
            |..:..|.|:|:             |.:|.||  .:...:|.|.:|.:|           |.|..
Mouse   312 CSQNIDDCATAV-------------CFHGATCHDRVASFYCACPMGKTG-----------LLCHL 352

  Fly   699 PMVCVQNQCLCPENKVCNQCATQPCQNGGECVDLPNGDYECKCTRGWTGRTCGNDVDECTLHPKI 763
            ...||.|.  |.|:.:|:   |.|.          :|...|.|..|:||..|..|||||::....
Mouse   353 DDACVSNP--CHEDAICD---TNPV----------SGRAICTCPPGFTGGACDQDVDECSIGANP 402

  Fly   764 CGN-GICKNEKGSYKCYCTPGFTGVHCDSDVDECLSFPCLNGATCHNKINAYECVCQPGYEGENC 827
            |.: |.|.|.:||:.|.|..|:||..|::||:||||.||.|.|||.::|..:.|:|..|:.|..|
Mouse   403 CEHLGRCVNTQGSFLCQCGRGYTGPRCETDVNECLSGPCRNQATCLDRIGQFTCICMAGFTGTYC 467

  Fly   828 EVDIDECGSNPCSNGSTCIDRINNFTCNCIPGMTGRICDIDIDDCVGDPCLNGGQCIDQLGGFRC 892
            |||||||.|:||.||..|.||:|.|:|.|..|.:|.:|.:|:|:|...||.||.:|:||..|:.|
Mouse   468 EVDIDECQSSPCVNGGVCKDRVNGFSCTCPSGFSGSMCQLDVDECASTPCRNGAKCVDQPDGYEC 532

  Fly   893 DCSGTGYEGENCELNIDECLSNPCTNGAKCLDRVKDYFCDCHNGYKGKNCEQDINECESNPCQYN 957
            .|: .|:||..||.|:|:|..:||.:| :|:|.:..:.|.|..||.|..||..::||.|.||:|.
Mouse   533 RCA-EGFEGTLCERNVDDCSPDPCHHG-RCVDGIASFSCACAPGYTGIRCESQVDECRSQPCRYG 595

  Fly   958 GNCLERSNITLYQMSRITDLPKVFSQPFSFENASGYECVCVPGIIGKNCEININECDSNPCSKHG 1022
            |.||              ||            ...|.|.|.||..|.|||:||::|.||||: .|
Mouse   596 GKCL--------------DL------------VDKYLCRCPPGTTGVNCEVNIDDCASNPCT-FG 633

  Fly  1023 NCNDGIGTYTCECEPGFEGTHCEINIDECD----------------------------------- 1052
            .|.|||..|.|.|:|||.|..|.:.|:||.                                   
Mouse   634 VCRDGINRYDCVCQPGFTGPLCNVEINECASSPCGEGGSCVDGENGFHCLCPPGSLPPLCLPANH 698

  Fly  1053 --RYNPCQRGTCYDQIDDYDCDCDANYGGKNCSVLL--KGCDQNPCLNGGACLPYLINEVTHLYN 1113
              .:.||..|.|:|....:.|.|:..:.|..||..|  ..|:..||..||.|....|.     :.
Mouse   699 PCAHKPCSHGVCHDAPGGFRCVCEPGWSGPRCSQSLAPDACESQPCQAGGTCTSDGIG-----FR 758

  Fly  1114 CTCENGFQGDKCEKTTTLSMVATSLISVTTEREEGYDINLQFRTTL---PNGVLAFGTTGEKNEP 1175
            |||..||||.:||   .||....||.......|...|     |.|:   |.|             
Mouse   759 CTCAPGFQGHQCE---VLSPCTPSLCEHGGHCESDPD-----RLTVCSCPPG------------- 802

  Fly  1176 VSYILELINGRLNLHSSLLNKWEGVFIGSKLNDSNWHKVFVAINTSHLVLSANDEQAIFPVGSYE 1240
                                 |:|......:                      ||.|        
Mouse   803 ---------------------WQGPRCQQDV----------------------DECA-------- 816

  Fly  1241 TANNSQPSFPRTYLGGTIPNLKSYLRHLTHQPSAFVGCMQDIMVNGKWIFPDEQDANISYTKLEN 1305
               .:.|..|.    ||..||....|.:.|:......|.|||                       
Mouse   817 ---GASPCGPH----GTCTNLPGNFRCICHRGYTGPFCDQDI----------------------- 851

  Fly  1306 VQSGCPRTEQCKPNPCHSNGECTDLWHTFACHCPRPFFGHTCQHNMTAATFGHENTTHSAVIVET 1370
                    :.|.||||...|.|.|...:|:|.|...|.|..|..::...                
Mouse   852 --------DDCDPNPCLHGGSCQDGVGSFSCSCLDGFAGPRCARDVDEC---------------- 892

  Fly  1371 TDVARRAIRSILDISMFIRTREPTGQVFYLGTDPRKAPTKNIGDSYVAAKLHGGELLVKMQFSGT 1435
                               ...|.|.    ||     .|.::. |:..|               .
Mouse   893 -------------------LSSPCGP----GT-----CTDHVA-SFTCA---------------C 913

  Fly  1436 PEAYTVGGQKLDNGYNHLIEVVRNQTLVQVKLNGTEYFRKTLSTTGLLDAQVLYLGGPAPTRESL 1500
            |..|        .|::..|:                                             
Mouse   914 PPGY--------GGFHCEID--------------------------------------------- 925

  Fly  1501 LGATTEPGIIPVPGAGIPIEDTTVPKEADDSRDYFKGIIQDVKVSNGSLNLIVEMYSLNVTDVQV 1565
                                                                             
Mouse   926 ----------------------------------------------------------------- 925

  Fly  1566 NAKPLGAVTIDRASVLPGEVSDDLCRKNPCLHNAECRNTWNDYTCKCPNGYKGKNCQ-EIEFCQH 1629
                           ||.      |..:.|.:...|.:..:.::|.|..||.|.:|| |.:.|..
Mouse   926 ---------------LPD------CSPSSCFNGGTCVDGVSSFSCLCRPGYTGTHCQYEADPCFS 969

  Fly  1630 VTCPGQSLCQNLDDGYECVTNTTFTGQERSPLAFFYFQEQQSDDIVSEASPKQTLKPVIDIAFRT 1694
            ..|....:|.....|:||.....|||.          |.|...|..|:| |.|            
Mouse   970 RPCLHGGICNPTHPGFECTCREGFTGS----------QCQNPVDWCSQA-PCQ------------ 1011

  Fly  1695 RAGGTLLYIDNVDGFFEIGVNGGRVTITWKLSALHFGESARFEKENTDGEWSRIYLRAHNSKLEG 1759
                                ||||...|                                    |
Mouse  1012 --------------------NGGRCVQT------------------------------------G 1020

  Fly  1760 GW----KGWESMVDPTPAFSTDIDQAAFQSLIATSTQVYLGGMPESRQARGSTLSAQQGSQFKGC 1820
            .:    .||...:       .||     |||..|..                  :||.|      
Mouse  1021 AYCICPPGWSGRL-------CDI-----QSLPCTEA------------------AAQMG------ 1049

  Fly  1821 VGEARVGDLLLPYFSMAELYSRTNVSVQQKAQFRLNATRPEEGCILCFQSDCKNDGFCQSPSDEY 1885
                                    |.::|.                     |:..|.|......:
Mouse  1050 ------------------------VRLEQL---------------------CQEGGKCIDKGRSH 1069

  Fly  1886 ACTCQPGFEGDDCGTDIDECLNTECLNNGTCINQVAAFFCQCQPGFEGQHCEQNIDECADQPCHN 1950
            .|.|..|..|..|..::|.|....|.:.|||...:..:.|:|..|:.|..||.||||||.|||.|
Mouse  1070 YCVCPEGRTGSHCEHEVDPCTAQPCQHGGTCRGYMGGYVCECPAGYAGDSCEDNIDECASQPCQN 1134

  Fly  1951 GGNCTDLIASYVCDCPEDYMGPQCDVLKQMTCENEP-CRNGSTC-QNGFNASTGNNFTCTCVPGF 2013
            ||:|.||:|.|:|.||...:|..|:: .:..|:..| ..:|..| .||........|.|.|.||:
Mouse  1135 GGSCIDLVARYLCSCPPGTLGVLCEI-NEDDCDLGPSLDSGVQCLHNGTCVDLVGGFRCNCPPGY 1198

  Fly  2014 EGPLCDIPFCEITPCDNGGL-------CL-TTGAVPMCKCSLGYTGRLCEQDINECESNPCQNGG 2070
            .|..|:   .:|..|..|..       || ..|....|.|..|:||..|:..::.|||.|||:||
Mouse  1199 TGLHCE---ADINECRPGACHAAHTRDCLQDPGGHFRCVCHPGFTGPRCQIALSPCESQPCQHGG 1260

  Fly  2071 QCKDLVGR-----YECDCQGTGFEGIRCENDIDECNMEGDYCGGLGRCFNKPGSFQCICQKPYCG 2130
            ||:..:||     :.|.|. ..|.|:|||.....|. |.....|: .|.......:|.|.....|
Mouse  1261 QCRHSLGRGGGLTFTCHCV-PPFWGLRCERVARSCR-ELQCPVGI-PCQQTARGPRCACPPGLSG 1322

  Fly  2131 AYCNFT--DPCNATDL------CSNGGRC--VESCGAKPDYYCECPEGFAGKNCTAPITAKE 2182
            ..|..:  .|..||:.      |.:||.|  |:|.   |.:.|.|..|:.|..|..|..|.|
Mouse  1323 PSCRVSRASPSGATNASCASAPCLHGGSCLPVQSV---PFFRCVCAPGWGGPRCETPSAAPE 1381

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
crbNP_001247284.1 LamG 91..228 CDD:238058
EGF_CA 386..423 CDD:238011 15/37 (41%)
EGF_CA 425..460 CDD:238011 14/35 (40%)
EGF 466..495 CDD:278437 15/28 (54%)
EGF 605..633 CDD:278437 11/27 (41%)
EGF_CA 716..750 CDD:238011 8/33 (24%)
EGF_CA 753..789 CDD:238011 16/36 (44%)
EGF_CA 792..828 CDD:238011 17/35 (49%)
EGF_CA 830..865 CDD:238011 19/34 (56%)
EGF_CA 868..905 CDD:238011 16/36 (44%)
EGF_CA 907..943 CDD:238011 13/35 (37%)
EGF_CA 1009..1045 CDD:238011 19/35 (54%)
EGF_CA 1047..1082 CDD:238011 11/71 (15%)
Laminin_G_1 1155..1290 CDD:278483 21/137 (15%)
EGF 1316..1346 CDD:278437 13/29 (45%)
Laminin_G_1 1388..1550 CDD:278483 11/161 (7%)
EGF_CA <1593..1622 CDD:238011 7/28 (25%)
Laminin_G_2 1692..1828 CDD:280389 17/139 (12%)
EGF_CA 1901..1937 CDD:238011 10/35 (29%)
EGF_CA 1939..1974 CDD:238011 21/34 (62%)
EGF_CA 2057..2094 CDD:238011 17/41 (41%)
EGF_CA 2096..2133 CDD:238011 7/36 (19%)
EGF_CA 2137..2175 CDD:238011 14/45 (31%)
Notch3XP_017172782.1 EGF_CA 159..196 CDD:238011 15/37 (41%)
EGF_CA 237..273 CDD:238011 17/48 (35%)
EGF_CA 275..312 CDD:238011 18/122 (15%)
EGF_CA 315..350 CDD:238011 12/58 (21%)
EGF_CA 392..430 CDD:238011 16/37 (43%)
EGF_CA 432..468 CDD:238011 17/35 (49%)
EGF_CA 470..506 CDD:238011 19/35 (54%)
EGF_CA 508..544 CDD:238011 16/36 (44%)
EGF_CA 546..581 CDD:238011 13/35 (37%)
EGF_CA 584..619 CDD:238011 18/60 (30%)
EGF_CA 621..655 CDD:238011 19/34 (56%)
EGF_CA 659..>687 CDD:238011 3/27 (11%)
EGF_CA 697..730 CDD:238011 8/32 (25%)
EGF_CA 737..771 CDD:238011 14/38 (37%)
EGF_CA 811..847 CDD:238011 11/72 (15%)
EGF_CA 850..885 CDD:238011 15/65 (23%)
EGF_CA 888..923 CDD:238011 10/102 (10%)
EGF_CA 930..961 CDD:238011 7/30 (23%)
EGF_CA 965..999 CDD:238011 10/43 (23%)
EGF_CA 1086..1121 CDD:238011 10/34 (29%)
EGF_CA 1123..1159 CDD:238011 21/35 (60%)
EGF_CA 1172..1204 CDD:238011 10/31 (32%)
NL 1381..1418 CDD:197463 1/1 (100%)
NL 1422..1459 CDD:197463
Notch 1475..1501 CDD:365847
NOD 1506..1558 CDD:369091
NODP 1579..1634 CDD:369464
ANKYR <1786..1906 CDD:223738
ANK repeat 1801..1849 CDD:293786
ANK repeat 1851..1882 CDD:293786
ANKYR 1871..2037 CDD:223738
ANK repeat 1884..1916 CDD:293786
ANK repeat 1918..1949 CDD:293786
ANK repeat 1951..1982 CDD:293786
ANK repeat 1984..2015 CDD:293786
PHA03247 <2040..2327 CDD:223021
DUF3454 2224..2286 CDD:371809
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E33208_3BAFT
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100271
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
54.710

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