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Protein Alignment crb and Notch1

DIOPT Version :9

Sequence 1:	NP_001247284.1	Gene:	crb / 42896	FlyBaseID:	FBgn0259685	Length:	2253	Species:	Drosophila melanogaster
Sequence 2:	NP_032740.3	Gene:	Notch1 / 18128	MGIID:	97363	Length:	2531	Species:	Mus musculus

Alignment Length:	2069	Identity:	540/2069 - (26%)
Similarity:	707/2069 - (34%)	Gaps:	788/2069 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   223 SGCLLDGPGLQFVNNSTVQNVVFG-----------HCPLTP----GPCS--DH----DLFTRLP- 265
            ||..|:| |...|.|.|...|..|           .|..||    |.|.  ||    |.....|
Mouse    28 SGTCLNG-GRCEVANGTEACVCSGAFVGQRCQDSNPCLSTPCKNAGTCHVVDHGGTVDYACSCPL 91

  Fly   266 -----------DNFCLNDPCMGHGTCS-SSPEGYECRCTARYSGKNCQKDNGSPCAKNPCENGGS 318
                       ||.||.:||...|||. .:...|:|||...:|||:||:  ..|||.|||.|||.
Mouse    92 GFSGPLCLTPLDNACLANPCRNGGTCDLLTLTEYKCRCPPGWSGKSCQQ--ADPCASNPCANGGQ 154

  Fly   319 CL---------------------------------------ENSRGDYQCFCDPNHSGQHCETEV 344
            ||                                       .|..|.|:|.|...|:|.|||..
Mouse   155 CLPFESSYICRCPPGFHGPTCRQDVNECSQNPGLCRHGGTCHNEIGSYRCACRATHTGPHCELP- 218

  Fly   345 NIHPLCQTNPCLNNGACVVIGGSGALTCECPKGYAGARCEVDTDECASQPCQNNGSCIDRINGFS 409
              :..|..:||.|.|.|...|.: ...|.|..|:||..||.:.|:|....|:|.|:|:|.:|.::
Mouse   219 --YVPCSPSPCQNGGTCRPTGDT-THECACLPGFAGQNCEENVDDCPGNNCKNGGACVDGVNTYN 280

  Fly   410 CDCSGTGYTGAFCQTNVDECD--KNPCLNGGRCFDTYGWYTCQCLDGWGGEICDRPM-TCQTQQC 471
            |.|. ..:||.:|..:||||.  .|.|.|||.|.:|:|.|.|.|::||.||.|...: .|.:..|
Mouse   281 CRCP-PEWTGQYCTEDVDECQLMPNACQNGGTCHNTHGGYNCVCVNGWTGEDCSENIDDCASAAC 344

  Fly   472 LNGGTCLDKPIGFQCLCPPEYTGELCQIAPSC-AQQCPIDSEC----VGGK--CVCKPGSSGPIG 529
            ..|.||.|:...|.|.||...||.||.:..:| :..|...|.|    |.||  |.|..|.:||.
Mouse   345 FQGATCHDRVASFYCECPHGRTGLLCHLNDACISNPCNEGSNCDTNPVNGKAICTCPSGYTGPA- 408

  Fly   530 HCLPTTTTPTPEQEPTTTPRTTPNPNPAIPNTLTTTTKIPPITTSRTLVGTTTGSRRPPQQPLQS 594
             |                                                              |
Mouse   409 -C--------------------------------------------------------------S 410

  Fly   595 PTQRSASLNACPQENCLNGGTCLGYSGNYSCICASGYTGYNCQTSTGDGASALALTPINCNATNG 659
            ......:|.|.|   |.:.|.||...|::.|.|..||||..|:....:             ..:.
Mouse   411 QDVDECALGANP---CEHAGKCLNTLGSFECQCLQGYTGPRCEIDVNE-------------CISN 459

  Fly   660 KCLNGGTC--SMNGTHCYCAVGYSGDRCEKAENCSPLNCQEPMVCVQNQCLCPENKVCNQCATQP 722
            .|.|..||  .:....|.|..||.|..||       :|..|                   ||:.|
Mouse   460 PCQNDATCLDQIGEFQCICMPGYEGVYCE-------INTDE-------------------CASSP 498

  Fly   723 CQNGGECVDLPNGDYECKCTRGWTGRTCGNDVDECTLHPKICGNGI-CKNEKGSYKCYCTPGFTG 786
            |.:.|.|:|..| :::|:|.:|:.|..|..|||||...|  |.||. |.:...:|.|.||.|:||
Mouse   499 CLHNGHCMDKIN-EFQCQCPKGFNGHLCQYDVDECASTP--CKNGAKCLDGPNTYTCVCTEGYTG 560

  Fly   787 VHCDSDVDECLSFPCLNGATCHNKINAYECVCQPGYEGENCEVDIDECGSNPCSNGSTCIDRINN 851
            .||:.|:|||...||..| :|.:.:..:.|:|||||.|.:||.:|:||.|.||.:|.||.||.|:
Mouse   561 THCEVDIDECDPDPCHYG-SCKDGVATFTCLCQPGYTGHHCETNINECHSQPCRHGGTCQDRDNS 624

  Fly   852 FTCNCIPGMTGRICDIDIDDCVGDPCLNGGQCIDQLGGFRCDCSGTGYEGENCELNIDECLSNPC 916
            :.|.|:.|.||..|:|::|||..:|| :.|.|:|::.|:.|.|. .||.|..|.:|||||..:||
Mouse   625 YLCLCLKGTTGPNCEINLDDCASNPC-DSGTCLDKIDGYECACE-PGYTGSMCNVNIDECAGSPC 687

  Fly   917 TNGAKCLDRVKDYFCDCHNGYKGKNCEQDINECESNPCQYNGNCLERSNITLYQMSRITDLPKVF 981
            .||..|.|.:..:.|.|..||....|..::|||.|||| .:|.|.:..|
Mouse   688 HNGGTCEDGIAGFTCRCPEGYHDPTCLSEVNECNSNPC-IHGACRDGLN---------------- 735

  Fly   982 SQPFSFENASGYECVCVPGIIGKNCEININECDSNPCSKHGNCNDGIGTYTCECEPGFEGTHCEI 1046
                      ||:|.|.||..|.||:||.|||:||||...|.|.|....|.|.|..||.|.:|:.
Mouse   736 ----------GYKCDCAPGWSGTNCDINNNECESNPCVNGGTCKDMTSGYVCTCREGFSGPNCQT 790

  Fly  1047 NIDECDRYNPC-QRGTCYDQIDDYDCDCDANYGGKNCSVLLKGCDQNPCLNGGACLPYLINEVTH 1110
            ||:|| ..||| .:|||.|.:..|.|:|...|.|..|.|:|..|..:||.|.|.|..   :|...
Mouse   791 NINEC-ASNPCLNQGTCIDDVAGYKCNCPLPYTGATCEVVLAPCATSPCKNSGVCKE---SEDYE 851

  Fly  1111 LYNCTCENGFQGDKCEKTTTLSMVATSLISVTTEREEGYDINLQFRTTLPNGVLAFGTTGEKNEP 1175
            .::|.|..|:||..||                      .|||...::...:|.....|.|
Mouse   852 SFSCVCPTGWQGQTCE----------------------VDINECVKSPCRHGASCQNTNG----- 889

  Fly  1176 VSYILELINGRLNLHSSLLNKWEGVFIGSKLNDSNWHKVFVAINTSHLVLSANDEQAIFPVGSYE 1240
             ||                                                    :.:...|
Mouse   890 -SY----------------------------------------------------RCLCQAG--- 898

  Fly  1241 TANNSQPSFPRTYLGGTIPNLKSYLRHLTHQPSAFVGCMQDIMVNGKWIFPDEQDANISYTKLEN 1305
                        |.|.                    .|..||
Mouse   899 ------------YTGR--------------------NCESDI----------------------- 908

  Fly  1306 VQSGCPRTEQCKPNPCHSNGECTDLWHTFACHCPRPFFGHTCQHNMTAATFGHENTTHSAVIVET 1370
                    :.|:|||||:.|.|||..:|..|.|...|.|..|:.::....   .|...:.  ...
Mouse   909 --------DDCRPNPCHNGGSCTDGINTAFCDCLPGFQGAFCEEDINECA---SNPCQNG--ANC 960

  Fly  1371 TDVARRAIRSILDISMFIRTREPTGQVFYLGTDPRKAPTKNIGDSYVAAKLHGGELLVKMQFSGT 1435
            ||..                                       |||...
Mouse   961 TDCV---------------------------------------DSYTCT---------------- 970

  Fly  1436 PEAYTVGGQKLDNGYNHLIEVVRNQTLVQVKLNGTEYFRKTLSTTGLLDAQVLYLGGPAPTRESL 1500
                                       ..|..||......|                |..|..|.
Mouse   971 ---------------------------CPVGFNGIHCENNT----------------PDCTESSC 992

  Fly  1501 L-GATTEPGI-----IPVPGAGIPIEDTTVPKEADDSRDYFKGIIQDVKVSNGSLNLIVEMYSLN 1559
            . |.|...||     :..||                    |.|
Mouse   993 FNGGTCVDGINSFTCLCPPG--------------------FTG---------------------- 1015

  Fly  1560 VTDVQVNAKPLGAVTIDRASVLPGEVSDDLCRKNPCLHNAECRNTWNDYTCKCPNGYKGKNCQE- 1623
                               |....:|::  |...||||...|::::..|.|.||.||.|.|||.
Mouse  1016 -------------------SYCQYDVNE--CDSRPCLHGGTCQDSYGTYKCTCPQGYTGLNCQNL 1059

  Fly  1624 IEFCQHVTCPGQSLCQNLDDGYECVTNTTFTGQERSPLAFFYFQEQQSDDIVSEASPKQTLKPVI 1688
            :.:|....|.
Mouse  1060 VRWCDSAPCK------------------------------------------------------- 1069

  Fly  1689 DIAFRTRAGGTLLYIDNVDGFFEIGVNGGRVTITWKLSALHFGESARFEKENTDGEWSRIYLRAH 1753
                                      ||||   .|              :.||.          :
Mouse  1070 --------------------------NGGR---CW--------------QTNTQ----------Y 1081

  Fly  1754 NSKLEGGWKGWESMVDPTPAFSTDIDQAAFQSLIATSTQVYLGGMPESRQARGSTLSAQQGSQFK 1818
            :.:...||.|          .:.|:        ::.|.:|       :.|.||..::
Mouse  1082 HCECRSGWTG----------VNCDV--------LSVSCEV-------AAQKRGIDVT-------- 1113

  Fly  1819 GCVGEARVGDLLLPYFSMAELYSRTNVSVQQKAQFRLNATRPEEGCILCFQSDCKNDGFCQSPSD 1883
                       ||                                        |::.|.|....|
Mouse  1114 -----------LL----------------------------------------CQHGGLCVDEGD 1127

  Fly  1884 EYACTCQPGFEGDDCGTDIDECLNTECLNNGTCINQVAAFFCQCQPGFEGQHCEQNIDECADQPC 1948
            ::.|.||.|:.|..|..::|||....|.|..||.:.:..|.|:|..|:.|.:|.:.|:||..|||
Mouse  1128 KHYCHCQAGYTGSYCEDEVDECSPNPCQNGATCTDYLGGFSCKCVAGYHGSNCSEEINECLSQPC 1192

  Fly  1949 HNGGNCTDLIASYVCDCPEDYMGPQCDVLKQMTC--------ENEPCRNGSTC--QNGFNASTGN 2003
            .|||.|.||..||.|.||....|..|:: ....|        .:..|.|..||  |.|
Mouse  1193 QNGGTCIDLTNSYKCSCPRGTQGVHCEI-NVDDCHPPLDPASRSPKCFNNGTCVDQVG------- 1249

  Fly  2004 NFTCTCVPGFEGPLC--DIPFCEITPCDNGGLCLTTGAVPM-----CKCSLGYTGRLCEQDINEC 2061
            .:||||.|||.|..|  |:..|...|||..|   |...|..     |:|..|:|||.||..||.|
Mouse  1250 GYTCTCPPGFVGERCEGDVNECLSNPCDPRG---TQNCVQRVNDFHCECRAGHTGRRCESVINGC 1311

  Fly  2062 ESNPCQNGGQC---KDLVGRYECDCQGTGFEGIRCENDIDECNMEGDY-CGGLGRCFNKPGSFQC 2122
            ...||:|||.|   .:....:.|.|. .||||..||||...|   |.. |...|.|.:.|.|..|
Mouse  1312 RGKPCKNGGVCAVASNTARGFICRCP-AGFEGATCENDARTC---GSLRCLNGGTCISGPRSPTC 1372

  Fly  2123 ICQKPYCGAYCNF--TDPCNATDLCSNGGRCVESCGAKPDYYCECPEGFAGKNC 2174
            :|...:.|..|.|  :.||..::.|.|.|.| |.....|.|.|.||..|.|..|
Mouse  1373 LCLGSFTGPECQFPASSPCVGSNPCYNQGTC-EPTSENPFYRCLCPAKFNGLLC 1425

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.