DRSC/TRiP Functional Genomics Resources

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Protein Alignment crb and glp-1

DIOPT Version :9

Sequence 1:NP_001247284.1 Gene:crb / 42896 FlyBaseID:FBgn0259685 Length:2253 Species:Drosophila melanogaster
Sequence 2:NP_499014.1 Gene:glp-1 / 176286 WormBaseID:WBGene00001609 Length:1295 Species:Caenorhabditis elegans


Alignment Length:770 Identity:199/770 - (25%)
Similarity:271/770 - (35%) Gaps:214/770 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   274 CMGHGTCSSSP--EGYECRCTARYSGKNCQKDNGSPCAKNPCENGGSCLENSRGDY-QCFCDPNH 335
            |..:|.|.:..  |.|.|||...:.|..|:::    |..: |:.|..|:.:..|:. .|.|    
 Worm    29 CSVNGKCYNGKLIETYWCRCKKGFGGAFCERE----CDLD-CKRGEKCIYDVYGENPTCIC---- 84

  Fly   336 SGQHCETEVNIHPLCQTNPCLNNGACVVIGGSGALTCECPKGYAGARCEV----DTDECASQPCQ 396
              |.||.|.  .|..:|..                  .|.:||.|..|:.    ..:.|.|.|| 
 Worm    85 --QDCEDET--PPTERTQK------------------GCEEGYGGPDCKTPLFSGVNPCDSDPC- 126

  Fly   397 NNGSCIDRINGFSCDCSGTGYTGAFCQTNVDECDKNPCLNGGRCFDTYGWYTCQCLDGWGGEICD 461
            |||.|.....||.|.|: .||.|::|:..:|.|.:|.|..|..|.::...|.|.|..|..|..|:
 Worm   127 NNGLCYPFYGGFQCICN-NGYGGSYCEEGIDHCAQNECAEGSTCVNSVYNYYCDCPIGKSGRYCE 190

  Fly   462 RPMTCQTQQCLNGGTCL---DKPIGFQCLCPPEYTGELCQIAPSCAQQCPIDSECVGGK------ 517
            |..........|.|.|:   |:...|:|:|...|.||.|.   ....:|.|:..||...      
 Worm   191 RTECALMGNICNHGRCIPNRDEDKNFRCVCDSGYEGEFCN---KDKNECLIEETCVNNSTCFNLH 252

  Fly   518 ----CVCKPGSSGPIGHCLPTTTTPTPEQEPTTTPRTTPNPNPAIPNTLTTTTKIPPITTSRTLV 578
                |.||||.:|.  :|                                               
 Worm   253 GDFTCTCKPGYAGK--YC----------------------------------------------- 268

  Fly   579 GTTTGSRRPPQQPLQSPTQRSASLNACPQENCLNGGTCLGYSGNYS-CICASGYTGYNCQTSTGD 642
                                ..:::.|....|.|.|.|...|.... |.|..|:||..|:.....
 Worm   269 --------------------EEAIDMCKDYVCQNDGYCAHDSNQMPICYCEQGFTGQRCEIECPS 313

  Fly   643 GASA----LALTPINCNATNGKCLNGGTCSMNGTHCYCAVGYSGDRCEKAENCSPLNCQE---PM 700
            |...    |.|...:|:.:||.|.|.|.| :|| .|.|...|.|||||       :|.::   |.
 Worm   314 GFGGIHCDLPLQRPHCSRSNGTCYNDGRC-ING-FCVCEPDYIGDRCE-------INRKDFKFPD 369

  Fly   701 VCVQNQCLCPENKVCNQCATQPCQNGGECVDLPNGDYECKCTRGWTGRTCGNDVDECTLHPKICG 765
            :              ..|...||.|...|:||.|..|.|.|..|:.|..|...: .||  |..|.
 Worm   370 I--------------QSCKYNPCVNNATCIDLKNSGYSCHCPLGFYGLNCEQHL-LCT--PTTCA 417

  Fly   766 N-GICKNEKGSYKCYCTPGFTGVHCD-SDVDECLSFPCLNGATCHNKINAYECVCQPGYEGENCE 828
            | |.|:...|..:|.|..||:|.:|: .|...|...||.||..|.|  ..| |.||.||.|..||
 Worm   418 NGGTCEGVNGVIRCNCPNGFSGDYCEIKDRQLCSRHPCKNGGVCKN--TGY-CECQYGYTGPTCE 479

  Fly   829 -----------VDIDECGSNPCSNGSTCIDRINNFTCNCIPGMTGRICDIDIDDCVG-----DPC 877
                       |..|.|...      .|:|..:|..||  |......|:.|..||.|     ..|
 Worm   480 EVLVIEKSKETVIRDLCEQR------KCMDLASNGICN--PECNLEECNFDGGDCSGGQRPFSKC 536

  Fly   878 LNGGQCIDQLGGFRC--DCSGTG--YEGENCELNIDECLSNPCTNGAKCLDRVKDYFCDCHNGYK 938
            ....:|.||.....|  :|:...  |:|.:|:..:..|   |......|::|..|..|:.     
 Worm   537 QYPARCADQFANGVCNQECNNEECLYDGLDCQSELFRC---PAHIRKHCIERRGDGVCNL----- 593

  Fly   939 GKNCEQDINECESNPCQYN-GNCLERSNITLYQMSRITDLPKVFSQPFSFENASG 992
                     ||....|.:: |:|...:...:....||    ||...|..|:...|
 Worm   594 ---------ECSFIGCGFDGGDCNNGTEAIILSDIRI----KVQIDPIEFQATGG 635

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
crbNP_001247284.1 LamG 91..228 CDD:238058
EGF_CA 386..423 CDD:238011 15/36 (42%)
EGF_CA 425..460 CDD:238011 11/34 (32%)
EGF 466..495 CDD:278437 8/31 (26%)
EGF 605..633 CDD:278437 9/28 (32%)
EGF_CA 716..750 CDD:238011 13/33 (39%)
EGF_CA 753..789 CDD:238011 13/36 (36%)
EGF_CA 792..828 CDD:238011 15/35 (43%)
EGF_CA 830..865 CDD:238011 8/34 (24%)
EGF_CA 868..905 CDD:238011 12/45 (27%)
EGF_CA 907..943 CDD:238011 6/35 (17%)
EGF_CA 1009..1045 CDD:238011
EGF_CA 1047..1082 CDD:238011
Laminin_G_1 1155..1290 CDD:278483
EGF 1316..1346 CDD:278437
Laminin_G_1 1388..1550 CDD:278483
EGF_CA <1593..1622 CDD:238011
Laminin_G_2 1692..1828 CDD:280389
EGF_CA 1901..1937 CDD:238011
EGF_CA 1939..1974 CDD:238011
EGF_CA 2057..2094 CDD:238011
EGF_CA 2096..2133 CDD:238011
EGF_CA 2137..2175 CDD:238011
glp-1NP_499014.1 EGF_CA 118..152 CDD:238011 15/35 (43%)
EGF_CA 155..190 CDD:238011 11/34 (32%)
EGF_CA 232..269 CDD:238011 11/105 (10%)
EGF_CA 369..406 CDD:238011 13/50 (26%)
EGF_CA 451..479 CDD:238011 13/30 (43%)
NL 489..526 CDD:197463 11/44 (25%)
Notch 533..568 CDD:278494 8/34 (24%)
Notch 573..608 CDD:278494 10/51 (20%)
NOD 612..661 CDD:284282 7/28 (25%)
NODP 698..755 CDD:284987
ANK repeat 921..959 CDD:293786
ANK 926..1054 CDD:238125
Ank_5 949..1002 CDD:290568
ANK 956..1127 CDD:238125
ANK repeat 961..992 CDD:293786
ANK repeat 994..1028 CDD:293786
Ank_2 999..1105 CDD:289560
ANK repeat 1030..1061 CDD:293786
ANK repeat 1071..1105 CDD:293786
Ank_2 1079..1171 CDD:289560
ANK repeat 1107..1138 CDD:293786
ANK repeat 1140..1170 CDD:293786
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E33208_3BAFT
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm14569
orthoMCL 1 0.900 - - OOG6_100271
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
54.710

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