DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment crb and F35D2.3

DIOPT Version :9

Sequence 1:	NP_001247284.1	Gene:	crb / 42896	FlyBaseID:	FBgn0259685	Length:	2253	Species:	Drosophila melanogaster
Sequence 2:	NP_495588.2	Gene:	F35D2.3 / 174229	WormBaseID:	WBGene00018041	Length:	256	Species:	Caenorhabditis elegans

Alignment Length:	230	Identity:	66/230 - (28%)
Similarity:	85/230 - (36%)	Gaps:	75/230 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   610 CLNGGTCLGYSGNYSCICASGYTGYNCQTSTGDGASALALTPINCNATNGKCLNGG-TCSMNGT- 672
            |.|||:.:    |..|.|...|.|..|:..                    :||||| ..|..||
Worm    32 CKNGGSIV----NGKCECTLRYEGPQCERE--------------------RCLNGGRRHSAKGTV 72

  Fly   673 HCYCAVGYSGDRCEKAENCSPLNCQEPMVCVQNQCLCPENKVCNQCATQPCQNGGECVDLPNG-- 735
            .|:|..|.|||||||...|.|...:    .|:.:|.|.|......|..:.|.||     :|.|
Worm    73 RCHCPYGLSGDRCEKVTYCEPGKGK----LVEGKCECFERWTGLFCNMRTCFNG-----IPTGGL 128

  Fly   736 DYECKCTRGWTGRTCGNDVDECTLHPKICGNGICKNEKGSYKCYCTPGFTGVHCDSDVDECLSFP 800
            |..|.|..|:||..|.        .|.||.||....::.  :|.||.|:||.||:.
Worm   129 DGFCLCDVGYTGPFCD--------APLICENGGSVTQEN--ECACTAGYTGDHCEQ--------- 174

  Fly   801 CLNGATCHNKINAYECVCQPGY--EGENCEVDIDE 833
                             |..||  |.:.|..::.|
Worm   175 -----------------CAIGYIKEAQYCVPEVSE 192

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crb	NP_001247284.1	LamG	91..228	CDD:238058
		EGF_CA	386..423	CDD:238011
		EGF_CA	425..460	CDD:238011
		EGF	466..495	CDD:278437
		EGF	605..633	CDD:278437	8/22 (36%)
		EGF_CA	716..750	CDD:238011	12/35 (34%)
		EGF_CA	753..789	CDD:238011	11/35 (31%)
		EGF_CA	792..828	CDD:238011	4/37 (11%)
		EGF_CA	830..865	CDD:238011	1/4 (25%)
		EGF_CA	868..905	CDD:238011
		EGF_CA	907..943	CDD:238011
		EGF_CA	1009..1045	CDD:238011
		EGF_CA	1047..1082	CDD:238011
		Laminin_G_1	1155..1290	CDD:278483
		EGF	1316..1346	CDD:278437
		Laminin_G_1	1388..1550	CDD:278483
		EGF_CA	<1593..1622	CDD:238011
		Laminin_G_2	1692..1828	CDD:280389
		EGF_CA	1901..1937	CDD:238011
		EGF_CA	1939..1974	CDD:238011
		EGF_CA	2057..2094	CDD:238011
		EGF_CA	2096..2133	CDD:238011
		EGF_CA	2137..2175	CDD:238011
F35D2.3	NP_495588.2	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910