DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment crb and Crb1

DIOPT Version :9

Sequence 1:NP_001247284.1 Gene:crb / 42896 FlyBaseID:FBgn0259685 Length:2253 Species:Drosophila melanogaster
Sequence 2:NP_573502.2 Gene:Crb1 / 170788 MGIID:2136343 Length:1405 Species:Mus musculus


Alignment Length:1743 Identity:511/1743 - (29%)
Similarity:727/1743 - (41%) Gaps:453/1743 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   592 LQSPTQRSASLNACPQEN--CLN-----------------GGTCLGYS--------GNYSCICAS 629
            |..|.|.:::....||:|  ||:                 ...|.|.:        ||:.|.|..
Mouse    35 LSGPCQNNSTCKHFPQDNNCCLDTANNLDKDCEDLKDPCFSSPCQGIATCVKIPGEGNFLCQCPP 99

  Fly   630 GYTGYNCQTSTGDGASALALTPINCNATNGK-CLNGGTCSMNGTH--CYCAVGYSGDRCEKAENC 691
            ||:|.||:|:|              |:..|. |.:||||..:..|  |.|..||:|..||...  
Mouse   100 GYSGLNCETAT--------------NSCGGNLCQHGGTCRKDPEHPVCICPPGYAGRFCETDH-- 148

  Fly   692 SPLNCQEPMVCVQNQCLCPENKVCNQCATQPCQNGGECVDLPNGDYECKCTRGWTGRTCGNDVDE 756
                                    |:||:.||.||..|.|..||                     
Mouse   149 ------------------------NECASSPCHNGAMCQDGING--------------------- 168

  Fly   757 CTLHPKICGNGICKNEKGSYKCYCTPGFTGVHCDSDVDECLSFPCLNGATCHNKINAYECVCQPG 821
                               |.|:|.||:.|.|||.:||||:|.||.|.|.|.|:|..|.|||...
Mouse   169 -------------------YSCFCVPGYQGRHCDLEVDECVSDPCKNEAVCLNEIGRYTCVCPQE 214

  Fly   822 YEGENCEVDIDECGSNPCSNGSTCIDRINNFTCNCIPGMTGRICDIDIDDCVGDPCLNGGQCIDQ 886
            :.|.|||::||||.|.||.:|:||.|....::|:|.||..|..|::.:::|...|||:||.|:|.
Mouse   215 FSGVNCELEIDECRSQPCLHGATCQDAPGGYSCDCAPGFLGEHCELSVNECESQPCLHGGLCVDG 279

  Fly   887 LGGFRCDCSGTGYEGENCELNIDECLSNPCTNGAKCLDRVKDYFCDCHNGYKGKNCEQDINECES 951
            ...:.|||:|:|:.|.:||..|..|.|.||.|.|.|.|.|..|.|.|..||.|..||.|||||.|
Mouse   280 RNSYHCDCTGSGFTGMHCESLIPLCWSKPCHNDATCEDTVDSYICHCRPGYTGALCETDINECSS 344

  Fly   952 NPCQYNGNCLERSNITLYQMSRITDLPKVFSQPFSFENASGYECVCVPGIIGKNCEININECDSN 1016
            ||||:.|.|:|.|:..||  .....||    ..||:..||||.|:|.||..|.:||.:::||..:
Mouse   345 NPCQFWGECVELSSEGLY--GNTAGLP----SSFSYVGASGYVCICQPGFTGIHCEEDVDECLLH 403

  Fly  1017 PCSKHGNCNDGIGTYTCECEPGFEGTHCEINIDECDRYNPCQRGTCYDQIDDYDCDCDANYGGKN 1081
            ||...|.|.:..|.|.|.|.           .|:..|                     ..|||:|
Mouse   404 PCLNGGTCENLPGNYACHCP-----------FDDTSR---------------------TFYGGEN 436

  Fly  1082 CSVLLKGCDQNPCLNGGACLPYLINEVTHLYNCTCENGFQGDKCEKTTTLSMVATSLISVTTERE 1146
            ||.:|.||..:.|||.|.|:|:..|. .|.:.|.|.:|:.|..||..||||..:...:.||:...
Mouse   437 CSEILLGCTHHQCLNNGKCIPHFQNG-QHGFTCQCLSGYAGPLCETVTTLSFGSNGFLWVTSGSH 500

  Fly  1147 EGY----DINLQFRTTLPNGVLAFGTTGEKNEPVSYILELINGRLNLHSSLLNKWEGVF-IGSKL 1206
            .|.    :|:|:|.|..||.:|..    ..|:.||..|||:||.::|...:.|:.:.:. |....
Mouse   501 TGIGPECNISLRFHTVQPNALLLI----RGNKDVSMKLELLNGCVHLSIEVWNQLKVLLSISHNT 561

  Fly  1207 NDSNWHKVFVAI-NTSHLVL---SANDE---QAIFPVGSYETANNSQPSFPRTYLG----GTIPN 1260
            :|..||.|.|.| .|..|.|   |..::   ::..||.::::....|.||    ||    ||..|
Mouse   562 SDGEWHFVEVTIAETLTLALVGGSCKEKCTTKSSVPVENHQSICALQDSF----LGGLPMGTANN 622

  Fly  1261 LKSYLRHLTHQPS--AFVGCMQDIMVNGKWIFPDEQDANISYTKLENVQSGCPRTEQCKPNPCHS 1323
            ..|.| ::.:.||  :||||:|||..:...|..:    |:|.....||::||...:.|:..||.:
Mouse   623 SVSVL-NIYNVPSTPSFVGCLQDIRFDLNHITLE----NVSSGLSSNVKAGCLGKDWCESQPCQN 682

  Fly  1324 NGECTDLWHTFACHCPRPFFGHTCQHNMTAATFGHENTTHSAVIVETTDVARRAIRSILDISMFI 1388
            .|.|.:||..:.|.|.||:.|..|.....|..||.:::|..|......:..:.     ..:|||:
Mouse   683 RGRCINLWQGYQCECDRPYTGSNCLKEYVAGRFGQDDSTGYAAFSVNDNYGQN-----FSLSMFV 742

  Fly  1389 RTREPTGQVFYLGTDPRKAPTKNIGDSYVAAKLHGGELLVKMQFSGTPEAYTVGGQKLDNGYNHL 1453
            |||:|.|.:..|         :|....||:..|..|.|  .:|..|:|:...  ...|.:|..||
Mouse   743 RTRQPLGLLLAL---------ENSTYQYVSVWLEHGSL--ALQTPGSPKFMV--NFFLSDGNVHL 794

  Fly  1454 IEVVRNQTLVQVKLNGTEYFRK-------TLSTTGLLDAQVLYLGGPAPTRESLLGATTEPGIIP 1511
            |.       :::|.|..|.::.       ::.|..:....|:::|| .|.||.     ||     
Mouse   795 IS-------LRIKPNEIELYQSSQNLGFISVPTWTIRRGDVIFIGG-LPDREK-----TE----- 841

  Fly  1512 VPGAGIPIEDTTVPKEADDSRDYFKGIIQDVKVSNGSLNLIVEMYSLNVTD--VQVNAKPLGAVT 1574
            |.|.                  :|||.:|||::::.:|.......: |..|  :.||        
Mouse   842 VYGG------------------FFKGCVQDVRLNSQTLEFFPNSTN-NAYDDPILVN-------- 879

  Fly  1575 IDRASVLPGEVSDDLCRKNPCLHNAECRNTWNDYTCKCPNGYKGKNCQEIEFCQHVTCPGQSLCQ 1639
                 |..|...|:.|:.|||.:...|.:.|:|::|.||....|:.|:::::||...||..:.||
Mouse   880 -----VTQGCPGDNTCKSNPCHNGGVCHSLWDDFSCSCPTNTAGRACEQVQWCQLSPCPPTAECQ 939

  Fly  1640 NLDDGYECVTNTTFTGQERSPLAFFYFQEQQSDDIVSEASPKQTLKPVIDIAFRTR-AGGTLLYI 1703
            .|..|:||:.|..|:|..|..|.      :.:.:|..|.:.       |..||||. ....:|:.
Mouse   940 LLPQGFECIANAVFSGLSREILF------RSNGNITRELTN-------ITFAFRTHDTNVMILHA 991

  Fly  1704 DNVDGFFEIGVNGGRVTITWK----LSALHFGESARFEKENTDGEWSRIYLRAHNSKLEGGWKGW 1764
            :....|..|.:...|:....:    ...||...|...    .||.|.::..              
Mouse   992 EKEPEFLNISIQDARLFFQLRSGNSFYTLHLMGSQLV----NDGTWHQVTF-------------- 1038

  Fly  1765 ESMVDP---TPAFSTDI-DQAAFQ-SLIAT--------STQVYLGGMPESRQARGSTLSAQQGSQ 1816
             ||:||   |..:..:: ||..|. |.:||        :|.:|:|..           |......
Mouse  1039 -SMIDPVAQTSRWQMEVNDQTPFVISEVATGSLNFLKDNTDIYVGDQ-----------SVDNPKG 1091

  Fly  1817 FKGCVGEARVGDLLLPYFSMAELYSRTNVSVQQKAQF-RLNATRPEEGCI---LCFQSDCKNDGF 1877
            .:||:....:|.:.|.||.....:.    ...|:.|| :::......||:   .|..|.|.:.|.
Mouse  1092 LQGCLSTIEIGGIYLSYFENLHGFP----GKPQEEQFLKVSTNMVLTGCLPSNACHSSPCLHGGN 1152

  Fly  1878 CQSPSDEYACTCQPGFEGDDCGTDIDECLNTECLNNGTCINQVAAFFCQCQPGFEGQHCEQNIDE 1942
            |:.....|.|.|..|:.|..|..:||||.::.|: :|.|.:.|||:.|:|:||:.|.:||.::|.
Mouse  1153 CEDSYSSYRCACLSGWSGTHCEINIDECFSSPCI-HGNCSDGVAAYHCRCEPGYTGVNCEVDVDN 1216

  Fly  1943 CADQPCHNGGNCTDLIASYVCDCPEDYMGPQC--DVLKQMTCENEPCRNGSTCQNGFNASTGNNF 2005
            |....|.||..|......|.|.|..::.|..|  ..|....|.||.                .||
Mouse  1217 CKSHQCANGATCVPEAHGYSCLCFGNFTGRFCRHSRLPSTVCGNEK----------------RNF 1265

  Fly  2006 TCTCVPGFEGPLCDIPFCEITPCDNGGLCLTTGAVPMCKCSLGYTGRLCEQDINECESNPCQNGG 2070
            ||.                     |||.|........|.|..|:||..||:|||||.|:||.|||
Mouse  1266 TCY---------------------NGGSCSMFQEDWQCMCWPGFTGEWCEEDINECASDPCINGG 1309

  Fly  2071 QCKDLVGRYECDCQGTGFEGIRCENDIDECNMEGDYCGGLGRCFNKPGSFQCICQKPYCGAYCNF 2135
            .|:|||.|:.|.|. ..|.|.|||.|:.:..:.|        .|...||          |....|
Mouse  1310 LCRDLVNRFLCICD-VAFAGERCELDLADDRLLG--------IFTAVGS----------GTLALF 1355

  Fly  2136 TDPCNATDLCSNGGRCVESCGAKPDYYCECPEGFAGKNCTAPITAKEDGPSTTDIAIIVIPVVVV 2200
                                                                            .
Mouse  1356 ----------------------------------------------------------------F 1356

  Fly  2201 LLLIAGALLGTFLVMARNKRATRGTYSPSAQEYCNPRLEMDNVLKPPPEERLI 2253
            :||:||..    .::|.|||||:||||||.||...||:||...:.||..||||
Mouse  1357 ILLLAGVA----SLIASNKRATQGTYSPSGQEKAGPRVEMWIRMPPPALERLI 1405

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
crbNP_001247284.1 LamG 91..228 CDD:238058
EGF_CA 386..423 CDD:238011
EGF_CA 425..460 CDD:238011
EGF 466..495 CDD:278437
EGF 605..633 CDD:278437 13/54 (24%)
EGF_CA 716..750 CDD:238011 11/33 (33%)
EGF_CA 753..789 CDD:238011 6/35 (17%)
EGF_CA 792..828 CDD:238011 18/35 (51%)
EGF_CA 830..865 CDD:238011 16/34 (47%)
EGF_CA 868..905 CDD:238011 14/36 (39%)
EGF_CA 907..943 CDD:238011 16/35 (46%)
EGF_CA 1009..1045 CDD:238011 10/35 (29%)
EGF_CA 1047..1082 CDD:238011 5/34 (15%)
Laminin_G_1 1155..1290 CDD:278483 47/148 (32%)
EGF 1316..1346 CDD:278437 12/29 (41%)
Laminin_G_1 1388..1550 CDD:278483 40/168 (24%)
EGF_CA <1593..1622 CDD:238011 10/28 (36%)
Laminin_G_2 1692..1828 CDD:280389 30/153 (20%)
EGF_CA 1901..1937 CDD:238011 15/35 (43%)
EGF_CA 1939..1974 CDD:238011 10/34 (29%)
EGF_CA 2057..2094 CDD:238011 21/36 (58%)
EGF_CA 2096..2133 CDD:238011 6/36 (17%)
EGF_CA 2137..2175 CDD:238011 0/37 (0%)
Crb1NP_573502.2 EGF 113..143 CDD:394967 12/29 (41%)
EGF_CA 147..182 CDD:238011 17/100 (17%)
EGF_CA 186..221 CDD:238011 18/34 (53%)
EGF_CA 224..259 CDD:238011 16/34 (47%)
EGF_CA 262..298 CDD:238011 14/35 (40%)
EGF_CA <308..336 CDD:238011 13/27 (48%)
EGF_CA 338..394 CDD:238011 29/61 (48%)
EGF_CA 396..437 CDD:214542 15/72 (21%)
Laminin_G_2 513..648 CDD:396680 47/143 (33%)
EGF_CA 675..706 CDD:238011 12/30 (40%)
Laminin_G_2 742..859 CDD:396680 40/165 (24%)
EGF_CA 888..922 CDD:238011 11/33 (33%)
Laminin_G_2 979..1104 CDD:396680 31/154 (20%)
EGF_CA 1140..1174 CDD:238011 10/33 (30%)
EGF_CA 1176..1211 CDD:238011 15/35 (43%)
EGF_CA 1213..1248 CDD:238011 10/34 (29%)
EGF_CA 1296..1332 CDD:238011 21/36 (58%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 70 1.000 Domainoid score I9549
eggNOG 1 0.900 - - E33208_3BAFT
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0 Normalized mean entropy S6671
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0003041
OrthoInspector 1 1.000 - - otm42733
orthoMCL 1 0.900 - - OOG6_100271
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3765
SonicParanoid 1 1.000 - - X4671
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
98.690

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