DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment crb and Jag1

DIOPT Version :9

Sequence 1:	NP_001247284.1	Gene:	crb / 42896	FlyBaseID:	FBgn0259685	Length:	2253	Species:	Drosophila melanogaster
Sequence 2:	NP_038850.1	Gene:	Jag1 / 16449	MGIID:	1095416	Length:	1218	Species:	Mus musculus

Alignment Length:	1243	Identity:	326/1243 - (26%)
Similarity:	465/1243 - (37%)	Gaps:	427/1243 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 AYFNGSTYLRLTTPMPIWDHSAISFRSCRGGEILAQQYNKNSIVISVLNDFLQISLAGPAVHGPN 155
            ::.:|||        |:...:..:.::.||.:       :|.||       |..|.|.|.
Mouse    93 SFGSGST--------PVIGGNTFNLKASRGND-------RNRIV-------LPFSFAWPR----- 130

  Fly   156 NRLDVKLPYQLLDNRWHTLQFKYEYGNLYLHVDRAASIFANSTYNSQFLTNQDIGYKDAILILGN 220
                   .|.||...|.:                     :|.|..           .|:| |...
Mouse   131 -------SYTLLVEAWDS---------------------SNDTIQ-----------PDSI-IEKA 155

  Fly   221 SFSGCLLDGPGLQFVNNSTVQNVVFGH----CPLTPGPCSDH------DLFTRLPDNF-----C- 269
            |.||.:  .|..|:  .:..||....|    ..:|   |.||      :.|.|..|:|     |
Mouse   156 SHSGMI--NPSRQW--QTLKQNTGIAHFEYQIRVT---CDDHYYGFGCNKFCRPRDDFFGHYACD 213

  Fly   270 --LNDPCM-------------------GHGTCSSSPEGYECRCTARYSGKNCQKDNGSPCAKNPC 313
              .|..||                   .||:|....   :|||...:.|..|.|     |..:|.
Mouse   214 QNGNKTCMEGWMGPDCNKAICRQGCSPKHGSCKLPG---DCRCQYGWQGLYCDK-----CIPHPG 270

  Fly   314 ENGGSCLENSRGDYQCFCDPNHSGQHCETEVNIHPLCQTN-PCLNNGACVVIGGSGALTCECPKG 377
            ...|:|.|    .:||.|:.|..||.|:.::|   .|.|: ||||.|.|... |.....|.||:|
Mouse   271 CVHGTCNE----PWQCLCETNWGGQLCDKDLN---YCGTHQPCLNRGTCSNT-GPDKYQCSCPEG 327

  Fly   378 YAGARCEVDTDECASQPCQNNGSCIDRINGFSCDCSGTGYTGAFCQTNVDECDKNPCLNGGRCFD 442
            |:|..||:....|.|.||.|.|||.:..:||.|:|| .|:||..|.||:|:|..|
Mouse   328 YSGPNCEIAEHACLSDPCHNRGSCKETSSGFECECS-PGWTGPTCSTNIDDCSPN---------- 381

  Fly   443 TYGWYTCQCLDGWGGEICDRPMTCQTQQCLNGGTCLDKPIGFQCLCPPEYTGELCQIAPSCAQQC 507
                                       .|.:||||.|...||:|:|||::||:.||:
Mouse   382 ---------------------------NCSHGGTCQDLVNGFKCVCPPQWTGKTCQL-------- 411

  Fly   508 PIDSECVGGKCVCKPGSSGPIGHCLPTTTTPTPEQEPTTTPRTTPNPNPAIPNTLTTTTKIPPIT 572

Mouse   412 ----------------------------------------------------------------- 411

  Fly   573 TSRTLVGTTTGSRRPPQQPLQSPTQRSASLNACPQENCLNGGTCLGYSGNYSCICASGYTGYNCQ 637
                                        ..|.|..:.|:|..:|.....:|.|.|..|:.|.||.
Mouse   412 ----------------------------DANECEAKPCVNARSCKNLIASYYCDCLPGWMGQNCD 448

  Fly   638 TSTGDGASALALTPINCNATNGKCLNGGTCS--MNGTHCYCAVGYSGDRCEK-AENCSPLNCQEP 699
                          ||.|...|:|.|..:|.  :||..|.|..||:||.||: .:.|:...|...
Mouse   449 --------------ININDCLGQCQNDASCRDLVNGYRCICPPGYAGDHCERDIDECASNPCLNG 499

  Fly   700 MVCVQN-----QCLCP---ENKVC----NQCATQPCQNGGECVDLPNGDYECKCTRGWTGRTCGN 752
            ..| ||     |||||   ...:|    :.|...|||||.:|.:..: ||.|||...:.|:.|.:
Mouse   500 GHC-QNEINRFQCLCPTGFSGNLCQLDIDYCEPNPCQNGAQCYNRAS-DYFCKCPEDYEGKNCSH 562

  Fly   753 -----------DVDECT--------------LHPKICG-NGICKNEK-GSYKCYCTPGFTGVHCD 790
                       .:|.||              :...:|| :|.||::. |.:.|.|..||||.:|.
Mouse   563 LKDHCRTTTCEVIDSCTVAMASNDTPEGVRYISSNVCGPHGKCKSQSGGKFTCDCNKGFTGTYCH 627

  Fly   791 SDVDECLSFPCLNGATCHNKINAYECVCQPGYEGENCEVDIDECGSNPCSNGSTCIDRINNFTCN 855
            .::::|.|.||.||.||.:.:|:|:|:|..|:||.:||.:|::|..|||..|.||.|.:|:|.|:
Mouse   628 ENINDCESNPCKNGGTCIDGVNSYKCICSDGWEGAHCENNINDCSQNPCHYGGTCRDLVNDFYCD 692

  Fly   856 CIPGMTGRICDIDIDDCVGDPCLNGGQCIDQLGGFRCDCSGTGYEGENCEL-NIDECLSNPCTNG 919
            |..|..|:.|......|....|.|||.|.|::..|:|.|.| |:||..|.: ....||.|||.||
Mouse   693 CKNGWKGKTCHSRDSQCDEATCNNGGTCYDEVDTFKCMCPG-GWEGTTCNIARNSSCLPNPCHNG 756

  Fly   920 AKCLDRVKDYFCDCHNGYKGKNCEQDINECESNPCQYNGNCLERSNITLYQMSRITDLPKVFSQP 984
            ..|:.....:.|.|..|::|..|.|:.|:|..:||..:|.|::..|
Mouse   757 GTCVVNGDSFTCVCKEGWEGPICTQNTNDCSPHPCYNSGTCVDGDN------------------- 802

  Fly   985 FSFENASGYECVCVPGIIGKNCEININECDSNPCSKHGNCNDGIGTYTCECEPGFEGTHC-EINI 1048
                   .|.|.|.||..|.:|.||||||.|:||:....|.|.|..|.|.|.||..|..| |::.
Mouse   803 -------WYRCECAPGFAGPDCRININECQSSPCAFGATCVDEINGYQCICPPGHSGAKCHEVSG 860

  Fly  1049 DEC--------DRYNPCQRGTCYDQIDDYDCD-CDANYGGKNCSVLLKG---C----DQNPCLNG 1097
            ..|        |       |..:|.    ||: |....|...||.:..|   |    ..|.|.:|
Mouse   861 RSCITMGRVILD-------GAKWDD----DCNTCQCLNGRVACSKVWCGPRPCRLHKSHNECPSG 914

  Fly  1098 GACLPYL-----INEVTHLYNCTCENGFQGDKCEKTTTLSMVATSLISVTTEREEGYDINLQFRT 1157
            .:|:|.|     :...|.:..|            ::::|..|.|...|.:..::...:|...|..
Mouse   915 QSCIPVLDDQCFVRPCTGVGEC------------RSSSLQPVKTKCTSDSYYQDNCANITFTFNK 967

  Fly  1158 TLPNGVLAFGTTGEKNEPVSYILELINGRLNLHSSLLNKWEGVFIGSKLNDSNWHKVFVAINTSH 1222
            .:    ::.|.|.|                ::.|.|.|      :....|.|..:.:::|...|
Mouse   968 EM----MSPGLTTE----------------HICSELRN------LNILKNVSAEYSIYIACEPS- 1005

  Fly  1223 LVLSANDE 1230
              ||||:|
Mouse  1006 --LSANNE 1011

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crb	NP_001247284.1	LamG	91..228	CDD:238058	25/136 (18%)
		EGF_CA	386..423	CDD:238011	16/36 (44%)
		EGF_CA	425..460	CDD:238011	4/34 (12%)
		EGF	466..495	CDD:278437	13/28 (46%)
		EGF	605..633	CDD:278437	8/27 (30%)
		EGF_CA	716..750	CDD:238011	13/33 (39%)
		EGF_CA	753..789	CDD:238011	15/51 (29%)
		EGF_CA	792..828	CDD:238011	15/35 (43%)
		EGF_CA	830..865	CDD:238011	15/34 (44%)
		EGF_CA	868..905	CDD:238011	14/36 (39%)
		EGF_CA	907..943	CDD:238011	12/35 (34%)
		EGF_CA	1009..1045	CDD:238011	18/36 (50%)
		EGF_CA	1047..1082	CDD:238011	8/43 (19%)
		Laminin_G_1	1155..1290	CDD:278483	16/76 (21%)
		EGF	1316..1346	CDD:278437
		Laminin_G_1	1388..1550	CDD:278483
		EGF_CA	<1593..1622	CDD:238011
		Laminin_G_2	1692..1828	CDD:280389
		EGF_CA	1901..1937	CDD:238011
		EGF_CA	1939..1974	CDD:238011
		EGF_CA	2057..2094	CDD:238011
		EGF_CA	2096..2133	CDD:238011
		EGF_CA	2137..2175	CDD:238011
Jag1	NP_038850.1	MNNL	32..106	CDD:284966	4/20 (20%)
		DSL	167..229	CDD:279722	15/66 (23%)
		Important for interaction with NOTCH1. /evidence=ECO:0000250	199..207		3/7 (43%)
		EGF_CA	296..334	CDD:238011	16/41 (39%)
		EGF	340..370	CDD:278437	16/30 (53%)
		EGF_CA	374..410	CDD:238011	18/72 (25%)
		EGF_CA	412..447	CDD:238011	10/34 (29%)
		EGF_CA	450..485	CDD:238011	14/34 (41%)
		EGF_CA	487..523	CDD:238011	10/36 (28%)
		EGF_CA	525..560	CDD:238011	13/35 (37%)
		EGF_CA	629..665	CDD:238011	15/35 (43%)
		EGF_CA	667..702	CDD:238011	15/34 (44%)
		EGF_CA	<714..740	CDD:238011	13/26 (50%)
		EGF	748..777	CDD:278437	11/28 (39%)
		EGF_CA	782..817	CDD:238011	13/60 (22%)
		EGF_CA	820..855	CDD:238011	17/34 (50%)
		VWC_out	863..930	CDD:214565	18/77 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1181..1218
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	49	1.000	Domainoid score	I11756
eggNOG	1	0.900	-	-		E33208_3BAFT
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810