DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment crb and jag2b

DIOPT Version :9

Sequence 1:	NP_001247284.1	Gene:	crb / 42896	FlyBaseID:	FBgn0259685	Length:	2253	Species:	Drosophila melanogaster
Sequence 2:	NP_571937.1	Gene:	jag2b / 140422	ZFINID:	ZDB-GENE-011128-3	Length:	1254	Species:	Danio rerio

Alignment Length:	1585	Identity:	360/1585 - (22%)
Similarity:	528/1585 - (33%)	Gaps:	547/1585 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 KQRQAETATTTTTTV-AASVETATTTARSRDRTKSAAQITSHLLKRAISVYSSPQWIPLFILIYL 77
            |:.|:|..||...|. :.|.:.......|....|::...||.:.|..|..:.:  |...:.||..
Zfish    76 KEYQSEVTTTGQCTFGSGSTDVLGGNIFSFKTAKNSPSKTSDVGKIIIPFHFA--WPRSYTLILE 138

  Fly    78 ATDVASVAVPTKEAYFNGSTYLRLTTPMPIWDHSAISFRSCRGGEILAQQYNKNSIVISVLNDFL 142
            |.|                           ||:|..:    .|.|.|.:::             :
Zfish   139 AWD---------------------------WDNSTQN----NGEENLIERH-------------I 159

  Fly   143 QISLAGPAVHGPNNRLDVKLPYQLLDNRWHTLQFKYEYGNLYLHVDRAASIFANSTY-----NSQ 202
            ..|:..|..|                  |.:::    :..:..|::....:..:..|     |.|
Zfish   160 HASMVNPGDH------------------WQSIR----HPGITAHIEYRIRVRCDENYYGSKCNKQ 202

  Fly   203 FLTNQD-IGY-----KDAILILGNSF----------SGCLLDGPGLQFVNNSTVQNVVFGHCPLT 251
            .....| .|:     ...|:.|....          .||                |::.|.|.:
Zfish   203 CRPRDDYFGHYRCDPSGNIVCLDGWMGEDCRTAICKQGC----------------NLIHGGCAV- 250

  Fly   252 PGPCS-DHDLFTRLPDNFCLNDPCMGHGTCSSSPEGYECRCTARYSGKNCQKDNGSPCAKNPCEN 315
            ||.|. ::....:..|. ||..|...||||...   ::|.|...:.|..|.||.......:||.|
Zfish   251 PGECKCNYGWQGQFCDE-CLPYPGCLHGTCVMP---WQCTCEKNWGGLLCDKDLNYCGTHHPCVN 311

  Fly   316 GGSCLENSRGDYQCFCDPNHSGQHCETEVNIHPLCQTNPCLNNGAC--VVIGGSGALTCECPKGY 378
            ||:|:.:...:|.|.|...:||::||...:   .|.:|||.|.|.|  |..|    ..|.||.|:
Zfish   312 GGTCMNSEPDEYNCACPEGYSGKNCEIAEH---ACVSNPCANGGTCHEVPTG----FECHCPPGW 369

  Fly   379 AGARCEVDTDECASQPCQNNGSCIDRINGFSCDCSGTGYTGAFCQTNVDECDKNPCLNGGRCFDT 443
            .|..|..|.|||||.||...|:|||..|||.|.|. ..:.|..||.:.:||...||:|...|.:.
Zfish   370 EGPTCAKDMDECASSPCAQGGTCIDLENGFECVCP-PQWVGKTCQIDANECMGKPCVNAHSCKNM 433

  Fly   444 YGWYTCQCLDGWGGEICDRPMTCQTQQCLNGGTCLDKPIGFQCLCPPEYTGELCQIAPSCAQQCP 508
            .|.|.|.|..||.|:.||
Zfish   434 IGGYHCDCFQGWAGQNCD----------------------------------------------- 451

  Fly   509 IDSECVGGKCVCKPGSSGPIGHCLPTTTTPTPEQEPTTTPRTTPNPNPAIPNTLTTTTKIPPITT 573

Zfish   452 ----------------------------------------------------------------- 451

  Fly   574 SRTLVGTTTGSRRPPQQPLQSPTQRSASLNACPQENCLNGGTCLG-YSGNYSCICASGYTGYNCQ 637
                                      .:||.| ...|.||.||.. ..|.|.|.|.:|:.|.:|:
Zfish   452 --------------------------INLNGC-HGQCQNGATCKELVHGGYHCQCPAGFVGLHCE 489

  Fly   638 TSTGDGASALALTPINCNATNGKCLNGGTCS--MNGTHCYCAVGYSGDRCEKAENCSPLNCQEPM 700
            .|....||             |.|.|||.|.  ::...|.|...|:|..||......|
Zfish   490 VSRNKCAS-------------GPCQNGGRCHVILDSFVCECPSNYAGMLCEVESLSHP------- 534

  Fly   701 VCVQNQCLCPENKVCNQCATQPCQNGGECVDLPNGDYECKCTRGWTGRTCGNDVDECTLHP---- 761
                           |.|...||||...|..|| ||:.|.|...:.|:||.|..|.|.:.|
Zfish   535 ---------------NPCEPNPCQNTALCYSLP-GDFYCACPEDYEGKTCENRKDHCKMTPCQVI 583

  Fly   762 ---------------------KICG-NGICKNEK-GSYKCYCTPGFTGVHCDSDVDECLSFPCLN 803
                                 .:|| :|.|.::. |::.|.|..||||.:|..:|::|:|.||.|
Zfish   584 DSCTIAVASNSSDGGVRHINSNVCGPHGRCISQPGGNFTCTCELGFTGTYCHENVNDCVSNPCRN 648

  Fly   804 GATCHNKINAYECVCQPGYEGENCEVDIDECGSNPCSNGSTCIDRINNFTCNCIPGMTGRICDID 868
            |.||.:.|::::|.|..|:||:.|.::::||..:||.||..|:|.:|:|.|.|..|..|:.|...
Zfish   649 GGTCIDGISSFQCFCPDGWEGDLCSINVNECSRSPCKNGGHCVDLVNDFYCECANGWKGKTCHSR 713

  Fly   869 IDDCVGDPCLNGGQCIDQLGGFRCDCSGTGYEGENCE-LNIDECLSNPCTNGAKCLDRVKDYFCD 932
            ...|....|.|||.|.|....|||.|. .|:||..|. .....|.|.||.||..|:.....:.|.
Zfish   714 ESQCDSSTCSNGGTCYDHGDAFRCACP-PGWEGSTCNTAKNSTCASGPCLNGGTCVGGGDTFTCI 777

  Fly   933 CHNGYKGKNCEQDINECESNPCQYNGNCLERSNITLYQMSRITDLPKVFSQPFSFENASGYECVC 997
            |.:|::|..|.|:.|:|..:||...|.|::..|                          .:.|.|
Zfish   778 CKDGWEGATCAQNTNDCNPHPCYNGGICVDGVN--------------------------WFRCEC 816

  Fly   998 VPGIIGKNCEININECDSNPCSKHGNCNDGIGTYTCECEPGFEGTHCE--INIDECDRYNPCQ-- 1058
            .||..|.:|.|||:||.|:||:....|.|.|..:.|.|..|..|..|:  |.|.:...|...|
Zfish   817 APGFAGPDCRINIDECQSSPCAYGATCVDEINGFRCVCPLGRTGPQCQEFIGIGKTCHYAGLQFP 881

  Fly  1059 RGTCYDQIDDYDCD-CDANYGGKNCSVLLKGCDQNPCL-------------NGGACLPYLINEVT 1109
            .|:.:::    :|: |....|...|:.::  |.:.|||             .|..||.:  |.:|
Zfish   882 HGSRWEE----ECNTCQCVNGKVECTKVV--CGRKPCLLPGTPGRELHYCPGGRECLEH--NFLT 938

  Fly  1110 HLYNCTCENGFQGD---------KCEKTTTLSMVATSLISVTTEREEGYDINLQFRTTLPNGVLA 1165
            .|.....:.||...         |||..:.....:.:.|::...|::           ||.
Zfish   939 CLSPPCHQWGFCSSPETPPTLQTKCEPNSVYLDKSCARITLIFNRDK-----------LPT---- 988

  Fly  1166 FGTTGEKNEPVSYILELINGRLNLHSSL--------LNKWEGVFIGSKLNDSNWHKVFVAINTSH 1222
             |||.|                |:.|.|        |.|...:.:...|:..|...|.|||:..|
Zfish   989 -GTTVE----------------NVCSELRYMPATRSLAKDHKLLVLCDLSYKNQDAVEVAISFQH 1036

  Fly  1223 LVLSANDEQAIFPVGSYETANNSQPSFPRTYLGGTIPNLKSYLRH----------------LTHQ 1271
                  |||          .::||.....:.:..|:..     ||                :|.|
Zfish  1037 ------DEQ----------PSHSQIQEAASTIVSTLSK-----RHNSTVMLAVIEVKVEMPVTSQ 1080

  Fly  1272 PSAFVGCMQDIMVNGKWIF----------------------PDEQDANISYTKLENVQSGCPRTE 1314
            |..::..:..:::...|:|                      |.|:..|..:..|..|
Zfish  1081 PVDYLVPVLCVVLCVLWVFCVIVCVWWTRKRRKERERRERVPVEESVNNQWEPLRPV-------- 1137

  Fly  1315 QCKPNPCHSNGECTDLWHTFACHCPRPFFGHTCQHNMTAATFGHENTTHSAVIVETTDVARRAIR 1379
               ..|.|.:                   ....|...|......:.|.:|.  .:..|:....:.
Zfish  1138 ---TRPQHKD-------------------NRDAQFERTKLMGSPDRTCNSG--DDEEDMEEDELE 1178

  Fly  1380 SILDISMFIRTREPTGQVFYLGTDPRKAPTKNIGDSYVAAKLHGGELLVKMQFSGTPE-----AY 1439
            .:.:               :.||:..|.|.:....|  ||:...|.:......||:..     ||
Zfish  1179 LVEE---------------WCGTEGGKHPVQKYSKS--AARTKNGLICTTRSTSGSSSPSLKAAY 1226

  Fly  1440 TVGGQKLDNGYNHLIEVVRNQTLVQ 1464
            ..|....||...:    |.|.|..|
Zfish  1227 WTGFSPKDNNCKN----VNNATAGQ 1247

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crb	NP_001247284.1	LamG	91..228	CDD:238058	20/157 (13%)
		EGF_CA	386..423	CDD:238011	18/36 (50%)
		EGF_CA	425..460	CDD:238011	13/34 (38%)
		EGF	466..495	CDD:278437	0/28 (0%)
		EGF	605..633	CDD:278437	11/28 (39%)
		EGF_CA	716..750	CDD:238011	14/33 (42%)
		EGF_CA	753..789	CDD:238011	14/62 (23%)
		EGF_CA	792..828	CDD:238011	15/35 (43%)
		EGF_CA	830..865	CDD:238011	14/34 (41%)
		EGF_CA	868..905	CDD:238011	14/36 (39%)
		EGF_CA	907..943	CDD:238011	11/35 (31%)
		EGF_CA	1009..1045	CDD:238011	14/35 (40%)
		EGF_CA	1047..1082	CDD:238011	7/37 (19%)
		Laminin_G_1	1155..1290	CDD:278483	30/158 (19%)
		EGF	1316..1346	CDD:278437	2/29 (7%)
		Laminin_G_1	1388..1550	CDD:278483	19/82 (23%)
		EGF_CA	<1593..1622	CDD:238011
		Laminin_G_2	1692..1828	CDD:280389
		EGF_CA	1901..1937	CDD:238011
		EGF_CA	1939..1974	CDD:238011
		EGF_CA	2057..2094	CDD:238011
		EGF_CA	2096..2133	CDD:238011
		EGF_CA	2137..2175	CDD:238011
jag2b	NP_571937.1	MNNL	28..101	CDD:284966	7/24 (29%)
		DSL	170..232	CDD:279722	9/65 (14%)
		EGF_CA	299..337	CDD:238011	12/37 (32%)
		EGF_CA	<346..374	CDD:238011	13/31 (42%)
		EGF_CA	377..413	CDD:238011	18/36 (50%)
		EGF_CA	415..450	CDD:238011	13/34 (38%)
		EGF_CA	458..489	CDD:238011	11/30 (37%)
		EGF_CA	493..527	CDD:238011	12/46 (26%)
		EGF_CA	535..569	CDD:238011	15/34 (44%)
		EGF_CA	637..672	CDD:238011	15/34 (44%)
		EGF_CA	675..710	CDD:238011	14/34 (41%)
		EGF	756..786	CDD:278437	11/29 (38%)
		EGF_CA	790..825	CDD:238011	12/60 (20%)
		EGF_CA	828..864	CDD:238011	14/35 (40%)
		VWC_out	873..944	CDD:214565	17/78 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	50	1.000	Domainoid score	I11640
eggNOG	1	0.900	-	-		E33208_3BAFT
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.900