DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment crb and DLL3

DIOPT Version :9

Sequence 1:NP_001247284.1 Gene:crb / 42896 FlyBaseID:FBgn0259685 Length:2253 Species:Drosophila melanogaster
Sequence 2:NP_058637.1 Gene:DLL3 / 10683 HGNCID:2909 Length:618 Species:Homo sapiens


Alignment Length:305 Identity:100/305 - (32%)
Similarity:129/305 - (42%) Gaps:55/305 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly   671 GTHC--YCAVGYSGDRCEKA-ENCSPL--NCQEPMVCVQNQCLCPENKVCNQCATQPCQNGGECV 730
            ||.|  .|....:..||... ..|:||  .|:.|:|| :..| .||:..|.|             
Human   184 GTACTRLCRPRSAPSRCGPGLRPCAPLEDECEAPLVC-RAGC-SPEHGFCEQ------------- 233

  Fly   731 DLPNGDYECKCTRGWTGRTCGNDVD-----------------------ECTLHPKICGN-GICKN 771
              |.   ||:|..||||..|...|.                       .|..:|  |.| |.|..
Human   234 --PG---ECRCLEGWTGPLCTVPVSTSSCLSPRGPSSATTGCLVPGPGPCDGNP--CANGGSCSE 291

  Fly   772 EKGSYKCYCTPGFTGVHCDSDVDECLSFPCLNGATC---HNKINAYECVCQPGYEGENCEVDIDE 833
            ...|::|.|..||.|:.|:.....|...||.||..|   .:..:||.|.|.||::|.|||..:|.
Human   292 TPRSFECTCPRGFYGLRCEVSGVTCADGPCFNGGLCVGGADPDSAYICHCPPGFQGSNCEKRVDR 356

  Fly   834 CGSNPCSNGSTCIDRINNFTCNCIPGMTGRICDIDIDDCVGDPCLNGGQCIDQLGGFRCDCSGTG 898
            |...||.||..|:|..:...|.|..|..|..|:.|:|||.|..|.|||.|::..|..||.|: .|
Human   357 CSLQPCRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDCAGRACANGGTCVEGGGAHRCSCA-LG 420

  Fly   899 YEGENCELNIDECLSNPCTNGAKCLDRVKDYFCDCHNGYKGKNCE 943
            :.|.:|....|.|.:.||.:|.:|........|.|..||.|..||
Human   421 FGGRDCRERADPCAARPCAHGGRCYAHFSGLVCACAPGYMGARCE 465

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
crbNP_001247284.1 LamG 91..228 CDD:238058
EGF_CA 386..423 CDD:238011
EGF_CA 425..460 CDD:238011
EGF 466..495 CDD:278437
EGF 605..633 CDD:278437
EGF_CA 716..750 CDD:238011 9/33 (27%)
EGF_CA 753..789 CDD:238011 13/59 (22%)
EGF_CA 792..828 CDD:238011 14/38 (37%)
EGF_CA 830..865 CDD:238011 12/34 (35%)
EGF_CA 868..905 CDD:238011 16/36 (44%)
EGF_CA 907..943 CDD:238011 11/35 (31%)
EGF_CA 1009..1045 CDD:238011
EGF_CA 1047..1082 CDD:238011
Laminin_G_1 1155..1290 CDD:278483
EGF 1316..1346 CDD:278437
Laminin_G_1 1388..1550 CDD:278483
EGF_CA <1593..1622 CDD:238011
Laminin_G_2 1692..1828 CDD:280389
EGF_CA 1901..1937 CDD:238011
EGF_CA 1939..1974 CDD:238011
EGF_CA 2057..2094 CDD:238011
EGF_CA 2096..2133 CDD:238011
EGF_CA 2137..2175 CDD:238011
DLL3NP_058637.1 MNNL 27..84 CDD:284966
DSL 158..248 CDD:302925 26/83 (31%)
EGF_CA 279..310 CDD:238011 11/32 (34%)
EGF 316..349 CDD:278437 13/32 (41%)
EGF_CA 354..389 CDD:238011 12/34 (35%)
EGF_CA 391..426 CDD:238011 16/35 (46%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 546..566
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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