DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment crb and svep1

DIOPT Version :9

Sequence 1:NP_001247284.1 Gene:crb / 42896 FlyBaseID:FBgn0259685 Length:2253 Species:Drosophila melanogaster
Sequence 2:XP_012808841.2 Gene:svep1 / 100493788 XenbaseID:XB-GENE-5996067 Length:3695 Species:Xenopus tropicalis


Alignment Length:2741 Identity:544/2741 - (19%)
Similarity:807/2741 - (29%) Gaps:1122/2741 - (40%)


- Green bases have known domain annotations that are detailed below.


  Fly   267 NFCLNDPCMGHGTCSSSPEGYECRCTARYSGKNCQKDNGSPCAKNPCENGGSCLENSRGDYQCFC 331
            |.||.:||...|||:....||.|.|...|:|..|:.:. :.|:..||.|.|.|::.. |::.|.|
 Frog  1198 NECLLNPCQNSGTCTQIGSGYICSCIKGYTGAKCENEI-NECSSIPCRNNGICIDRV-GEFDCQC 1260

  Fly   332 DPNHSGQHCETEVNIHPLCQTNPCLNNGACVVIGGSGALTCECPKGYAGARCEVDTDECASQPCQ 396
            ....||..||..:|   .|.:|||||...|  |.|..|..|.|..|:.|.|||::.|||.|:||.
 Frog  1261 LSGFSGTLCEENIN---ECSSNPCLNEAIC--IDGINAFYCRCANGFLGPRCEIEIDECLSRPCL 1320

  Fly   397 NNGSCIDRINGFSCDCSGTGYTGAFCQTNVDECDKNPCLNGGRCFDTYGWYTCQCLDGWGGEICD 461
            |||.|.|...||.|.|. .||||..|:.::|||...||.||..|.|....:.|||.:|:.|::|:
 Frog  1321 NNGVCDDLKAGFQCLCP-AGYTGKVCEKDIDECLSGPCKNGASCTDGINSFRCQCPEGFTGQVCE 1384

  Fly   462 RPM-TCQTQQCLNGGTCLDKPIGFQCLCPPEYTGELCQIAPSCAQQCP----IDSECVGGKCVCK 521
            ..: .|.:..|||..||:|....:.|.|.|.|:|..|:      .:.|    :|.|.        
 Frog  1385 INVDDCVSNPCLNNATCVDGLNSYICKCQPGYSGIRCE------TEQPFGFNLDFEV-------- 1435

  Fly   522 PGSSGPIGHCLPTTTTPTPE--------QEPTTTPRTTP------------------NPNPAIPN 560
               ||..|:.|.....||..        :...||...||                  |......|
 Frog  1436 ---SGIYGYVLLDNVMPTLSAITCAFWMRSSDTTNYGTPISYALDNGSDNAFLLTDYNGWVLYIN 1497

  Fly   561 TLTTTTKIPPITTSR------TLV-------------------GTTTGSRRPPQQPL---QSPTQ 597
            .....|..|.:..::      |..                   |.:.|...|....|   |...|
 Frog  1498 GKEKITDCPSVNDAKWHHIAVTWTNTDGSWKVYIDGKQSDGGKGLSVGESIPGGGALVLAQEQDQ 1562

  Fly   598 RSASLN-----------------------------ACPQENCLNGGTCLGYS------------G 621
            |....|                             :||.|  |..|..|.::            .
 Frog  1563 RGEGFNPAESFVGSLSQLNIWDHPLTPAQIKSLAISCPVE--LQKGNVLAWADFLPGVVGRVKVD 1625

  Fly   622 NYSCICASGYTGYNCQTSTGDGASALALTPINCNATNGKCLNGGTCSMNGTHCYCAVGYS----- 681
            :.|..||      :|        .||..|..:.:||......|...|:     :|..|:.     
 Frog  1626 HKSKFCA------DC--------PALEGTSPHLHATKSDHKPGSKISL-----FCNPGFQIVGKP 1671

  Fly   682 -------GDRCEKAENCSPLNCQEPMVCVQNQCLCPENKVCNQCATQPCQNGGECVDLPNGDYEC 739
                   |:..:...:|..::|.:| ..::|.....|:.......|..|..|...:    ||...
 Frog  1672 ERQCLNLGEWDQPLPHCERISCGKP-PRLENGFYNAEDLFAGSTVTYQCNIGYYLL----GDSRM 1731

  Fly   740 KCT--RGWTG--RTCGNDVDECTLHPKICGNGICKNEKGSYKCYCTPGFTG--------VHCDS- 791
            .||  ..|.|  .:| .|||||.:......:..|.|..|||.|.|.|.:.|        |.|.. 
 Frog  1732 FCTDNGSWNGISPSC-LDVDECEIGSDCDEHASCMNTNGSYICTCIPPYHGDGKKCLEPVKCKDP 1795

  Fly   792 -------------DVDECLSFPCLNGATCHNKINAYECVCQPGYEGEN----CEVDIDECGSNPC 839
                         .|...|.|.|..|   ::.|...:..|....|.::    |:.  ..||..|.
 Frog  1796 GEIENGNYSGNHFGVGSQLMFSCHEG---YDLIGLVKVTCLESGEWDDALPYCQA--VSCGKVPA 1855

  Fly   840 SNGSTCIDRINNFT--------CN------------------------------C---------- 856
            .|....:.  :|||        ||                              |          
 Frog  1856 PNNGEILG--SNFTFGEIVTFRCNEGYTLIGNEETVCLANRSWSHALPTCESVTCSKPKEIENGI 1918

  Fly   857 --IPGMTGR-------------------ICD-----------IDIDDCVGDPCLNGGQCIDQLGG 889
              :.|:|..                   ||:           .|:..|...|.:...   |..|.
 Frog  1919 FSLSGLTFNSTASYACKTGYSLQGPATLICEASGNWSSEVPSCDLVSCGPPPLVRDA---DATGD 1980

  Fly   890 ---------FRC------------DCSGTGYEGENCELNIDECLSNPCTNGAKCLDRVKDY---- 929
                     ::|            :||.:|...|    :|.:|::..|......     ||    
 Frog  1981 NYTYSNIITYKCKEGYTLVGPDTINCSSSGKWSE----HIPQCMAVSCDEPPNV-----DYASSH 2036

  Fly   930 -----FCD-----CHNGYKGKNCEQDINECESNPCQYNG----NCL----ERSNITLYQMSRITD 976
                 |.|     |.:||...:..|.:...|.|....:|    ||:    ||.:...:.:....:
 Frog  2037 SSHRLFGDTAYYYCSDGYSMVDNAQMLCNTEGNWVPPDGKEIPNCIADFCERPSSVAHSILESVN 2101

  Fly   977 LPK-VFSQPFSFENASGY--------ECV----CVPGIIGKNCEININECDSNPCSKHG---NCN 1025
            ..| |.....||:...|:        |||    .:|..:...| |.: .|...|..|:|   ..|
 Frog  2102 KAKFVSGSTVSFKCMEGFVLNTTARIECVRGGQWIPSSLTIQC-IPV-RCGEPPSIKNGYVSGTN 2164

  Fly  1026 DGIGTYTC-ECEPGF-----EGTHCEINIDECDRYNPCQRGTC------------------YDQI 1066
            ...|:... .|:.|:     :...|..:.:...|...|..|:|                  |:..
 Frog  2165 YSFGSVVAYSCDKGYYIKGEKKRTCLASGEWSGRLPACHPGSCDDPPKLENGFVKSKTGLLYESK 2229

  Fly  1067 DDYDCD------------CDAN---YGGKNCSVLLKGCDQNPCLNGGACLPYLINEVTHLYNCTC 1116
            ..|.|:            |..|   |.....:.:|..|::.|.:..|:...... ||.......|
 Frog  2230 VIYACNPGYKLVGSNVRVCQLNRHWYSESPPTCVLLTCEKPPPVKYGSMKGENF-EVGSKVEFFC 2293

  Fly  1117 ENGFQ--GDKCEKTTTLSMVATSLISVTTEREEGYDINLQFRTTLPNGVLAFGTTGEKNEPVSY- 1178
            |:|::  ||               :|.|.::...:| ..|..|.:|:         :..:|..| 
 Frog  2294 EDGYELSGD---------------LSWTCQKNGEWD-KKQTPTCMPS---------KCQDPPLYE 2333

  Fly  1179 ----ILELIN--GRLNLHSSLLNKWEGVFIGSKLNDSNWHKVFVAINTSHLVLSANDEQAIFPVG 1237
                :.|:.|  |.:.......:..||..:...|....|:..|...            :.:|...
 Frog  2334 NHLVLKEVPNEVGIVRFSCKEGHVLEGSSVLKCLPSQQWNDSFPLC------------KLVFCSS 2386

  Fly  1238 SYETANNSQPSFPRTYLGGTI----------------------------PNLKSY---------- 1264
            ..|.|.....|.|..|.|.|:                            ||....          
 Frog  2387 PPELAYGEPISVPSLYFGSTVKYTCVDGFLLKGESVITCNASGMWSPDFPNCSPIECPQPEEILN 2451

  Fly  1265 ----LRHLTHQPSAFVGCMQDI---------------------------------MVNGKWIFPD 1292
                ::.||...:|...|....                                 ::|||:.|  
 Frog  2452 GIVDVQGLTFLSAALYTCKPGYELIGNSTLICGADGYWQGGKPICKPIKCSKAKEILNGKFSF-- 2514

  Fly  1293 EQDAN----ISYT-----KLE--NVQSGCPRTEQCKPNP-------CH-----SNG--ECTDLWH 1332
             |..|    |:||     :||  ||.: |..|.:...||       |.     .||  |..|..:
 Frog  2515 -QSLNYGQTITYTCNRGFRLEGQNVLT-CLETGEWNSNPPICKEITCDPPQGIDNGFVEGADYSY 2577

  Fly  1333 ----TFACHCPRPFFG------HTCQHNMTAAT----------------FGHENTTHSAVIVETT 1371
                .|:|   .|.|.      .||:.:..:::                ||..........:.|.
 Frog  2578 GAMIIFSC---MPGFQLVGLAMQTCEESGWSSSTPVCLHTDCGLPPHIDFGQYTIVTFEEKILTD 2639

  Fly  1372 DVARRAIRSILDISMFIRTREPTGQVFYLGTDPRKAPTKNIGD-SYVAAKLHGGELLVKMQFSGT 1435
            |..:.:|..:.:|.:     .||       |......|:|..: |.::..|:|..::        
 Frog  2640 DELKHSIFGVSNIIL-----SPT-------TTSNTLKTENHSENSQLSEYLYGTNVI-------- 2684

  Fly  1436 PEAYTVGGQKLDNGYNHLIEVVRNQTLVQVKLNGTEYFRKTLSTTGLLDAQVLYLGGPAPTRESL 1500
                    ...:|||.     :...:::..|.:||                   ..|.||     
 Frog  2685 --------YSCNNGYE-----ILGMSVLTCKEDGT-------------------WNGSAP----- 2712

  Fly  1501 LGATTEPGIIPVPGAGIPIEDTTVPKEADDSRDYFKGIIQDVKVSNGSLNLIVEMYSLNV--TDV 1563
                          |..||| .::|.:.:                ||.::     |:.|.  :.|
 Frog  2713 --------------ACAPIE-CSIPTDPE----------------NGVMH-----YTDNTIGSSV 2741

  Fly  1564 QVNAKPLGAVTIDRASVLPGEVSDDLCRKNPCLHNAECRNTWND-------YTCKCPN----GYK 1617
            ....||        ...|.|  ||    |:.||.|.:    ||:       .:||.||    ||.
 Frog  2742 HFECKP--------GYELNG--SD----KSICLANKQ----WNNEIPKCVIISCKTPNKILHGYT 2788

  Fly  1618 GKNCQEIEFCQHVTCPGQSLCQNLDDGYE--------CVTNTTFTGQE---------RSPLAFFY 1665
            ..:........|..|         |.||:        |..:..:.|:|         :.|:..  
 Frog  2789 EVSNYTYMSVIHYKC---------DKGYQIYGLSQRTCQISKQWDGEEPICVPVSCGQPPMVI-- 2842

  Fly  1666 FQEQQSDDIVSEASPKQTLKPVIDIAFRTRAGGTLLYIDNVDGFFEIG----------------- 1713
                ....|.:|.:..:|::.|.:..:|       ||.:.:....|.|                 
 Frog  2843 ----NGKVIGNEYTFSKTIEYVCNEGYR-------LYGEEIRTCLENGNWSGTTPSCLAITCKIS 2896

  Fly  1714 --VNGGRVTITW---------------------KLSALHFGESARFEKENTDGEW---------- 1745
              ||.|.||.|.                     ||:.|:            ||.|          
 Frog  2897 TTVNNGEVTGTECGVGKEILYRCNHGYKMQGTPKLTCLN------------DGTWNSNAPLCEPI 2949

  Fly  1746 --------SRIYLRAHNSK------------------------LEGGWKGWESMVDPTPAFSTDI 1778
                    |..||.:.|.|                        ..|.|.|     .|......:.
 Frog  2950 HCEPPEDISNGYLNSSNFKYNEYIHYVCFPGYEMHGSSTRQCLANGAWSG-----SPPTCLPCEC 3009

  Fly  1779 DQAAFQSLIATSTQVYLGGMPESRQARG------STLSAQQ----GSQFKGCVGEARVGDLLLPY 1833
            .....|:.|.:......|.....:...|      |.|:.|.    .|.|..| |:...|    |.
 Frog  3010 PTPVVQNGIMSGDDFTCGHSVSIKCREGFKLLGSSELTCQSAGKWSSGFPHC-GKVPCG----PP 3069

  Fly  1834 FSMAELYSRTNVSVQQKAQFRLNATRPEEGCILCFQSD--CKNDGFCQSP--------------- 1881
            .|:...:...:.|..:.| .|.|..   .|.|:..:|:  |..:|....|               
 Frog  3070 PSIPNAFINGSSSTDEDA-IRYNCV---AGYIMQGKSELLCTKEGVWSKPYPNCQLLSCGLPPSV 3130

  Fly  1882 ------SDEYA------CTCQPGF--------------------------------------EGD 1896
                  :|.|.      ..||.|:                                      :.|
 Frog  3131 LNAVLIADSYTYGSTANYRCQDGYVMHQDVSSKTCLEDGSWSPGDIVCVPKKCLLQSTLIQIKND 3195

  Fly  1897 DCGTDIDECL--------------NTECLNNGTCINQVAAFFC---------------------- 1925
            :...||::.:              .:.|:|:|..|.:|....|                      
 Frog  3196 ETEYDINKTITIVCKEGYTLTGPSTSTCMNDGNWIPEVNNNICTPVSCGEPAAPEHGIVLGTRYL 3260

  Fly  1926 -------QCQPGFE-----GQHCEQN------IDECADQPCH------NG-----GNCTDLIASY 1961
                   ||..|||     .:.|:.|      ..:|....||      ||     |...:....|
 Frog  3261 FKDSVLYQCNAGFEIHGPTERVCQINGLWSDVEPQCKKISCHPPEPLENGVIHGAGYLFEDELHY 3325

  Fly  1962 VCDCPEDYMGPQ---CDVLKQM-----TCENEPCRNGSTCQNGFNASTGN----NFTCTCVPGFE 2014
            .|:...:..||.   |.:.||.     ||.:..|.:....:|....||||    |.|.||..|:.
 Frog  3326 SCNHGFELNGPSRRICHIDKQWIPPPPTCVSVTCDSLPYIENAVYTSTGNTYTHNITFTCNFGYH 3390

  Fly  2015 --GP---LC--------DIPFCEITPC------DNGGL---CLTTGAVPMCKCSLGYTGRLCEQD 2057
              ||   .|        .:|.|:.|.|      :||..   .:|.|:....:|..|||  |..:|
 Frog  3391 LVGPPHVRCLVNGTWSKPLPQCKETRCEVPQQPENGHAEYENVTVGSTVRYQCQNGYT--LEGED 3453

  Fly  2058 INE-------------CESNPC-------QNG---------GQ-----CK---DLVGR--YECDC 2083
            :.|             |::|||       :|.         ||     |:   .|.|:  ..|:.
 Frog  3454 LAECTTNGTWSHPVPICKANPCPVPFVIPENAILTETDFYVGQKVSIKCRKGYQLQGQAVITCNA 3518

  Fly  2084 QGTGFE-GIRCENDIDECNMEGDYCGGLGR-------------CFN---KPGSFQCICQK----- 2126
            ..|..: .::||.  ..|........|:.|             |::   ..|||:.:|.:     
 Frog  3519 DETWTDANVKCEK--ISCGPPHTIQNGILRGMYHQFGDVVTYSCYSGYMLLGSFRSVCLENGTWT 3581

  Fly  2127 --PYCGAYCNFTDPC---------NATDL-----------------CSNGGRCVESCGAKPDYYC 2163
              |.|.|.|.|  ||         ||...                 |.|||||.      ..:.|
 Frog  3582 APPSCKAVCRF--PCQNGGVCERPNACSCPKGWMGRLCEEPICPLPCLNGGRCT------APFRC 3638

  Fly  2164 ECPEGFAGKNC 2174
            |||.|:.|..|
 Frog  3639 ECPNGWTGSRC 3649

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
crbNP_001247284.1 LamG 91..228 CDD:238058
EGF_CA 386..423 CDD:238011 19/36 (53%)
EGF_CA 425..460 CDD:238011 14/34 (41%)
EGF 466..495 CDD:278437 11/28 (39%)
EGF 605..633 CDD:278437 9/39 (23%)
EGF_CA 716..750 CDD:238011 9/37 (24%)
EGF_CA 753..789 CDD:238011 15/43 (35%)
EGF_CA 792..828 CDD:238011 8/39 (21%)
EGF_CA 830..865 CDD:238011 12/103 (12%)
EGF_CA 868..905 CDD:238011 10/57 (18%)
EGF_CA 907..943 CDD:238011 10/49 (20%)
EGF_CA 1009..1045 CDD:238011 8/44 (18%)
EGF_CA 1047..1082 CDD:238011 10/67 (15%)
Laminin_G_1 1155..1290 CDD:278483 29/216 (13%)
EGF 1316..1346 CDD:278437 11/53 (21%)
Laminin_G_1 1388..1550 CDD:278483 24/162 (15%)
EGF_CA <1593..1622 CDD:238011 11/39 (28%)
Laminin_G_2 1692..1828 CDD:280389 37/227 (16%)
EGF_CA 1901..1937 CDD:238011 13/83 (16%)
EGF_CA 1939..1974 CDD:238011 11/54 (20%)
EGF_CA 2057..2094 CDD:238011 14/76 (18%)
EGF_CA 2096..2133 CDD:238011 11/59 (19%)
EGF_CA 2137..2175 CDD:238011 17/64 (27%)
svep1XP_012808841.2 vWFA_subfamily_ECM 74..236 CDD:238727
Ephrin_rec_like 302..352 CDD:311571
PHA02927 <365..550 CDD:222943
CCP 430..486 CDD:153056
HYR 552..634 CDD:367105
DUF5011 646..716 CDD:383419
Ephrin_rec_like 1008..1055 CDD:311571
Ephrin_rec_like 1062..1109 CDD:311571
Ephrin_rec_like 1116..1163 CDD:311571
EGF_CA 1198..1232 CDD:238011 14/33 (42%)
EGF_CA 1235..1270 CDD:238011 11/36 (31%)
EGF_CA 1272..1308 CDD:238011 16/40 (40%)
EGF_CA 1311..1346 CDD:238011 19/35 (54%)
EGF_CA 1348..1384 CDD:238011 14/35 (40%)
EGF_CA 1386..1422 CDD:238011 12/35 (34%)
LamG 1422..1625 CDD:389952 32/221 (14%)
Sushi 1631..1688 CDD:365861 13/75 (17%)
CCP 1693..1746 CDD:214478 13/57 (23%)
EGF_CA 1748..1786 CDD:214542 14/37 (38%)
PHA02927 <1791..1961 CDD:222943 24/176 (14%)
PHA02639 1904..>2082 CDD:165022 30/189 (16%)
PHA02927 2081..2322 CDD:222943 49/259 (19%)
PHA02817 2321..>2439 CDD:165167 21/138 (15%)
PHA02927 2404..2612 CDD:222943 36/214 (17%)
PHA02927 2518..2773 CDD:222943 68/369 (18%)
CCP 2777..2830 CDD:214478 14/61 (23%)
PHA02927 2830..3061 CDD:222943 40/260 (15%)
CCP 3066..3119 CDD:214478 13/60 (22%)
PHA02927 3119..3355 CDD:222943 35/235 (15%)
PHA02927 3257..3470 CDD:222943 51/214 (24%)
PHA02927 3366..3586 CDD:222943 51/223 (23%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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