DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment crb and ltbp4

DIOPT Version :9

Sequence 1:NP_001247284.1 Gene:crb / 42896 FlyBaseID:FBgn0259685 Length:2253 Species:Drosophila melanogaster
Sequence 2:XP_031747134.1 Gene:ltbp4 / 100488208 XenbaseID:XB-GENE-992148 Length:1805 Species:Xenopus tropicalis


Alignment Length:2230 Identity:432/2230 - (19%)
Similarity:622/2230 - (27%) Gaps:1097/2230 - (49%)


- Green bases have known domain annotations that are detailed below.


  Fly   313 CENGGSCLENSRGDYQCFCDPNHSGQHC------------------------------------- 340
            |:|||.||:..:    |.|.||.:|:.|                                     
 Frog   286 CQNGGVCLKKDK----CLCPPNFTGKFCQIPISTDGGNIKQDHKNSSVEQNTMTKSVHTLLLSNY 346

  Fly   341 -------------------ETEVNIH---------------------------PL----CQTNPC 355
                               |..||||                           ||    .|::|.
 Frog   347 HPEKDGAASVVKVHVEHPPEASVNIHQVERIDGQSGDRARNGIQNHEQLGARIPLYGVQAQSSPR 411

  Fly   356 LN----------------NGAC------------------VVIGGSGALTCECPKGYAGARCEVD 386
            :|                ||.|                  |..|......|...:|...:...:|
 Frog   412 INGYTENSGFGYCFRRLENGQCASPIPGLRTQEVCCRSSGVAWGVHDCTPCNGHQGDVLSASVID 476

  Fly   387 TDECASQPCQN-----NGSCIDRINGFSCDCSGTGYTGAFCQTNVDEC-DKNPCLNGGRCFDTYG 445
            |      ||..     ||:|||                      :||| |...|:||. |.:|.|
 Frog   477 T------PCPKGFERINGTCID----------------------IDECTDSTLCVNGD-CTNTRG 512

  Fly   446 WYTCQCLDGWGGEICDRP-MTCQTQ-----------QCLNGGTC-----------------LDKP 481
            .|||.|.:|:   :.|.. .:|.:.           :.|..|.|                 :.|.
 Frog   513 SYTCMCREGY---LLDSSRSSCISHHVISEVKGPCFRILRDGKCSLPILRNITKQICCCSRVGKA 574

  Fly   482 IGFQC-LCPP---EYTGELCQIAPS---CAQQCPIDSECVGGKCVCKPGSSGPIGHCLP-TTTTP 538
            .|..| .|||   |...|.|...|.   .|....|::..||......|....|.....| ||.:|
 Frog   575 WGKGCEQCPPFGTEGFKETCPAGPGYHYSASDLRINTRYVGQDQARVPLLRQPASRGFPFTTASP 639

  Fly   539 ---------TPEQEPTTTPRTTPNPNPAIPNTLTTTTKIPPITTSRTLVGTTTGSRRPPQQPL-- 592
                     |.|::.........:||..:|:.       .|::.:|::.|....|..|...|.  
 Frog   640 VYHAVTGHITVERQQDIDQSRISSPNQRVPSR-------EPVSANRSISGPDRVSVLPAPVPTET 697

  Fly   593 --QSPTQRSASLNACPQENCLNGGTCLGYSGNYSCICASGYTGYNCQTSTGDGASALALTPINCN 655
              ::|:|.|:.....||  ....|.|:...|:|:|:|.:||                        
 Frog   698 QKEAPSQESSICELNPQ--ICGPGRCVPRLGSYTCVCNTGY------------------------ 736

  Fly   656 ATNGKCLNGGTCSMNGTHCYCAVGYSGDRCEKAENCSPLNCQEPMVCVQNQCLCPENKVCNQCAT 720
                      ..|..||||     ...|.|.          |.|.:|...:|   ||.|      
 Frog   737 ----------WLSTQGTHC-----IDMDECR----------QRPSLCTNGRC---ENTV------ 767

  Fly   721 QPCQNGGECVDLPNGDYECKCTRGWT----GRTCGNDVDECTLHPKICGNGICKNEKGSYKCYCT 781
                          |.|.|.|:.|::    |..| .|:|||:.....|.||.|:|..|||:|:|:
 Frog   768 --------------GSYRCACSAGFSTNPQGTEC-TDIDECSTDQTPCDNGRCENTPGSYRCFCS 817

  Fly   782 PGFT----GVHCDSDVDECLSFP---CLNGATCHNKINAYECVCQPGY----EGENCEVDIDECG 835
            ||||    |..| .|:|||...|   ||:| .|.|...::.|||..||    :|.:|: |.|||.
 Frog   818 PGFTLNPQGKSC-IDIDECRISPRRFCLSG-RCENTPGSFLCVCPVGYTANPQGTDCQ-DTDECR 879

  Fly   836 SNPCSNGSTCIDRINNFTCNCIPGMTGRICDIDIDDCVGDPCLNGGQCIDQLGGFRCDCSGTGY- 899
            ..|                        |||             ..|:|.:..|.|||.|. .|| 
 Frog   880 QTP------------------------RIC-------------GSGRCQNTPGSFRCSCP-VGYR 906

  Fly   900 ---EGENCELNIDECLSNP--CTNGAKCLDRVKDYFC-DCHNGYKGKN--CEQDINECES-NPCQ 955
               :|..| ::|:|| .||  |. |.:||:....:.| .||:||:.:|  | .|||||:: :.|.
 Frog   907 LTPQGNEC-IDINEC-ENPGACA-GQECLNTPGSFQCRQCHSGYRLQNRRC-VDINECQTDSACG 967

  Fly   956 YNGNCLERSNITLYQMSRITDLPKVFSQPFSFENASG-YECVCVPG--IIGKNCEININEC-DSN 1016
            .:|.|:                           |..| :||.|:||  :..:|...:|||| :.:
 Frog   968 RHGKCI---------------------------NTEGSFECECLPGYHLNDRNRCTDINECLEGD 1005

  Fly  1017 PCSKHGNCNDGIGTYTCECEPGF----EGTHCEINIDECDRYNPCQRGTCYDQIDDYDCDCDANY 1077
            .|...|.|.:..|:|.|.|..|:    :|..| ::.|||.:...||.|.|.:....:.|.|...:
 Frog  1006 FCFPRGECQNTEGSYICVCAEGYVTTPDGASC-VDKDECQQGTLCQGGRCINTQGSFQCQCPTGF 1069

  Fly  1078 GGKNCSVLLKGCDQNPCLNGGACLPYLINEVTHLYNCTCENGFQGDKCEKTTTLSMVATSLISVT 1142
                          ....|..||...                   |:|::.      .|||.   
 Frog  1070 --------------RVTFNKAACTDI-------------------DECQER------GTSLC--- 1092

  Fly  1143 TEREEGYDINLQFRTTLPNGVLAFGTTGEKNEPVSYILELINGRLNLHSSLLNKWEGVFIGSKLN 1207
                                    ||...:|                                  
 Frog  1093 ------------------------GTQSCEN---------------------------------- 1099

  Fly  1208 DSNWHKVFVAINTSHLVLSANDEQAIFPVGSYETANNSQPSFPRTYLGGTIPNLKSYLRHLTHQP 1272
                                       .:|||.........:..|..|                 
 Frog  1100 ---------------------------TLGSYRCIAQCDTGYRLTASG----------------- 1120

  Fly  1273 SAFVGCMQDIMVNGKWIFPDEQDANISYTKLENVQSGCPRTEQCKPNPCHSNGECTDLWHTFACH 1337
                               |.:|.|                |......|..|..|.:|..::.|.
 Frog  1121 -------------------DCEDIN----------------ECANSTICGDNAVCKNLLGSYRCT 1150

  Fly  1338 CPRPFFGHTCQHNMTAATFGHENTTHSAVIVETTDVARRAIRSILDISMFIRTREPTGQVFYLGT 1402
            |                .:|||.::.                                       
 Frog  1151 C----------------NWGHEMSSE--------------------------------------- 1160

  Fly  1403 DPRKAPTKNIGDSYVAAKLHGGELLVKMQFSGTPEAYTVGGQKLDNGYNHLIEVVRNQTLVQVKL 1467
                                                    ||       |.|:|  ::.|     
 Frog  1161 ----------------------------------------GQ-------HCIDV--DECL----- 1171

  Fly  1468 NGTEYFRKTLSTTGLLDAQVLYLGGPAPTRESLLGATTEPGIIPVPGAGIPIEDTTVPKEADDSR 1532
               ||.|....|....:                           .||:...|.|.....:...|.
 Frog  1172 ---EYGRSICGTKRCEN---------------------------TPGSYRCISDCEPGYQLSSSG 1206

  Fly  1533 DYFKGIIQDVKVSNGSLNLIVEMYSLNVTDVQVNAKPLGAVTIDRASVLPGEVSDDLCRKNPCLH 1597
            |                          .||:                       ::...|..|..
 Frog  1207 D--------------------------CTDI-----------------------NECLNKTVCGD 1222

  Fly  1598 NAECRNTWNDYTCKCPNGYKG----KNCQEIEFC---QHVTCPGQSLCQNLDDGYECVTNTTFTG 1655
            :|.|.|....|.|.|..||:|    ::|.::..|   |.| | |.:||:|::..:.|....  :.
 Frog  1223 HAMCHNLAGTYQCLCDQGYEGARGERHCVDVNECLTLQSV-C-GTALCENVEGSFLCTCPN--SK 1283

  Fly  1656 QERSPLAFFYFQEQQSDDIVSEASPKQTLKPVIDIAFRTRAGGTLLYIDNVDGFFEIGVNGGRVT 1720
            :|..|:         |...:...|   |::||:.         :|.....||             
 Frog  1284 EEFDPM---------SGKCIRSNS---TIRPVLP---------SLPSPSQVD------------- 1314

  Fly  1721 ITWKLSALHFGESARFEKENTDGEWSRIYLRAHNSKLEGG---------------WKGWESMVDP 1770
               .|::.|        ||        .|.....|::.|.               .:||....:.
 Frog  1315 ---TLTSGH--------KE--------CYYNLEESEVCGNVLARNVSRDECCCSIGEGWGQNCER 1360

  Fly  1771 TPAFSTDIDQAAFQSLIATSTQVYLGGMPESRQARGSTLSAQQGSQFKGCVGEARV-GDLLLPYF 1834
            .||    ||.|.:|:|...      ||        |.|:| |||.:   .:.|.:: |:.|    
 Frog  1361 CPA----IDTAEYQALCPR------GG--------GYTIS-QQGLK---DINECQIFGNQL---- 1399

  Fly  1835 SMAELYSRTNVSVQQKAQFRLNATRPEEGCILCFQSDCKNDGFCQSPSDEYACTCQPGFEGD--- 1896
                                                 ||. |||.:....::|.|..|:..|   
 Frog  1400 -------------------------------------CKG-GFCLNKIPSFSCYCSNGYYYDVQR 1426

  Fly  1897 -DCGTDIDECLNTECLNNGTCINQVAAFFCQCQPGF----EGQHCEQNIDECADQPCHNGGNC-T 1955
             :| .|.|||...|....|.|||.|.:::|.|.|..    ..:.|..|..:..|:   |...| .
 Frog  1427 LEC-VDNDECHEEELCEGGNCINTVGSYYCTCNPPLVLDSTQRRCVANTSQTIDE---NLSYCWQ 1487

  Fly  1956 DLIASYVCDCPEDYMGPQCDVLKQMTCENEPCRN--------------------GSTCQNGFNAS 2000
            ::.|..:|..|         :|::.|...|.|.:                    .|.|.:.....
 Frog  1488 EIGADMLCKRP---------LLERQTTYTECCCHYGEAWGLHCALCPGRDTDDFESLCIDWRPTD 1543

  Fly  2001 TGNNFTCTCVPG------------------------FEGPLCDI--PFCEITPCDNGGLCLTTGA 2039
            |||       ||                        |..|...|  |..|..|...||  ::.|:
 Frog  1544 TGN-------PGPPQPSLYDYGTEYGGYGVPYGPDAFANPPPRIVRPGYESYPAAPGG--MSFGS 1599

  Fly  2040 VPMCKCSLGYTGR-----------------------------------LCEQDINECESNPCQNG 2069
            .|    ||.|..|                                   ...:|.|...|.| ::.
 Frog  1600 RP----SLPYGPRDSLYSLPPYESPDFDSDIYYPDPSVEEPRNPFRRTDSSRDPNPYPSAP-RSR 1659

  Fly  2070 GQCKDLVGRYECDCQG----------------------------------TGFEGIRCENDIDEC 2100
            .:..|:..|:|.|..|                                  ..|||::.|.     
 Frog  1660 SRSTDISSRFEVDAGGRRVQPRRPGSRDPGSVSSISSWRGDPREAFDDRYEQFEGLQAEE----- 1719

  Fly  2101 NMEGDYCGGL-----GRCFNKPGSFQCICQKPYCGAYCNFT-------DPCNATD----LCSNGG 2149
                  ||.|     |||...|..:.|.|   |.|...:.|       :.|:..:    ||.| |
 Frog  1720 ------CGILNGCENGRCIRVPEGYTCDC---YDGYRLDITLMACVDINECDEAEDLSLLCLN-G 1774

  Fly  2150 RCVESCGAKPDYYCECPEGF 2169
            :|..:.|:   |.|.||.|:
 Frog  1775 QCRNTDGS---YECVCPRGY 1791

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
crbNP_001247284.1 LamG 91..228 CDD:238058
EGF_CA 386..423 CDD:238011 9/41 (22%)
EGF_CA 425..460 CDD:238011 15/35 (43%)
EGF 466..495 CDD:278437 11/60 (18%)
EGF 605..633 CDD:278437 10/27 (37%)
EGF_CA 716..750 CDD:238011 6/37 (16%)
EGF_CA 753..789 CDD:238011 19/39 (49%)
EGF_CA 792..828 CDD:238011 16/42 (38%)
EGF_CA 830..865 CDD:238011 6/34 (18%)
EGF_CA 868..905 CDD:238011 10/40 (25%)
EGF_CA 907..943 CDD:238011 15/40 (38%)
EGF_CA 1009..1045 CDD:238011 13/40 (33%)
EGF_CA 1047..1082 CDD:238011 9/34 (26%)
Laminin_G_1 1155..1290 CDD:278483 8/134 (6%)
EGF 1316..1346 CDD:278437 6/29 (21%)
Laminin_G_1 1388..1550 CDD:278483 16/161 (10%)
EGF_CA <1593..1622 CDD:238011 10/32 (31%)
Laminin_G_2 1692..1828 CDD:280389 28/151 (19%)
EGF_CA 1901..1937 CDD:238011 13/39 (33%)
EGF_CA 1939..1974 CDD:238011 7/35 (20%)
EGF_CA 2057..2094 CDD:238011 12/70 (17%)
EGF_CA 2096..2133 CDD:238011 11/41 (27%)
EGF_CA 2137..2175 CDD:238011 12/37 (32%)
ltbp4XP_031747134.1 EGF_CA 492..>522 CDD:214542 15/52 (29%)
TB 553..595 CDD:395554 9/41 (22%)
cEGF 727..750 CDD:403760 10/61 (16%)
EGF_CA 747..787 CDD:311536 15/72 (21%)
EGF_CA 789..830 CDD:214542 20/41 (49%)
EGF_CA 831..872 CDD:311536 16/41 (39%)
EGF_CA 874..914 CDD:311536 18/77 (23%)
EGF_CA 916..955 CDD:214542 16/41 (39%)
EGF_CA 956..996 CDD:214542 16/66 (24%)
EGF_CA 997..1038 CDD:214542 14/41 (34%)
EGF_CA 1039..1070 CDD:214542 9/44 (20%)
EGF_CA 1124..1165 CDD:238011 15/158 (9%)
EGF_CA 1210..1245 CDD:238011 12/57 (21%)
TB 1333..1374 CDD:395554 10/44 (23%)
EGF_CA 1431..>1459 CDD:214542 12/27 (44%)
TB 1495..1536 CDD:395554 7/49 (14%)
PHA03247 <1543..1695 CDD:223021 28/165 (17%)
EGF_CA 1757..1796 CDD:214542 12/39 (31%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 52 1.000 Domainoid score I11238
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.000

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