DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment crb and crb2

DIOPT Version :9

Sequence 1:NP_001247284.1 Gene:crb / 42896 FlyBaseID:FBgn0259685 Length:2253 Species:Drosophila melanogaster
Sequence 2:XP_002937280.2 Gene:crb2 / 100487355 XenbaseID:XB-GENE-989701 Length:1456 Species:Xenopus tropicalis


Alignment Length:1899 Identity:566/1899 - (29%)
Similarity:787/1899 - (41%) Gaps:583/1899 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   465 TCQTQQCLNGGTCLDKPIGFQCLCPPE---YTGELC-QIAPSCA-QQCPIDSECVGG------KC 518
            ||.:..|||||||.:...||.||||.|   :||..| .:..:|| .:||....|...      :|
 Frog    31 TCVSSPCLNGGTCQETASGFTCLCPAEPLAFTGTTCGDLYDACAIDRCPSTHSCQSTPGHPHFQC 95

  Fly   519 VCKPGSSGPIGHCLPTTTTPTPEQEPTTTPRTTPNPNPAIPNTLTTTTKIPPITTSRTLVGTTTG 583
            ||:||                                      |..|.:                
 Frog    96 VCQPG--------------------------------------LNCTNE---------------- 106

  Fly   584 SRRPPQQPLQSPTQRSASLNACPQEN--CLNGGTCLGYSGNYSCICASGYTGYNCQTSTGDGASA 646
                        .||    |:||.:|  |..|      ..::.|.|.|||.|.:|....      
 Frog   107 ------------CQR----NSCPFQNFQCTVG------EDSFMCKCQSGYGGVDCNFEV------ 143

  Fly   647 LALTPINCNATNGKCLNGGTCSMNGTHCYCAVGYSGDRCEKAENCSPLNCQEPMVCVQNQCLCPE 711
                                                         ||        |.||      
 Frog   144 ---------------------------------------------SP--------CFQN------ 149

  Fly   712 NKVCNQCATQPCQNGGECVDLPNGD-YECKCTRGWTGRTCGNDVDECTLHPKICGN-GICKNEKG 774
                      ||||...|  |..|| :.|.|..|:||:.|..:|:||..:|  |.| .:|.::..
 Frog   150 ----------PCQNNATC--LAEGDSFRCVCEPGFTGQECEVNVNECASNP--CQNEALCVDKVD 200

  Fly   775 SYKCYCTPGFTGVHCDSDVDECLSFPCLNGATCHNKINAYECVCQPGYEGENCEVDIDECGSNPC 839
            .|.|:|.|||.|.||:.|::||.|.||.|..||.|:::.|||.|..||.|.|||::||||.|.||
 Frog   201 RYMCFCVPGFQGHHCEIDINECASRPCQNNGTCMNQLDQYECACANGYTGINCEMEIDECQSVPC 265

  Fly   840 SNGSTCIDRINNFTCNCIPGMTGRICDIDIDDCVGDPCLNGGQCIDQLGGFRCDCSGTGYEGENC 904
            .||:||.|.|..|||:|..|..|..|..|||:|...||.|||||:|::..||||||.||:.|..|
 Frog   266 QNGATCRDHIGYFTCDCPAGYDGEQCQHDIDECQSQPCQNGGQCMDEINRFRCDCSNTGFVGGRC 330

  Fly   905 ELNIDECLSNPCTNGAKCLDRVKDYFCDCHNGYKGKNCEQDINECESNPCQYNGNCLERSNITLY 969
            |:.|.||.||||.|...|::||..|.|.|..||.|.:||.|.|||...||...|.|||.||.:.|
 Frog   331 EVEILECDSNPCQNNGTCMERVNGYECLCWKGYSGIHCEIDDNECFEEPCVNGGLCLELSNQSYY 395

  Fly   970 QMSRITDLPKVFSQP----FSFENASGYECVCVPGIIGKNCEININECDSNPCSKHGNCNDGIGT 1030
            .           ::|    ||:..|:||.|.|..|..|.||.:||:||:|.||...|.|.|.|..
 Frog   396 G-----------TEPEFNKFSYSQAAGYLCRCQQGFTGPNCSVNIDECESWPCLNGGTCTDLING 449

  Fly  1031 YTCECEPGFEGTHCEINIDECDRYNPCQRG-TCYDQIDDYDCDC-----DAN-YGGKNCSVLLKG 1088
            :.|.|..|:.|..|.|||||| :.:||:.| :|.|.:.||.|.|     |.. :|||||||:|.|
 Frog   450 FLCNCASGYTGFDCSINIDEC-KDSPCKNGASCEDGVADYSCICPPAAQDGTVWGGKNCSVMLIG 513

  Fly  1089 CDQNPCLNGGACLPYLINEVTHLYNCTCENGFQGDKCEKTTTLSMVATSLISVTTE-REEGYDIN 1152
            |.::.|.|...|:| |....:|.|.|.|:.||.|:.|...||.|.::...:...:. ..|.|..|
 Frog   514 CLEHSCQNAAECIP-LYTGQSHSYTCKCQPGFVGNNCSTPTTFSFLSQGYLMYDSPLSNESYQSN 577

  Fly  1153 L--QFRTTLPNGVLAFGTTGEKNEPVSYI-LELINGRLNLHSSLLNKWEG-----VFIGSKLNDS 1209
            :  :||||||:.||.:     :.:..|:: ||:.||.|::..    |..|     |....|:||.
 Frog   578 MSVRFRTTLPDMVLMY-----RGDEDSFLALEIYNGFLHMRL----KGNGRLFPLVIDDYKVNDG 633

  Fly  1210 NWHKVFV-AINTSHLVLSA--ND------EQAIFPVGSYETANNSQP----SFPRTYLGGTIPNL 1261
            :||.|.| .::.|.|.:|.  ||      .|...|...::      |    ||...|:||.|.  
 Frog   634 HWHNVEVDLLSNSFLKISLFHNDCRNGLCSQKQTPTEGFD------PYLPESFRSLYIGGLIQ-- 690

  Fly  1262 KSYLRHLTHQPSAFVGCMQDIMVNGKWIFPDEQDANISYTKLENVQSGCPRTEQCKPNPCHSNGE 1326
            :|.:::...|.: |.||::|::|:.....|.    |:|..:...:..||.:.|.|.|||||:...
 Frog   691 ESLIKNTLSQQN-FTGCLEDLVVDLVTQLPH----NVSSDRSFGMVLGCKKAEVCHPNPCHNGAN 750

  Fly  1327 CTDLWHTFACHCPRPFFGHTCQHNMTAATFGHENTTHSAVIVETTDVARRAIRSILDISMFIRTR 1391
            |.|||.:|.|.|.|||.|.||.....|.||..|.....:......|..     :..:||.||||.
 Frog   751 CIDLWSSFTCECIRPFKGSTCMQEYIAGTFFREGIPSHSYFELNQDFG-----TSFNISAFIRTL 810

  Fly  1392 EPTGQVFYLGTDPRKAPTKNIGDSYVAAKLHGGELLVKMQFSGTPEAYTVGGQKLDNGYNHLIEV 1456
            :..|                              ||:::.:..||...|.    |:|.:.| ||.
 Frog   811 KSNG------------------------------LLLQISYGTTPYFRTY----LNNSWIH-IET 840

  Fly  1457 VRNQTLVQVK--LNGTEYF------RKTLSTTGLLDAQVLYLGGPAPTRESLLGATTEPGIIPVP 1513
            :..|.||..|  .:|.::|      ...::.|.|  .|.:|||        :|     |.:|...
 Frog   841 LSAQPLVFKKNVSDGMKHFISISVREGNVTVTDL--QQEVYLG--------ML-----PPVIITK 890

  Fly  1514 G-----AGIPIEDTTVPKEADDSRDYFKGIIQDVKVSNGSL--------NLIVEMYSLNVTDVQV 1565
            |     .|:...|:|:     ....||||.:||::::|..|        |:...:|..|.|:|..
 Frog   891 GDAVHVGGLATADSTI-----FWGGYFKGCVQDLRINNDHLEFFHPEHINVQETLYFGNNTNVTE 950

  Fly  1566 NAKPLGAVTIDRASVLPGEVSDDLCRKNPCLHNAECRNTWNDYTCKCPNGYKGKNCQEIEFCQHV 1630
            |.                 :|||:|.:.||.:...|..||||:.|.||..:.||.|:|..:|:..
 Frog   951 NC-----------------ISDDVCHQGPCRNEGNCSVTWNDFVCSCPANFTGKRCEEPVWCRRS 998

  Fly  1631 TCPGQSLCQNLDDGYECVTNTTFTGQERSPLAFFYFQEQQSDDIVSEASPKQTLKPVIDIAFRTR 1695
            .|...|.|.::..|:.|:.|.:|.|...:...          .|:||.....:    |.:|||||
 Frog   999 PCLPGSTCVDVPKGFVCLANVSFQGHSSAVFT----------PIISEEHNLTS----ISLAFRTR 1049

  Fly  1696 -------------------AGGTLLYID-----NVDGFFEIGVNGGRVTITWKLSALHFGESARF 1736
                               ..|..|::|     ||||   :.:||   ||               
 Frog  1050 DRDAVLLQSSKNVDSVLIEIQGGYLFVDLQSGNNVDG---VQLNG---TI--------------- 1093

  Fly  1737 EKENTDGEWSRIYLRAHN-SKLEGGWKGWESMVDPTPAFSTDID-QAAFQ------SLIATSTQV 1793
              :..|..|.|:.:.... :|:...|           .|..|.. |..||      :.:..:..:
 Frog  1094 --DVADAIWHRVVITMERATKVNSHW-----------TFQLDDSVQKKFQWEGDNLNFMRNNISI 1145

  Fly  1794 YLGGMPESRQARGSTLSAQQGSQFKGCVGEARVGDLLLPYFSMAELYSRTNVSVQQKAQFRLNAT 1858
            .|        |.|.|          ||:|:..:|.:.||:         |:..:.|:.||...:.
 Frog  1146 VL--------AEGYT----------GCLGDVSIGGIYLPF---------TDHVLPQQDQFIRKSD 1183

  Fly  1859 RPEEGC---ILCFQSDCKNDGFCQSPSDEYACTCQPGFEGDDCGTDIDECLNTECLNNGTCINQV 1920
            ..|.||   .:|.:|.|.:.|.||...:.::|||:.|:.|..|..:||:|.::.|| :|.||:..
 Frog  1184 ALELGCRGADVCSESPCLHGGTCQDLFNSFSCTCRIGWNGHRCEINIDDCKSSPCL-HGFCIDLE 1247

  Fly  1921 AAFFCQCQPGFEGQHCEQNIDECADQPCHNGGNCTDLIASYVCDCPEDYMGPQCDVLKQMTCENE 1985
            |.:.|.|:.|:..::||.||::|....|.|||.|.|.:.:|.|.||.:|.|..|    |.....|
 Frog  1248 ADYQCSCEAGYTSRNCEININDCQHHQCLNGGTCVDGVNNYTCKCPANYAGTFC----QWPFPPE 1308

  Fly  1986 PCRNGSTCQNGFNASTGN-NFTCTCVPGFEGPLCDIPFCEITPCDNGGLCLTTGAVPMCKCSLGY 2049
            .|....||.||...::|. ...|||.|||                                    
 Frog  1309 QCNKNITCFNGGRCNSGIWGANCTCRPGF------------------------------------ 1337

  Fly  2050 TGRLCEQDINECESNPCQNGGQCKDLVGRYECDCQGTGFEGIRCENDIDECNMEGDYCGGLGRCF 2114
            :||.||.::|:||||||.|||.|:|.|..::|.| .:.|.|:|||                    
 Frog  1338 SGRRCEINVNDCESNPCLNGGTCQDSVNTFKCIC-NSSFSGVRCE-------------------- 1381

  Fly  2115 NKPGSFQCICQKPYCGAYCNFTDPCNATDLCSNGGRCVESCGAKPDYYCECPEGFAGKNCTAPIT 2179
                                                                             
 Frog  1382 ----------------------------------------------------------------- 1381

  Fly  2180 AKEDGPSTTDIAI--IVIPVV--VVLLLIAGALLGTFLVM-ARNKRATRGTYSPSAQEYCNPRLE 2239
             |.|..|.....:  :.:||.  |:|||:.|.:   |:|: ||.:|.:.||||||.||....|||
 Frog  1382 -KSDAASMFPFPLVGVAVPVTCGVLLLLVIGVI---FMVLTARKRRQSEGTYSPSQQEVAGARLE 1442

  Fly  2240 MDNVLKPPPEERLI 2253
            ||:|||.|||||||
 Frog  1443 MDSVLKVPPEERLI 1456

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
crbNP_001247284.1 LamG 91..228 CDD:238058
EGF_CA 386..423 CDD:238011
EGF_CA 425..460 CDD:238011
EGF 466..495 CDD:278437 16/31 (52%)
EGF 605..633 CDD:278437 10/29 (34%)
EGF_CA 716..750 CDD:238011 13/34 (38%)
EGF_CA 753..789 CDD:238011 14/36 (39%)
EGF_CA 792..828 CDD:238011 18/35 (51%)
EGF_CA 830..865 CDD:238011 19/34 (56%)
EGF_CA 868..905 CDD:238011 21/36 (58%)
EGF_CA 907..943 CDD:238011 17/35 (49%)
EGF_CA 1009..1045 CDD:238011 15/35 (43%)
EGF_CA 1047..1082 CDD:238011 18/41 (44%)
Laminin_G_1 1155..1290 CDD:278483 45/153 (29%)
EGF 1316..1346 CDD:278437 17/29 (59%)
Laminin_G_1 1388..1550 CDD:278483 41/182 (23%)
EGF_CA <1593..1622 CDD:238011 12/28 (43%)
Laminin_G_2 1692..1828 CDD:280389 32/167 (19%)
EGF_CA 1901..1937 CDD:238011 12/35 (34%)
EGF_CA 1939..1974 CDD:238011 15/34 (44%)
EGF_CA 2057..2094 CDD:238011 18/36 (50%)
EGF_CA 2096..2133 CDD:238011 0/36 (0%)
EGF_CA 2137..2175 CDD:238011 0/37 (0%)
crb2XP_002937280.2 EGF_CA <149..178 CDD:238011 14/46 (30%)
EGF_CA 180..216 CDD:238011 15/37 (41%)
EGF_CA 218..254 CDD:238011 18/35 (51%)
EGF_CA 257..292 CDD:238011 19/34 (56%)
EGF_CA 294..331 CDD:238011 21/36 (58%)
EGF_CA 336..369 CDD:238011 16/32 (50%)
EGF_CA 428..463 CDD:238011 15/34 (44%)
EGF_CA 466..>494 CDD:214542 14/28 (50%)
Laminin_G_2 582..712 CDD:366983 44/147 (30%)
EGF_CA 742..771 CDD:238011 16/28 (57%)
Laminin_G_2 807..921 CDD:366983 39/168 (23%)
EGF_CA <961..990 CDD:238011 12/28 (43%)
Laminin_G_2 1046..1160 CDD:366983 32/165 (19%)
EGF_CA 1196..1227 CDD:238011 10/30 (33%)
EGF_CA 1229..1264 CDD:238011 12/35 (34%)
EGF_CA 1266..1302 CDD:238011 16/39 (41%)
EGF_CA 1345..1381 CDD:238011 18/36 (50%)
Insulin_TMD <1396..1427 CDD:375394 12/33 (36%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 62 1.000 Domainoid score I10176
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 1 1.000 - - H134710
Inparanoid 1 1.050 762 1.000 Inparanoid score I548
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D111153at2759
OrthoFinder 1 1.000 - - FOG0003041
OrthoInspector 1 1.000 - - otm47837
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X4671
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
87.970

Return to query results.
Submit another query.