DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5715 and TLL1

DIOPT Version :9

Sequence 1:	NP_651242.1	Gene:	CG5715 / 42895	FlyBaseID:	FBgn0039180	Length:	295	Species:	Drosophila melanogaster
Sequence 2:	NP_036596.3	Gene:	TLL1 / 7092	HGNCID:	11843	Length:	1013	Species:	Homo sapiens

Alignment Length:	305	Identity:	93/305 - (30%)
Similarity:	142/305 - (46%)	Gaps:	51/305 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 ISLGDSMPLEDMDSQEMIDLTDLGDTLFGNPDVETTGAL------------------VEALGVES 65
            |:|.|    ||::..::....||....|||.. .|||.|                  :..:|...
Human    63 IALDD----EDLNIFQIDRTIDLTQNPFGNLG-HTTGGLGDHAMSKKRGALYQLIDRIRRIGFGL 122

  Fly    66 PLNPEELGTYHEGDILIPLSYRDARFNG--TRNGI-LALSSR----WPGGVVPYEIKGPFTSQEL 123
            ..|....|.       :||     :|:|  .:|.: .|.:||    |||||:||.|.|.||..:.
Human   123 EQNNTVKGK-------VPL-----QFSGQNEKNRVPRAATSRTERIWPGGVIPYVIGGNFTGSQR 175

  Fly   124 GNINHAFKEYHTKTCVRFKPRTTEKDYISIGSGKSGCWSSIGRLG-GRQEVNLQSPNCLRTYGTP 187
            .....|.:.:...|||.|..|:.|:.||.......||.|.:||.| |.|.::: ..||.: :|..
Human   176 AMFKQAMRHWEKHTCVTFIERSDEESYIVFTYRPCGCCSYVGRRGNGPQAISI-GKNCDK-FGIV 238

  Fly   188 IHELMHALGFFHEQNRHERDSYVRVMKDNIKPEMMVNFEKSSSRTQYGFGVEYDYGSVMHYSPTS 252
            :|||.|.:||:||..|.:||::|.::::||:|....||.|.........|..||:.|:|||:..:
Human   239 VHELGHVIGFWHEHTRPDRDNHVTIIRENIQPGQEYNFLKMEPGEVNSLGERYDFDSIMHYARNT 303

  Fly   253 FTRNGQPTLKALRATSDAS----QMGQRKGFSAGDVRKINAMYKC 293
            |:|.  ..|..:..:.|.:    .:|||...|.||:.:...:|:|
Human   304 FSRG--MFLDTILPSRDDNGIRPAIGQRTRLSKGDIAQARKLYRC 346

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5715	NP_651242.1	Astacin	104..295	CDD:279708	69/199 (35%)
CG5715	NP_651242.1	ZnMc_astacin_like	107..291	CDD:239807	64/188 (34%)
TLL1	NP_036596.3	ZnMc_BMP1_TLD	148..347	CDD:239808	71/203 (35%)
		Astacin	155..348	CDD:279708	68/196 (35%)
		CUB	349..458	CDD:278839
		CUB	462..571	CDD:278839
		FXa_inhibition	582..614	CDD:291342
		CUB	618..727	CDD:278839
		FXa_inhibition	734..769	CDD:291342
		CUB	774..883	CDD:278839
		CUB	887..1000	CDD:278839
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810