DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5715 and astl2c

DIOPT Version :9

Sequence 1:	NP_651242.1	Gene:	CG5715 / 42895	FlyBaseID:	FBgn0039180	Length:	295	Species:	Drosophila melanogaster
Sequence 2:	NP_001037864.1	Gene:	astl2c / 594901	XenbaseID:	XB-GENE-6449741	Length:	496	Species:	Xenopus tropicalis

Alignment Length:	296	Identity:	101/296 - (34%)
Similarity:	145/296 - (48%)	Gaps:	35/296 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 NNTGSLLLLIILGISLGDSMPLEDMDSQEMIDLTDLGDTLFGNPDVETTGALVEALGVESPLNPE 70
            ::|.|.:||..|.: ...|.|:     |.:....:..||...:.|.:..|.::.|       |..
Frog     2 SSTISFILLFGLFV-CATSFPI-----QIVFPHVEQNDTEVPDNDDDVFGRILRA-------NKG 53

  Fly    71 ELGTYHEGDILIPLSYRDARFNGTRNGILALSSRWP---GGV--VPYEIKGPFTSQELGNINHAF 130
            :...:.:|||....|         |:.|......||   .|:  |||.|...::..|...|..|.
Frog    54 KRNFHVQGDIAHKFS---------RSAINCKECLWPKDSNGIVNVPYTISSDYSQNEASLIMAAM 109

  Fly   131 KEYHTKTCVRFKPRTTEKDYISIGSGKSGCWSSIGRLGGRQEVNLQSPNCLRTYGTPIHELMHAL 195
            :|:.|.|||:|.|:|.|.|||:| ....||||.||..||.|:|:|....|: .||...|||.|.|
Frog   110 QEFATLTCVQFIPQTDEDDYIAI-QPLDGCWSYIGVNGGAQQVSLGKGGCI-YYGVIQHELNHVL 172

  Fly   196 GFFHEQNRHERDSYVRVMKDNIKPEMMVNFEKSSSRTQYGFGVEYDYGSVMHYSPTSFTR-NGQP 259
            ||.||.:|.:||:||.:....|.|:.:..|:|..:.   ..|:||||.|||||...|::. .|:.
Frog   173 GFVHEHSRSDRDNYVHINYQYISPDNIAFFDKKDTD---NLGLEYDYSSVMHYPGYSYSNTTGKN 234

  Fly   260 TLKALRATSDASQMGQRKGFSAGDVRKINAMYKCKV 295
            |:..:...:  ..:|||.|.|..||.|||.:|:|.|
Frog   235 TIVPIPNAN--VPIGQRYGLSTLDVSKINRLYQCDV 268

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5715	NP_651242.1	Astacin	104..295	CDD:279708	80/196 (41%)
CG5715	NP_651242.1	ZnMc_astacin_like	107..291	CDD:239807	76/186 (41%)
astl2c	NP_001037864.1	ZnMc_hatching_enzyme	84..266	CDD:239810	77/188 (41%)
		Astacin	89..266	CDD:279708	76/183 (42%)
		CUB	270..380	CDD:238001
		CUB	383..495	CDD:238001
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	160	1.000	Inparanoid score	I4140
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm9530
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.050