DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5715 and MEP1B

DIOPT Version :9

Sequence 1:	NP_651242.1	Gene:	CG5715 / 42895	FlyBaseID:	FBgn0039180	Length:	295	Species:	Drosophila melanogaster
Sequence 2:	NP_005916.2	Gene:	MEP1B / 4225	HGNCID:	7020	Length:	701	Species:	Homo sapiens

Alignment Length:	282	Identity:	99/282 - (35%)
Similarity:	140/282 - (49%)	Gaps:	42/282 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LLIILGISLGDSMPLEDMDSQEMIDLTDLGDTLFGNPDVETTGALVEALGVESPLNPEELGTYHE 77
            ||:|.|::..::..::....|::.|:.                   |.||::          ..|
Human    15 LLVISGLATPENFDVDGGMDQDIFDIN-------------------EGLGLD----------LFE 50

  Fly    78 GDILIPLSYRDARFNGTRNGILALSSRWPGGVVPYEIKGPFTSQELGNINHAFKEYHTKTCVRFK 142
            |||.:..:.       .||.|:....||| ..:||.::........|.|.:||:.|..|||:.||
Human    51 GDIRLDRAQ-------IRNSIIGEKYRWP-HTIPYVLEDSLEMNAKGVILNAFERYRLKTCIDFK 107

  Fly   143 PRTTEKDYISIGSGKSGCWSSIG-RLGGRQEVNLQSPNCLRTYGTPIHELMHALGFFHEQNRHER 206
            |...|.:|||:..| ||||||:| |..|:||::: ..||.| ..|..||.:|||||:|||:|.:|
Human   108 PWAGETNYISVFKG-SGCWSSVGNRRVGKQELSI-GANCDR-IATVQHEFLHALGFWHEQSRSDR 169

  Fly   207 DSYVRVMKDNIKPEMMVNFEKSSSRTQYGFGVEYDYGSVMHYSPTSFTRNGQPTLKALRATSDAS 271
            |.|||:|.|.|......||...|........|.|||.||||||.|:|....:||: ..|.:....
Human   170 DDYVRIMWDRILSGREHNFNTYSDDISDSLNVPYDYTSVMHYSKTAFQNGTEPTI-VTRISDFED 233

  Fly   272 QMGQRKGFSAGDVRKINAMYKC 293
            .:|||..||..|:.|:|.:|.|
Human   234 VIGQRMDFSDSDLLKLNQLYNC 255

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5715	NP_651242.1	Astacin	104..295	CDD:279708	83/191 (43%)
CG5715	NP_651242.1	ZnMc_astacin_like	107..291	CDD:239807	78/184 (42%)
MEP1B	NP_005916.2	ZnMc_meprin	26..255	CDD:239809	94/269 (35%)
		Astacin	69..257	CDD:279708	83/192 (43%)
		MAM	260..427	CDD:214533
		MAM	265..427	CDD:99706
		MATH	427..586	CDD:295307
		Required for proteolytic processing	595..607
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	146	1.000	Domainoid score	I4542
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S6346
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8634
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10127
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2664
SonicParanoid	1	1.000	-	-		X245
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.890