DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5715 and MEP1A

DIOPT Version :9

Sequence 1:	NP_651242.1	Gene:	CG5715 / 42895	FlyBaseID:	FBgn0039180	Length:	295	Species:	Drosophila melanogaster
Sequence 2:	XP_011512930.1	Gene:	MEP1A / 4224	HGNCID:	7015	Length:	774	Species:	Homo sapiens

Alignment Length:	221	Identity:	81/221 - (36%)
Similarity:	111/221 - (50%)	Gaps:	21/221 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 EGDILIPLSYRDARFNGTRNGILALSSRW--PGGVVPYEIKGPFTSQELGNINHAFKEYHTKTCV 139
            :||||:..|         |||:...::||  |   :||.:.........|.|.:||:.:..|:||
Human    84 QGDILLQKS---------RNGLRDPNTRWTFP---IPYILADNLGLNAKGAILYAFEMFRLKSCV 136

  Fly   140 RFKPRTTEKDYISIGSGKSGCWSSIGRLGGRQEVNLQSPNCLRTYGTPI-HELMHALGFFHEQNR 203
            .|||...|..|| |.....||||.:|.....|.::: ...|  .|...| ||::|||||:|||:|
Human   137 DFKPYEGESSYI-IFQQFDGCWSEVGDQHVGQNISI-GQGC--AYKAIIEHEILHALGFYHEQSR 197

  Fly   204 HERDSYVRVMKDNIKPEMMVNFEKSSSRTQYGFGVEYDYGSVMHYSPTSFTRNGQ-PTLKALRAT 267
            .:||.||.:..|.|......||:.............|||.|:|||.|.||.:|.. ||:.| :..
Human   198 TDRDDYVNIWWDQILSGYQHNFDTYDDSLITDLNTPYDYESLMHYQPFSFNKNASVPTITA-KIP 261

  Fly   268 SDASQMGQRKGFSAGDVRKINAMYKC 293
            ...|.:|||..|||.|:.::|.||.|
Human   262 EFNSIIGQRLDFSAIDLERLNRMYNC 287

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5715	NP_651242.1	Astacin	104..295	CDD:279708	73/194 (38%)
CG5715	NP_651242.1	ZnMc_astacin_like	107..291	CDD:239807	67/185 (36%)
MEP1A	XP_011512930.1	ZnMc_meprin	58..287	CDD:239809	80/219 (37%)
		Astacin	101..289	CDD:279708	73/195 (37%)
		MAM	292..459	CDD:214533
		MAM	297..459	CDD:99706
		MATH_Meprin_Alpha	459..622	CDD:239752
		EGF_CA	700..738	CDD:238011
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	146	1.000	Domainoid score	I4542
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8634
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10127
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X245
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.910