DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5715 and Astl

DIOPT Version :9

Sequence 1:	NP_651242.1	Gene:	CG5715 / 42895	FlyBaseID:	FBgn0039180	Length:	295	Species:	Drosophila melanogaster
Sequence 2:	NP_001099974.1	Gene:	Astl / 296129	RGDID:	1562279	Length:	436	Species:	Rattus norvegicus

Alignment Length:	302	Identity:	96/302 - (31%)
Similarity:	144/302 - (47%)	Gaps:	51/302 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LLLLIILGISLG------------DSMPLEDMDSQEMIDLTDLGDTLFGNPDVETTGALVEALGV 63
            |.||.:.|:.||            .|:|         ...|..|..:..:.|:.....     |:
  Rat    12 LTLLSLTGLILGAPSASRCSGVCSTSVP---------EGFTPEGSRVSQDKDIPAINQ-----GL 62

  Fly    64 ESPLNPEELGTYHEGDILIPLSYRDARFNGTRNGILAL-SSRWPGGV-----VPYEIKGPFTSQE 122
            .|...||. ....||||:.|..:|          :|:: :::||.||     :|:.:...:....
  Rat    63 ISEETPES-SFLVEGDIIRPSPFR----------LLSVTNNKWPKGVDGIVEIPFLLSSKYDEPS 116

  Fly   123 LGNINHAFKEYHTKTCVRFKPRTTEKDYISIGSGKSGCWSSIGRLGGRQEVNLQSPNCL-RTYGT 186
            ...|..||.|:...||:||.....::|::|| ...:||:|.:||.||.|.|:| :|.|| :..|.
  Rat   117 RQVIMEAFAEFERFTCIRFVAYRGQRDFVSI-LPMAGCFSGVGRSGGMQVVSL-APTCLQKGRGI 179

  Fly   187 PIHELMHALGFFHEQNRHERDSYVRVMKDNIKPEMMVNFEKSSSRTQYGFGVEYDYGSVMHYSPT 251
            .:|||||.|||:||.:|.:||.|:||..:.|.|...:||.||.:....   ..|||.|||||...
  Rat   180 VLHELMHVLGFWHEHSRADRDRYIRVNWNEILPGFEINFIKSRNSNML---APYDYSSVMHYGRF 241

  Fly   252 SFTRNGQPTLKALRATSDASQMGQRKGFSAGDVRKINAMYKC 293
            :|:..||||:..|..:|  ..:|||...|..|:.::..:|.|
  Rat   242 AFSWRGQPTIIPLWTSS--VHIGQRWNLSTSDITRVCRLYSC 281

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5715	NP_651242.1	Astacin	104..295	CDD:279708	74/196 (38%)
CG5715	NP_651242.1	ZnMc_astacin_like	107..291	CDD:239807	70/189 (37%)
Astl	NP_001099974.1	Astacin	92..283	CDD:279708	74/197 (38%)
		ZnMc	99..281	CDD:294052	69/188 (37%)
		ImpA_N	<305..420	CDD:303075
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353350
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H128191
Inparanoid	1	1.050	150	1.000	Inparanoid score	I4289
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D472790at33208
OrthoFinder	1	1.000	-	-		FOG0000240
OrthoInspector	1	1.000	-	-		otm46226
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10127
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X245
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.900