DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5715 and Astl

DIOPT Version :9

Sequence 1:	NP_651242.1	Gene:	CG5715 / 42895	FlyBaseID:	FBgn0039180	Length:	295	Species:	Drosophila melanogaster
Sequence 2:	NP_001277932.1	Gene:	Astl / 215095	MGIID:	3046414	Length:	435	Species:	Mus musculus

Alignment Length:	302	Identity:	99/302 - (32%)
Similarity:	148/302 - (49%)	Gaps:	51/302 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LLLLIILGISLG------------DSMPLEDMDSQEMIDLTDLGDTLFGNPDVETTGALVEALGV 63
            |.:|.:||:|:|            .|:|         ...|..|..:|.:.|:.....     |:
Mouse    12 LTMLSLLGLSMGAPSASRCSGVCSTSVP---------EGFTPEGSPVFQDKDIPAINQ-----GL 62

  Fly    64 ESPLNPEELGTYHEGDILIPLSYRDARFNGTRNGILAL-SSRWPGGV-----VPYEIKGPFTSQE 122
            .|...||. ....||||:.|..:|          :|:: :::||.||     :|:.:...:....
Mouse    63 ISEETPES-SFLVEGDIIRPSPFR----------LLSVTNNKWPKGVGGFVEIPFLLSRKYDELS 116

  Fly   123 LGNINHAFKEYHTKTCVRFKPRTTEKDYISIGSGKSGCWSSIGRLGGRQEVNLQSPNCLRT-YGT 186
            ...|..||.|:...||:||.....::|::|| ...:||:|.:||.||.|.|:| :|.|||. .|.
Mouse   117 RRVIMDAFAEFERFTCIRFVAYHGQRDFVSI-LPMAGCFSGVGRSGGMQVVSL-APTCLRKGRGI 179

  Fly   187 PIHELMHALGFFHEQNRHERDSYVRVMKDNIKPEMMVNFEKSSSRTQYGFGVEYDYGSVMHYSPT 251
            .:|||||.|||:||.:|.:||.|::|..:.|.|...:||.||.|....   |.|||.|||||...
Mouse   180 VLHELMHVLGFWHEHSRADRDRYIQVNWNEILPGFEINFIKSRSTNML---VPYDYSSVMHYGRF 241

  Fly   252 SFTRNGQPTLKALRATSDASQMGQRKGFSAGDVRKINAMYKC 293
            :|:..||||:..|..:|  ..:|||...|..|:.::..:|.|
Mouse   242 AFSWRGQPTIIPLWTSS--VHIGQRWNLSTSDITRVCRLYNC 281

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5715	NP_651242.1	Astacin	104..295	CDD:279708	76/196 (39%)
CG5715	NP_651242.1	ZnMc_astacin_like	107..291	CDD:239807	72/189 (38%)
Astl	NP_001277932.1	Astacin	92..282	CDD:279708	76/197 (39%)
		ZnMc	100..281	CDD:294052	71/187 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	318..356
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849691
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H128191
Inparanoid	1	1.050	152	1.000	Inparanoid score	I4329
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000240
OrthoInspector	1	1.000	-	-		otm44135
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10127
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2664
SonicParanoid	1	1.000	-	-		X245
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.920