DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5715 and nas-7

DIOPT Version :9

Sequence 1:	NP_651242.1	Gene:	CG5715 / 42895	FlyBaseID:	FBgn0039180	Length:	295	Species:	Drosophila melanogaster
Sequence 2:	NP_495552.2	Gene:	nas-7 / 182368	WormBaseID:	WBGene00003526	Length:	382	Species:	Caenorhabditis elegans

Alignment Length:	291	Identity:	100/291 - (34%)
Similarity:	154/291 - (52%)	Gaps:	29/291 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LLLLIILGISLGDSMPLEDMDSQEMIDLTDLGDTLFGNPDVETTGALV--EALGVESPLNPEELG 73
            :.::.::..:||....::|   .||:.::|..|:| ...|.|....|.  |..|...|:   |:.
Worm     7 ITIVTVIPATLGHRNRVQD---DEMLVISDSTDSL-NLEDFEFADKLTREELFGKHIPV---EVV 64

  Fly    74 TYHEGDILIPLSYRDARFNGTRNGILALSSRWPGGVVPYEIKGPFTSQELGNINHAFKEYHTKTC 138
            ...:.||.:|..::       |||:...:..||...:||.|...::..|...:..|.|:||.|||
Worm    65 NDFKSDIRLPRRHK-------RNGVSRAAKLWPNARIPYAISPHYSPHERALLAKAVKQYHEKTC 122

  Fly   139 VRFKPRTT-EKDYISIGSGKSGCWSSIGRLGGRQEVNLQSPNCLRTYGTPIHELMHALGFFHEQN 202
            :||.||.| |.||:.||. ..||:|.:||..|.|.::|.: .|:. |.|.|||:||.:||:||..
Worm   123 IRFVPRQTGEPDYLFIGK-VDGCFSEVGRTSGVQVLSLDN-GCME-YATIIHEMMHVVGFYHEHE 184

  Fly   203 RHERDSYVRVMKDNIKPEMMVNFEK-SSSRTQYGFGVEYDYGSVMHYSPTSFTRNGQPTL--KAL 264
            |.:||:::.::..||....:..|.| ..|:|.| :|..|||.|::||...:|::||.||:  |..
Worm   185 RWDRDNFIDIIWQNIDRGALDQFGKVDLSKTSY-YGQPYDYKSILHYDSLAFSKNGFPTMLPKVK 248

  Fly   265 RATSDASQMGQRKGFSAGDVRKINAMYKCKV 295
            .||     :|..:.||..|:.|||.||.|.|
Worm   249 SAT-----IGNARDFSDVDISKINRMYNCPV 274

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5715	NP_651242.1	Astacin	104..295	CDD:279708	78/194 (40%)
CG5715	NP_651242.1	ZnMc_astacin_like	107..291	CDD:239807	73/187 (39%)
nas-7	NP_495552.2	Astacin	87..274	CDD:279708	78/195 (40%)
		ZnMc_astacin_like	91..270	CDD:239807	73/187 (39%)
		ShK	347..382	CDD:279838
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	170	1.000	Domainoid score	I2268
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D472790at33208
OrthoFinder	1	1.000	-	-		FOG0000240
OrthoInspector	1	1.000	-	-		mtm4854
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10127
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X245
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.920