DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5715 and astl2a

DIOPT Version :9

Sequence 1:	NP_651242.1	Gene:	CG5715 / 42895	FlyBaseID:	FBgn0039180	Length:	295	Species:	Drosophila melanogaster
Sequence 2:	XP_002934118.2	Gene:	astl2a / 100492493	XenbaseID:	XB-GENE-5966804	Length:	492	Species:	Xenopus tropicalis

Alignment Length:	293	Identity:	107/293 - (36%)
Similarity:	154/293 - (52%)	Gaps:	39/293 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 GSLLLLIILGISLGDSMPL-EDMDSQEMIDLTDL-GDTLFGNPDVETTGALVEALGVESPLNPEE 71
            |:.:.::||...||.::|. ..:.|...|:.|:: |:.:|.  .:..|             |...
Frog     2 GTHIRVVILSQLLGLALPSPTQILSNSTINATNMNGNDIFS--QILRT-------------NQGH 51

  Fly    72 LGTYHEGDILIPLSYRDARFNGTRNGILALSSRWP----GGV-VPYEIKGPFTSQELGNINHAFK 131
            .|.:::|||    ..|..|.:||....|     ||    |.| |||.|...:...::.:|..|..
Frog    52 GGLHYQGDI----DVRVERSDGTCKDCL-----WPKSQNGSVLVPYRISADYGVSDIESITDAML 107

  Fly   132 EYHTKTCVRFKPRTTEKDYISIGSGKSGCWSSIGRLGGRQEVNLQSPNCLRTYGTPIHELMHALG 196
            |:.|.|||||.||:.|:|::.|.| ::||:||.|||||.|.|:|..|:|:. :|...|||.|.||
Frog   108 EFSTLTCVRFVPRSAERDHVIIRS-ENGCFSSKGRLGGAQTVSLLKPDCVE-FGIIQHELNHVLG 170

  Fly   197 FFHEQNRHERDSYVRVMKDNIKPEMMVNFEKSSSRTQYGFGVEYDYGSVMHYSPTSFTR-NGQPT 260
            ..||.:|.:||.|:.|::.||..|...:|||..|..   .|:||||.|||||...:|:. .|..|
Frog   171 LAHENSRMDRDEYITVIETNIPAEFHRDFEKPESDI---VGMEYDYNSVMHYGSGAFSNTGGMST 232

  Fly   261 LKALRATSDASQMGQRKGFSAGDVRKINAMYKC 293
            |...|  :..:|:||..|.|..||.|||.:|:|
Frog   233 LVPKR--NPNAQLGQLYGLSNLDVSKINRLYEC 263

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5715	NP_651242.1	Astacin	104..295	CDD:279708	85/196 (43%)
CG5715	NP_651242.1	ZnMc_astacin_like	107..291	CDD:239807	81/185 (44%)
astl2a	XP_002934118.2	ZnMc	81..263	CDD:412141	82/188 (44%)
		CUB	267..377	CDD:238001
		CUB	380..491	CDD:238001
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	166	1.000	Domainoid score	I3822
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	160	1.000	Inparanoid score	I4140
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D681837at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm9530
Panther	1	1.100	-	-	O	PTHR10127
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.070