DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Uck and UCK1

DIOPT Version :9

Sequence 1:	NP_001138105.1	Gene:	Uck / 42894	FlyBaseID:	FBgn0263398	Length:	305	Species:	Drosophila melanogaster
Sequence 2:	XP_005272281.1	Gene:	UCK1 / 83549	HGNCID:	14859	Length:	291	Species:	Homo sapiens

Alignment Length:	239	Identity:	149/239 - (62%)
Similarity:	181/239 - (75%)	Gaps:	20/239 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 PFLIGVAGGTASGK--------------STVCKKIMEQLGQAEMDHTQRQVVSISQDSFYRELTP 77
            ||||||:|||||||              ||||:||||.|||.|::..||:||.:|||.||:.||.
Human    23 PFLIGVSGGTASGKDERFQAGIPLLCLQSTVCEKIMELLGQNEVEQRQRKVVILSQDRFYKVLTA 87

  Fly    78 AEKAKAQKGLFNFDHPDAFNEELMYSTLQNILKGHKVEIPSYDYRTNSLDFENVLVIYPADVVLF 142
            .:||||.||.:||||||||:.:||:.||:||::|..||:|:||:.|:| ......|:||||||||
Human    88 EQKAKALKGQYNFDHPDAFDNDLMHRTLKNIVEGKTVEVPTYDFVTHS-RLPETTVVYPADVVLF 151

  Fly   143 EGILVFYFPKIRELFHMKLFVDTDSDTRLARRVPRDINERGRDLDAVLTQYMTFVKPAFEEFCSP 207
            |||||||..:||::||::||||||||.||:|||.||: .|||||:.:||||.|||||||||||.|
Human   152 EGILVFYSQEIRDMFHLRLFVDTDSDVRLSRRVLRDV-RRGRDLEQILTQYTTFVKPAFEEFCLP 215

  Fly   208 TKKFADVIIPRGADNTVAIDLIVQHIRDFLNNR----SRHGSTG 247
            |||:||||||||.||.|||:||||||:|.||..    .|.||.|
Human   216 TKKYADVIIPRGVDNMVAINLIVQHIQDILNGDICKWHRGGSNG 259

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Uck	NP_001138105.1	UMPK	29..235	CDD:238981	140/219 (64%)
UCK1	XP_005272281.1	Udk	22..246	CDD:223645	143/224 (64%)
UCK1	XP_005272281.1	UMPK	25..244	CDD:238981	140/220 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145815
Domainoid	1	1.000	269	1.000	Domainoid score	I1858
eggNOG	1	0.900	-	-		E1_COG0572
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	291	1.000	Inparanoid score	I2801
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG61683
OrthoDB	1	1.010	-	-		D509086at33208
OrthoFinder	1	1.000	-	-		FOG0002695
OrthoInspector	1	1.000	-	-		otm41030
orthoMCL	1	0.900	-	-		OOG6_100147
Panther	1	1.100	-	-	LDO	PTHR10285
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1606
SonicParanoid	1	1.000	-	-		X2455
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800