DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Uck and UCK2

DIOPT Version :9

Sequence 1:	NP_001138105.1	Gene:	Uck / 42894	FlyBaseID:	FBgn0263398	Length:	305	Species:	Drosophila melanogaster
Sequence 2:	NP_036606.2	Gene:	UCK2 / 7371	HGNCID:	12562	Length:	261	Species:	Homo sapiens

Alignment Length:	237	Identity:	152/237 - (64%)
Similarity:	186/237 - (78%)	Gaps:	13/237 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 QDLRNADTLRLPNGDGAAANDEVKSPFLIGVAGGTASGKSTVCKKIMEQLGQAEMDHTQRQVVSI 66
            |.|:|.   :.|||.         .||||||:||||||||:||.||::.|||.|:|:.|:|||.:
Human     7 QTLQNH---QQPNGG---------EPFLIGVSGGTASGKSSVCAKIVQLLGQNEVDYRQKQVVIL 59

  Fly    67 SQDSFYRELTPAEKAKAQKGLFNFDHPDAFNEELMYSTLQNILKGHKVEIPSYDYRTNSLDFENV 131
            |||||||.||..:||||.||.|||||||||:.||:..||:.|.:|..|:||.||:.::|.. |..
Human    60 SQDSFYRVLTSEQKAKALKGQFNFDHPDAFDNELILKTLKEITEGKTVQIPVYDFVSHSRK-EET 123

  Fly   132 LVIYPADVVLFEGILVFYFPKIRELFHMKLFVDTDSDTRLARRVPRDINERGRDLDAVLTQYMTF 196
            :.:||||||||||||.||..::|:||.||||||||:||||:|||.|||:||||||:.:|:||:||
Human   124 VTVYPADVVLFEGILAFYSQEVRDLFQMKLFVDTDADTRLSRRVLRDISERGRDLEQILSQYITF 188

  Fly   197 VKPAFEEFCSPTKKFADVIIPRGADNTVAIDLIVQHIRDFLN 238
            |||||||||.||||:|||||||||||.|||:||||||:|.||
Human   189 VKPAFEEFCLPTKKYADVIIPRGADNLVAINLIVQHIQDILN 230

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Uck	NP_001138105.1	UMPK	29..235	CDD:238981	141/205 (69%)
UCK2	NP_036606.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24		9/28 (32%)
		UMPK	22..228	CDD:238981	141/206 (68%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	236..261
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145816
Domainoid	1	1.000	269	1.000	Domainoid score	I1858
eggNOG	1	0.900	-	-		E1_COG0572
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H40850
Inparanoid	1	1.050	291	1.000	Inparanoid score	I2801
Isobase	1	0.950	-	0	Normalized mean entropy	S1209
OMA	1	1.010	-	-		QHG61683
OrthoDB	1	1.010	-	-		D509086at33208
OrthoFinder	1	1.000	-	-		FOG0002695
OrthoInspector	1	1.000	-	-		otm41030
orthoMCL	1	0.900	-	-		OOG6_100147
Panther	1	1.100	-	-	O	PTHR10285
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1606
SonicParanoid	1	1.000	-	-		X2455
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750