DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Uck and CTNNB1

DIOPT Version :9

Sequence 1:	NP_001138105.1	Gene:	Uck / 42894	FlyBaseID:	FBgn0263398	Length:	305	Species:	Drosophila melanogaster
Sequence 2:	NP_001091679.1	Gene:	CTNNB1 / 1499	HGNCID:	2514	Length:	781	Species:	Homo sapiens

Alignment Length:	238	Identity:	50/238 - (21%)
Similarity:	86/238 - (36%)	Gaps:	69/238 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 KIMEQLGQAEMDHTQRQVVSISQDSFYRELTPAEKAKAQKGLFNFDHPDAFNE------------ 98
            ::::.|.:|..|..:|..:..:|..|...:...|..:...|..:....|..|.
Human   535 RLVQLLVRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLF 599

  Fly    99 -ELMYSTLQNILK---GHKVEIPSYDYRTNSLDFENVLVIYPADVVLFEGILVFYFPKIRELFHM 159
             :|:||.::||.:   |...|:        :.|.|      .|:.:..||...    .:.||.|.
Human   600 VQLLYSPIENIQRVAAGVLCEL--------AQDKE------AAEAIEAEGATA----PLTELLHS 646

  Fly   160 K-----------LFVDTDSDTRLARRVPRDINERGRDLDAVLTQYMTFVKP-AFEEFCSPTKKFA 212
            :           ||       |::...|:|..:|   |...||..:...:| |:.|       .|
Human   647 RNEGVATYAAAVLF-------RMSEDKPQDYKKR---LSVELTSSLFRTEPMAWNE-------TA 694

  Fly   213 DVIIPRGADNTVAIDLIVQHIRDFLNNRSRH-GSTGNMALYMN 254
            |:.:..||....     :.:.:|..:.||.| |..|..||.|:
Human   695 DLGLDIGAQGEP-----LGYRQDDPSYRSFHSGGYGQDALGMD 732

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Uck	NP_001138105.1	UMPK	29..235	CDD:238981	41/216 (19%)
CTNNB1	NP_001091679.1	Interaction with VCL. /evidence=ECO:0000250	2..23
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	34..57
		SRP1	142..>431	CDD:227396
		ARM 1	151..191
		armadillo repeat	153..178	CDD:293788
		Interaction with BCL9. /evidence=ECO:0000269\|PubMed:17052462	156..178
		armadillo repeat	188..221	CDD:293788
		ARM 2	193..234
		armadillo repeat	230..262	CDD:293788
		ARM	230..262	CDD:214547
		ARM 3	235..276
		armadillo repeat	270..306	CDD:293788
		ARM 4	277..318
		armadillo repeat	312..347	CDD:293788
		ARM 5	319..360
		ARM	350..390	CDD:214547
		armadillo repeat	354..389	CDD:293788
		ARM 6	361..389
		ARM 7	400..441
		armadillo repeat	402..427	CDD:293788
		Arm	431..473	CDD:395413
		armadillo repeat	435..473	CDD:293788
		ARM 8	442..484
		armadillo repeat	482..517	CDD:293788
		ARM 9	489..530
		armadillo repeat	524..582	CDD:293788	8/46 (17%)
		ARM 10	531..571		7/35 (20%)
		Arm	583..622	CDD:395413	9/46 (20%)
		armadillo repeat	587..621	CDD:293788	6/33 (18%)
		ARM 11	594..636		11/55 (20%)
		armadillo repeat	629..662	CDD:293788	7/43 (16%)
		ARM 12	637..666		6/39 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	705..781		9/33 (27%)
		Interaction with SCRIB. /evidence=ECO:0000250	772..781
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0572
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900