DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Uck and UPRT

DIOPT Version :9

Sequence 1:	NP_001138105.1	Gene:	Uck / 42894	FlyBaseID:	FBgn0263398	Length:	305	Species:	Drosophila melanogaster
Sequence 2:	NP_659489.1	Gene:	UPRT / 139596	HGNCID:	28334	Length:	309	Species:	Homo sapiens

Alignment Length:	306	Identity:	55/306 - (17%)
Similarity:	102/306 - (33%)	Gaps:	128/306 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 GAAANDEVKSPFLIGVAGGTASGKST---------------VCKKIMEQLGQAEMDHTQRQVVSI 66
            |::.|.|          |.:.||.|:               :.::|..||....|:...|::.:|
Human    71 GSSLNSE----------GNSGSGDSSSYDAPAGNSFLEDCELSRQIGAQLKLLPMNDQIRELQTI 125

  Fly    67 SQDSFYRELTPAEKAKAQKGLFNFDHPDAFNEELMYSTLQNILKGHKVEIPSYDYRTNSLDFENV 131
            .:|.           .|.:|.|.|.     .:.|:...::..|              |.|.::..
Human   126 IRDK-----------TASRGDFMFS-----ADRLIRLVVEEGL--------------NQLPYKEC 160

  Fly   132 LVIYPA----DVVLFE----GILVFYFPK---------IRELFHMKLFVDTDSDTRLAR----RV 175
            :|..|.    :.|.||    |:.:....:         .|.:...|:.:.:|.:|:.|:    :.
Human   161 MVTTPTGYKYEGVKFEKGNCGVSIMRSGEAMEQGLRDCCRSIRIGKILIQSDEETQRAKVYYAKF 225

  Fly   176 PRDINERGRDLDAVLTQYMTFVKPAFEEFCSPTKKFADVIIPRGADNTV--AIDLIVQHIRDFLN 238
            |.||..|     .||..|                    .|:..|  |||  |:.::::
Human   226 PPDIYRR-----KVLLMY--------------------PILSTG--NTVIEAVKVLIE------- 256

  Fly   239 NRSRHGSTGNMALYMNLDLNATGAGFAGPDGSNLGTYNAIRRFSTI 284
                ||...::.:.::|        |:.|.|:.    :.|:.|..|
Human   257 ----HGVQPSVIILLSL--------FSTPHGAK----SIIQEFPEI 286

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Uck	NP_001138105.1	UMPK	29..235	CDD:238981	43/243 (18%)
UPRT	NP_659489.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..38
		UPRTase	118..308	CDD:317125	44/249 (18%)
		5-phospho-alpha-D-ribose 1-diphosphate binding. /evidence=ECO:0000250\|UniProtKB:Q26998	238..246		3/29 (10%)
		Uracil binding. /evidence=ECO:0000250\|UniProtKB:Q26998	299..301
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D929897at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100147
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1606
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.850