DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6356 and SLC22A14

DIOPT Version :9

Sequence 1:	NP_651240.1	Gene:	CG6356 / 42893	FlyBaseID:	FBgn0039178	Length:	570	Species:	Drosophila melanogaster
Sequence 2:	XP_006713479.2	Gene:	SLC22A14 / 9389	HGNCID:	8495	Length:	675	Species:	Homo sapiens

Alignment Length:	578	Identity:	133/578 - (23%)
Similarity:	236/578 - (40%)	Gaps:	92/578 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 DLLTKQLEVVGSGGAFVWAIFFLCVTPNILNGFHV--SSYTLLGHLPDDQWCGIPELQDTNW--- 81
            |.....|:.||..|.|...:..|...|:|::.|.:  ..:......|   :|      :|:|
Human   131 DKFANLLDAVGEFGTFQQRLVALTFIPSIMSAFFMFADHFVFTAQKP---YC------NTSWILA 186

  Fly    82 --THAQKRE---IVAKGLDSGG---CTVW---DWNYGHLAKMSYEAALNYTGHLTQISPPAEVSC 135
              .|..|.|   :......:|.   |.::   .||...:.:.    .||.|.           :|
Human   187 VGPHLSKAEQLNLTIPQAPNGSFLTCFMYLPVPWNLDSIIQF----GLNDTD-----------TC 236

  Fly   136 RVKGQHEFAHPET---TFVADWDLTCDRSIQRTSAQVSISLGKFCGSFSFGILADKFGRKSSFTL 197
                |..:.:|:.   :.:.::||.|....::.:||:....|...||..|.::.||.||..:..|
Human   237 ----QDGWIYPDAKKRSLINEFDLVCGMETKKDTAQIMFMAGLPIGSLIFRLITDKMGRYPAILL 297

  Fly   198 GAAFFIVGSFFCTFSPWYSLFLAGRFALGAASSGLFYPAFTMIVENICLKHRSWMSIAFSASYPV 262
            .....|:..|...|...:.|:|..||.:..:..|....:.::..|.:..:||:...|.....:.|
Human   298 SLLGLIIFGFGTAFMNSFHLYLFFRFGISQSVVGYAISSISLATEWLVGEHRAHAIILGHCFFAV 362

  Fly   263 GMIILAIVGYVIQPWRHLQLA---LTIPSLLLILNCYLMSESPRWLITNQRYDRVYKILFRQPSH 324
            |.::|..:.|.:..|:.|.|.   |.||.:..|   :::.||||||:...:.....::|
Human   363 GAVLLTGIAYSLPHWQLLFLVGGILVIPFISYI---WILPESPRWLMMKGKVKEAKQVL------ 418

  Fly   325 YQIQPAVAAPSQVASDKKSLEPEEGFSFGQKLKNGPLKSIIELYANSKVRRMIFASYFMFCV--- 386
                 ..||    :.:||::............|.....|:::...|   |::...:..|.||
Human   419 -----CYAA----SVNKKTIPSNLLDELQLPRKKVTRASVLDFCKN---RQLCKVTLVMSCVWFT 471

  Fly   387 TSLSYYVTALNAANLSVSRYLYIIGTGLVDIPSYLVPVIMLRFTGRRLTTMFLFLWTGVSLLLVL 451
            .|.:|:..:|....|.||.:...:...::::|:.|..:.:|:..||:.:.....|...:..||:|
Human   472 VSYTYFTLSLRMRELGVSVHFRHVVPSIMEVPARLCCIFLLQQIGRKWSLAVTLLQAIIWCLLLL 536

  Fly   452 AVPAGS----TTW-----------IVAFAMLGRFGISATYSVVTLYTAELYPTQIRNSALGTCST 501
            .:|.|.    ..|           .:...||..|.::||.:|..||||||.||.:|.:.||..|.
Human   537 FLPEGEDGLRLKWPRCPATELKSMTILVLMLREFSLAATVTVFFLYTAELLPTVLRATGLGLVSL 601

  Fly   502 FAHVGSISAPYVVDVLGALGWYIPTTICGCCVLVAGLLTLTLPETGTGKLSDKVESSA 559
            .:..|:|.:..::....:|   :|..:|....:||..|:..||||....||:.:..|:
Human   602 ASVAGAILSLTIISQTPSL---LPIFLCCVLAIVAFSLSSLLPETRDQPLSESLNHSS 656

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6356	NP_651240.1	MFS	167..544	CDD:119392	96/397 (24%)
SLC22A14	XP_006713479.2	2A0119	141..650	CDD:273328	128/560 (23%)
SLC22A14	XP_006713479.2	MFS	270..641	CDD:119392	94/394 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153689
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	7	6.910