DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6356 and SLC22A6

DIOPT Version :9

Sequence 1:	NP_651240.1	Gene:	CG6356 / 42893	FlyBaseID:	FBgn0039178	Length:	570	Species:	Drosophila melanogaster
Sequence 2:	NP_004781.2	Gene:	SLC22A6 / 9356	HGNCID:	10970	Length:	563	Species:	Homo sapiens

Alignment Length:	564	Identity:	153/564 - (27%)
Similarity:	233/564 - (41%)	Gaps:	69/564 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 LEVVGSGGAFVWAIFFLCVTPNILNGFHVSSYTLLGHLPDDQWCGIPELQDTNWTHAQKREIVAK 92
            |:.||..|.|......|.|.|.:|...|.:.......:|               ||..:....|.
Human     7 LQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIP---------------THHCRPPADAN 56

  Fly    93 GLDSGGCTVW------------------DWNYGHLAKMSYEAALNYTGHLTQISPPAEVSCRVKG 139
            ...:||..||                  .|....|  ...||  |.||        |...|....
Human    57 LSKNGGLEVWLPRDRQGQPESCLRFTSPQWGLPFL--NGTEA--NGTG--------ATEPCTDGW 109

  Fly   140 QHEFAHPETTFVADWDLTCDRSIQRTSAQVSISLGKFCGSFSFGILADKFGRKSSFTLGAAFFIV 204
            .::.:...:|.|.:|||.|.....|..||....:|...|:..||.|||:.||:....|......|
Human   110 IYDNSTFPSTIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAV 174

  Fly   205 GSFFCTFSPWYSLFLAGRFALGAASSGLFYPAFTMIVENICLKHRSWMSIAFSASYPVGMIILAI 269
            ......|:|.:.::.|.|...|.|.:|:.....|:.||.:.:..|:.:.......|.:|..:||.
Human   175 SGTCAAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYVYSLGQFLLAG 239

  Fly   270 VGYVIQPWRHLQLALTIPSLLLILNCYLMSESPRWLITNQRYD-------RVYKILFRQPSHYQI 327
            |.|.:..||||||.::.|.....:..:...||.||..::.|.|       ||.:|..::....::
Human   240 VAYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVARINGKREEGAKL 304

  Fly   328 QPAVAAPSQVASDKKSLEPEEGFSFGQKLKNGPLKSIIELYANSKVRRMIFASYFMFCVTSLSYY 392
            ...|.        :.||:.|.....||       .|.:||.....:|.:......::..||.:||
Human   305 SMEVL--------RASLQKELTMGKGQ-------ASAMELLRCPTLRHLFLCLSMLWFATSFAYY 354

  Fly   393 VTALNAANLSVSRYLYIIGTGLVDIPSYLVPVIMLRFTGRRLTTMFLFLWTGVSLLLVLAVPAGS 457
            ...::.....||.||..:..|.||:|:.||..:::...|||...|...|..|:.:||...:|...
Human   355 GLVMDLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGICILLNGVIPQDQ 419

  Fly   458 TTWIVAFAMLGRFGISATYSVVTLYTAELYPTQIRNSALGTCSTFAHVGSISAPYVVDVLGALGW 522
            :....:.|:||:..::|:::.:.|||.|||||.||.:.:|..||.|.||||.:| :|.:...|..
Human   420 SIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRQTGMGMGSTMARVGSIVSP-LVSMTAELYP 483

  Fly   523 YIPTTICGCCVLVAGLLTLTLPETGTGKLSDKVESSASS-TPTE 565
            .:|..|.|...:.|..:|:.||||....|.|.|:...|. .||:
Human   484 SMPLFIYGAVPVAASAVTVLLPETLGQPLPDTVQDLESRWAPTQ 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6356	NP_651240.1	MFS	167..544	CDD:119392	109/383 (28%)
SLC22A6	NP_004781.2	2A0119	11..515	CDD:273328	146/546 (27%)
		MFS	135..505	CDD:119392	109/385 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	525..563		2/3 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153686
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.950