DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6356 and Slc22a8

DIOPT Version :9

Sequence 1:	NP_651240.1	Gene:	CG6356 / 42893	FlyBaseID:	FBgn0039178	Length:	570	Species:	Drosophila melanogaster
Sequence 2:	NP_112622.1	Gene:	Slc22a8 / 83500	RGDID:	632286	Length:	536	Species:	Rattus norvegicus

Alignment Length:	410	Identity:	124/410 - (30%)
Similarity:	196/410 - (47%)	Gaps:	13/410 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   149 TFVADWDLTCDRSIQRTSAQVSISLGKFCGSFSFGILADKFGRKSSFTLGAAFFIVGSFFCTFSP 213
            |.|.:|||.|..:..:..||.....|...|....|.|:|:||||...|..............|||
  Rat   107 TIVIEWDLVCSSNKLKEMAQSIFMAGILVGGPVIGELSDRFGRKPILTWSYLMLAASGSGAAFSP 171

  Fly   214 WYSLFLAGRFALGAASSGLFYPAFTMIVENICLKHRSWMSIAFSASYPVGMIILAIVGYVIQPWR 278
            ...:::..||..|.:.||:......:.||.:....|:..|.:....|.:|..||:.:.|.|..||
  Rat   172 SLPVYMIFRFLCGCSISGISLSTVILNVEWVPTSMRAISSTSIGYCYTIGQFILSGLAYAIPQWR 236

  Fly   279 HLQLALTIPSLLLILNCYLMSESPRWLITNQRYDRVYKILFRQPSHYQIQPAVAAPSQVASDKKS 343
            .|||..:.|..:..|..:.:.||.|||:.:.:|.:..|.|.|          ||..:....:.|.
  Rat   237 WLQLTSSAPFFIFSLLSWWVPESIRWLVLSGKYSKALKTLQR----------VATFNGKKEEGKK 291

  Fly   344 LEPEE-GFSFGQKLKNGPLK-SIIELYANSKVRRMIFASYFMFCVTSLSYYVTALNAANLSVSRY 406
            |..|| .|:..:.:.:..:| .:.:|:..|.:||:.|.....:..|..:||..|:......|:.|
  Rat   292 LTIEELKFNLQKDITSAKVKYGLSDLFRVSILRRVTFCLSLAWFSTGFAYYSLAMGVEEFGVNIY 356

  Fly   407 LYIIGTGLVDIPSYLVPVIMLRFTGRRLTTMFLFLWTGVSLLLVLAVPAGSTTWIVAFAMLGRFG 471
            :..|..|.||||:..:.::.|.:.|||:|..||.|..|.::|.::.||:.......|.|:.|:..
  Rat   357 ILQIIFGGVDIPAKFITILSLSYLGRRITQSFLLLLAGGAILALIFVPSEMQLLRTALAVFGKGC 421

  Fly   472 ISATYSVVTLYTAELYPTQIRNSALGTCSTFAHVGSISAPYVVDVLGALGWYIPTTICGCCVLVA 536
            :|.::|.:.|||:|||||.:|.:.:|..:.:|.|||:.|| :|.:.|.|..:||..|.|...|:.
  Rat   422 LSGSFSCLFLYTSELYPTVLRQTGMGISNVWARVGSMIAP-LVKITGELQPFIPNVIFGTTALLG 485

  Fly   537 GLLTLTLPETGTGKLSDKVE 556
            |.....|.||....|.:.:|
  Rat   486 GSAAFFLLETLNRPLPETIE 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6356	NP_651240.1	MFS	167..544	CDD:119392	113/378 (30%)
Slc22a8	NP_112622.1	2A0119	11..503	CDD:273328	123/406 (30%)
		MFS	124..492	CDD:119392	113/378 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	515..536
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347270
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.950